- In a very real way, the entire movie can be seen as one for the classic Universal monsters. When Count Dracula, the Frankenstein Monster, and Larry Talbot went out, they did it with style.
- This was the movie that inspired Quentin Tarantino to make movies. Watching it as a little kid made him a cinephile for life.
- At one point when they've escaped Dracula's castle, the vampire goes after Lou to bring him back with his powers of Mind Control. Lou actually holds out for a few moments before giving in and skipping merrily to his (intended) doom. Hey, it's not much, but how many people ever beat Dracula's powers of control, even temporarily?
- Doubling as two Crowning Comic Moments, when being chased through the castle by the Monster, Lou jerks a black tablecloth off a table, leaving the lights standing. He does a double take before boastfully showing it to the audience and retreating behind a door. The Monster opens it and Lou comes out, using the tablecloth to make like Dracula:
Lou: Back... back...The Monster: Yes, Master.
- Dracula, running from the Wolf Man, turns into a bat and flies off a balcony. Wolf Man leaps, grabs the bat in both hands, and they both fall into the sea to their apparent deaths.
- The last-minute "appearance" of Vincent Price as the Invisible Man.
- On a meta level, the mere fact that it's Bela Lugosi playing Dracula for the Count's final appearance in the Universal canon. Proving one final time that no one can play Dracula like he can.
- Behind the scenes, Lugosi's manager earned one when he discovered that Universal wanted to hire another actor instead. He met with the head of Universal and shamed the man into reconsidering, saying "He IS Dracula! You owe this role to Lugosi!" (Especially given that since the original Dracula Lon Chaney Jr. and John Carradine had been hired instead of Lugosi.)
- For an Abbott and Costello film, this had a violent ending. And although the monsters seem to meet their demise, Pop Culture Osmosis had kicked in by this time and audiences figured that they won't stay down for long. However, there was one human death (Sandra), a rarity for Abbott and Costello adventures, even when it's a villain.