In What's Up, Doc?, Judy recalls how she accidentally blew up a school chemistry lab. Howard though she was part of the student protest movements, but she said she was just taking a class there.
The Big Bang Theory, episode 22 of the third season "The Staircase Implementation", a series of flashbacks to sometime before the series began, shows Leonard explains to Penny the story of why the elevator in their building has been out of order since before she moved in. As it turns out, Leonard was testing an experimental rocket fuel in a giant model rocket that he was going to launch with his buddies. Sheldon realizes the chemistry is unstable and quickly moves the smoldering rocket into the elevator where it promptly explodes moments after the door closes. This lead to a change of heart for Leonard who felt indebted to Sheldon for saving his life.
Willy Wonka and the Chocolate Factory. Charley Bucket's science teacher has him help mix nitric acid, glycerine and a special mixture of his own to create a wart remover. Do you know what you get when you mix nitric acid and glycerine together? You get nitroglycerine. The mixture exploded but only created a lot of smoke. With the amount they mixed together it could have leveled the entire building.
The beginning of the original The Nutty Professor, the one with Jerry Lewis, may qualify. Prof. Kelp blows up his lab and gets chewed out.
At the end of Flubber, Robin Williams's character is getting married via video screen as he continues his experiments. He mixes two smoking chemicals together assuring his bride that "there is no chance, that anything could go wroooonnnngggg!!" as his house explodes. Again.
Invoked trope in the Stargate SG-1 episode "Bounty", where Dr Lee is giving a "demonstration" of a new device to the wider scientific community not in on The Masquerade and has rigged it to short out, smoke and spark, to make believe it is a highly temperamental prototype and not something they stole wholesale from Aliens.
Jonny Quest TOS episode "The Invisible Monster". Dr. Isaiah Norman is conducting experiments with energy and mass. The process gets away from him and a large explosion occurs. Dr. Norman finds out too late that the explosion is the least of his worries.
The Simpsons: When Homer decided to become an inventor, there's a big explosion. Description from snpp.com:
Down in the basement, Homer works out a few equations on the chalkboard, hammers, saws, welds, and finally blows up the basement. Walking over to a chart, he changes a "greater than" sign to a "less than" sign, and goes back to work. Later, a much bigger explosion rocks the house; walking over to the chalkboard, he erases a stick of dynamite from his schematics.
Another Simpsons example occurs in the episode where Bart is mistaken for a child genius, in which he blows up the school during a chemistry lesson.
There's an episode where Homer manages to make cereal catch on fire, just by pouring milk, does that count?
In the second act of the Mr. Bogus episode "Babysitting Bogus", Bogus is dressed up as a chemistry professor on TV where he is preparing to pour one chemical into another beaker. When he does so, however, this causes an explosion that destroys the interior of the laboratory.
Similar to the Simpsons example, an episode of Phineas and Ferb has the title characters working on rockets. Each time they try and fail, a major explosion, accompanied with stock footage from the 50's wipes out the backyard and most of their clothes and, each time, they go back to their chalkboard and modify their equations.
In Anno2070, anytime your laboratories are building something, there's a set chance of them spontaneously blowing up, setting the whole building on fire and (sometimes) spreading disease throughout the nearby area. This is true even when they're working on things you generally wouldn't expect to be particularly combustible, like a water-filter - or maybe some firefighting gear...
This is part of game mechanic in Deadlands, especially in the simplified Savage Worlds edition (the first edition had way more fun and destructive ways for inventions to malfunction).
Pajama Sam: No Need To Hide When It's Dark Outside had a mad scientist's laboratory room with a bench containing color chemicals. A recipe book displayed all the spell combinations, but if a three-color permutation that wasn't in the book would be mixed, the result was harmless Ash Face, which Sam would wipe off with his cape and remark that he should have read the instructions.
The basic plot element at the beginning of Half-Life. A failed experiment causes the test chamber to explode, in what is termed a "resonance cascade".
Later in the game, a scientist and security guard are overheard discussing a new type of gun the scientist developed, called the Tau Cannon. The scientist warns the guard that the gun has a possibility of overloading, when suddenly there's an explosion, killing both and blowing out a wall.
Professor Layton and the Unwound Future: The time machine explodes both times it is powered on. Lives are affected. [spoiler:The case in the present was intentional, making this an invoked trope.]
Warhammer 40K: Any ork teknology, since to them a good explosion and the ensuing destruction is just as desirable an outcome as the intended use. Their heavy use of Tim Taylor Technology doesn't hurt either.
Champions supplement the Blood and Dr. McQuark. Dr. McQuark is an absent minded scientist/inventor. The first time the PCs visit his laboratory there's a minor explosion caused by one of McQuark's experiments/inventions.
Dungeons & Dragons 1st Edition. Module L1 The Secret of Bone Hill. The PCs could find a number of potions that had been experimentally mixed together. Under the standard rules, mixing potions together could cause an explosion.
In Genius: The Transgression this is the safest thing a wonder can do when it malfunctions (which can happen if it's damaged or if a [[Muggle mere mortal]] gets too close and starts pointing out that it shouldn't work).
Forgot in Magic: The Gathering in the Ravnica expansion the Izzet Guild has a huge amount of explosions.
Alfred Nobel is a serious example - before he got the formula for dynamite right, his brother died in a lab explosion.
Building bombs and other devices intended to explode. The failure here being the bomb detonating while in its stages of development.
A practical way of making guncotton (the first smokeless propellant/explosive found) was discovered when Christian Friedrich Schönbein spilled nitric acid and sulfuric acid in the kitchen. He dried it up with his wife's apron, and left it to dry near the fire. Shortly, he had a violent and spontaneous combustion.
Five hats means that five tropers think it is ready to publish.
You are saying that you think this draft is ready to be published. That means the description is not ambiguous,
it doesn't duplicate an existing trope, there are at least three examples, and the title makes sense.
Is that what you meant to do?
You are saying this draft has a ready-to-publish hat it does not deserve and you are taking it back.