History Main / BestFriend

* ''Series/YoungSheldon'': In "Snoopin' Around and the Wonder Twins of Atheism", Coach Wilkins claims his wife is his best friend. George might not even be Wilkins's best male friend, but at least George is Wilkins's best white friend. Considering that Wilkins' wife [[apoiler:ends up cheating on him and getting pregnant]], this isn't exactly the best scenario.

* ''Series/YoungSheldon'': In "Snoopin' Around and the Wonder Twins of Atheism", Coach Wilkins claims his wife is his best friend. George might not even be Wilkins's best male friend, but at least George is Wilkins's best white friend. Considering that Wilkins' wife [[apoiler: ends up cheating on him and getting pregnant]], this isn't exactly the best scenario.

* ''Series/YoungSheldon'': In "Snoopin' Around and the Wonder Twins of Atheism", Coach Wilkins claims his wife is his best friend. George might not even be Wilkins's best male friend, but at least George is Wilkins's best white friend.

* ''Literature/HarryPotter'': Ron Weasley quickly becomes Harry's best friend, and sticks with him for the rest of the series, through the good and the bad. Hermione also becomes Harry's other best and most loyal friend after he and Ron save her from the Troll. She and Ron tend to be more VitriolicBestBuds with a helping of BelligerentSexualTension thrown in. Eventually FieryRedhead (and future wife) Ginny, resident CloudCuckooLander Luna, and the bumbling NiceGuy Neville become Harry's other closest friends, the six of them forming a group of TrueCompanions. Luna even painted of mural of the other five to show how much she valued their friendships.

** Mr. Satan eventually becomes best friends with, of all people, Majin Buu, despite Mr. Satan’s initial efforts to try to (fruitlessly) kill Buu. It’s his friendship with Buu that actually manages to make the blob monster pull a HeelFaceTurn, as Mr. Satan is able to convince him on what’s right from wrong, and allows him to live peacefully on Earth.

** Future!Trunks considered 8i both his mentor and best friend as the last two saiyans. Present Trunks' best friend is Goten since they're much closer in age. They are rarely seen apart as kids to the point that their signature technique is to FusionDance into Gotenks.

** While Bizarro isn’t usually considered a member of the Superman family per say, he’s been recently hanging around with Jason Todd/Red Hood [[ComicBook/RedHoodAndTheOutlaws for a time]], and he’s grown quite close with both him and Artemis as a OneTrueThreesome.

* In ''WesternAnimation/TheSimpsons,'' Bart's default best friend and sidekick is Milhouse Van Houten, with whom he shares a close but [[ToxicFriendInfluence abrasive]] [[WithFriendsLikeThese relationship]]. In the episode "Milhouse Doesn't Live Here Anymore," Bart finds a new best friend in his sister Lisa when Milhouse [[StatusQuoIsGod temporarily]] moves out of town, while "The Haw-Hawwed Couple" sees him being forcibly adopted as a best friend by bully Nelson Muntz, only to [[DoesThisRemindYouOfAnything two-time him with Milhouse]]. (By "The Debarted" Bart defines Nelson as his "[[BullyTurnedBuddy other best friend]].") It's also occasionally implied that even Milhouse is second to [[CanineCompanion Santa's Little Helper]].

* In ''WesternAnimation/TheSimpsons,'' Bart's default best friend and sidekick is Milhouse Van Houten, with whom he shares a close but [[ToxicFriendInfluence abrasive]] [[WithFriendsLikeThese relationship]]. In the episode "Milhouse Doesn't Live Here Anymore," Bart finds a new best friend in his sister Lisa when Milhouse [[StatusQuoIsGod temporarily]] moves out of town, while "The Haw-Hawwed Couple" sees him being forcibly adopted as a best friend by bully Nelson Muntz, only to [[DoesThisRemindYouOfAnything two-time him with Milhouse]]. (By "The Debarted" Bart defines Nelson as his "[[BullyTurnedBuddy other best friend]].") It's also occasionally implied that Milhouse is second to [[CanineCompanion Santa's Little Helper]].

* In ''WesternAnimation/TheSimpsons,'' Bart's default best friend and sidekick is Milhouse Van Houten, with whom he shares a close but [[ToxicFriendInfluence abrasive]] [[WithFriendsLikeThese relationship]]. In the episode "Milhouse Doesn't Live Here Anymore," Bart finds a new best friend in his sister Lisa when Milhouse [[StatusQuoIsGod temporarily]] moves out of town, while "The Haw-Hawwed Couple" sees him being forcibly adopted as a best friend by bully Nelson Muntz, only to [[DoesThisRemindYouOfAnything two-time him with Milhouse]]. It's also occasionally implied that Milhouse is second to [[CanineCompanion Santa's Little Helper]].

* ''Manga/WanderingSon'': Nitori and Takatsuki meet in fifth grade and quickly become best friends, However, SurprisinglyRealisticOutcome happens when they [[spoiler:go to separate high schools and their friendship dwindles to the point where they go years without seeing one another]].

* ''Manga/MakenKi'': Kimi Satou used to spend her time [[{{otaku}} reading manga alone]], until she met [[ForeignExchangeStudent Akaza]] [[DarkskinnedBlonde Chacha]] who noticed what she was reading. They soon bonded over [[BirdsOfAFeather their mutual interests]] in manga and cosplay and have been virtually inseparable ever since.

