[[AC: ''WesternAnimation/AvatarTheLastAirBender'']]
* Zuko from ''Embers''. The [=GAang=] assumes that getting blasted off a mountain killed him simply because he did not show up the next day to snarl at them.

[[AC: ''Franchise/BuffyTheVampireSlayer'']]
* Xander in ''The Journeyverse''. One particular example is in ''Fallen Angel'' when he keeps getting up to fight Glory (a hellgod) and almost kills himself defeating her.
** Dragan from the same fight.

[[AC: CrossOver]]
* Ga'ri in the early parts of ''FanFic/BigSister'', still trying to recover from [[spoiler: the Gadget Drone incident mentioned in ''[[NanohaStrikerS StrikerS]]'']] carries a baby across a volcanic DeathWorld with what little power she has left, crippling herself ''again'' in the process, then manages to fight off a lethal infection ''and'' regain use of both her legs and her magic, this time ''without'' the help of high-{{Magitek}} rehabilitation facilities.
* The FiveManBand ''and'' the BigBad and his [[TheDragon Dragon]] in ''Fanfic/ChildrenOfTime'': [[Series/DoctorWho the (Tenth) Doctor]], Literature/SherlockHolmes, Dr. Watson, [[WesternAnimation/SherlockHolmesInTheTwentySecondCentury Beth Lestrade]], [[Recap/DoctorWhoS29E10Blink Sally Sparrow]], the TARDIS, Professor Moriarty, and Colonel Moran.
** It should be noted that, while though some of the heroes make [[DealWithTheDevil Deals with the Devil]], they still do so to protect loved ones at all costs.
** The TARDIS comes across as ''very'' stubborn and [[MamaBear mother hen-ishly protective]] of her Time Lord and his Companions.
** Moriarty is ''unbelievably'' determined to survive at any cost...
** Moran spends several months hunting a seventeen-year-old girl. Considering that he spent over two years hunting ''Holmes'', however, the surprise is not that he kept up the hunt but that the hunt kept ''him'' up.
* Littlepip from ''Fanfic/FalloutEquestria'':
--> ''I would fight to to make that bright and innocent past our future again. Even if it means dashing myself against the evil and cruelty of this wasteland until there is nothing left of me. And then, when I am too broken to go on, I will float my dying body right down into the throat of the darkness and make it choke on me.''
--> ''Or, you know, this could all end in sunshine and rainbows. No need to get pessimistic.''
* In ''Fanfic/AHero'', [[Series/DoctorWho Dalek Sec]] describes the Last Great Time War thus to [[Anime/PuellaMagiMadokaMagica Homura]]: On one side, The [[SufficientlyAdvancedAlien Time]] [[TimeMaster Lords]], undisputable masters of the universe and the most experienced Temporal Power there is. On the other, the [[OmnicidalManiac Daleks]], a race born in a [[DeathWorld world torn apart by war]] and with a technology that was woefully behind that of the Time Lords. The only thing going for the pepperpots? ''[[ImplacableMan Sheer]], [[IWillFightSomeMoreForever bloody]]-[[VillainousValor minded]] [[AttackAttackAttack determination]].''
* ''[[http://www.bladeandepsilon.com/hybridtheory.htm Hybrid Theory]]''. Determination is sufficiently central to the magical system and core plot that little can be said without spoiling the whole thing, except for "Holy crap!" and "Did you just punch out ?"

[[AC: ''Anime/CodeGeass'']]
* In ''Fanfic/CodeGeassMaoOfTheDeliverance'', Mao definitely qualifies. He gambles, blackmails, steals, does drugs, flies through a frickin hurricane, takes on soldiers and terrorists and gets shot repeatedly all in his quest to save C.C. and be with her forever.

