History Main / ArtificiaLHuman

* ''ComicBook/{{Copperhead}}'': The artificial humans ([[FantasticSlur "arties"]]) were specifically built to serve as soldiers in wartime but were afforded full personhood rights in the courts. They are still discriminated against both for being unnatural (true) and for being prone to violence (debated).

** ''ComicBook/{{Supergirl}}'': The first ComicBook/PostCrisis version of Supergirl, known as "Matrix", is an artificial life-form called the "protoplasmic matrix", that Lex Luthor of the Pocket Universe has used to create her, who resembled his true love, the deceased Lana Lang. Lex had also patterned her physiology to resemble Superman's, whom he had seen by using one of his many inventions to look into the mainstream DC Universe.

** ''ComicBook/TheAvengers'': The Vision's body is a {{temporal duplicat|ion}}e of the android Human Torch's body, with some modifications and a different personality. Whatever those modifications were, the Vision is usually depicted as having a lot more inorganic bits than the Torch does. In ''ComicBook/TheVision2015'', Vision creates three other synthezoids -- Virginia, Viv, and Vin -- using brain patterns from [[spoiler:the Scarlet Witch]].
** ''Characters/GuardiansOfTheGalaxy'': Drax the Destroyer is an Artificial [[ComicBook/TheEternals Eternal]] created to destroy [[Characters/MarvelComicsThanos Thanos]].
** ''ComicBook/{{The Invaders|MarvelComics}}'': The Human Torch, android hero of WWII, is visually indistinguishable from a human being aside from bursting into flame when exposed to oxygen-rich air.

** ''ComicBook/{{Guardian}}'': Cadmus got permission to clone the original Guardian on his deathbead, though it's unlikely he knew just how many clones, DesignerBabies, and other genetically engineered [=DNAliens=]/Genomorphs would be created by the project using his DNA. His most prominent "clone" used the Guardian title for a while himself as the head of security at Cadmus, and adopted a young OppositeSexClone of himself when he left.

*** S-13, alias Superboy and later named [[ComicBook/Superboy1994 Kon-El]] and Conner Kent, a version of whom is pictured above, [[spoiler:is a clone created by the Cadmus organisation in secret, as they knew that at some point, Superman would either die or otherwise become incapacitated in his current role. He's technically not a perfect clone, however; they had to splice in some Lex Luthor DNA to stabilize him, making him... slightly different in powers and personality -- though, peculiarly, the ComicBook/New52 [[ComicBook/SuperboyNew52 version]] was actually a clone of the future son of Clark and Lois, with hints at a relation to Lex being nothing more than a RedHerring]]. Oh, and [[BerserkButton don't call him Superboy]].

* In ''ComicBook/EightBillionGenies'', people created through a wish — such as a dead relative brought back to life, or a historical figure brought to present day — are not actual people, but "remnants". They have all of the memories and mannerisms of the real person, but disappear soon after the person making the wish dies.

* ''WesternAnimation/TheOwlHouse'' has an example of what's technically an artificial [[MageSpecies witch]]. A FreezeFrameBonus from "Eclipse Lake" shows a book containing a recipe for something called a Grimwalker, a humanoid being made of palistrom wood, selkiedomus scales, a Galderstone, and a bone of the person one would want to clone. [[spoiler:"Hollow Mind" reveals that Hunter, as well as every Golden Guard before him, is a Grimwalker, cloned from the bones of Belos's brother Caleb, in an attempt to make a "[[ReplacementGoldfish better version]]" of him. Hunter doesn't look any different from your average witch, with the exception of his bright pink eyes, and the fact that [[FictionalDisability he can't cast magic by himself]]. He's not ''completely'' identical to Caleb, but they're similar enough that one could mistake them for identical twins.]]

** The girls were created by Professor Utonium with "Sugar and Spice and Everything Nice" mixed into a vat; when he accidentally spilled in Chemical X.
** Similarly, The [[EvilCounterpart Rowdyruff]] [[SpearCounterpart Boys]], by Mojo Jojo, only with "Snips, Snails and Puppy Dog Tails", again, with the Chemical X.

