It can be a good source of angst
to have a character acquire a disability. It's even more so if the character had some kind of special talent, and the disability 'robs them' of this talent.
Some examples I can think of:
- Alice in Still Alice is a university professor, a very intelligent woman, until she gets Alzheimer's Disease.
- One episode of Glee - Rachel gets a temporary form of this by developing laryngitis, and she also meets a football star who became quadriplegic.
- Robert Munch and Christopher Reeve would both be real-life examples: a quadriplegic stunt man and an author with aphasia.