[[AC: ''Manga/DeathNote'']]
* [[PlayingWithATrope Deconstructed]] in ''Fanfic/AllYouNeedIsLove'':
-->'''[[Manga/DeathNote Matsuda]]''' (throwing himself against a door, repeatedly): You know… Duck… I don't think this is working…
-->'''[[EnfantTerrible Duck]]:''' I'm sure you'll get it eventually. The trick is to keep trying and to believe in yourself, then any task can be accomplished. Or so public educational television tells me.
* In the climax of ''FanFic/FeverDreams'' Light [[spoiler: holds the [[ArtifactOfDoom Death Note]] [[KillItWithFire in the fire until it burns to ash]] even though [[{{Fingore}} his hands are burning along with it.]]]]
* Light and Misa in ''FanFic/GodsOfThisNewWorld'' but especially Misa, [[NormallyIWouldBeDeadNow who gets up and keeps fighting after]] [[ImpaledWithExtremePrejudice she's been stabbed in the chest with a sword.]]

[[AC: ''Franchise/{{Digimon}}'']]
* [[FanFic/TamersForeverSeries Takato]] , OH DEAR LORD '''''TAKATO'''''. If [[spoiler: continuing to fight againgst a hoard of ''Mega'' level digimon. despite the fact that your clothes are literaly '''''soaked''''' in your own blood, and you are almost paralysed from your brain cells dying doesn't count as this, nothing does.]]
** Daemon as well.
-->'''Takeru''': ''"Daemon is an extremely powerful foe, and his power has increased in the past fifteen years. His anger and desire for vengeance makes him practically invincible, a berserk fighter who will do anything to win."''
-->'''Takato''': ''"But…my friends will never give up! Rika will never give up!"''
-->'''Takeru''': ''"Neither will he."''

[[AC: ''Franchise/DragonAge'']]
* In DragonAgeTheCrownOfThorns, the WisePrince protagonist keeps on going and [[spoiler: [[ThePlan pulling one plan after another]], even though the fact he grew up in a DeadlyDecadentCourt could have long ago turned him into a self-centered cynic. He also displayed a high physical resilience in the deep roads, up until he stumbled upon a certain someone else and finally decided to ''allow'' himself to faint after two days of no sleep, fighting, getting repeatedly injured, tried for fratricide that never happened, dragged through streets in chains, spat on and generally not having a very nice time]].

[[AC: ''{{Exalted}}'']]
* In ''Fanfic/TheOdyssey'', this Ulyssian's defining trope; he is forever striving to equal and surpass his more powerful classmates, who are all Dragon-Blooded. It's a rather grim interpretation of the trope.

[[AC: ''Series/{{Firefly}}''|''Film/{{Serenity}}'']]
* In the ''Series/{{Firefly}}'' fic ''Fanfic/{{Forward}}'', Mal shows his canon tendencies, but on top of that there's Book, who pulls a YouShallNotPass when [[spoiler: defending River from Reavers]]. As the story progresses, River herself becomes one as well, up to the "Fourth Interlude" chapter, where little things like [[spoiler: a bunch of cracked ribs]] or [[spoiler: having a leg broken, getting shot in the stomach, and getting a concussion from a ricocheting bullet]] don't stop her from kicking ass.

[[AC: ''Franchise/HarryPotter'']]
* Harry James Potter Evans Verres of ''FanFic/HarryPotterAndTheMethodsOfRationality'' becomes this in chapter 89 after [[spoiler: Hermione gets killed by the troll]]. It's not good news for the safety of the universe.

