Every time a character mentions "tacos" "pigs" "monkeys" or "doom", take a sip. Have 911 at the ready when trying to survive GIR singing "The Doom Song" in the first episode.
Every time Zim screams. Good luck surviving the first five minutes of the series.
Take a drink any time Dib provides rambling exposition, and two any time it's lampshaded that he's talking to himself or to someone apathetic to the episode's plot.