History Main / ImmunityDisability

* ''VideoGame/{{Minecraft}}'': The Illagers' [[BeastOfBattle Ravagers]] have a 50% chance of [[ImmuneToFlinching immunity to knockback]]. This backfires against the Villagers' Iron Golems, whose attacks cause a knockback that launches targets into the air and away from them, usually requiring the Golem to get back into range for the next attack. If a Ravager's knockback immunity activates, it just allows the Iron Golem to attack and kill them faster.

* This is one of the reasons why fighting the BonusBoss of ''VideoGame/Persona3'' is hard and tedious. You can at most resist her attacks. If you happen to null, absorb or reflect the element she's going to use, you get a 9999 damage [[NonElemental Megidolaon]] to your face instead. This is an exception however, as other times being immune will greatly help you throughout the game.

The kinds of disability vary - You FeelNoPain? You might not know what hit you or how much it damages your body. ImmuneToDrugs? It's gonna stab you in the back next time you need medicine. You're immortal? [[ImmortalityHurts You'd be surprised at]] [[AndIMustScream what you can live through.]] And so on and so forth.

Subtrope of PowerAtAPrice and BlessedWithSuck. If your particular immunity is to death, it becomes the subtrope WhoWantsToLiveForever.

[[folder: Anime and Manga ]]

* ''Franchise/OnePiece''. While fighting a giant zombie, Chopper, the team's doctor, tells it that the fact that it can't feel pain is its greatest weakness, as it has no way of knowing how much damage its body parts are accumulating until they're so injured that they simply stop responding altogether. The Straw Hats eventually beat it by shattering its spine, leaving the thing laying on the ground wondering why it can't move.
* Likewise, ''{{Manga/Loveless}}'' is a universe in which WordsCanBreakMyBones and magical duels are usually determined by using verbal imagery to curse the opposition's existence, limiting their capacities or inflicting pain until one side can take no more. A personal project involved artificially creating interchangeable human duelists able to use magic and possessing no nerve endings. Unlike zombies nothing makes these too stupid to see things like hypothermia coming, but being so easily able to defeat most opposition means they tend not to ''learn'' to protect themselves... and their casual brutality makes a more dangerous opponent unlikely to leave them alive ''to'' learn.
* In Part 2 of ''Manga/JojosBizarreAdventure'', the villain Cars ends up gaining immortality and an auto-evolution ability after combining the Stone Mask and Red Stone of Asia. Joseph uses this ability against him by throwing him into an active volcano where he hardens in defense as it's about to erupt. He gets launched into space and is stuck floating around forever; eventually his mind shuts down completely.
* Touma in ''LightNovel/ACertainMagicalIndex'' has his enchanted right arm, Imagine Breaker, that functions as an AntiMagic. In a world filled with mages, this gives him a great advantage. However, among other sucky things, it also cancels beneficial magic such as HealingHands. If not for his expert surgeon friend, he would have died of many non-magical things that his enemy can use. And apparently, in this setting, luck is a gift from God. So his luck is non-existent because it is nullified.

* ''Manga/RosarioPlusVampire'': Similar to the ''One Piece'' example above, Kahlua Shuzen can temporarily make herself FeelNoPain for better performance in a fight, and as a result, she has no way of knowing how much damage her body's taking until it simply quits on her. In fact, [[SpannerInTheWorks this]] was what forced Fairy Tale to retreat from Mizore's homeland, as Miyabi realized that she was approaching her limit and would kill herself otherwise.
* ''Manga/{{InuYasha}}'': Exploited by [[BigBad Naraku]] during Sango's introductory arc. After manipulating Sango into believing that Inuyasha attacked her village and slaughtered everyone there for the [[MacGuffin Shikon Jewel shard]] Sango had found earlier (unsurprisingly, Naraku was the real culprit), he embeds another shard in her body that completely negates her ability to feel pain, intending that she'll fight Inuyasha to the death without ever realizing how badly she was hurt. Indeed, she doesn't even notice she's ''bleeding out'' until Inuyasha calls attention to her wounds.

