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* In ''Literature/HarryPotterAndTheOrderOfThePhoenix'' Ron gets attacked by tentacled brains in the Department of Mysteries that MindRape and leave gouges behind when they touch someone.
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* In Creator/RudyRucker's ''Master of Time and Space'', a giant brain became the Messiah of a ReligionOfEvil in an alternate dimension. Then it spawned regular-sized brains that can move around by crawling, attach to people's backs and mind-control them.
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* In Creator/RudyRucker's ''Master of Time Space and Space'', Time'', a giant brain became the Messiah of a ReligionOfEvil in an alternate dimension. Then it spawned regular-sized brains that can move around by crawling, attach to people's backs and mind-control them.
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* In Rudy Rucker's ''Master of time and space'', a giant brain became the Messiah of a ReligionOfEvil in an alternate dimension. Then it spawned regular-sized brains that can move around by crawling, attach to people's backs and mind-control them.
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* In Rudy Rucker's Creator/RudyRucker's ''Master of time Time and space'', Space'', a giant brain became the Messiah of a ReligionOfEvil in an alternate dimension. Then it spawned regular-sized brains that can move around by crawling, attach to people's backs and mind-control them.
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** Lampshaded in TeamFourStar's Abridged version of the movie. Wheelo is told his brain has absorbed a lot of the embalming fluid it's suspended in, which caused it to grow. To his dismay.
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** Lampshaded in TeamFourStar's Abridged version of the movie. Wheelo is unaware, and has to be told his brain has absorbed a lot of the embalming fluid it's suspended in, which caused it to grow. To his dismay.
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* Ben's Alien Brainsorm from ''WesternAnimation/Ben10AlienForce'' can open his head to reveal his [[MyBrainIsBig oversized brain]] and shot electricity from it.
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* Ben's Alien Brainsorm from ''WesternAnimation/Ben10AlienForce'' can open his head to reveal his [[MyBrainIsBig oversized brain]] and shot shoot electricity from it.
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** Lampshaded in TeamFourStar's Abridged version of the movie. Wheelo is told his brain has absorbed a lot of the embalming fluid it's suspended in, which caused it to grow. To his dismay.
---> "Why is it the size of a greyhound?"
---> "''THE BUS?!''"
---> "Why is it the size of a greyhound?"
---> "''THE BUS?!''"
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* ''Webcomic/{{Paranatural}}'': Hijack, the arc villain of chapter 5, is a spirit who has the appearance of a floating brain with a face and arms.
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* Amadeus Cho's subplot in the Hercules title pitted him against Boltzmann Brains; disembodied brains that are hypercomputer quantum constructs capable of creating virtual scenarios in pocket dimensions at will. They also shoot bolts of electricity.
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* The first ''VideoGame/{{X-COM}}'' game also features the Alien Brain on Mars as the BigBad.
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* The first ''VideoGame/{{X-COM}}'' ''VideoGame/{{XCOM}}'' game also features the Alien Brain on Mars as the BigBad.
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* '''Acranial Monster''': A monster that has its skull being incomplete, thus exposing their brain.
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* '''Acranial Monster''': A monster that has its skull being incomplete, an incomplete skull, thus exposing their brain.
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* The principal antagonist of the French film ''WesternAnimation/{{Gandahar}}'', a/k/a ''Light Years'', is a giant brain, made by the people of the utopian city of Gandahar as a prototype organic computer. When the superbrain didn't work out as planned, it was dumped in the ocean and forgotten. Interestingly, when the heroes first encounter this giant brain, it seems docile, and even gives the heroes the tool for its own destruction.
to:
* The principal antagonist of the French film ''WesternAnimation/{{Gandahar}}'', a/k/a a.k.a ''Light Years'', is a giant brain, made by the people of the utopian city of Gandahar as a prototype organic computer. When the superbrain didn't work out as planned, it was dumped in the ocean and forgotten. Interestingly, when the heroes first encounter this giant brain, it seems docile, and even gives the heroes the tool for its own destruction.
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[[folder: Web Original ]]
* ''{{Website/Neopets}}'' has the [[http://images.neopets.com/halloween/braintree.gif Brain Tree]], which gives out quests in the form of a questions you must answer. The rationale behind this behavior is that the Brain Tree loves knowledge but, being rooted to the spot, it must rely on others to find information.
[[/folder]]
* ''{{Website/Neopets}}'' has the [[http://images.neopets.com/halloween/braintree.gif Brain Tree]], which gives out quests in the form of a questions you must answer. The rationale behind this behavior is that the Brain Tree loves knowledge but, being rooted to the spot, it must rely on others to find information.
