* Heller gets one in the ''tutorial'', when a Brawler jumps him. This is a beast capable of tearing apart tanks and can casually bite a human head off. Heller, pinned beneath this thing and armed only with a knife, ''kills it'' with a combination of fury and repeated stabs to the head and neck. There's a ''reason'' why Mercer was impressed enough to convert Heller without any further credentials.
* The Bio-bomb. Heller's quote the first time he sees it in action just about mimics the reaction of any Prototype fan who saw the trailer
-->'''Heller''': Now that right there, that is ''the shit''.
* Some of the EnemyChatter hammer it [[MookHorrorShow in how much]] [[CurbStompBattle you're trashing the enemy.]]
-->'''Blackwatch Soldier''': [[OhCrap Holy God in Heaven. HE'S GOT FUCKING CLAWS!]]
* [[spoiler:Heller [[DidYouJustPunchOutCthulhu consuming Alex Mercer]]. Sure, it was the entire point of the game, but many didn't think that [[LikeYouWouldReallyDoIt the developers would go through with it.]]]]
** In the preceding fight, if you do the dodges even halfway right, you come off as if (and Heller explicitly notes) that you're running rings around your opponent. Heller's so fast that [[spoiler: Mercer]] can't even keep up with him.
* [[UpToEleven In terms of gameplay, Prototype 2 blows Prototype out of the water]]. Now you have shields on both arms and you can perform shield bashes, which means you can leave enemies open for a devastating attack. Sometimes it's slicing off their arms, some times it's giving them a German Suplex from 15ft. high. You can consume people in the air now, by slamming them back first into the pavement and crushing them, bouncing back up to continue gliding. It's so amazing.
* From the "Excessive Force" DLC Pack...Two words: [[EyeBeams Medusa's. Wrath.]]
* After consuming a scientist in the Red Zone and getting into a helicopter while disguised as the Dr, an [[spoiler:Evolved]] comes and attacks the helicopter, demanding to know where the scientist is. Heller gladly responds.
-->'''Heller''': The Doctor is out motherfucker! *kicks [[spoiler:Evolved]] out of the Helicopter*
* Step 1: equip the claws. Step 2: target a helicopter. Step 3: use the pounce move, and feel like wolverine as you tear it to shreds.
* The finisher moves against vehicles. If it's a tank, Heller rips the turret off it and ''swaps'' the hull with it. If it a helicopter, Heller uppercuts it.
* In the opening, Mercer karate kicks a helicopter. AscendedMeme, anyone?
* See a blue barrel in a Gentek facility? Punch it, sit back, and enjoy as all the mooks and civilians in the area become zombified and goes to attack and infect other people. Yes, this game allows you to start your own ZombieApocalypse.