- ''"Jock: Does the Crazy Eddie Drive affect humans like that?"Hardy: "Like what?"Jock: "Disorientation. Vertigo. Inability to concentrate. Muscles out of control. Nausea. Death wish."
- Played for laughs in Spaceballs. Dark Helmet orders his ship to "Ludicrous Speed" without putting on a seatbelt. He ends up clinging to the back of his chair by his fingertips when the ship accelerates, then flying forward and smashing into a panel when the ship stops.
- In Forbidden Planet the crew need to assume secured positions before jumping.
- When R2-D2 gets the Millennium Falcon's hyperdrive back online in The Empire Strikes Back the sudden acceleration knocks him back into the maintenance pit.
- In the Wing Commander film, making an FTL jump seems to suspend everything in freeze-frame for a few moments, in addition to shaking everything around. It's typical for crew members to strap themselves in. Except for Maniac, who intentionally launches himself into the air so that he can be suspended that way for a few moments before crashing back to the deck.
- Exiting an Alderson point in the CoDominium universe is rather disorienting to crewmen and scrambles computer systems. In The Mote in God's Eye the effects are considerably worse for Moties, which helps make the Empire's blockade of their system viable
- In C. J. Cherryh's Alliance/Union universe most oxygen-breathing species are knocked unconscious by jumping to lightspeed (if not sedated like humans and stsho prefer) and remain unconscious for the duration of the jump. Which is usually about three subjective days so crews are almost always pretty dehydrated when they come out.
- Using Infinite Improbability Drive in The Hitchhiker's Guide to the Galaxy has an annoying tendency to temporarily turn passengers into sofas.
- In the Honor Harrington series, a 'crash translation' allows a ship to retain a much higher base velocity than normal upon leaving hyperspace, but leaves everyone on board disorientated and nauseous for several minutes, so it tends to only be done when it gives a major tactical advantage.
- In The Stars Are Cold Toys hyperspace travel kills or drives insane any species but humans.
- The Andre Norton novel Uncharted Stars. Murdoc Jern guides his lifeboat into the starship Wendwind's docking bay just before the ship goes into hyper. Since he was not bedded down and prepared for the transition, he is knocked unconscious and wakes up with blood in his mouth.
- In the Stargate franchise entering or exiting hyperspace tends to knock back people who haven't had the chance to brace themselves.
- Slipstream transitions in Andromeda are accompanied by afterimage effects.
- The pilot miniseries of the 2003 Battlestar Galactica portrays FTL jumps as being somewhat, uncomfortable, accompanied by horizontal visual distortion. This bit was largely dropped from the series proper though.
- In Babylon 5 The Lost Tales, the transition back and forth between Quantum Space is... unpleasant. Sheridan enjoys subjecting annoying reporters to this.
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