[[/folder]]
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* An episode of ''George Shrinks'' featured these in a B-movie.
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* An episode of ''George Shrinks'' ''WesternAnimation/GeorgeShrinks'' featured these in a B-movie.
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* In ''VideoGame/{{Terraria}}'', the boss of [[BloodyBowelsOfHell the Crimson]] is the Brain of Cthulhu, a giant demon brain with some tentacles and a few vertebrae sticking out of the bottom. Once you kill the Creepers surrounding it, the two hemispheres open up, revealing a beating heart with an eye on it.
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* ''VideoGame/{{Bloodborne}}'' has Amygdala and its brethren, whose head consists of a mostly-exposed brain occasionally covered in eyes. As well, the Brain of Mensis is a giant brain covered in eyes.
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[[AC:{{Anime}} and {{Manga}}]]
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[[folder: Anime and
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[[folder: Comic Books ]]
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[[folder: Film ]]
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[[folder: Literature ]]
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[[folder: Live Action TV ]]
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[[folder: Tabletop Games ]]
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[[folder: Video Games ]]
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[[folder: Web Comics ]]
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[[folder: Western Animation ]]
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* What other show has such a creature as its [[VillainProtagonist main character]] other than ''Main/EvilConCarne''?
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* What other show has such a creature as its [[VillainProtagonist main character]] other than ''Main/EvilConCarne''?''WesternAnimation/EvilConCarne''?
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* The fourth guardian in ''VideoGame/{{Unepic}}'', the aptly-named [[http://unepic.wikia.com/wiki/Neuron Neuron]], is a giant floating brain with a single eye which lives in the castle's library. It has an ungodly amount of PsychicPowers -- up to an including mind-controlling your character or causing an InterfaceScrew -- that make it one of the [[ThatOneBoss trickiest (and most annoying)]] enemies in the game.
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* An episode of WesternAnimation/DarkwingDuck revolves around a machine that gives the user PsychicPowers and [[MyBrainIsBig enlarges their brain]] as a side effect. At the episode's climax, the villain crank the machine UpToEleven and turns himself into a truck-sized, floating brain. They beat him by [[spoiler: making him think too much during the power-up process, which [[YourHeadASplode blows him up]]]], making this one of the {{Squick}}iest episodes of the series.
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* In Rudy Rucker's ''Master of time and space'', a giant brain became the Messiah of a ReligionOfEvil in an alternate dimension. Then it spawned regular-sized brains that can move around by crawling, attach to people's backs and mind-control them.
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* What other show has such a creature as its [[VillainProtagonist main character]] other than ''Main/EvilConCarne''?
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* An episode of ''George Shrinks'' featured these in a B-movie.
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* The Weirdboy in ''DawnOfWar 2'' has an upgrade called Bigger Brains, the icon for which shows his brain swelling out of his skull.
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* The Weirdboy in ''DawnOfWar ''VideoGame/DawnOfWar 2'' has an upgrade called Bigger Brains, the icon for which shows his brain swelling out of his skull.
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* The Brains from ''WesterAnimation/TheAdventuresOfJimmyNeutronBoyGenius'', contestants in the Galactic Showdown game. They bragged on how they evolved to not need bodies anymore, as they consisted of nothing but floating brains.
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* The Brains from ''WesterAnimation/TheAdventuresOfJimmyNeutronBoyGenius'', ''WesternAnimation/TheAdventuresOfJimmyNeutronBoyGenius'', contestants in the Galactic Showdown game. They bragged on how they evolved to not need bodies anymore, as they consisted of nothing but floating brains.
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* Mojo Jojo from ''ThePowerpuffGirls'' has his enlarged brain protected by a transparent helmet.
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* Mojo Jojo from ''ThePowerpuffGirls'' ''WesternAnimation/ThePowerpuffGirls'' has his enlarged brain protected by a transparent helmet.
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** The first final boss - the Spider Mastermind - was essentially a giant brain carried by a robot body.
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** The first final boss - the Spider Mastermind - was essentially a giant brain carried by a robot body. Its children in Doom II are the Arachnotrons, which are basically smaller versions with plasma guns.
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* In ''VideoGame/StarFox64'', the FinalBoss, Andross, is a ([[RoboticReveal possibly robotic?]]) giant monkey head with [[RaymanianLimbs unattached hands]] that attacks the player's Arwing SpaceFighter with {{telekinesis}}. After [[TurnsRed taking a certain amount of damage]], the surface layer of the...thing [[MadeOfExplodium explodes]] to reveal an equally giant brain with attached eyeballs. [[BigLippedAlligatorMoment No in-game explanation is given]] for how his brain got so large or why it can operate without a body.
