A character when is depressed, like suffering a Heroic BSOD
or crossing the Despair Event Horizon
, sometimes he/she has lost his/her appetite, meaning that the character can't eat and sometimes refuse food. The character is too depressed to eat. Depression affects the character's appetite.
See also Lost My Appetite
and I'm Not Hungry
. Contrast Heartbreak and Ice Cream
Needs a Better Description Needs More Examples