[[AC: ''WesternAnimation/MyLittlePonyFriendshipIsMagic'']]
* [[SemperFi Major Shane t. Doran]], from ''{{FanFic/Article 2}}''. When completely surrounded, wounded, and telekinetically pinned to the ground by Luna, he still struggles. It takes a knockout spell to subdue the man.
* Greg, the protagonist of the [[RecursiveFanfiction recursive fanfic]] ''FanFic/FriendshipIsOptimalAlwaysSayNo'' doesn't even seem to know the meaning of the phrase "give up", given how determined he is. [[spoiler: Even being blown up won't stop him from trying]].
* {{FanFic/Jericho}} has the eponymous [[FirstPersonSmartass narrator]], Jericho, a stallion from the nation of ''Teutschland''. He appears to be this, since he walked to Equestria, where the story begins, all the way from his homeland of ''Teutschland'', which is ''across the world and several oceans'' from Equestria.
--> According to him in the summary: "Still, with enough [[GuileHero wit]], some [[ProudWarriorRaceGuy Prussian ingenuity]], [[DeadpanSnarker a droll sense of humor]], and [[BreadEggsMilkSquick wanton murder]], [[{{Determinator}} I might just survive this]]. Then again, when you’re going up against an unending list of things like [[GovernmentConspiracy government conspiracies]], that [[OurAngelsAreDifferent guardian angel]] who [[GoodAngelBadAngel keeps telling you]] to [[SerialKillerKiller kill people]], [[AllWomenAreLustful psycho Equestrian girls]] with [[EveryoneLooksSexierIfFrench allophilia]], a [[NoSocialSkills lunatic]] [[EverythingsBetterWithPrincesses prin]][[FishOutOfTemporalWater cess]], the [[TheLegionsOfHell legions of the Inferno]], the [[CultureClash Equestrian]] [[YourNormalIsOurTaboo culture]] itself, swashbuckling [[HeroesPreferSwords sword]] [[SwordFight fights]], and [[ArsonMurderAndJaywalking laissez-faire economists]], you begin to [[OhCrap realize]] why there’s [[DoomedProtagonist a big “if” in the middle of your]] l''if''e."
* ''[[Fanfic/ThePartyNeverEnded The Party Never Ended]]'' has the poor addle-sounding Derpy Hooves determined to fight the supernatural storm, no matter what. And the climax features a BattleInTheCenterOfTheMind. In one corner, the entity that drove Luna into Nightmare Moon via BreakTheCutie. In the other, Pinkie Pie with Twilight Sparkle helping. [[spoiler: Then Rainbow Dash with Pinkie Pie helping. Then Pinkie Pie ''by herself''. Break The Breaker Of Cuties, anypony?]]
* In the ''Fanfic/PonyPOVSeries'', the Mane Cast [[spoiler:and their SixthRanger Trixie]] stop at nothing to [[spoiler:defeat Nightmare Whisper, Fluttershy's SuperpoweredEvilSide, and save her from herself. By the end of the battle, Pinkie Pie and Applejack are severely cut up by glass (Pinkie Pie from being throw out of a glass window and Applejack from having glass daggers ''embedded in her back''), Twilight and Rainbow Dash have both been sent dangerously close to the DespairEventHorizon, and Trixie has been electrocuted and broken one or more ribs. But the one who takes the cake is Rarity, who has her legs broken and keeps herself in the fight by ''moving her legs with telekinesis''!]] And ''then'' [[spoiler:Fluttercruel [[LikeABadassOutOfHell fights her way out of]] a JuryOfTheDamned, getting pretty much mauled by demonic creatures, to get back to help save Fluttershy. She then proceeds to tear the tubes connecting her to Nightmare Whisper out '''by hand'', despite the agonizing pain it causes.]]
** This is actually a distinct plot point from a "side story" (AlternateUniverse, but declared part of the POV multiverse by WordOfGod). An alternate Discord notes that the Ponies of the "Reharmonized" timeline, "Would never give up, no matter how hopeless the situation."
** Also happens with [[spoiler:Queen Cadence in the [[BadFuture Dark World]] Timeline. She promised Twilight Tragedy she'd redeem her, but was vaporized before she could. Five hundred years later, her spirit appears to Twilight when she's suffering a VillainousBSOD and helps guide her back to the light, just like she promised.]]
** Dark World!Derpy. To put this in perspective, she endured ''1000 years'' of living Hell so Discord would remove the curse from Dinky. She marched around Discord's palace, assaulted constantly by crows trying to eat Dinky, and according to [[spoiler:Dinky herself]], she ''never let them touch her]]. And she did this with ''crippled wings and legs''. Is it any wonder at all she becomes an [[SixthRanger Element of Loyalty]]? After she's healed by the redeemed six [[spoiler:and Dinky is restored]], this determination extends to protecting her new friends.
* Sunset Shimmer, from ''Fanfic/SevenDaysInSunnyJune'', is willing to face down [[spoiler: date rape gangs, nightmarish unicorns and a death threat from Princess Celestia]] if it means saving those she loves.