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* In ''VideoGame/StarFox64'', the FinalBoss, Andross, is a ([[RoboticReveal possibly robotic?]]) giant monkey head with [[RaymanianLimbs [[FloatingLimbs unattached hands]] that attacks the player's Arwing SpaceFighter with {{telekinesis}}. After [[TurnsRed taking a certain amount of damage]], the surface layer of the...thing [[MadeOfExplodium explodes]] to reveal an equally giant brain with attached eyeballs. [[BigLippedAlligatorMoment No in-game explanation is given]] for how his brain got so large or why it can operate without a body.
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!Examples
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* In the ''Series/DoctorWho'' episode "Evolution of the Daleks", Dalek Sec turns himself into a Dalek/Human hybrid, which has a large exposed brain.
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* In the ''Series/DoctorWho'' episode [[Recap/DoctorWhoS29E5EvolutionOfTheDaleks "Evolution of the Daleks", Daleks"]], Dalek Sec turns himself into a Dalek/Human hybrid, which has a large exposed brain.
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[[quoteright:280:[[MetalSlug http://static.tvtropes.org/pmwiki/pub/images/d4d541fd7e4d9fc1930eec6837693c5a.gif]]]]
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* Mojo Jojo from ''ThePowerpuffGirls'' has his enlarged brain protected by a transparent helmet.
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* Mojo Jojo from ''ThePowerpuffGirls'' has his enlarged brain protected by a transparent helmet.helmet.
----
----
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* In ''TabletopGame/{{Warhammer 40000}}'', several [[HordeOfAlienLocusts Tyranid]] creatures, especially those with strong psychic powers, have partially exposed brains.
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* Violet's monster in ''Webcomic/MonsterPulse''. It's literally her brain pulled out of her body and given monster form, like other monsters in the comic. Unlike other monsters, [[spoiler:it's also where her personality now resides, remote-controlling her human body]].
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There are two types of this:
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There are two types of this:monstrous brains:
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Oops, forgot
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* The giant squid monster from ''Comicbook/{{Watchmen}}''. '''ZCE'''
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* Featured in ''VideoGame/{{Gradius}}'', ''VideoGame/{{Gradius}} 3'' and ''VideoGame/{{Gradius}} 5''. '''ZCE'''
* ''VideoGame/{{Shinobi}} 3'' final boss. '''ZCE'''
* ''VideoGame/{{Shinobi}} 3'' final boss. '''ZCE'''
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* The final boss of ''VideoGame/QuakeIV'', the Nexus. '''ZCE'''
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* Big Brain (that's his name) from ''WesternAnimation/FairlyOddParents''. '''ZCE'''
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[[quoteright:280:[[MetalSlug http://static.tvtropes.org/pmwiki/pub/images/d4d541fd7e4d9fc1930eec6837693c5a.gif]]]]
[[caption-width-right:280:I can has Metal Slug?]]
The brain. A big, juicy, wrinkled organ on our head that is protected by the skull for a good reason. Now, imagine when it's not...
There are two types of this:
* '''Just Brain''': The brain moves around by itself. It might have some bits attached, such as legs, hovering jets or helicopter rudders, but its main "body" is a brain. Alternatively, it is stationary, and attached to something.
* '''Acranial Monster''': A monster that has its skull being incomplete, thus exposing their brain.
A sister-trope of BrainInAJar, although of lot of these brains don't really need the jar life-support system, as well as the furthest extension of MyBrainIsBig.
Subtrope of EvilIsVisceral and BodyHorror, and thusly, is always played for NauseaFuel.
----
!Examples
[[AC:{{Anime}} and {{Manga}}]]
* Vademon from ''Anime/DigimonAdventure'' has a huge exposed brain, seeing that he's an alien Digimon.
* BigBad Dr. Wheelo of ''Anime/DragonBallZ: The World's Strongest'' had his [[BrainInAJar brain preserved in a jar]] by his assistant before he died, and is currently searching for [[TitleDrop the world's strongest warrior]] to serve as [[GrandTheftMe a host body]]. [[FridgeLogic For some reason]], the process also made his brain gigantic; how he expects to transplant it into a human-sized skull is unknown.
[[AC:ComicBooks]]
* Several incarnations of Brain of ''Franchise/TheDCU'' -- as the disembodied, preserved, sentient BrainInAJar of a MadScientist. Together with his sentient gorilla servant/boyfriend Mallah, the two of them would go on to gather the Brotherhood of Evil.
