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* ''Webcomic/CirqueRoyale'': If Quinn and Leo had never sent the exploding glitter bomb to antagonize Dusty Pockets, Scorpowitz wouldn't have dropped his one of a kind ceramic My Tiny Hippo and broken it and attacked them in a rage, and Leo wouldn't have been injected with scorpion venom, skirted the edge of death, and become disabled. [[spoiler:And if Dusty hadn't sold him a fake one in the first place.]]
* One ''Webcomic/ElGoonishShive'' storyline featured a rampaging boar which was enchanted to grow to an enormous size. Said enchantment is heavily implied to have come from [[spoiler:Rhoda]], who was unwittingly given a [[PowerTattoo magic mark]] and unknowingly used it on the boar while in a state of panic.
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* One ''Webcomic/ElGoonishShive'' storyline featured a rampaging boar which was enchanted to grow to an enormous size. Said enchantment is heavily implied to have come from [[spoiler:Rhoda]], who was unwittingly given a [[PowerTattoo magic mark]] and unknowingly used it on the boar while in a state of panic.
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* ''Webcomic/{{TREVOR}}'': It’s pretty safe to say that Dr. Madison never imagined that his attempts to find a CureForCancer would lead to Trevor’s leukemia [[spoiler: morphing into a severe case of BodyHorror]], and that the [[spoiler: military’s subsequent involvement]] would turn the whole thing into [[spoiler: a SuperSoldier project]] with [[spoiler: ColdBloodedTorture-style]] experiments regularly preformed on his former patient.
to:
* ''Webcomic/{{TREVOR}}'': ''Webcomic/Trevor2020'': It’s pretty safe to say that Dr. Madison never imagined that his attempts to find a CureForCancer would lead to Trevor’s leukemia [[spoiler: morphing into a severe case of BodyHorror]], and that the [[spoiler: military’s subsequent involvement]] would turn the whole thing into [[spoiler: a SuperSoldier project]] with [[spoiler: ColdBloodedTorture-style]] experiments regularly preformed on his former patient.
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* ''Webcomic/{{TREVOR}}'': It’s pretty safe to say that Dr. Madison never imagined that his attempts to find a CureForCancer would lead to Trevor’s leukemia [[spoiler: morphing into a severe case of BodyHorror]], and that the [[spoiler: military’s subsequent involvement]] would turn the whole thing into [[spoiler: a SuperSoldier project]] with [[spoiler: ColdBloodedTorture-style]] experiments regularly preformed on his former patient.
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* ''Webcomic/SleeplessDomain'': Sally's temper tantrum about Tessa being the leader and bossing everyone around just because she had the strongest powers of Team Alchemical results in [[spoiler:the deaths of herself, Sylvia, and Gwen, with Tessa depowering herself to save Undine.]]
** Later on, Vedika has a conversation with Cassidy and says that Undine is probably dealing with issues that she can’t really talk about. Unfortunately, with Cassidy already jealous of how much time Undine has been spending with H.P., she takes this to mean that Undine is somehow [[spoiler:complicit in the deaths of Team Alchemical]]. This leads to Cassidy harshly interrogating Undine, then storming off when the rest of the club [[WhatTheHellHero chews her out]], and ultimately [[spoiler:Cassidy herself getting murdered by Goops]]. Vedika is brought to tears when she tells everyone about this.
** Later on, Vedika has a conversation with Cassidy and says that Undine is probably dealing with issues that she can’t really talk about. Unfortunately, with Cassidy already jealous of how much time Undine has been spending with H.P., she takes this to mean that Undine is somehow [[spoiler:complicit in the deaths of Team Alchemical]]. This leads to Cassidy harshly interrogating Undine, then storming off when the rest of the club [[WhatTheHellHero chews her out]], and ultimately [[spoiler:Cassidy herself getting murdered by Goops]]. Vedika is brought to tears when she tells everyone about this.
to:
* ''Webcomic/SleeplessDomain'': Sally's temper tantrum about ''Webcomic/SleeplessDomain'':
** In Chapter 2, Sally gets in a fight with Tessa over her being the team's leaderand bossing everyone around just because she had the strongest powers of Team Alchemical results in [[spoiler:the deaths of herself, Sylvia, and Gwen, with powers. This leads to Tessa depowering herself deciding to save Undine.[[AchillesInHisTent sit out the night's patrol]], to give her teammates a chance to prove themselves right. [[spoiler:That night, the team gets caught off guard by a powerful monster, and without Tessa to help them, three of them -- including Sally -- end up dead.]]