[[folder: Audio Play ]]

[[folder: Comic Books ]]

* Franchise/{{Superman}}'s near invulnerability also prevents him from shaving because even his beard is too tough to cut, so he [[https://www.youtube.com/watch?v=cvkDcrbLP2s uses his heat vision]]. (In post-Crisis comics, he also has to use a bit of his spaceship, since a normal mirror would melt. In pre-Crisis comics, his hair just doesn't grow while he has his powers.)
* In ''ComicBook/RisingStars'' one man's power is invulnerability from external harm--but this also leaves him highly insensitive to any form of touch, except on the back of his tongue, where he could still taste. He developed an eating disorder and became an indestructible obese man. [[spoiler:He's murdered when someone tapes a plastic bag over his head while he's asleep; he suffocates because he can't feel it]].
* ''ComicBook/TheIncredibleHulk'': In one storyline, the Hulk gets poisoned and has to give a blood sample; however, the needles can't penetrate his tough skin. He resorts to [[KickingMyOwnButt hitting himself over and over again]] till he bleeds enough to fill a test tube.
* ''ComicBook/TheSandman'' covers the trope as it applies to immortality:

* In ''ComicBook/{{PS238}}'', Ambriel's power is what she calls her "Guardian Angel," a sort of semi-sentient force that protects her from harm. When it's temporarily [[PowerNullifier turned off]] she quickly becomes sick--it seems her power kept germs away from her, which means that she never built up much of an immune system. It's made worse because now by now her power is working again and won't let Nurse Newbie give her a shot. Ultimately [[spoiler:Ambriel dies, becomes a ghost, and is then resurrected]], after which her "angel" becomes more discerning about what it keeps out.
* ''Franchise/TheFlash'': In one story, Bart Allen's kneecap was blasted apart by Deathstroke, and he was rushed to the hospital. During the surgery, his SuperSpeed meant that his flesh kept trying to heal improperly before an artificial kneecap could be placed, forcing the doctors to cut him open repeatedly. His metabolism meant that [[AndIMustScream no anesthesia could be used either]].
* During the Giffen/[=DeMatteis=] run on ''ComicBook/JusticeLeague'', ComicBook/PowerGirl was badly injured in a battle but the doctors could not perform surgery because no scalpel could cut through her invulnerable skin. Superman ended up saving her life, using his heat vision as a laser scalpel while [[ComicBook/GreenLantern Kilowog]], then serving as the Justice League's engineer and tech expert, whipped up a device that could hold Superman's head perfectly still to allow him to use his heat vision with precision.

[[folder: Fan Works ]]

** Paul, being NighInvulnerable, finds that being caught in a dust storm is an inconvenience because his eyeballs don't get irritated and tear up to clear out his eyes.

* In Fanfic/SnugglesTheSymbiote, the RequiredSecondaryPowers of Ashley's superhuman hormone production doesn't discriminate, making her immune or resistant to all drugs and toxins... Including pain killers, antibiotics, and other medications. This is a problem because her chemical resistance is only enough to keep her from [=ODing=] on her own hormones, it's not calibrated to perfectly counter her increased production and potency meaning that she's physically weak with a severely compromised immune system.
* In Fanfic/AshesOfThePast, the fact that Dark-types are immune to psychic powers results in occasional (usually humourous) inconvenience as they can't hear telepathic speech or be teleported when not in a Pokeball.

[[folder: Film ]]

* This sets off the whole plot of ''Film/SantoVsLaHijaDeFrankestein'' -- Frieda Frankenstein has developed an immunity to the youth serum she needs to survive.

* ''Film/{{Darkman}}'': After being horribly burned in a lab accident, the title character was subjected to an experimental medical procedure that destroyed the nerve endings close to his skin. As a result, he's now [[FeelNoPain immune to pain]]... and [[SenseLossSadness has no sense of touch whatsoever]].

[[folder: Literature ]]

* ''Literature/{{Chrestomanci}}'': At birth, it was foretold that Christopher Chant's weakness would be silver, so his father cast his strongest spells against silver affecting him. Ultimately, silver causes him to be BroughtDownToNormal; when Christopher isn't touching it, he's the most powerful enchanter in the worlds. (It's implied that it was a SelfFulfillingProphecy.)