* The ''Comicbook/{{BPRD}}'' short comic that introduced Lobster Johnson involves a scientist who gained psychic powers in an experiment, then used those powers to kill his colleagues. When the Lobster shoots the psychic in the head, his brain crawls out of the bullet hole, grows several times larger, then flies around the room. The Lobster barely kills the mutant brain before it strangles him with its spinal cord.
* The giant squid monster from ''Comicbook/{{Watchmen}}''. '''ZCE'''
[[AC:{{Film}}]]
* Gor and Vol from ''Film/TheBrainFromPlanetArous'' are aliens that resemble giant disembodied floating brains. The former wants to take over the universe, the latter wants to stop him.
* The 1958 film ''Film/FiendWithoutAFace'' featured invisible monsters that when revealed are actually slimy crawling human brains. Said brains strangle victims with their spinal cords.
* The 1988 film ''Film/TheBrain'' featured an alien that resembled a gigantic brain with a face as the titular monster.
* In ''Film/TheTimeMachine2002'', the Morlock leader is of a caste in which the brain has become so enlarged that it's not only visibly exposed on the back of his head, but its lobes extend halfway down his back as well.
* The invading Martians from Creator/TimBurton's ''Film/MarsAttacks'' are the acranial type. Their brains visibly pulsate and explode inside their clear helmets when exposed to their WeaksauceWeakness: really bad singing.
[[AC:{{Literature}}]]
* Creator/MadeleineLEngle's novel ''Literature/AWrinkleInTime''. The BigBad IT is a huge disembodied brain. It has MindControl abilities that involved making the victim think in repetitive patterns.
* The Grand Lunar from Creator/HGWells' work ''Literature/TheFirstMenInTheMoon'' is the ruler of the "Moonies," and rests in the throne room with his exposed brain taking up most of the cathedral-like ceiling space. There are lesser Moonies that hover around moistening this huge brain. The Grand Lunar is LawfulNeutral, but takes Doctor Cavor prisoner on the belief that humans are intelligent anarchists.
* In the ''Literature/{{Lensman}}'' series novel ''Galactic Patrol'', Mentor of Arisia is revealed to Kimball Kinnison to be (barring a few minor bits and appendages) "simply and solely a brain." Then in ''Second Stage Lensmen'' the Boskonian Prime Minister Fossten is revealed to be a nearly identical brain, explained by his being a renegade Arisian. [[spoiler:Except that this was a false appearance in both cases, arranged by Mentor to hide from Kinnison that Fossten was really Gharlane of Eddore.]]
[[AC:LiveActionTV]]
* ''Series/{{Farscape}}''. [[spoiler: The evil version of Crichton of the "[[Recap/FarscapeS02E10MyThreeCrichtons My Three Crichtons]]" episode is the future version with the wrinkly head to show off his advanced brain lobes.]]
* In an episode of ''Series/{{Angel}}'' [[Recap/AngelS03E02ThatVisionThing "That Vision Thing"]] Wolfram & Hart hire a psychic with an exposed brain to torture Cordelia, forcing Angel to release a soul from torment in return for stopping the torture.
* In the ''Series/DoctorWho'' episode "Evolution of the Daleks", Dalek Sec turns himself into a Dalek/Human hybrid, which has a large exposed brain.
[[AC:TabletopGames]]
* ''TabletopGame/DungeonsAndDragons''
** [[http://forgottenrealms.wikia.com/wiki/Elder_brain Illithid elder brains]], which float in large brine pools in illithid cities. They are made up of the combined brains of old illithids that sacrificed themselves to join it.
** The Intellect Devourer is basically a brain running around on four little legs. Its modus operandi is to crack a victim's skull open, remove the brain and then [[GrandTheftMe squeeze inside, taking over the body]].
[[AC:VideoGames]]
* ''Franchise/{{Metroid}}''
** In ''VideoGame/{{Metroid}}'' the final boss, Mother Brain, is a massive brain in a tank, with a laser shooting eye. It's stated that it started off as an organic computer built by the [[BenevolentPrecursors Chozo]], which took command of the SpacePirates.
** In ''VideoGame/SuperMetroid'', Mother Brain reappears as the final boss [[spoiler: this time as an "acranial" example, having gained a massive mechanised body.]]
* Featured in ''VideoGame/{{Gradius}}'', ''VideoGame/{{Gradius}} 3'' and ''VideoGame/{{Gradius}} 5''. '''ZCE'''
* ''VideoGame/{{Shinobi}} 3'' final boss. '''ZCE'''
* In ''VideoGame/StarFox64'', the FinalBoss, Andross, is a ([[RoboticReveal possibly robotic?]]) giant monkey head with [[RaymanianLimbs unattached hands]] that attacks the player's Arwing SpaceFighter with {{telekinesis}}. After [[TurnsRed taking a certain amount of damage]], the surface layer of the...thing [[MadeOfExplodium explodes]] to reveal an equally giant brain with attached eyeballs. [[BigLippedAlligatorMoment No in-game explanation is given]] for how his brain got so large or why it can operate without a body.
