History YouCantGoHomeAgain / AnimeAndManga

* In the later installments of the ''Anime/{{Macross}}'' franchise, human civilization is spread across multiple colony ships and colonized planets, and it is implied that it is virtually impossible to travel back to Earth from most of them, at least unless you happen to be very rich and/or influential.

** Hohenheim is convinced they did it so as not to face up to the whole "brought back an abomination of nature instead of our dead mother" thing every time they walked by the study.

* Youko spends the first arc of ''TheTwelveKingdoms'' trying to get back to her own world. [[spoiler:Eventually, she comes to realize that she is needed far more in Kei than she is at home, and reluctantly agrees to become the Glory-King.]]

* ''TsubasaReservoirChronicle'': [[spoiler:Syaoran can't go home because he wasn't meant to exist in the first place, and he and his replacement Watanuki are stuck in similar predicaments: Syaoran will wander the worlds forever while Watanuki is stuck in the TheLittleShopThatWasntThereYesterday forever, lest their existences destabilize time and space. At least they both have company, which includes Faye, who destroyed his world.]]

* In the later installments of the [[Anime/{{Macross}} the Macross franchise]], there are colony ships and it is implied that it is virtually impossible to travel back to Earth from such a ship, at least unless you happen to be very rich and / or influential.

* In ''Manga/SchoolLive'', it initially seemed a bit strange that Yuki was living in the school and doesn't even think to go home until later in the first episode. But once TheReveal that they are living in a ZombieApocalypse, it makes sense that none of the girls can return home.
** Later, [[spoiler: a rescue helicopter crashes near the school, starting a fire that destroys most of the girls' supplies and survival gear. With the school no longer a viable shelter, the girls "graduate" and leave to find a government safe zone.]]

----

* ''{{Manga/Berserk}}'': Guts had to flee from his original mercenary band after he killed his adoptive father in self defense and the other members sought to avenge their leader's death. Later, it was revealed that Casca joined the Band of the Hawk because if she were to go home, she would be [[spoiler: arrested and tortured for killing a noble in self defense of AttemptedRape]]. On the grander scale of things, the whole Band of the Hawk was forced to flee the Kingdom of Midland upon [[spoiler: Griffith's arrest for high treason - which was popping the cherry of the princess.]]

* This happens in [[VampirePrincessMiyu Vampire Princess Yui]], after [[spoiler:Yui's powers fully awaken ''and'' her last surviving relative, her grandmother, died.]]

* The protagonists of ''Anime/{{Gunbuster}}'', due to [[spoiler:the time dilation effect.]]

* Zoro of ''OnePiece'' sets out to sea to find Mihawk, but is unable to find his way back due to his [[NoSenseOfDirection poor sense of direction]].

* In ''RecordOfLodossWar'', Parn is kicked out of his village at the beginning of the story. He dons his father's armor and subsequently burns his house down and from then has to go WalkingTheEarth.

* Holo of ''SpiceAndWolf''. Her hometown might be the only place she belongs, and it's rumored to have been destroyed centuries after she left. Even if it still exists, she knows that the passage of time has likely changed it into something completely different. She won't give up until she acknowledges it herself, though.
* ''SpiritedAway'' has young Chihiro and her ignorant parents wander into what appears to be a bankrupt theme park and explore. Long story short, she is forced to sign a contract, which turns her into Sen, a serving girl who must work in Yubaba's Bath House of the Gods for all eternity, unless she wants her TransformationTrauma'd parents to be ground up and [[ItMakesSenseInContext made into sausages]]. The whole point of the film is her learning how to be more mature and resourceful in order to reverse this fate.

* In ''PrincessMononoke'', Ashitaka is permanently exiled from his home village to protect everyone from his curse.

* In ''LightNovel/KamisamaNoInaiNichiyoubi'', after Ai's [[DoomedHometown village is destroyed]], she decides to travel the world God has abandoned in hopes of finding a way to save it.

* The protagonists of ''{{Gunbuster}}'', due to [[spoiler:the time dilation effect.]]

* ''TsubasaReservoirChronicle'': [[spoiler:Syaoran can't go home because he wasn't meant to exist in the first place, and he and his replacement Watanuki are stuck in similar predicaments: Syaoran will wander the worlds forever while Watanuki is stuck in the TheLittleShopThatWasntThereYesterday forever, least their existences destabilize time and space. At least they both have company, which includes Faye, who destroyed his world.]]

* ''{{Berserk}}'': Guts had to flee from his original mercenary band after he killed his adoptive father in self defense and the other members sought to avenge their leader's death. Later, it was revealed that Casca joined the Band of the Hawk because if she were to go home, she would be [[spoiler: arrested and tortured for killing a noble in self defense of AttemptedRape]]. On the grander scale of things, the whole Band of the Hawk was forced to flee the Kingdom of Midland upon [[spoiler: Griffith's arrest for high treason - which was popping the cherry of the princess.]]

* In the later installments of the [[Franchise/{{Macross}} the Macross franchise]], there are colony ships and it is implied that it is virtually impossible to travel back to Earth from such a ship, at least unless you happen to be very rich and / or influential.

* In the later installments of SuperDimensionFortressMacross franchise, there are colony ships and it is implied that it is virtually impossible to travel back to Earth from such a ship, at least unless you happen to be very rich and / or infuential.

* ''RanmaOneHalf'' - [[GenderBender Ranma]] can't go home because his father made a vow to his mother that if he failed to make their son into a real man, father and son would commit seppuku and their mother would be the one to cut off their heads. [[NoSenseOfDirection Ryoga]] can't go home because he can't find it, and it's not like his parents would be home if he did. Shampoo can't go home until she claims Ranma as her husband. It's not clear if Ukyo even ''had'' a home other than her dad's ''okonomiyaki'' cart.

* In ''Anime/AttackOnTitan'', even though she is taken in by Eren's family right afterward, Mikasa goes through this when her parents are killed by human traffickers ("I need to go home, where should I go? Now I have nowhere left to go."). Five years later, this happens to her ''again'', along with Eren and Armin when the wall is broken and Zhiganshina is overrun with Titans.

** Honestly, every ''kaikyaku'' ("People from Beyond the Sea") deals with this, since going to the "[=12K=]" world is a one-way trip[[hottip:*: The only kaikyaku who ''aren't'' absolutely miserable in the new world are those who were meant to be there in the first place (like Youko, Enki, and King En), or those who are given the gods' blessing and become immortals (Suzu, although it takes over a century for her to cheer up). This is due mostly to the Kingdoms' language being utterly incomprehensible to outsiders, and also prejudice]]. In the animated version, Yoko's companions Sugimoto and Asano (the latter an anime-only character) both have to come to grips with this.

* In the later installments of SuperDimensionFortressMacrosss franchise, there are colony ships and it is implied that it is virtually impossible to travel back to Earth from such a ship, at least unless you happen to be very rich and / or infuential.