** Later on, Vedikahas a conversation with mentions to Cassidy and says that Undine is probably dealing with issues that she can’t can't really talk about. Unfortunately, with Cassidy already jealous of how much time Undine has been spending with H.P., HP, she takes this to mean that Undine is hiding something -- more specifically, that she [[spoiler:was somehow [[spoiler:complicit complicit in the deaths of Team Alchemical]].her teammates]]. This leads to Cassidy harshly interrogating Undine, then storming off when the rest of the club [[WhatTheHellHero chews her out]], and ultimately [[spoiler:Cassidy herself getting murdered by Goops]]. Vedika is brought to tears when she tells everyone about this.
** In Chapter 2, Sally gets in a fight with Tessa over her being the team's leader
** Later on, Vedika
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* ''Webcomic/AnecdoteOfError'': When [[SternTeacher Talshko]] tells Atshi to shape up and prove herself, she means that Atshi had better improve her studies lest she get expelled. But Atshi interprets it to mean, [[LeeroyJenkins “Run headlong into danger to try to save everybody yourself.”]] This leads directly to [[spoiler:Luntsha getting expelled]], and it’s a miracle that no one gets seriously injured.
* ''Webcomic/DarthsAndDroids:'' Pretty much everything in the plot stems from Jim, in-character (loosely) as Qui-Gon Jinn, deciding to search a meeting room for traps. From there, events lead to Anakin Skywalker joining the Jedi, the destruction of the Jedi, the corruption of the Senate, the creation of the Empire, and Palpatine becoming Emperor (and that's the ''short'' list). Jim never catches on. The other players do.
-->'''Pete:''' ''(after the latest disaster)'' Actually, like most things, it's Qui-Gon's fault.
* In ''Webcomic/{{Freefall}}'', Florence has suspicions that Maxwell Post might be this when she learns that he is the spiritual advisor to the [[AIIsACrapshoot sapient robot]] population. [[SubvertedTrope So far, his efforts have been among the least of her worries.]]
* ''Webcomic/GirlGenius'':
** Dr. Beetle was the one who inspired Lucrezia's experiments with mind-transferral, meaning a good deal of issues in the story and the longest lasting plot thread tied to the BigBad's danger to the main cast can be traced back to him.
** Still later, it's Beetle's ill-advised plot against Klaus Wulfenbach that ultimately attracts the Baron's attention to Agatha, thus kicking off the plot.
* One ''Webcomic/ElGoonishShive'' storyline featured a rampaging boar which was enchanted to grow to an enormous size. Said enchantment is heavily implied to have come from [[spoiler:Rhoda]], who was unwittingly given a [[PowerTattoo magic mark]] and unknowingly used it on the boar while in a state of panic.
* [[spoiler:Virtually everyone]] in ''Webcomic/{{Homestuck}}''. Turns out [[spoiler:pretty much the entire universe (or at least, the correct timeline) and everyone's actions in it were a specially orchestrated sequence of events in time designed to bring [[BigBad Lord English]] into existence, and vice versa: English's existence is so intrinsic to the proper workings of the comic that any timeline deviating from the main one doesn't fulfill the requirements to result in his birth and consequently ''becomes a [[BadFuture doomed timeline]]'', so it can't really be considered their fault.]] Naturally, in keeping with the messed-up time shenanigans ingrained into the comic, [[spoiler:English]] set this up himself beforehand/afterward. The ''single'' good character who doesn't manage this is Nepeta[[note]]largely because she's never shown actually ''doing'' much of anything; the one time she tries to do something significant she's hopelessly outclassed and dies pointlessly and almost immediately[[/note]].