* In ''VideoGame/{{Salamander}}'', the first boss is the Brain Golem, which resembles a giant brain with an eye at one end. It attacks mostly by waving two serpentine arms around. Brain Golem reappears in another WombLevel in ''VideoGame/MonsterMaulers'', now equipped with EyeBeams. A frozen-over cousin, "Brain Freeze," appears as an exclusive boss in the UsefulNotes/GameBoy version of ''VideoGame/{{Parodius}}'', and wields a PaperFanOfDoom in its second attack phase.
* ''VideoGame/AlienSyndrome'''s level 1 boss (A big brain with bonus supplemental brain attached).
* The final boss of ''VideoGame/QuakeIV'', the Nexus. '''ZCE'''
* The first boss of ''VideoGame/Stinkoman20X6'' is the brain of the HumongousMecha Stinkoman defeated in the opening cutscene.
* ''VideoGame/{{Doom}}'' series
** The first final boss - the Spider Mastermind - was essentially a giant brain carried by a robot body.
** ''VideoGame/{{Doom}} 2''[='=]s final boss is the Icon of Sin, a giant skeletal goat face with an exposed brain as a weak point. It is only vulnerable to rockets, however.
* One of ''VideoGame/DukeNukem3D'''s monsters is Octobrain, a large floating brain-like creature with tentacles hanging down beneath, 3 red eyes and a large mandibled mouth.
* The first ''VideoGame/{{X-COM}}'' game also features the Alien Brain on Mars as the BigBad.
* The demon [[http://megamitensei.wikia.com/wiki/Omoikane Omoikane]] from ''Franchise/ShinMegamiTensei'' series isn't evil, but is a floating brain with tentacles nevertheless.
* ''VideoGame/MetalSlug 3'': Rootmars, the FinalBoss, is an alien with a big exposed brain that serves as his weak point. Said brain can occasionally emit a shockwave that is hard to dodge.
* The final boss of ''VideoGame/{{Vectorman}} 2'' is a giant black widow spider with an exposed brain in her thorax. Sure enough, that exposed brain is her weak point.
* The Lickers of ''Franchise/ResidentEvil'' are [[OurZombiesAreDifferent T-Virus zombies]] which have mutated further and have had their brain extend out of their cranium. Despite the (relative) boost in intelligence, they also become more bestial; crawling on all fours and attacking based on sound with an elongated tongue.
* ''VideoGame/TheBindingOfIsaac'' has enemies that are large brains that crawl around the floor, leaving a trail of blood that damages you if you step on it. There's also an even larger variant that [[AsteroidsMonster splits into two smaller ones when it dies]].
* The Mind Cripplers in ''VideoGame/UnderworldAscendant'' are floating humanoid brains that aggressively attack the unwary with psychic powers.
* ''VideoGame/DeadlyRoomsOfDeath'' has the brain enemy. It just sits there and doesn't attack. The problem is that it gives all other enemies much improved path finding, greatly complicating avoiding being overrun by them.
* The Weirdboy in ''DawnOfWar 2'' has an upgrade called Bigger Brains, the icon for which shows his brain swelling out of his skull.
[[AC:WebComics]]
* Gestaltians from ''Webcomic/QuentynQuinnSpaceRanger'' are a non-villainous example. They are born as just a brain with eyes and rudimentary limbs, and [[BizarreAlienBiology assemble a body out of various symbiotes]].
* {{Parodied}} in ''Webcomic/SaturdayMorningBreakfastCereal'', where a MadScientist discovers that his creation, a T-Rex with its brain in a giant jar, [[NightmareRetardant is anything but terrifying]].
[[AC:WesternAnimation]]
* Big Brain (that's his name) from ''WesternAnimation/FairlyOddParents''. '''ZCE'''
* The Brain Spawn of ''WesternAnimation/{{Futurama}}'' are a race of giant, flying, telekinetic brains with the ability to telepathically drain the intelligence of animals, robots, and some plants. Their goal is to store all knowledge in the universe in a giant database, then destroy the universe so that no new knowledge will be generated, because apparently that's less work than making continual updates for all eternity.
