David Hudson [=DePatie=] and [[Creator/FrizFreleng Isidore "Friz" Freleng]] founded this animation studio in 1963 after Creator/WarnerBros shut down its animation department. [=DePatie=] was the executive in charge of Warner Bros. animation at the time of the shutdown; his and Freleng's new company leased the former animation studio building from Warner. Their first collaboration was the opening titles to Creator/BlakeEdwards' comedy-mystery ''Film/ThePinkPanther1963''. The Pink Panther character later starred in a long-running series of [[WesternAnimation/ThePinkPanther short theatrical cartoons]] released by Creator/UnitedArtists (which also released the film), most of which were {{No Dialogue Episode}}s. (The first one, ''WesternAnimation/ThePinkPhink'', won an Oscar.) Other theatrical series included ''WesternAnimation/TheInspector'', ''Roland and Rattfink'', ''WesternAnimation/TheAntAndTheAardvark'', ''Tijuana Toads'', ''Hoot Kloot'', ''The Dogfather'' and ''Misterjaw'', all of which are also released by UA. They also produced new ''WesternAnimation/LooneyTunes'' shorts from 1963 to 1967, with the majority of them (at least not the ones outsourced to Format Films) directed by WB veteran Creator/RobertMcKimson.

[=DePatie=] and Freleng also produced several {{Saturday morning cartoon}}s, including ''WesternAnimation/HereComesTheGrump'', ''Bailey's Comets'' (created by [=DePatie=] and Freleng "in association with [[Creator/RubySpears Joe Ruby and Ken Spears]]"), ''WesternAnimation/TheHoundcats'', ''WesternAnimation/TheSuper6'', ''Super President'' (an OldShame for [=DePatie=]; he admitted he was relieved when it was cancelled after one season), ''[[WesternAnimation/MrMagoo What's New, Mr. Magoo?]]'', ''Baggy Pants and the Nitwits'', ''WesternAnimation/TheOddballCouple'', ''[[Franchise/PlanetOfTheApes Return to the Planet of the Apes]]'' and ''WesternAnimation/TheFantasticFour1978''. They also took the reins for TV adaptations of Creator/DrSeuss books after Chuck Jones's studio closed down. Their biggest success in TV, however, would come after DFE was sold to Creator/MarvelComics after Freleng retired; renamed '''Marvel Productions Ltd.''', the studio produced some of the most famous animated shows of TheEighties, including ''WesternAnimation/TheTransformers'', the first few series of ''WesternAnimation/GIJoe'', and ''WesternAnimation/MuppetBabies'', as well as a considerable amount of Marvel superhero programs.

In 1986, as Marvel Comics entered into financial trouble, Marvel Productions was sold to New World Pictures, who renamed it to '''New World Animation''' in 1993. Several years later, New World was sold in its entirety to News Corporation, who in turn placed the Marvel/DFE catalog into Creator/SabanEntertainment. Saban merged with Fox's Children's Entertainment division that year to form Fox Family Worldwide, Inc. Finally, in 2001, Fox Family Worldwide, Inc. was sold to Creator/{{Disney}}. Currently, with some exceptions, most of the all-original [=DePatie=]-Freleng and Marvel Productions library are owned by Disney, through Marvel Entertainment.

One of the company's animators, Nelson Shin, was also the creator of the ''Franchise/StarWars'' Lightsaber effect and founder of Creator/{{AKOM}}, and Lord knows how they've been treated.