Late in the game, when Travis tells Constance that Kaylee is dead, her initial reaction is disbelief, saying that there isn't anything that could kill Kaylee in "her condition." While that's borne out by what we see Laura survive after infection, we also know from Chapter 7 that the Hacketts only have a very slight handle on what the werewolf infection does and doesn't do. Combined with Kaylee's letter, which Ryan can find in Chapter 8, it suggests that Constance knows how hard it is to kill Kaylee from experience... because Kaylee may have tried to kill herself.
In Episode 7, we see that Max is dressed in a gray shirt and blue overalls when he and Laura escape the prison. He then places them in a bag and is locked above a trapdoor, knowing that any clothes will be ruined by his werewolf transformation. Later in the night, in Chapter 4, Emma will find this bag of clothes, and gets dressed (assuming she doesn't instead open the trapdoor first and be immediately slaughtered by werewolf Max). For the rest of the night, Emma will wear a gray shirt and blue pants, with the overall's straps being jerry rigged as a belt. Why not just keep using the overall straps? It might simply be personal preference (suspenders will keep the pants from falling, but it doesn't help with fit like belts do, the pants would still be loose), or it could be because Emma is an influencer and fashion icon that was fully expecting to keep recording videos for her followers throughout the night and was not going to be caught dead in oversized men's overalls while on camera. At this point, she had no idea she was in any actual danger, as this happens RIGHT before she encounters a werewolf for the first time.
There are three dates in the game which feature werewolves. They are June 24, July 23, and August 22. These were the actual dates of the full moon in 2021.
The tarot cards you can find all over the game feature wolves. This is a hint towards the main threat of the game, and their owner, Eliza.
The campsite has a bunch of signposts pointing to different cities (Toledo, Boston, Burbank...). If you check the sign again at night, you might notice that the sign for Death Valley is pointing at the moon◊.
Eliza's voice is heard by four of the main characters during the game, Laura, Ryan, Dylan and either Abigail or Emma depending on who survives. When your realize her ultimate goal this makes a lot more sense as she is attempting to orchestrate a certain outcome and these four all directly contribute to it. Laura is the one who will always kill Kaylee Hackett and overall can have the highest Hackett body count of potentially 4/7 of them. Ryan is the only one who can kill Chris and can possibly kill Travis. Dylan surviving to the scrapyard prevents Kaitlyn from dying allowing her to potentially kill Caleb. Finally, Emma/Abigail are the only ones who can find the bullet to kill Caleb without also killing Silas.
Dylan seems remarkably chill in the path where he loses a hand less than halfway through the game, and oddly doesn't even change his usual stance (even though you'd expect an injury so severe and traumatic to influence his gait and way of holding himself, especially in the immediate aftermath when he's presumably still in pain), let alone the tone or content of his dialogue. Of course, the out-of-universe explanation is that it would have been expensive and time-consuming to re-do all of his mocap and voice lines for a path that only appears in about 1/4 of all possible outcomes. In-universe, though, Ryan makes brief mention of giving Dylan whatever is in an old nearby medical kit when patching him up. The guy is most likely at least somewhat stoned for the rest of the game, which might account for him retaining his sense of humour while barely missing a beat; with adrenaline and shock accounting for the rest of his unusually calm reaction to suffering a life-changing injury. Additionally, Kaitlyn will give him an entire bottle of painkillers, which Dylan will joyfully swallow in a single gulp.
Both Kaitlyn and Jacob can use the specific and odd phrase "Jesus wept!" as an expletive (Jacob after Emma kisses Nick and Kaitlyn during her run-in with Bobby Hackett in the lodge). One might chalk it up to the developers trying to come up with slang they think teenagers would use. However, this makes a lot more sense when you remember that Kaitlyn and Jacob are actually childhood friends. Of course they'd have similar phrases they use and pick up from one another.
The camp's motto is "What Doesn't Kill You Will Make You Stronger." This comes into play quite literally via the werewolf infection. For 7 out of 9 counselors, allowing them to be infected by the werewolf curse will actually make it much easier for them to survive the night.
For Max, Nick, and Laura, this is inevitable. Max and Nick both survive massive wounds due to the werewolf attack that would otherwise likely have been fatal. Additionally, Laura's eye will grow back.
Ryan: Accepting the werewolf infection is the only way Ryan has a chance of surviving, after he gets stabbed in the chest and suffers massive blood loss.
Dylan: Should Dylan get infected in Chapter 5 and NOT have his hand removed, his survival is guaranteed for the rest of the game. Likewise, if Dylan survives the scrapyard in Chapter 9, but gets infected then, he is immune to death during the battle with Caleb in Chapter 10.
Kaitlyn: Getting infected in Chapter 9 makes Kaitlyn immune to death in Chapter 10 during her showdown with Caleb in the lodge. In fact, it is one of only 3 ways Kaitlyn can survive this encounter, and the only one that is guaranteed to work. The other two ways require previous choices to be made (either the stuffed rabbit needs to be in the kitchen, or Abigail/Emma need to give Kaitlyn silver shells), and Kaitlyn can still die before she ever gets to the point where these come into play, and even during the attempt.
Jacob: Getting infected in Chapter 6 and then surviving the encounter with Caleb will make Jacob unkillable for the rest of the game, although it may lead to Emma's death later on.
Abigail is one of two counselors whose night is not made easier by her werewolf infection, although it doesn't make it any more difficult either. This is because Laura kills Kaylee Hackett, Abigail's infector, before any effects can come into play, negating its usefulness.
Emma is the only counselor whose night is actively made worse if she gets infected. First off, Emma is the first character that can have their survival guaranteed, which happens if she escapes the island alive and uninfected. Should she be infected on the island, Emma can kill Dylan or Abigail, get killed by Kaitlyn in Chapter 8, or torn apart by werewolf Jacob in Chapter 10. If she is instead infected in Chapter 6, Emma will survive the game, but can potentially kill Abigail in Chapter 9.
It's theorized that the bloated corpse Jacob can find in Lake Septimus may have been one of the missing hikers, who was bound in barbed wire and chained to the bottom of the lake by the Hacketts after becoming infected. But if that's true, how could water alone have killed him? We see no indication that water is lethal to werewolves, only extremely painful, and it seems unlikely that drowning could be any likelier to kill someone who's infected when we see others regenerating lost body parts and surviving stabbed lungs and point-blank headshots while infected, even before they've turned. Multiple characters and at least one piece of in-universe literature repeatedly make it clear that only silver can kill a werewolf, so what gives? Recall what kinds of silver weaponry we see throughout the game: Silver buckshot, Jedediah Hackett's (presumably) silver knife, a silver bracelet, and a shard from a silver-backed mirror. Anything silver or containing silver appears to be enough to damage and potentially kill a werewolf, and the Hackett family knows this. Who's to say they didn't either tip that barbed wire in silver or make it from silver, thus ensuring the bloated corpse would be unable to heal from the lacerations he picked up when he tried to struggle free and would ultimately bleed out?
In additional to their traditional weakness of silver, the werewolves feel intense pain whenever they're submerged or soaked in water. Rabies, a Real Life inspiration for werewolf stories and an early guess at the reason for Nick's odd behavior post-bite, famously causes hydrophobia in its victims.
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