* The principal antagonist of the French film ''WesternAnimation/{{Gandahar}}'', a/k/a ''Light Years'', is a giant brain, made by the people of the utopian city of Gandahar as a prototype organic computer. When the superbrain didn't work out as planned, it was dumped in the ocean and forgotten. Interestingly, when the heroes first encounter this giant brain, it seems docile, and even gives the heroes the tool for its own destruction.
* Krang, as seen in the [[WesternAnimation/TeenageMutantNinjaTurtles1987 old Teenage Mutant Ninja Turtles Cartoon]] has been reduced to a brain thanks to a judgment in his home dimension of Dimension X. He went through several iterations of armor to protect this squishy body until he reached a full robotic suit of armor.
* Ben's Alien Brainsorm from ''WesternAnimation/Ben10AlienForce'' can open his head to reveal his [[MyBrainIsBig oversized brain]] and shot electricity from it.
* The Brains from ''WesterAnimation/TheAdventuresOfJimmyNeutronBoyGenius'', contestants in the Galactic Showdown game. They bragged on how they evolved to not need bodies anymore, as they consisted of nothing but floating brains.
* Gunter briefly becomes this leading up to the sixth season finale of ''WesternAnimation/AdventureTime'', after a head injury literally splits his head open, and Gunter remembers that he is in fact [[spoiler: Orgalorg, an [[TheOldGods ancient]] EldritchAbomination from space]], prompting his brain to hijack Princess Bubblegum's spaceship.
* Mojo Jojo from ''ThePowerpuffGirls'' has his enlarged brain protected by a transparent helmet.
[[caption-width-right:280:I can has Metal Slug?]]
The brain. A big, juicy, wrinkled organ on our head that is protected by the skull for a good reason. Now, imagine when it's not...
There are two types of this:
* '''Just Brain''': The brain moves around by itself. It might have some bits attached, such as legs, hovering jets or helicopter rudders, but its main "body" is a brain. Alternatively, it is stationary, and attached to something.
* '''Acranial Monster''': A monster that has its skull being incomplete, thus exposing their brain.
A sister-trope of BrainInAJar, although of lot of these brains don't really need the jar life-support system, as well as the furthest extension of MyBrainIsBig.
Subtrope of EvilIsVisceral and BodyHorror, and thusly, is always played for NauseaFuel.
----
!Examples
[[AC:{{Anime}} and {{Manga}}]]
* Vademon from ''Anime/DigimonAdventure'' has a huge exposed brain, seeing that he's an alien Digimon.
* BigBad Dr. Wheelo of ''Anime/DragonBallZ: The World's Strongest'' had his [[BrainInAJar brain preserved in a jar]] by his assistant before he died, and is currently searching for [[TitleDrop the world's strongest warrior]] to serve as [[GrandTheftMe a host body]]. [[FridgeLogic For some reason]], the process also made his brain gigantic; how he expects to transplant it into a human-sized skull is unknown.
[[AC:ComicBooks]]
* Several incarnations of Brain of ''Franchise/TheDCU'' -- as the disembodied, preserved, sentient BrainInAJar of a MadScientist. Together with his sentient gorilla servant/boyfriend Mallah, the two of them would go on to gather the Brotherhood of Evil.
* The ''Comicbook/{{BPRD}}'' short comic that introduced Lobster Johnson involves a scientist who gained psychic powers in an experiment, then used those powers to kill his colleagues. When the Lobster shoots the psychic in the head, his brain crawls out of the bullet hole, grows several times larger, then flies around the room. The Lobster barely kills the mutant brain before it strangles him with its spinal cord.
* The giant squid monster from ''Comicbook/{{Watchmen}}''. '''ZCE'''
[[AC:{{Film}}]]
* Gor and Vol from ''Film/TheBrainFromPlanetArous'' are aliens that resemble giant disembodied floating brains. The former wants to take over the universe, the latter wants to stop him.
* The 1958 film ''Film/FiendWithoutAFace'' featured invisible monsters that when revealed are actually slimy crawling human brains. Said brains strangle victims with their spinal cords.
* The 1988 film ''Film/TheBrain'' featured an alien that resembled a gigantic brain with a face as the titular monster.
* In ''Film/TheTimeMachine2002'', the Morlock leader is of a caste in which the brain has become so enlarged that it's not only visibly exposed on the back of his head, but its lobes extend halfway down his back as well.
* The invading Martians from Creator/TimBurton's ''Film/MarsAttacks'' are the acranial type. Their brains visibly pulsate and explode inside their clear helmets when exposed to their WeaksauceWeakness: really bad singing.
[[AC:{{Literature}}]]
* Creator/MadeleineLEngle's novel ''Literature/AWrinkleInTime''. The BigBad IT is a huge disembodied brain. It has MindControl abilities that involved making the victim think in repetitive patterns.
