The Adaptational Personality Change of several characters from Vampire: The Masquerade: Bloodlines and the main game make sense when you take into account events as well as who they're talking to.
Isaac Abrams is now the lead Anarch in Los Angeles after the departure of Jeremy Macneil. It now falls to him to keep everything in order in the Free States. The vamily are also technically his subordinates, unlike the Fledgling, who was theoretically just passing through. He also lost his childe Ash to the events of the game.
Ramona has had a decade and a half to come to terms with her Kindred nature. She's also apparently developed an affinity with animals as more than just food. As such, she's not quite the badass loner she used to be.
Therese has been outed as a Malkavian due to the events of that period. There's also been changes in the perception of mentail illness, so she's capable of claiming to be subject to unfair prejudice rather than dismissed outright. It's just another method of claiming power for her now.
Gary Golden strongly disliked the Fledgling due to the fact that they were an errand boy for LaCroix. The vamily, however, showed him a remarkable amount of restraint and respect compared to most Kindred. As such, he was willing to let his more humorous side show.
Vannevar Thomas has lost his city and is suffering from some sort of terrible affliction that is eroding his sanity.
Vannevar Thomas came to warn François Villon of an imminent revolution that could destroy him and was an Ignored Expert. Victor Temple came to warn Vannevar Thomas of an imminent Anarch revolution and was an Ignored Expert.
Lucita is offended by the suggestion she should bow before Marie Antoinette. This is not just because Marie Antoinette is a Dumb Blonde (in this continuity) or even Kindred superiority to a mortal ghoul; Lucita was born the Princess of Aragon and is technically her equal in rank.
In Season Three, the discovery that the Labyrinth under Griffith Park was built by Zelios the Master Builder. The Nosferatu architect from the Transylvania Chronicles. If anyone could construct something that could teleport across the globe and bewitch even the strongest Kindred, it would probably be the vampire who used geomancy to bind the demon Kupala.
Isaac Abrams killed Annabelle's herd member at Griffith College on the flimsiest of justifications. How many would die if Annabelle's status as a consensualist (i.e. who informs her prey she's feeding on them) came out?
While Victoria Ash murdering a hundred or more mortals in her Succubus Club party is horrifying, it's even more horrifying to realize that the Anarchs participated - including ostensible allies like Nines and Therese. Not so different after all.
Suzanne and Vannevar have gone from being Naïve NewcomerFriendly Neighborhood Vampires like the Vamily to being exactly like the evil Elders that they were so appalled by in Versailles during the French Revolution.
Eva said her potions will eventually cause anyone who drinks the potion drinker's blood to enter torpor, and that it wasn't instant. Notably, this exactly describes what happened to X so it is very possible that she helped cause his end.