** In ''WesternAnimation/TransformersAnimated'', [[spoiler:it turns out that Sari was a protoform, which is what a Transformer is before it has scanned anything for the first time. She scanned Isaac Sumdac when he found her, assimilating his DNA in a pretty ''Beast Wars''-like fashion and basically making him her Dad.]]

* ''WesternAnimation/YoungJustice2010'',

** ''Franchise/WonderWoman'': Diana is a "perfect woman" created from clay by her "mother", Hippolyta. In the ComicBook/PostCrisis reimagining of ''ComicBook/WonderWoman1987'' all of the Amazons are women crafted from clay and brought to life by a group of Greek goddesses.

[[folder:Fan Fiction]]

** Lise is a hybrid grown from a combination of human DNA and the DNA of a mysterious alien species who contacted Earth over radio communication in the [=1990s=]. She's been raised in a more supportive and enriching environment, but still has alien instincts that sometimes rear their head.
* ''Fanfic/ChildOfTheStorm'' twists expectations with this in the sequel, with the general assumption InUniverse and out being that [[spoiler:Maddie Pryor]] is this trope (the character in question believes it, having been raised as a SympatheticSentientWeapon), and that [[spoiler:Gambit]] isn't. In fact, the former was replaced at birth and stolen in a kind of ChangelingTale, while the latter is an altered clone who managed to escape captivity as a child, but isn't aware of it until much later. For added {{Irony}}, the latter was helping the former come to terms with the fact that despite they were artificial (or believed that they were), they had free will and the rights that came with it. When they find out the truth, the former more or less collapses, thanks to TomatoInTheMirror, while the latter has a more subdued freak out and leaves to rebuild their life.

* All of the ruling [[TheBeautifulElite Elites]] of ''Literature/AiNoKusabi'' are [[LEGOGenetics artificially created]] and their [[BioAugmentation hyper-evolved]] brains are the only organic human components they have left of their constructed bodies. They look and sound human, exhibit very little human emotion and look down on humans.

* ''Literature/Area51'': It's revealed that the Airlia created many people, partly with their DNA, to serve as agents. [[spoiler:It's eventually revealed that humanity in ''general'' were created by the Airlia.]] However, later on in the series it's revealed that [[spoiler:the Martians created them]].

* ''Literature/TheStoneSky'', the final book in the ''Broken Earth Trilogy'', reveals that [[spoiler:the original stone eaters were created by Syl Anagist to help create a new power source]].

* Several characters in Creator/BernardWerber's novels and short stories are androids or part of an artificial-life simulation software but don't know it. In fact, some of his works suggest that ''all'' of the characters and even [[spoiler:all of humankind, the gods, and the whole known universe]] might unwittingly be part of a giant software and/or experiment. Yup, Werber is a fan of Creator/PhilipKDick.

* Tanya, the android love interest from ''VisualNovel/BionicHeart'' has a metal skeleton, but she has artificial organs identical to a human’s. They don’t function, however. But Tanya does have a working human brain that is the [[AmnesiacDissonance cause of her memories]].
* From ''VisualNovel/DiesIrae'' [[spoiler:Ren is eventually revealed to have been created artificially by Mercurius to act as his Ahnenerbe. His sole purpose is to act as a worthy opponent for Reinhard and to serve as a host for Marie and to facilitate her growth into Mercurius's successor]].

* In ''Webcomic/BobAndGeorge'', [[http://www.bobandgeorge.com/archives/000409 the robots are brought to "life" in very Frankensteinian manner.]]

* ''Webcomic/TheFarSideOfUtopia'' has at least several -- Mium and Ila are all but confirmed to be (really the only question is what type).

* [[ColonelBadass Commander Badass]] and the rest of the super soldiers from the nondescript space-future in ''WebComic/ManlyGuysDoingManlyThings'' are eventually revealed to be these, literally created by the military to be badasses. Unfortunately for them, that means the military can modify them as they see fit, and it's left the Commander with serious hang-ups. Canadian Guy is revealed to be one too, namely [[spoiler:he's an unsanctioned regional variant clone of the Commander.]]