* The Grand Lunar from Creator/HGWells' work ''Literature/TheFirstMenInTheMoon'' is the ruler of the "Moonies," and rests in the throne room with his exposed brain taking up most of the cathedral-like ceiling space. There are lesser Moonies that hover around moistening this huge brain. The Grand Lunar is LawfulNeutral, but takes Doctor Cavor prisoner on the belief that humans are intelligent anarchists.
* In the ''Literature/{{Lensman}}'' series novel ''Galactic Patrol'', Mentor of Arisia is revealed to Kimball Kinnison to be (barring a few minor bits and appendages) "simply and solely a brain." Then in ''Second Stage Lensmen'' the Boskonian Prime Minister Fossten is revealed to be a nearly identical brain, explained by his being a renegade Arisian. [[spoiler:Except that this was a false appearance in both cases, arranged by Mentor to hide from Kinnison that Fossten was really Gharlane of Eddore.]]
[[AC:LiveActionTV]]
* ''Series/{{Farscape}}''. [[spoiler: The evil version of Crichton of the "[[Recap/FarscapeS02E10MyThreeCrichtons My Three Crichtons]]" episode is the future version with the wrinkly head to show off his advanced brain lobes.]]
* In an episode of ''Series/{{Angel}}'' [[Recap/AngelS03E02ThatVisionThing "That Vision Thing"]] Wolfram & Hart hire a psychic with an exposed brain to torture Cordelia, forcing Angel to release a soul from torment in return for stopping the torture.
* In the ''Series/DoctorWho'' episode "Evolution of the Daleks", Dalek Sec turns himself into a Dalek/Human hybrid, which has a large exposed brain.
[[AC:TabletopGames]]
* ''TabletopGame/DungeonsAndDragons''
** [[http://forgottenrealms.wikia.com/wiki/Elder_brain Illithid elder brains]], which float in large brine pools in illithid cities. They are made up of the combined brains of old illithids that sacrificed themselves to join it.
** The Intellect Devourer is basically a brain running around on four little legs. Its modus operandi is to crack a victim's skull open, remove the brain and then [[GrandTheftMe squeeze inside, taking over the body]].
[[AC:VideoGames]]
* ''Franchise/{{Metroid}}''
** In ''VideoGame/{{Metroid}}'' the final boss, Mother Brain, is a massive brain in a tank, with a laser shooting eye. It's stated that it started off as an organic computer built by the [[BenevolentPrecursors Chozo]], which took command of the SpacePirates.
** In ''VideoGame/SuperMetroid'', Mother Brain reappears as the final boss [[spoiler: this time as an "acranial" example, having gained a massive mechanised body.]]
* Featured in ''VideoGame/{{Gradius}}'', ''VideoGame/{{Gradius}} 3'' and ''VideoGame/{{Gradius}} 5''. '''ZCE'''
* ''VideoGame/{{Shinobi}} 3'' final boss. '''ZCE'''
* In ''VideoGame/StarFox64'', the FinalBoss, Andross, is a ([[RoboticReveal possibly robotic?]]) giant monkey head with [[RaymanianLimbs unattached hands]] that attacks the player's Arwing SpaceFighter with {{telekinesis}}. After [[TurnsRed taking a certain amount of damage]], the surface layer of the...thing [[MadeOfExplodium explodes]] to reveal an equally giant brain with attached eyeballs. [[BigLippedAlligatorMoment No in-game explanation is given]] for how his brain got so large or why it can operate without a body.
* In ''VideoGame/{{Salamander}}'', the first boss is the Brain Golem, which resembles a giant brain with an eye at one end. It attacks mostly by waving two serpentine arms around. Brain Golem reappears in another WombLevel in ''VideoGame/MonsterMaulers'', now equipped with EyeBeams. A frozen-over cousin, "Brain Freeze," appears as an exclusive boss in the UsefulNotes/GameBoy version of ''VideoGame/{{Parodius}}'', and wields a PaperFanOfDoom in its second attack phase.
* ''VideoGame/AlienSyndrome'''s level 1 boss (A big brain with bonus supplemental brain attached).
* The final boss of ''VideoGame/QuakeIV'', the Nexus. '''ZCE'''
* The first boss of ''VideoGame/Stinkoman20X6'' is the brain of the HumongousMecha Stinkoman defeated in the opening cutscene.
* ''VideoGame/{{Doom}}'' series
** The first final boss - the Spider Mastermind - was essentially a giant brain carried by a robot body.
** ''VideoGame/{{Doom}} 2''[='=]s final boss is the Icon of Sin, a giant skeletal goat face with an exposed brain as a weak point. It is only vulnerable to rockets, however.