** Tavros deserves special mention. At one point he attempts to save a young Jade from accidentally shooting herself by taking psychic control of her dog, Becquerel, and deflecting the shot at her grandfather (whom he believed was a hostile intruder), killing him. He then points out that Becquerel would have saved her even if he hadn't done anything (in a way that would not have killed Grandpa Harley) and that he only interfered so he could feel a little better about himself. Even when she points out that killing her grandfather was ''not'' appreciated, he still thinks he made the right choice.
* In ''Webcomic/KevinAndKell'', [[Webcomic/GeneralProtectionFault Nick and Ki's]] [[{{Crossover}} arrival in Domain]] by way of interdimensional travel disrupts the balance between the animal- and human-dominated worlds to the point at which the other two humans living on the animal side [[spoiler:Lindesfarne and Danielle]] are forced to leave lest the world suffer instinct loss. [[spoiler:Luckily, Catherine and Nigel do it instead]].
* In ''Webcomic/KidRadd'', two Moderators are given a large sum of money in order to hire an assassin to kill Radd, as Captain QB can't be directly implicated in illegal activities and needs to use a proxy. They reason that it can't be hard to kill someone in jail (as Radd is being imprisoned for illegally entering other games), and hire Kobayashi the discount ninja so that they can pocket the rest of the money. Radd survives the assassination attempt and Kobayashi becomes a recurring character who later meets up with Gnarl and, while training together, stumbles upon [[spoiler:Chimera Point, the keystone to Crystal's plans, which eventually results in ''her'' finding it too]].
* Several characters in ''Webcomic/{{minus}}'' take actions that, unbeknownst to them, lead to TheEndOfTheWorldAsWeKnowIt. First, a mysterious man pretty much "breaks" [[RealityWarper minus]] by stuffing her into a briefcase. She is freed, but becomes a CloudCuckooLander. In an attempt to cure her, the green-haired girl throws a rock at minus's head, causing her [[spoiler:[[LiterallyShatteredLives to shatter]]]]. Because she is now [[spoiler:a ghost]], minus starts to spend more time with her ghost friends than her live ones. Which leads to the biggest example of this trope in the comic: the red-haired ghost asks minus to bring her back to life, because she has some UnfinishedBusiness with certain humans that the readers don't get to see. minus agrees. Unfortunately, once the other ghosts find out, they demand that minus revive them too. She does, [[spoiler:only for the sheer influx of bodies on Earth to suffocate every living thing on the planet, including those who were just revived]]. [[SpaceWhaleAesop And that is why you should never ask anything of an omnipotent being, ever.]]
* In ''Webcomic/NobodyScores'' this is frequently the role of [[Main/{{CloudCuckoolander}} Jane Doe]]. [[http://nobodyscores.loosenutstudio.com/index.php?id=488 This]] for example.
* ''Webcomic/TheOrderOfTheStick'':
** [[KnightTemplar Miko Miyazaki]], having already [[DePower lost her Paladin abilities]] through the [[TheKingslayer unwarranted execution of of Lord Shojo]], ends up destroying the [[MacGuffin Sapphire Gate]], having once again misinterpreted what the gods wanted of her. Had she not been so hasty in doing this, the ghost of [[PrecursorHeroes Soon Kim]] could have permanently ended the threat of [[BigBad Xykon]] and [[DragonWithAnAgenda Redcloak]], who, themselves, were aiming for the gate, anyway.
** Right-Eye had the idea to recruit Xykon. If not for that one moment, Xykon never would have learned about the Snarl, probably never would have had the brains to become a lich on his own and would have continued his life of petty evil until he died and went to the Lower Planes without ever becoming the apocalyptic threat he is today.
** When Vaarsuvius went on a RoaringRampageOfRevenge and [[spoiler:cast Familicide, killing every creature related to the Ancient Black Dragon]], they didn't have any intentions beyond protecting their own family (and maybe enjoying the wildly DisproportionateRetribution way too much). Unfortunately for them, and also the world, [[spoiler:the Draketooth family guarding one of the Gates has a MeaningfulName, and Familicide wiped out every last one of them, leaving the Gate completely unprotected.]]
