Many return from the previous installment alongside several new ones, including:
- Robots of all stripes have Took a Level in Badass, particularly Protectrons but all of the machines. The Protectrons used to be unable to hit everything and fragile in the single player games. Instead, the arrival of robots is usually the precursor to the player going down in a few energy blasts. Part of this is due to the armor not protecting against energy blasts as well as normal damage. Also, their Damage Resistance is incredible.
- Wartoga, especially, is a Kill Zone for players so that most are encouraged to finish the "Mayor for a Day" to turn them non-hostile as quickly as possible as otherwise it is something that will be a nightmare to get through.
- Liberators. Small robots with only three real attacks, these little shits can be some of the most tedious enemies to kill. Their small size makes it easy for them to jump around and avoid being hit, they rarely are alone and thus tend to swarm players in large groups, and despite often being lower level enemies, they are surprisingly tough to kill and do decent damage to even high level players. It certainly doesn't help that you can encounter them right out of the gate, since a small pack of them have taken up residence on the road to Vault 76.
- High-Levelled Colonel Gutsys armed with pistols. They have high health with a pretty small frame, and they're the only enemies in the game capable of outright ignoring armor to a degree, making them all too capable of quickly killing a player in only 3-4 shots. There's a reason they're feared even more than Annhilator Sentry Bots. The ones armed with flamethrowers aren't any better and can rapidly widdle down a player character's health to nothing.
- Scorchbeasts. First off, they deal huge amounts of damage with their primary attack (which they love to spam and also takes up most of the screen), Secondly, due to them being mutated bats, they're flying most of the time, meaning they're well out of range for many guns (and also making melee-oriented builds useless). Thirdly, they're incredibly persistent, being nigh-impossible to lose once one has spotted you. And lastly, they can show up randomly around the map no matter where you are, and many show up at the same time in the Cranberry Bog region due to the many Fissure Sites there. Have fun with dealing with 3 of them at the same time! They were eventually toned down so they no longer spam their sonar blasts, but they're still incredibly difficult to deal with
- Wendigos are essentially Deathclaws but much harder to hit due to their skinnier bodies. They do craptons of damage even in Power Armor and despite their appearance are surprisingly tough to kill. Facing one without a strategy will easily get you killed.
- Floaters, but especially Freezer Floaters and Flamer Floaters. Freezer Floaters have a unique ability in DRAINING POWER ARMOR BATTERIES in addition to the slow effect. A 100/100-charged fusion core will get drained in a matter of 'seconds,'' and will quickly eat up whatever other cores you have in your inventory. Flamer Floaters aren't better either, as they spit fireballs at you with terrifying accuracy and damage. And if that doesn't kill you, the burning effect will. Even without taking their special abilities into account, all 3 types of Floaters deal obscene damage with their cloud attack regardless of what you're wearing for armor, and their Taking You with Me explosion-on-death is sure to kill players at low health.