* ''Literature/{{Twilight}}''--at one point Jacob breaks his leg, and his HealingFactor quickly causes it to mend incorrectly. The other heroes have no choice but to break it again so that they can set it properly.

[[folder: Live Action TV ]]

* ''Series/TheTwilightZone1959'' episode [[Recap/TheTwilightZoneS1E6EscapeClause "Escape Clause"]]. A man makes a DealWithTheDevil to gain immortality, which is effectively immunity to death. He murders his wife so that he can experience the electric chair, but his lawyer manages to get him life in prison. [[KarmicTwistEnding Since he can't die, he's going to be there a long time]]... at least until [[spoiler:the devil shows up and mercifully gives him a fatal heart attack]].
* In the final episode of ''Series/{{Alias}}'' BigBad Arvin Sloane has gotten his hands on enough [[MacGuffin Rambaldi documents]] to create a vat of fluid which somehow makes him immortal - and immediately thereafter a giant stone pillar falls on him, trapping him under it forever.

* ''Series/ForeverKnight'': If someone learns of vampires, a vampire will hypnotize them to forget. If they're one of the few people who are immune to hypnosis they'll usually be killed.
* ''Series/{{Angel}}:'' [[FullyEmbracedFiend Darla]] gets pregnant, [[ButICantBePregnant despite being a vampire]]. Darla tries to have an abortion, but can't--there's some sort of magical force field protecting the fetus from any harm. Good for the fetus, until said force field makes it impossible for him to actually be born. [[spoiler:Darla, who is sharing the baby's [[OurSoulsAreDifferent soul]] and can't stand the thought it losing it when the baby's born/dies, [[DrivenToSuicide stakes herself]], leaving the living baby there when she turns to dust]].
* ''Series/TheFlash2014'': Similar to the above Flash and Captain America examples, Barry Allen's superspeed gives him a super fast metabolism and super healing, so he's very hard to kill. Unfortunately, this means he needs to eat massive amounts of food to avoid passing out from low blood sugar levels. His body also burns through alcohol and anesthesia within a second, so he can't get drunk and, worse, is fully conscious during surgeries.
* On ''Series/{{Haven}},'' Nathan Wuornos's Trouble is that he [[FeelNoPain can't feel anything.]] And the show thoroughly explores how [[BlessedWithSuck much that sucks]], particularly since Nathan is a police officer. For the obvious, he can't feel when he's been injured on the job, such as one notable case where he was impaled by half a dozen industrial nails. But he also asks his partner, Audrey, to check the temperature of his coffee before he drinks it so he doesn't burn his mouth, and his kitchen is plastered in sticky notes reminding him to be careful around the stove and knife block. It sometimes gives him a DisabilityImmunity, but mostly he hates it.

[[folder: Tabletop Games ]]

* ''TabletopGame/DungeonsAndDragons'': Before 3rd Edition, Magic Resistance gave you a percentage chance to be unaffected by a spell. This applied to helpful spells like buffs or healing just as much as it applied to harmful effects. On top of this, races that had Magic Resistance as an inborn trait generally had it get stronger as they went up in level, so the higher level they got, the less likely the party cleric could heal them or some other useful magic. 3rd edition reduced the problem by allowing characters to voluntarily switch off spell resistance, though this requires them to not be unconscious.

[[folder: Video Games ]]