** The "civilized monster" races were Fenris's contribution to creating the world. He intended for the fast-breeding and resourceful goblinoids to outcompete the humanoids, but lost interest and turned to other projects. When the Dark One ascended to godhood, he assumed the goblins had been designed this way to provide [[CannonFodder easy targets for humanoid adventurers]], leading him and his priests to seek [[EldritchAbomination the Snarl]] to overthrow the gods. Because Fenris was careless.
* ''Webcomic/SchlockMercenary'': The Toughs accept a contract to deliver some food to what is referred to, in-story, as an 'UNS charity project'... Credomar. Due to the ship's AI interfering with a fuel delivery (which, in its defence, could have looked like an attack on the station if you squint right, particularly since the authorities take down the ''entire teraport denial field'' in order to teraport in the fuel), unrest in the station boils up quickly and leads to the station having several new holes in the side. [[CaptainObvious It's a space station floating in the vacuum of space]]. Of course the fact that one of their own 'build-a-bot' projects takes the opportunity to take charge, save everyone it could, become King, and inadvertently throwing a wrench in the UNS's plans to take over through other means (mainly by influencing the rebellion had it happened ''when expected'', along with using the Toughs to "prop up a pro-annexation group" without actually telling them this) was the icing on the cake.
* ''Webcomic/SleeplessDomain'': Sally's temper tantrum about Tessa being the leader and bossing everyone around just because she had the strongest powers of Team Alchemical results in [[spoiler:the deaths of herself, Sylvia, and Gwen, with Tessa depowering herself to save Undine.]]
** Later on, Vedika has a conversation with Cassidy and says that Undine is probably dealing with issues that she can’t really talk about. Unfortunately, with Cassidy already jealous of how much time Undine has been spending with H.P., she takes this to mean that Undine is somehow [[spoiler:complicit in the deaths of Team Alchemical]]. This leads to Cassidy harshly interrogating Undine, then storming off when the rest of the club [[WhatTheHellHero chews her out]], and ultimately [[spoiler:Cassidy herself getting murdered by Goops]]. Vedika is brought to tears when she tells everyone about this.
* ''Webcomic/StandStillStaySilent'': Reynir's older brother Bjarni to his LittleStowaway situation. While growing up, Reynir was told by his parents that only people who are TheImmune can travel internationally, while those who are not, such as himself, aren't allowed to do so. This, combined with having TheImmune DesignerBabies as siblings, gave him a quite bad case of SmallTownBoredom. Reynir eventually told Bjarni about it, and it goaded Bjarni into telling him that the international travel ban on non-immunes had actually been lifted a long time ago, and that their parents just didn't want an EmptyNest. Bjarni also mentioned that while military ships don't take non-immunes onboard, some merchant ships do. The merchant ship Reynir ended up on turned out to not have a license to let people disembark at its destination and its captain got blackmailed into making a detour to deliver food to the crew exploring an area with a high risk of ThePlague. All Reynir noticed about the latter situation was that the ship stopped moving and that crates big enough to fit a person were being taken out of the supply room.
----
* ''Webcomic/DarthsAndDroids:'' Pretty much everything in the plot stems from Jim, in-character (loosely) as Qui-Gon Jinn, deciding to search a meeting room for traps. From there, events lead to Anakin Skywalker joining the Jedi, the destruction of the Jedi, the corruption of the Senate, the creation of the Empire, and Palpatine becoming Emperor (and that's the ''short'' list). Jim never catches on. The other players do.
-->'''Pete:''' ''(after the latest disaster)'' Actually, like most things, it's Qui-Gon's fault.
* In ''Webcomic/{{Freefall}}'', Florence has suspicions that Maxwell Post might be this when she learns that he is the spiritual advisor to the [[AIIsACrapshoot sapient robot]] population. [[SubvertedTrope So far, his efforts have been among the least of her worries.]]
* ''Webcomic/GirlGenius'':
** Dr. Beetle was the one who inspired Lucrezia's experiments with mind-transferral, meaning a good deal of issues in the story and the longest lasting plot thread tied to the BigBad's danger to the main cast can be traced back to him.
** Still later, it's Beetle's ill-advised plot against Klaus Wulfenbach that ultimately attracts the Baron's attention to Agatha, thus kicking off the plot.