* One of ''VideoGame/DukeNukem3D'''s monsters is Octobrain, a large floating brain-like creature with tentacles hanging down beneath, 3 red eyes and a large mandibled mouth.
* The first ''VideoGame/{{X-COM}}'' game also features the Alien Brain on Mars as the BigBad.
* The demon [[http://megamitensei.wikia.com/wiki/Omoikane Omoikane]] from ''Franchise/ShinMegamiTensei'' series isn't evil, but is a floating brain with tentacles nevertheless.
* ''VideoGame/MetalSlug 3'': Rootmars, the FinalBoss, is an alien with a big exposed brain that serves as his weak point. Said brain can occasionally emit a shockwave that is hard to dodge.
* The final boss of ''VideoGame/{{Vectorman}} 2'' is a giant black widow spider with an exposed brain in her thorax. Sure enough, that exposed brain is her weak point.
* The Lickers of ''Franchise/ResidentEvil'' are [[OurZombiesAreDifferent T-Virus zombies]] which have mutated further and have had their brain extend out of their cranium. Despite the (relative) boost in intelligence, they also become more bestial; crawling on all fours and attacking based on sound with an elongated tongue.
* ''VideoGame/TheBindingOfIsaac'' has enemies that are large brains that crawl around the floor, leaving a trail of blood that damages you if you step on it. There's also an even larger variant that [[AsteroidsMonster splits into two smaller ones when it dies]].
* The Mind Cripplers in ''VideoGame/UnderworldAscendant'' are floating humanoid brains that aggressively attack the unwary with psychic powers.
* ''VideoGame/DeadlyRoomsOfDeath'' has the brain enemy. It just sits there and doesn't attack. The problem is that it gives all other enemies much improved path finding, greatly complicating avoiding being overrun by them.
* The Weirdboy in ''DawnOfWar 2'' has an upgrade called Bigger Brains, the icon for which shows his brain swelling out of his skull.
[[AC:WebComics]]
* Gestaltians from ''Webcomic/QuentynQuinnSpaceRanger'' are a non-villainous example. They are born as just a brain with eyes and rudimentary limbs, and [[BizarreAlienBiology assemble a body out of various symbiotes]].
* {{Parodied}} in ''Webcomic/SaturdayMorningBreakfastCereal'', where a MadScientist discovers that his creation, a T-Rex with its brain in a giant jar, [[NightmareRetardant is anything but terrifying]].
[[AC:WesternAnimation]]
* Big Brain (that's his name) from ''WesternAnimation/FairlyOddParents''. '''ZCE'''
* The Brain Spawn of ''WesternAnimation/{{Futurama}}'' are a race of giant, flying, telekinetic brains with the ability to telepathically drain the intelligence of animals, robots, and some plants. Their goal is to store all knowledge in the universe in a giant database, then destroy the universe so that no new knowledge will be generated, because apparently that's less work than making continual updates for all eternity.
* The principal antagonist of the French film ''WesternAnimation/{{Gandahar}}'', a/k/a ''Light Years'', is a giant brain, made by the people of the utopian city of Gandahar as a prototype organic computer. When the superbrain didn't work out as planned, it was dumped in the ocean and forgotten. Interestingly, when the heroes first encounter this giant brain, it seems docile, and even gives the heroes the tool for its own destruction.
* Krang, as seen in the [[WesternAnimation/TeenageMutantNinjaTurtles1987 old Teenage Mutant Ninja Turtles Cartoon]] has been reduced to a brain thanks to a judgment in his home dimension of Dimension X. He went through several iterations of armor to protect this squishy body until he reached a full robotic suit of armor.
* Ben's Alien Brainsorm from ''WesternAnimation/Ben10AlienForce'' can open his head to reveal his [[MyBrainIsBig oversized brain]] and shot electricity from it.
* The Brains from ''WesterAnimation/TheAdventuresOfJimmyNeutronBoyGenius'', contestants in the Galactic Showdown game. They bragged on how they evolved to not need bodies anymore, as they consisted of nothing but floating brains.
* Gunter briefly becomes this leading up to the sixth season finale of ''WesternAnimation/AdventureTime'', after a head injury literally splits his head open, and Gunter remembers that he is in fact [[spoiler: Orgalorg, an [[TheOldGods ancient]] EldritchAbomination from space]], prompting his brain to hijack Princess Bubblegum's spaceship.
* Mojo Jojo from ''ThePowerpuffGirls'' has his enlarged brain protected by a transparent helmet.