* In the original ''VideoGame/BaldursGate'', Viconia was a cleric who had a 65% resistance to magic, potentially incrementable. This made her a very effective asset against wizards, since she could avoid a lot of magic damage. Unfortunately, this meant also that often she wasn't able to heal herself or cast buff and protection spells to herself, rendering her a bit squishy. This was [[ObviousRulePatch later adjusted]] in ''VideoGame/BaldursGateII'' (where she had a 50% resistance against magic except healing and defensive spells) and in the Enhanced Edition (the same).
** By the end of ''VideoGame/BaldursGate2'' ''- Throne of Bhaal'', you can upgrade the Flail of Ages to the +5 version, which grants Free Action among other beneficial effects. That is, the character wielding the weapon is immune to spells affecting his mobility like Hold Person, Entangle, Stun or Web. The problem is that in the Enhanced Edition it also prevents buff like Haste. Since by the expansion it is rare to slip into anything like those spells, while Haste is practically mandatory to get the highest possible damage per round, many players don't upgrade the flail to its ultimate version, leaving it to the +4 one.
* In ''VideoGame/{{Disgaea}}'', Ninjas are the only class able to dodge special techniques. Unfortunately, that includes healing spells.
* Joshua Graham from ''Videogame/FalloutNewVegas'' suffers from horrific burns as a result of being covered in burning pitch as punishment [[YouHaveFailedMe for failing]] [[BigBad Caesar]]. He's also ImmuneToDrugs, meaning that no medicine can ease his constant pain.
* One of the reason why fighting the BonusBoss of ''VideoGame/{{Persona 3}}'' is hard and tedious. You can at most resist her attacks. If you happen to null, absorb or reflect the element she's going to use, you get a 9999 damage [[NonElemental Megidolaon]] to your face instead. This is an exception however, as other times being immune will greatly help you throughout the game.
* In ''VideoGame/{{Magicka}}'', accidentally casting immunity to Life makes you unhealable.

* In ''Videogame/{{Dota 2}}'', it's usually a good thing to cast Magic Immunity on yourself in the middle of battle to prevent the enemy from stunning you - but this also prevents your allies from casting healing spells on you.

* In ''VideoGame/MegaManXCommandMission'', Spider and Axl turn invisible in their Hyper Modes. In gameplay this makes them invincible, to reflect the fact that enemies attacking them can't actually aim at them. However, allies can't see them to heal them either.
* ''VideoGame/HeroesOfMightAndMagic'' games often feature one or more magic-immune creature, the most famous of which is the reoccurring [[FlyingBrick Black Dragon]]. Creatures with this ability are completely immune to all enemy spells as expected, but are also immune to friendly spells. This means they're unable to be buffed, healed, or resurrected, and instead rely purely on their raw stats.

* In ''VideoGame/GodOfWarPS4'', the Stranger / [[spoiler:Baldur]] is impervious to harm and [[FeelNoPain feels no pain.]] But because of this, he cannot feel the most mundane stimuli such as pain, temperature, taste or pleasure. This lack of sense [[SenseLossSadness drives him insane]], as well as destroying any level of empathy he possessed. He even flat out said he would rather die than to not feel anything.
* ''VideoGame/{{Minecraft}}'': The Illagers' [[BeastOfBattle Ravagers]] have a 50% chance of [[ImmuneToFlinching immunity to knockback]]. This backfires against the Villagers' Iron Golems, whose attacks cause a knockback that launches targets into the air and away from them, usually requiring the Golem to get back into range for the next attack. If a Ravager's knockback immunity activates, it just allows the Iron Golem to attack and kill them faster.

[[folder: Web Comics ]]

* In ''Webcomic/DominicDeegan'' resistance to magic is generally considered a disability, because while magic fireballs can't hurt you, white mages can't heal you when something non-magical almost kills you.

[[folder: Web Original ]]

* The ''WesternAnimation/BatmanTheAnimatedSeries'' version of ComicBook/PoisonIvy confesses that her immunity to all poisons, toxins, etc. extends to... well, she can't get pregnant.

[[folder: Real Life ]]

** Followers of Nurgle are generally immune to pain, due to their bodies being so much dead or festering tissue that they're only "alive" in the [[TechnicallyLivingZombies loosest sense of the word]].

** Followers of Nurgle are generally immune to pain, due to their bodies being so much dead or festering tissue.
** Likewise, Slaaneshi cultists are TooKinkyToTorture, but they require ever-greater amounts of sensory input to feel anything.

*** Blanks not only nullify psychic powers on themselves, but often in a small area around them. Psychics in the area can normally find people by seeking out their psychic signatures. The dead-zone created by a blank is even more of a sign that something odd is there.
*** As emotions are a form of psychic power, blanks tend to feel only muted emotion and drain emotions from those around them.

