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* ''Literature/WhenTheAngelsLeftTheOldCountry'': A dybbuk possessing a person for too long will kill them, as almost happens to [[spoiler:Isaak Shulman]].
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* This happens to everyone who's possessed by the ancient evil Tak in the Creator/StephenKing novel ''Literature/{{Desperation}}''. Tak is so powerful that it causes any body it possesses to expand and grow more powerful, but it also amplifies any physical ailments they have. A host with cancer will die within hours, a staph infection in days and even something as simple as being easily sunburned will cause a body's skin to blister and drop off within a week, yet again leading to death. With animals it's even worse: They last an hour at most even if it's a strong, healthy animal. They might even explode.

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* This happens to everyone who's possessed by the ancient evil spirit Tak in the Creator/StephenKing novel ''Literature/{{Desperation}}''. Tak is so powerful that it causes any body it possesses to expand and grow more powerful, but it also amplifies any physical ailments they have. A host with cancer will die within hours, a staph infection in days and even something as simple as being easily sunburned will cause a body's skin to blister and drop off within a week, yet again leading to death. With animals it's even worse: They they last an hour hours at most even if it's a strong, healthy animal. They might even explode.

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* In the ''Franchise/StarWarsExpandedUniverse'', [[BackFromTheDead Palpatine's spirit]] possessing clone bodies made them degenerate really fast, which provided a limit on his resurrections.

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* In the ''Franchise/StarWarsExpandedUniverse'', ''Franchise/StarWarsLegends'', [[BackFromTheDead Palpatine's spirit]] possessing clone bodies made them degenerate really fast, which provided a limit on his resurrections.


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* Also, in the current ''Franchise/StarWars'' canon, Palpatine transferred himself to a clone body after being chucked down a reactor shaft on the Second Death Star by Darth Vader. However, his dark essence proved to be much too powerful for the clone body he woke up in, and his new body rapidly deteriorated from the pure dark side power coursing through his body.

