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* ''TabletopGame/ArsMagica'': A fertility {{ritual|Magic}} for DesignerBabies can cause two human parents to conceive a hybrid child via a trait like Faerie Blood or [[HumanDemonHybrid Devil Child]], although the mage needs to possess a personal connection to the Faerie, Divine, or Infernal Realm in order to create one in the baby.
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* ''WesternAnimation/InsideJob2021'': Glenn Dolphman initially started out as a human, but turned himself into a human/dolphin hybrid as part of a Super Soldier project.
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* ''WesternAnimation/InsideJob2021'': Glenn Dolphman initially started out as a human, but turned himself into a human/dolphin hybrid as part of a Super Soldier project.SuperSoldier project.
* ''WesternAnimation/TheLegendOfKorra'': The Avatar was created when Wan, a human, merged with the Spirit of Light and Life Raava during Harmonic Convergence, a period of heightened spiritual activity when Raava is supposed to battle her EvilCounterpart Vaatu. [[spoiler:Ten thousand years later, [[BigBad Unaloq]] repeats the process with Vaatu, turning himself into a Dark Avatar to counter the original.]]
* ''WesternAnimation/TheLegendOfKorra'': The Avatar was created when Wan, a human, merged with the Spirit of Light and Life Raava during Harmonic Convergence, a period of heightened spiritual activity when Raava is supposed to battle her EvilCounterpart Vaatu. [[spoiler:Ten thousand years later, [[BigBad Unaloq]] repeats the process with Vaatu, turning himself into a Dark Avatar to counter the original.]]
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* ''WesternAnimation/TheLegendOfKorra''; the Avatar was created when Wan, a human, merged with the Spirit of Light and Life Raava during Harmonic Convergence, a period of heightened spiritual activity when Raava is supposed to battle her EvilCounterpart Vaatu. [[spoiler: Ten thousand years later, [[BigBad Unaloq]] repeats the process with Vaatu, turning himself into a Dark Avatar to counter the original]].
* In the last season of ''WesternAnimation/{{Trollhunters}}'', [[spoiler:Jim realizes he cannot win the day in his human form, and reluctantly agrees to undergo a process that will turn him into a human/troll hybrid. At first he enjoys his newfound strength and durability, but then suffers a HeroicBreakdown once he realizes he can't walk in the sun and must effectively abandon his human life forever.]]
* In the last season of ''WesternAnimation/{{Trollhunters}}'', [[spoiler:Jim realizes he cannot win the day in his human form, and reluctantly agrees to undergo a process that will turn him into a human/troll hybrid. At first he enjoys his newfound strength and durability, but then suffers a HeroicBreakdown once he realizes he can't walk in the sun and must effectively abandon his human life forever.]]
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[[quoteright:300:[[WesternAnimation/BatmanTheBraveAndTheBold https://static.tvtropes.org/pmwiki/pub/images/artificial_hybrid_batman_brave_1.png]]]]
[[caption-width-right:300:"Lions and boars and lion-boars, oh my!"]]
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[[caption-width-right:300:"Lions and boars and lion-boars, oh my!"]]
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[[quoteright:300:[[WesternAnimation/BatmanTheBraveAndTheBold https://static.tvtropes.org/pmwiki/pub/images/artificial_hybrid_batman_brave_1.png]]]]
[[caption-width-right:300:"Lions and boars and lion-boars, oh my!"]]
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[[quoteright:300:[[WesternAnimation/BatmanTheBraveAndTheBold https://static.tvtropes.org/pmwiki/pub/images/artificial_hybrid_batman_brave_1.png]]]]
[[caption-width-right:300:"Lions and boars and lion-boars, oh my!"]]
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* ''Series/DoctorWho'': In [[Recap/DoctorWhoS30E13JourneysEnd "Journey's End"]], a "biological metacrisis" turns [[spoiler:Donna Noble half-Time Lord]] and also creates a [[spoiler:half-human clone of the Doctor]]. Unfortunately for the new Artificial Hybrid, [[spoiler:Donna's brain is still human enough that she can't handle the entirety of the Doctor's knowledge being copied into it, so he has to wipe her memories of him to save her life, although she is still a hybrid.]]
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* ''Series/DoctorWho'': In [[Recap/DoctorWhoS30E13JourneysEnd "Journey's End"]], "[[Recap/DoctorWhoS30E13JourneysEnd Journey's End]]", a "biological metacrisis" turns [[spoiler:Donna Noble half-Time Lord]] and also creates a [[spoiler:half-human clone of the Doctor]]. Unfortunately for the new Artificial Hybrid, [[spoiler:Donna's brain is still human enough that she can't handle the entirety of the Doctor's knowledge being copied into it, so he has to wipe her memories of him to save her life, although she is still a hybrid.]]