*** Because blanks are so rare, once discovered, you'll be picked up by the Inquisition and trained into a commando. Depending on your viewpoint, this is either awesome or horrible.
*** Because the soul itself is connected to the Warp, nearly all sentient beings near a blank instinctively feel some level of instinctive hostility to blanks as they can sense their very souls being weakened in the Blank's presence. In weaker blanks, this is causes slight discomfort. For the strongest blanks, known as Pariahs, it becomes homicidal disgust. Blanks tend not to lead long lives thanks to this.
* ''TabletopGame/DungeonsAndDragons'': Before 3rd Edition, Magic Resistance gave you a percentage chance to be unaffected by a spell. This applied to helpful spells like buffs or healing just as much as it applied to harmful effects. On top of this, races that had Magic Resistance as an inborn trait generally had it get stronger as they went up in level, so the higher level they got, the less likely the party cleric could heal them or some other useful magic. 3rd edition reduced the problem by allowing characters to voluntarily switch off spell résistance, though this requires them to not be unconscious.

*** As emotions are a form of psychic power, blanks cannot feel emotion and drain emotions from those around them. This gives them an UncannyValley effect.

* In an ''ComicBook/IncredibleHulk'' storyline, the Hulk gets poisoned and has to give a blood sample; however, the needles can't penetrate his tough skin. He resorts to [[KickingMyOwnButt hitting himself over and over again]] till he bleeds enough to fill a test tube.
* ''Comicbook/TheSandman'' covers the trope as it applies to immortality:

** Retired superhero [[Comicbook/{{Metamorpho}} Element Girl]] longs for death because her freakish appearance leaves her socially isolated and agoraphobic. However, because her body can automatically transmute itself into most any element, she's effectively immortal, and [[ICannotSelfTerminate unable to commit suicide]] without the intervention of the god who bestowed her powers in the first place.

* In an ''ComicBook/IncredibleHulk'' storyline, the Hulk gets poisoned and has to give a blood sample; however, the needles can't penetrate his tough skin. He resorts to [[KickingMyOwnButt hitting himself over and over again]] till he bleeds out enough to fill a test tube.

The kinds of disability vary - You FeelNoPain? You might not know what hit you or how much it damages your body. ImmuneToDrugs? It's gonna stab you in the back next time you need medicine. You're immortal? [[AndIMustScream You'd be surprised at what you can live through.]] And so on and so forth.

* {{Superman}}'s near invulnerability is often parodied by having it also prevent him from shaving because even his beard is too tough to cut, leading to some [[https://www.youtube.com/watch?v=cvkDcrbLP2s memorable workarounds]].

* In the original ''VideoGame/BaldursGate'', Viconia was a cleric who had a 65% resistance to magic, potentially incrementable. This made her a very effective asset against wizards, since she could avoid a lot of magic damage. Unfortunately, this meant also that often she wasn't unable to heal herself or cast buff and protection spells to herself, rendering her a bit squishy. This was [[ObviousRulePatch later adjusted]] in ''VideoGame/BaldursGateII'' (where she had a 50% resistance against magic except healing and defensive spells) and in the Enhanced Edition (the same).

* In ''Fanfic/WeasleyGirl'', the core 4 ends up immune to all potions, meaning that [[DisabilitySuperpower they can't ever be poisoned or otherwise harmed by potions]], they also can't ever have useful potions used on them.
* In Fanfic/SnugglesTheSymbiote, the RequiredSecondaryPowers of Ashley's superhuman hormone production doesn't discriminate, making her immune or resistant to all drugs and toxics... Including pain killers, antibiotics, and other medications. This is a problem becuase her chemical resistance is only enough to keep her from ODing on her own hormones, it's not calibrated to perfectly counter her increased production and potency meaning that she's physically weak with a severely compromised immune system.
* In Fanfic/AshesOfThePast, the fact that Dark-types are immune to psychic powers results in occasional (usually humourous) inconvenience as they can't hear telepathic speech or be teleported when not in a Pokeball.