* One ''Webcomic/ElGoonishShive'' storyline featured a rampaging boar which was enchanted to grow to an enormous size. Said enchantment is heavily implied to have come from [[spoiler:Rhoda]], who was unwittingly given a [[PowerTattoo magic mark]] and unknowingly used it on the boar while in a state of panic.
* [[spoiler:Virtually everyone]] in ''Webcomic/{{Homestuck}}''. Turns out [[spoiler:pretty much the entire universe (or at least, the correct timeline) and everyone's actions in it were a specially orchestrated sequence of events in time designed to bring [[BigBad Lord English]] into existence, and vice versa: English's existence is so intrinsic to the proper workings of the comic that any timeline deviating from the main one doesn't fulfill the requirements to result in his birth and consequently ''becomes a [[BadFuture doomed timeline]]'', so it can't really be considered their fault.]] Naturally, in keeping with the messed-up time shenanigans ingrained into the comic, [[spoiler:English]] set this up himself beforehand/afterward. The ''single'' good character who doesn't manage this is Nepeta[[note]]largely because she's never shown actually ''doing'' much of anything; the one time she tries to do something significant she's hopelessly outclassed and dies pointlessly and almost immediately[[/note]].
** Tavros deserves special mention. At one point he attempts to save a young Jade from accidentally shooting herself by taking psychic control of her dog, Becquerel, and deflecting the shot at her grandfather (whom he believed was a hostile intruder), killing him. He then points out that Becquerel would have saved her even if he hadn't done anything (in a way that would not have killed Grandpa Harley) and that he only interfered so he could feel a little better about himself. Even when she points out that killing her grandfather was ''not'' appreciated, he still thinks he made the right choice.
* In ''Webcomic/KevinAndKell'', [[Webcomic/GeneralProtectionFault Nick and Ki's]] [[{{Crossover}} arrival in Domain]] by way of interdimensional travel disrupts the balance between the animal- and human-dominated worlds to the point at which the other two humans living on the animal side [[spoiler:Lindesfarne and Danielle]] are forced to leave lest the world suffer instinct loss. [[spoiler:Luckily, Catherine and Nigel do it instead]].
* In ''Webcomic/KidRadd'', two Moderators are given a large sum of money in order to hire an assassin to kill Radd, as Captain QB can't be directly implicated in illegal activities and needs to use a proxy. They reason that it can't be hard to kill someone in jail (as Radd is being imprisoned for illegally entering other games), and hire Kobayashi the discount ninja so that they can pocket the rest of the money. Radd survives the assassination attempt and Kobayashi becomes a recurring character who later meets up with Gnarl and, while training together, stumbles upon [[spoiler:Chimera Point, the keystone to Crystal's plans, which eventually results in ''her'' finding it too]].
* Several characters in ''Webcomic/{{minus}}'' take actions that, unbeknownst to them, lead to TheEndOfTheWorldAsWeKnowIt. First, a mysterious man pretty much "breaks" [[RealityWarper minus]] by stuffing her into a briefcase. She is freed, but becomes a CloudCuckooLander. In an attempt to cure her, the green-haired girl throws a rock at minus's head, causing her [[spoiler:[[LiterallyShatteredLives to shatter]]]]. Because she is now [[spoiler:a ghost]], minus starts to spend more time with her ghost friends than her live ones. Which leads to the biggest example of this trope in the comic: the red-haired ghost asks minus to bring her back to life, because she has some UnfinishedBusiness with certain humans that the readers don't get to see. minus agrees. Unfortunately, once the other ghosts find out, they demand that minus revive them too. She does, [[spoiler:only for the sheer influx of bodies on Earth to suffocate every living thing on the planet, including those who were just revived]]. [[SpaceWhaleAesop And that is why you should never ask anything of an omnipotent being, ever.]]
* In ''Webcomic/NobodyScores'' this is frequently the role of [[Main/{{CloudCuckoolander}} Jane Doe]]. [[http://nobodyscores.loosenutstudio.com/index.php?id=488 This]] for example.
