History NonStandardCharacterDesign / WesternAnimation

* ''WesternAnimation/OutOfTheInkwell'': Koko the Clown looks more realistic compared to the cartoony cast of Fleischer's works. Justified because he was rotoscoped.

** Squidward doesn't look much like a squid at all, and WordOfGod is that, despite his name, he's actually an octopus. With six legs. So he's apparently a hexopus. What's interesting is that his relatives and Squilliam are also hexopuses.

* ''WesternAnimation/MiloMurphysLaw'': While most of the cast has multicolored pupils in their eyes, Melissa has visible irises with black pupils inside.

** Squidward doesn't look much like a squid at all, and WordOfGod is that, despite his name, he's actually an octopus. With six legs. So he's apparently a hexopus.

* ''WesternAnimation/{{Kaeloo}}'': All of the recurring cast are FunnyAnimals except Rules, who is a [[AnthropomorphicTypography talking exclamation mark]] who can shapeshift.

** In "[[Recap/MyLittlePonyFriendshipIsMagicS7E19ToChangeAChangeling To Change a Changeling]]", Thorax's brother Pharynx had a purple shell, violet eyes and red crest and tail instead of the changelings' standard blue-and-cyan color scheme, and is the only changeling to do so. Even after he transforms into a more typical "bug-horse", he still retains a much darker color scheme than the other changelings.

** Then there's Thorax, the leader of the changelings after they defect from Queen Chrysalis. He is larger, has gem-like bumps on his chest, and a pair of stag-like antlers.

* Lampshaded in an episode in which Homer imagines his children as horrible mutant inbred freaks [[ItMakesSenseInContext if he and Marge become brother and sister.]] Bart, Lisa, and Maggie are briefly depicted as ordinary adorable cartoon children with Caucasian skintones, blue eyes, blond hair, five fingers on each hand, and no overbites.