* In the original ''VideoGame/BaldursGate'', Viconia was a cleric who had a 65% resistance to magic. This made her an unvaluable asset against wizards, since she could avoid a lot of magic damage. Unfortunately, this meant also that often she wasn't unable to heal herself or cast buff and protection spells to herself, which caused her to be a bit squishy. This was later adjusted in ''VideoGame/BaldursGateII'' (where she had a 50% resistance against magic except healing and defensive spells) and in the Enhanced Edition (the same).

* ''Manga/RosarioToVampire'': Similar to the ''One Piece'' example above, Kahlua Shuzen can temporarily make herself FeelNoPain for better performance in a fight, and as a result, she has no way of knowing how much damage her body's taking until it simply quits on her. In fact, [[SpannerInTheWorks this]] was what forced Fairy Tale to retreat from Mizore's homeland, as Miyabi realized that she was approaching her limit and would kill herself otherwise.

* ''Manga/RosarioToVampire'': Similar to the ''One Piece'' example above, Kahlua Shuzen has been charmed to FeelNoPain, and as a result, she has no way of knowing how much damage her body's taking until it simply quits on her. In fact, [[SpannerInTheWorks this]] was what forced Fairy Tale to retreat from Mizore's homeland, as Miyabi realized that she was approaching her limit and would kill herself otherwise.

* In ''ComicBook/RisingStars'' one man's power is invulnerability from external harm--but this also leaves him highly insensitive to any form of touch, except on the back of his tongue, where he could still taste. He developed an eating disorder and became an indestructible obese man. [[spoiler: He's murdered when someone tapes a plastic bag over his head while he's asleep; he suffocates because he can't feel it]].

* A minor example in ''Fanfic/TheKeysStandAlone: The Soft World'': Paul, being NighInvulnerable, finds that being caught in a dust storm is an inconvenience because his eyeballs don't get irritated and tear up to clear out his eyes.

* Followers of Nurgle in ''TabletopGame/{{Warhammer}}'' and ''TabletopGame/Warhammer40000'' are generally immune to pain, due to their bodies being so much dead or festering tissue. Likewise, Slaaneshi cultists are TooKinkyToTorture, but they require ever-greater amounts of sensory input to feel anything.

* Yunalesca in ''VideoGame/FinalFantasyX'' has the nasty habit of inflicting Zombie on your characters, which turns heals into damage and persists through death. You may be tempted to equip armor with zombieproof on it, but as the fight wears on she pulls out Mega Death, an attack which only targets non-zombie characters and deals an instant KO (unless your armor also has deathproof).
* In ''VideoGame/GodOfWarPS4'', the Stranger / [[spoiler: Baldur]] is impervious to harm and [[FeelNoPain feels no pain.]] But because of this, he cannot feel the most mundane stimuli such as pain, temperature, taste or pleasure. This lack of sense [[SenseLossSadness drives him insane]], as well as destroying any level of empathy he possessed. He even flat out said he would rather die than to not feel anything.

* Touma in ''LightNovel/ACertainMagicalIndex'' has his enchanted right arm, Imagine Breaker, that functions as an AntiMagic. In a world filled with mages, this gives him a great advantage. However, among other sucky things, it also cancels beneficial magic such as HealingHands. If not for his expert surgeon friend he would have died of many non-magical things that his enemy can use.
** And apparently, in this setting, luck is a gift from God. So his luck is non-existent because it is nullified.

* The ''WesternAnimation/BatmanTheAnimatedSeries'' version of Poison Ivy confesses that her immunity to all poisons, toxins, etc. extends to... well, she can't get pregnant.

* ''TabletopGame/DungeonsAndDragons'': Before 3rd Edition, Magic Resistance gave you a percentage chance to be unaffected by a spell. This applied to helpful spells like buffs or healing just as much as it applied to harmful effects. On top of this, races that had Magic Resistance as an inborn trait generally had it get stronger as they went up in level, so the higher level they got, the less likely the party cleric could heal them or some other useful magic.

* In ''ComicBook/RisingStars'' one man's power is invulnerability from external harm--but this also leaves him highly insensitive to any form of touch, except on the back of his tongue, where he could still taste. He developed an eating disorder and became an indestructible obese man.

* There is a medical condition that makes people pretty much immune to pain; however, as a result they tend to get extremely injured without realizing it.