[[AC: ''Manga/{{Naruto}}'']]
* Naruto in ''[[http://www.fanfiction.net/s/6051938/1/The_Sealed_Kunai The Sealed Kunai]]''. While fighting Hidan and Kakuzu, he holds Kakuzu inside his barrier trap jutsu for one full minute ''while being sympathetically mutilated by Hidan, who is specifically trying to break his handseal''. It eventually lapses when Hidan actually stabs through his hand, but enough time was bought for help to arrive.

[[AC: ''Anime/NeonGenesisEvangelion'']]
* ''Manga/{{Evangelion 303}}'':
** When Asuka ran away, Shinji finally gave up on her? No way! He searched and found a lead, drove one whole day –even though he had no reasons to think that she would remain in one place for so long-, and despite of her stubborn refusals to return, he [[spoiler:proposed her.]]
** Deconstructed with Rei. During a practice she entered a bad flat spin, [[http://eva303.smackjeeves.com/comics/1487157/043/ and she ejected too low because she refused giving up.]] She got brain damage because of it.

[[AC: ''Franchise/PowerRangers'']]
* The ''FanFic/PowerRangersGPX'' turn this into a ''motto'', declaring that [[BadassBoast they will never quit, surrender, or]] ''[[BadassBoast lose]]''.

[[AC: ''{{WebAnimation/RWBY}}'']]
* Ruby in the {{Gorn}}-laiden ''Blood Rose'' becomes one of these - of note is the end of chapter 22, where despite having lost both her legs and had most of the skin on her body burned off by an incendiary barrier, she starts crawling off to escape before her HealingFactor even begins to kick in.

[[AC: ''Franchise/SherlockHolmes'']]
* Literature/SherlockHolmes, [[TheWatson Dr. Watson]], and [[HyperCompetentSidekick Davy Wiggins]] in the ''Fanfic/DeliverUsFromEvilSeries'':
-->''[Holmes] would have died for a secret. But he will live now, for a friend.''
-->'''Watson:''' "Porlock, there is no use in arguing the point. I ''shall'' search for Holmes. Whether you help me or not is your choice, but you shan't stop me — you have my word on that."
-->'''Wiggins:''' "Mum, I've been running that risk ever since I was a mite. I can't tell you what I'm doing, but I ''need'' to see it through. Peter's a fine young man, and he'll take good care of you. I'll come back if I can, I ''promise''."

[[AC: ''Franchise/ShinMegamiTensei'']]
* ''FanFic/FairlyEnglishStory'': To the point where it's considered being a pussy if you react to a wound with anything more than casting Dia.

[[AC: ''TheSlenderManMythos'']]
* In ''Fanfic/ByTheFiresLight'', no matter how grim it gets, Detective Carl Rourke and Mira Grolinsky never give up in their quest to stop the Slender Man.

[[AC: ''Franchise/{{Transformers}}'']]
* Optimus and Starscream in ''Hate the Dark'', but mostly Optimus.
* ''FanFic/{{Eugenesis}}'' has Galvatron. [[spoiler:Imprisoned, damaged and implanted with technology designed to prevent him from transforming ever again, Galvatron still manages to break free, and more importantly, transform, utterly ignoring the fact that the pain and strain of doing so hurts more than anything he's ever experienced.]]