- Rebooting Cosmos on FOX (a channel not known for praising intellectualism and always going for the Lowest Common Denominator).
- His "Fellas at the Freakin' FCC" song on the Family Guy episode "PTV," for two reasons: 1) Seth sang all three parts (Peter, Brian, and Stewie), and 2) The real FCC actually liked the song and the episode.
- Another one from Family Guy: on the episode "8 Simple Rules for Buying My Teenage Daughter", Seth (as Stewie) perfectly delivers in one breath what has got to be the longest run-on sentence in the show's history:
Stewie: I'm not going to lie down for some frat boy bastard with his damn Teva sandals and his Skoal Bandits and his Abercrombie and Fitch long-sleeve open stitched crew-neck henley smoking his sticky buds out of a soda can while watching his favorite downloaded Simpsons episodes every night!
- When Reading Rainbow launched a Kickstarter campaign to bring back the show in a new format, Seth publicly offered a $1 million matching grant out of his own pocketó this after the campaign had already received $3 million out of a projected budget of $1 million. (The combined donations came to over $5.4 million.)