* In ''WesternAnimation/TheSimpsons,'' Bart's best friend and sidekick is typically Milhouse Van Houten, with whom he shares a close but [[ToxicFriendInfluence abrasive]] [[WithFriendsLikeThese relationship]]. In the episode "Milhouse Doesn't Live Here Anymore," Bart finds a new best friend in his sister Lisa when Milhouse [[StatusQuoIsGod temporarily]] moves out of town, while "The Haw-Hawwed Couple" sees him being forcibly adopted as a best friend by bully Nelson Muntz, a situation he has mixed feelings about. It's also occasionally implied that Milhouse is second to [[CanineCompanion Santa's Little Helper]].

* In ''WesternAnimation/TheSimpsons,'' Bart's best friend and sidekick is typically Milhouse Van Houten, with whom he shares a close but [[ToxicFriendInfluence abrasive]] [[WithFriendsLikeThese relationship]]. In the episode "Milhouse Doesn't Live Here Anymore," Bart finds a new best friend in his sister Lisa when Milhouse [[StatusQuoIsGod temporarily]] moves out of town, while "The Haw-Hawwed Couple" sees him being forcibly adopted as a best friend by bully Nelson Muntz, a situation he has mixed feelings about.

* Garrus Vakarian, Tali'Zorah, and Liara T'soni in the original ''Franchise/MassEffect'' trilogy gradually become Commander Shepard's closest confidantes (although Tali and Garrus are PromotedToLoveInterest in part two and Liara is pretty much [[UndyingLoyalty Shepard]][[SingleTargetSexuality sexual]] from the get-go). Depending on whether the player {{romance|Sidequest}}s one of them, either the other one or all three of them qualify for this trope. Overall, Garrus is best able to identify with Shepard as a fellow soldier and leader and the needs that come with those, Tali places absolute faith in Shepard's abilities as a leader and always supports his/her decisions, while Liara is best at being consistently able to get Shepard to drop their stoic mask and share their worries and stresses with a sympathetic ear. It's noted that out of all squadmates that Shepard gathers and assembles throughout their journey, only Garrus and Tali join Shepard in all three games. Liara too joins Shepard across the trilogy, but while she is an NPC during the second game's main campaign, she is a playable squadmate throughout the ''Lair of the Shadow Broker'' DLC which is pivotal to the whole story. Even with her non-involvement throughout the second game's main plotline, she is responsible for retrieving Shepard's body and gives it to Cerberus in order to revive them. On the non-playable squadmate side, [[AcePilot Joker]] is also the only character who is guaranteed to be by Shepard's side for the entire trilogy, given his role as the pilot of Shepard's ship.

* Garrus Vakarian, Tali'Zorah, and Liara T'soni in the original ''Franchise/MassEffect'' trilogy gradually become Commander Shepard's closest confidantes (although Tali and Garrus are PromotedToLoveInterest in part two and Liara is pretty much [[UndyingLoyalty Shepard]][[SingleTargetSexuality sexual]] from the get-go). Depending on whether the player {{romance|Sidequest}}s one of them, either the other one or all three of them qualify for this trope. Overall, Garrus is best able to identify with Shepard as a fellow soldier and leader and the needs that come with those, Tali places absolute faith in Shepard's abilities as a leader and always supports his/her decisions, while Liara is best at being consistently able to get Shepard to drop their stoic mask and share their worries and stresses with a sympathetic ear. It's noted that out of all squadmates that Shepard gathers and assembles throughout their journey, only Garrus and Tali join Shepard in all three games. Liara too joins Shepard across the trilogy, but while she is an NPC during the second game's main campaign, she is a playable squadmate throughout the ''Lair of the Shadow Broker'' DLC which is pivotal to the whole story. Even with her non-involvement throughout the second game's main plotline, she is responsible for retrieving Shepard's body and gives it to Cerberus in order to revive them. Also, [[AcePilot Joker]] is also a possibility as the only character who is guaranteed to be by Shepard's side for the entire trilogy.

* Every finished part of ''Anime/JoJosBizarreAdventure'' has a Best Friend as part of its cast.
** [[MuggleBestFriend REO Speedwagon]] to Jonathan in part 1, as a NobleMaleRoguishMale combo
** Caesar to Joseph in part 2, as VitriolicBestBuds and BashBrothers
** Kakyoin to Jotaro in part 3, [[TheOnlyOneITrust as the only person who Jotaro can have normal conversations with.]]
** Okuyasu and Koichi to Josuke in part 4. Rohan believes he's this to Koichi, but [[AbhorrentAdmirer Koichi isn't entirely convinced.]]
** Mista to Giorno in part 5, even while among the TrueCompanions of the rest of Bruno's gang
** Ermes to Jolyne in part 6, as the [[TomboyAndGirlyGirl Tomboy to Jolyne's (still fairly tomboyish) girl]]
** And Gyro to Johnny in part 7, doubling as StudentAndMasterTeam.

[[folder: WesternAnimation]]

** Bruno and Mista to Giorno in part 5, even while among the TrueCompanions of the rest of Bruno's gang

* ''Film/TheBabysitter'': 12-year old Melanie is Cole's closest ''and only'' friend at school. He explicitly refers to her as such, just before the film's climax, when he apologizes for putting her in danger by taking refuge at her house.

** Their Earth-Two counterparts, ComicBook/PowerGirl and ComicBook/{{Huntress}} -Helena Wayne- had a relationship even stronger. In the ''ComicBook/PowerTrip'' arc, Kara turns to Helena Bertinelli as undergoing considerable emotional turmoil because, even though her Pre-Crisis memories had been wiped out, she instinctively remembered she could always rely on Huntress.