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* Played with in ''Series/StarTrekVoyager''. At first it seems as though Seska is a Bajoran (an alien species) but then the doctor finds out that her DNA resembles that of a Cardassian (another alien species). She claims that she had a disease as a kid and got a blood transfusion from a Cardassian, [[spoiler:but it turns out that she's lying and is fully Cardassian]].
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* Played with in ''Series/StarTrekVoyager''. At first first, it seems as though that Seska is a Bajoran (an alien species) species), but then the doctor finds out that her DNA resembles that of a Cardassian (another alien species). She claims that she had a disease as a kid and got a blood transfusion from a Cardassian, [[spoiler:but it turns out that she's lying and is fully Cardassian]].
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* Kraka-Tur from ''Videogame/{{Arcanum}}'' is a former human who mutated himself into a DraconicHumanoid by killing Bellerogrim, the last dragon, and using his blood in a magic ritual.
* ''Videogame/{{Elsword}}'': Ciel, normally a human, becomes a half-demon after forming a soul-contract with the demoness Lu.
* ''Videogame/HeroesOfMightAndMagic Ashan'': The wizards of the Silver Cities have conducted experiments into the creation of new species by experimenting on human criminals. Some of these received blood transfusions from demons, mutating them into orcs, goblins, centaurs and cyclopses, while others were spliced with the body-parts of mundane animals and became the beast-men races.
* ''Videogame/HonkaiImpact3rd'': the game has various cases of artificial hybrids between human and "Honkai Beasts", which give them extra strength.
* ''Videogame/{{Elsword}}'': Ciel, normally a human, becomes a half-demon after forming a soul-contract with the demoness Lu.
* ''Videogame/HeroesOfMightAndMagic Ashan'': The wizards of the Silver Cities have conducted experiments into the creation of new species by experimenting on human criminals. Some of these received blood transfusions from demons, mutating them into orcs, goblins, centaurs and cyclopses, while others were spliced with the body-parts of mundane animals and became the beast-men races.
* ''Videogame/HonkaiImpact3rd'': the game has various cases of artificial hybrids between human and "Honkai Beasts", which give them extra strength.
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* Kraka-Tur from ''Videogame/{{Arcanum}}'' ''VideoGame/{{Arcanum}}'' is a former human who mutated himself into a DraconicHumanoid by killing Bellerogrim, the last dragon, and using his blood in a magic ritual.
*''Videogame/{{Elsword}}'': ''VideoGame/{{Elsword}}'': Ciel, normally a human, becomes a half-demon after forming a soul-contract with the demoness Lu.
*''Videogame/HeroesOfMightAndMagic ''VideoGame/HeroesOfMightAndMagic Ashan'': The wizards of the Silver Cities have conducted experiments into the creation of new species by experimenting on human criminals. Some of these received blood transfusions from demons, mutating them into orcs, goblins, centaurs and cyclopses, while others were spliced with the body-parts of mundane animals and became the beast-men races.
*''Videogame/HonkaiImpact3rd'': ''VideoGame/HonkaiImpact3rd'': the game has various cases of artificial hybrids between human and "Honkai Beasts", which give them extra strength.
*
*
*
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* Samus from the ''Franchise/{{Metroid}}'' series was spliced with Chozo DNA (specified in the manga to have been from Grey Voice, one of her adoptive fathers) as a child so that she could better survive on the planet Zebes. During the opening of ''VideoGame/MetroidFusion'', she also gets injected with Metroid DNA to help her fight off an infection from the X Parasites. Exactly what percentage of her is still human is never specified.
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* Samus from the ''Franchise/{{Metroid}}'' series was spliced with Chozo DNA (specified in [[Manga/MetroidManga the manga manga]] to have been from Grey Voice, one of her adoptive fathers) as a child so that she could better survive on the planet Zebes. During the opening of ''VideoGame/MetroidFusion'', she also gets injected with Metroid DNA to help her fight off an infection from the X Parasites. Exactly what percentage of her is still human is never specified.
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[[folder:Web Original]]
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* The warrioresses in ''Manga/{{Claymore}}'' are created by grafting yoma tissue into human women. They are half human and half a yoma. And they are trained to kill pure yoma because [[ToServeMan they eat human guts]].
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* ''Manga/{{Claymore}}'': The warrioresses in ''Manga/{{Claymore}}'' titular female warriors are created by grafting yoma tissue into human women. They are women, making them half human and half a yoma. And they are trained to kill pure yoma because [[ToServeMan they eat human guts]].
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* ''Manga/DeliciousInDungeon'': Beastkin like Lycion and Izutsumi are magically engineered {{Permafusion}}s of a human and an animal, right down to the [[MergerOfSouls soul]]. Lycion had his canine elements added in adulthood and suppresses them with magic when he wants to appear as an ordinary elf, whereas Izutsumi the [[CatFolk catgirl]] was created in infancy and would revert to a cat if she tried to do the same.