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* ''Franchise/StarTrek''
** ''Series/StarTrekDeepSpaceNine'': In the [[Literature/StarTrekDeepSpaceNineRelaunch relaunch]] novels, the neural parasites originally introduced in the ''Series/StarTrekTheNextGeneration'' episode "[[Recap/StarTrekTheNextGenerationS1E24Conspiracy Conspiracy]]" return and renew their campaign against the Trill. The novels state that if an individual is forced to host a parasite for too long not only is their original personality is completely destroyed, but that there's several internal damage to the host organs. After the assination of Shakaar Edon in the novel "Lesser Evil" by a Trill an autopsy is performed which shows that Shakaar had been essentially dead for several months and his body run completely first by a parasite spawnmother, then by a soldier parasite when the spawnmother left to start a mass spawning.
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PossessionBurnout in {{Literature}}.
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* In ''Literature/ADarkerShadeOfMagic'', bodies possessed by Vitari gradually char and eventually crumble to ash.
* In the YA UrbanFantasy Book Series beginning with ''Literature/TheDemonsLexicon'' by Sarah Rees Brennan, the heads of TheMasquerade keep Mezentius House, a hospital/prison for bodies possessed by demons, which basically keeps the demons under control (chained up) until the body decays and dies. However, in the third book, [[spoiler: a magician makes a deal with a demon who wants to possess her to ''share'' the body alternating days and nights, hoping to stave off this trope]].
* This happens to everyone who's possessed by the ancient evil Tak in the Creator/StephenKing novel ''Literature/{{Desperation}}''. Tak is so powerful that it causes any body it possesses to expand and grow more powerful, but it also amplifies any physical ailments they have. A host with cancer will die within hours, a staph infection in days and even something as simple as being easily sunburned will cause a body's skin to blister and drop off within a week, yet again leading to death. With animals it's even worse: They last an hour at most even if it's a strong, healthy animal. They might even explode.
* Sir Creator/TerryPratchett's Literature/{{Discworld}} novel ''Literature/AHatFullOfSky'' introduces an entity called the Hiver, which is surprisingly alike in description, purpose and occupation to Garner's Brollochan. (Although Garner says his conception is not original - he has updated it from Celtic mythology. Pratchett may have read the same root sources.) However, while the Brollochan possesses beings to experience senses, the Hiver possesses beings to ''dampen'' its senses, which [[SensoryOverload would otherwise overwhelm it]].
** Further Discworld example: The Cunning Man from ''Literature/IShallWearMidnight'', whose rage is so intense that it ''literally'' burns out whatever unfortunate person it chooses as a vessel.
* A variant of this occurs in the ''Literature/DresdenFiles'' novel ''Literature/SkinGame''. Harry's brain has been infected with a parasite which Mab is keeping at bay, in order to keep him under her thumb. If it keeps possessing him, it will cause him to degenerate wildly, starting with his brain. [[spoiler:Except that it's not -- not exactly. Rather, that's a spirit of intellect which is the end result of the thought patterns of Harry and Lash, and could be construed as his ''daughter''. Yes, he's pregnant. None of which means that it'll be any less detrimental to him when he, ahem, gives birth.]]
* This happens to most living people that the eponymous ''Literature/EightMillionGods'' inhabit, which is why most of the more benign ones inhabit inanimate objects.
* In ''Franchise/HarryPotter'', Voldemort goes through several host bodies before he can perform a resurrection ritual that gives him a stable new form. He has to resort to things like drinking unicorn blood to keep his hosts alive.
* ''Literature/HIVESeries'': In the later books, this is what happens to bodies that Overlord possesss via the animus fluid.
* In the ''[[Literature/HushHush Hush, Hush]]'' world, it's said that this happens when fallen angels possess humans. This is why they generally aim to possess immortal Nephilim -- those bodies don't wear out, so the Nephilim [[AndIMustScream can look forward to an eternity of being possessed]].
* This happens in ''Literature/JourneyToChaos'' when high level deities inhabit mortal bodies. Order, for instance, can possess any ordercrafter of sufficient power and piety but they all quickly implode from the strain of his power. Those possessed by Lady Chaos explode or turn into monsters. It turns out that [[spoiler:defying this trope is the entire point of the series. Lady Chaos wants a vessel that won't explode when she inhabits it, so she sent Tasio to fetch Eric and mold him into someone who could withstand her power indefinitely]].
* In Creator/WalterJonWilliams' ''Metropolitan'' and ''City On Fire'', there's a type of disembodied spirit called an "iceman", formerly human. It possesses people so it can experience physical sensation again, but because it doesn't belong, everything feels "muted", so it wears its hosts out with physical excess. Sucks to be the host, sucks even ''more'' to be the iceman.
* In Creator/AlanGarner's ''Literature/TheMoonOfGomrath'', an ancient Celtic demonic entity, the Brollochan, is released form its prison cell by human interference. The Brollochan is an entity that lives vicariously through the senses of people and animals it serially possesses -- but no host can contain it for long without burning from the inside and crumbling to death.
* ''Literature/{{Patternist}}'': Doro the {{Body Surf}}er can't inhabit a body for more than a year without it dying, and that's with him actively, carefully looking after it. Since he generally doesn't bother, his bodies usually only last a few weeks. {{Justified|Trope}} because he's also [[SoulEater devouring his victims' souls]] and needs the sustenance.
* Played very literally on rare and usually momentous occasions in ''Literature/PerryRhodan''. If a [[CosmicBeing Cosmocrat]] wishes to pay the "standard" universe a visit and a 'mere' [[FightingAShadow Projected Avatar]] (already indistinguishable from a normal life-form and potentially quite badass in its own right if challenged) won't suffice, there exists an alternative in which the entity possesses a specially prepared host body, typically drawn from a servant species of physically extremely tough and naturally long-lived cyclopean giants, which allows it to bring a significantly larger portion of its power to bear directly -- but which also results in said almost preternaturally durable host body ''immediately'' starting to smolder and then burn, held together and kept moving only by the willpower of its possessor. Cosmocrats using this approach will generally arrange to have several spare bodies available because they can go through them ''fast'' even in the course of a slightly extended conversation.
* In ''Literature/SkulduggeryPleasant'' [[spoiler:Darquesse plays this trope straight as a rod, describing in detail her organs melting whilst in the process of killing Stephanie whilst she is possessing the body of Obloquy.]]
* In the ''Franchise/StarWarsExpandedUniverse'', [[BackFromTheDead Palpatine's spirit]] possessing clone bodies made them degenerate really fast, which provided a limit on his resurrections.
** It was later revealed that [[spoiler:this was not the case, and that someone had tampered with the genetic sample for Palpatine, which is what actually caused the clone bodies to degrade so quickly. The fresh bodies start to degrade before they are even ready for possession, and Palpatine can't fix it because even the original genetic material used as the template is damaged]].

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