* ''Webcomic/TheOrderOfTheStick'':
** [[KnightTemplar Miko Miyazaki]], having already [[DePower lost her Paladin abilities]] through the [[TheKingslayer unwarranted execution of of Lord Shojo]], ends up destroying the [[MacGuffin Sapphire Gate]], having once again misinterpreted what the gods wanted of her. Had she not been so hasty in doing this, the ghost of [[PrecursorHeroes Soon Kim]] could have permanently ended the threat of [[BigBad Xykon]] and [[DragonWithAnAgenda Redcloak]], who, themselves, were aiming for the gate, anyway.
** Right-Eye had the idea to recruit Xykon. If not for that one moment, Xykon never would have learned about the Snarl, probably never would have had the brains to become a lich on his own and would have continued his life of petty evil until he died and went to the Lower Planes without ever becoming the apocalyptic threat he is today.
** When Vaarsuvius went on a RoaringRampageOfRevenge and [[spoiler:cast Familicide, killing every creature related to the Ancient Black Dragon]], they didn't have any intentions beyond protecting their own family (and maybe enjoying the wildly DisproportionateRetribution way too much). Unfortunately for them, and also the world, [[spoiler:the Draketooth family guarding one of the Gates has a MeaningfulName, and Familicide wiped out every last one of them, leaving the Gate completely unprotected.]]
** The "civilized monster" races were Fenris's contribution to creating the world. He intended for the fast-breeding and resourceful goblinoids to outcompete the humanoids, but lost interest and turned to other projects. When the Dark One ascended to godhood, he assumed the goblins had been designed this way to provide [[CannonFodder easy targets for humanoid adventurers]], leading him and his priests to seek [[EldritchAbomination the Snarl]] to overthrow the gods. Because Fenris was careless.
* ''Webcomic/SchlockMercenary'': The Toughs accept a contract to deliver some food to what is referred to, in-story, as an 'UNS charity project'... Credomar. Due to the ship's AI interfering with a fuel delivery (which, in its defence, could have looked like an attack on the station if you squint right, particularly since the authorities take down the ''entire teraport denial field'' in order to teraport in the fuel), unrest in the station boils up quickly and leads to the station having several new holes in the side. [[CaptainObvious It's a space station floating in the vacuum of space]]. Of course the fact that one of their own 'build-a-bot' projects takes the opportunity to take charge, save everyone it could, become King, and inadvertently throwing a wrench in the UNS's plans to take over through other means (mainly by influencing the rebellion had it happened ''when expected'', along with using the Toughs to "prop up a pro-annexation group" without actually telling them this) was the icing on the cake.
* ''Webcomic/SleeplessDomain'': Sally's temper tantrum about Tessa being the leader and bossing everyone around just because she had the strongest powers of Team Alchemical results in [[spoiler:the deaths of herself, Sylvia, and Gwen, with Tessa depowering herself to save Undine.]]
** Later on, Vedika has a conversation with Cassidy and says that Undine is probably dealing with issues that she can’t really talk about. Unfortunately, with Cassidy already jealous of how much time Undine has been spending with H.P., she takes this to mean that Undine is somehow [[spoiler:complicit in the deaths of Team Alchemical]]. This leads to Cassidy harshly interrogating Undine, then storming off when the rest of the club [[WhatTheHellHero chews her out]], and ultimately [[spoiler:Cassidy herself getting murdered by Goops]]. Vedika is brought to tears when she tells everyone about this.
* ''Webcomic/StandStillStaySilent'': Reynir's older brother Bjarni to his LittleStowaway situation. While growing up, Reynir was told by his parents that only people who are TheImmune can travel internationally, while those who are not, such as himself, aren't allowed to do so. This, combined with having TheImmune DesignerBabies as siblings, gave him a quite bad case of SmallTownBoredom. Reynir eventually told Bjarni about it, and it goaded Bjarni into telling him that the international travel ban on non-immunes had actually been lifted a long time ago, and that their parents just didn't want an EmptyNest. Bjarni also mentioned that while military ships don't take non-immunes onboard, some merchant ships do. The merchant ship Reynir ended up on turned out to not have a license to let people disembark at its destination and its captain got blackmailed into making a detour to deliver food to the crew exploring an area with a high risk of ThePlague. All Reynir noticed about the latter situation was that the ship stopped moving and that crates big enough to fit a person were being taken out of the supply room.
----