[[folder:Web Original]]
* ''AudioPlay/DoctorWhoovesAdventures'' has an adorable (if a bit [[InnocentProdigy spockish]] [[SpockSpeak at times]]) artificial 'filly'', Goodnight.
* Naturally, ''WebVideo/DragonBallZAbridged'' lampooned ''Anime/DragonBallZ'''s inconsistency regarding the series' Artificial humans being termed "Androids":
-->'''Cell''': ...Cyborgs 17 and 18.\\
'''Piccolo''': We call them Androids.\\
'''Cell''': Well, good for you. You're wrong.
** Later, when Cell tries to absorb Android 16:
-->'''Cell:''' What're you made of, pure metal!?\\
'''Android 16:''' [[AC: Affirmative. I am ''ANDROID'' 16.]]\\
'''Cell:''' Oh... errors have been made.
* [[http://www.futuretimeline.net/ FutureTimeline.net]] predicts these being created by [[http://www.futuretimeline.net/21stcentury/2050-2059.htm#synthetic-human-beings 2056]].
* ''WebVideo/MissionCodeHighSchool'': [=CAV=]s, the mooks in the series, are AI programs brought into the real world, [[spoiler:and so is the CDU when he makes a body based off Spike Hypothesis one of the heroes]].

* In ''WebAnimation/PhoenixWrightDevilsAttorney'', this is the case with [[spoiler:Judy Prava]], having been created by [[spoiler:Vulcanus]] in an attempt to disrupt the peace between angels and demons. [[spoiler:She]] is none too happy about this when [[spoiler:she]] finds out, though it ''does'' end up helping Phoenix in the trial by getting a [[spoiler:void]] verdict, due to [[spoiler:the prosecutor technically being too young to prosecute.]]
* ''Roleplay/WeAreOurAdventuringAvatars''
** Imca is not natural, but rather artificially created, and while mostly squishy and quite like a normal gijinka, even if she is synthetic, does have some electrical bits in her head.
** Mina, a protosapien clone, is created in an artificial womb as a supersoldier. Her cybernetics inside her are [[OrganicTechnology biomechanical]] and grow alongside her body.
* ''Literature/WhateleyUniverse'':
** Belphoebe is a cloned body based on Jobe's secret drow transformation serum. A mental copy of Belphegor is (accidentally) imprinted onto the body, and it wakes up. It's adapting quite nicely so far.
** Two of the members of the Crusader Cadets (a KidHero team for teens who aren't mutants, set up by [[BigApplesauce the DA's office of New York City]] in a desperate bid to maintain ''some'' semblance of sanity in the superhuman community), Aurora and Rubber Boy, were originally members of the Designer Heroes, a team of genetically-engineered SuperSoldier heroes created in a lab and trained in TheSpartanWay. The experiment wasn't a notable success: while they were indeed superpowered, those two are only survivors of the eight original team members after a near-TotalPartyKill wiped them out.

** Aelita was thought to be one of these (specifically, an AI) for two seasons, until it was revealed that she was, in fact, human, not to mention the daughter of the supercomputer's creator.

** These clones can also be utilized by the heroes themselves. Only two have been cloned this way: [[TheSmartGuy Jérémie]] and [[BrainwashedAndCrazy William]]. Jérémie's clone substituted for the original while he worked on several programs for Lyoko. Clone!William replaced his real world counterpart for several months while the real one was trapped in Lyoko. Unfortunately, while these clones were pretty much benign and harmless (unless possessed by XANA, which both have been), they have drastically different personalities than their originals: Jérémie's clone is a bold womanizer, while William's clone is profoundly naíve and stupid.
%%* Cyber 6 in ''WesternAnimation/{{Cybersix}}''; she sleeps, daydreams, eats, and for the most part doesn't even have any great trouble in socializing.
* ''WesternAnimation/GIJoeARealAmericanHero''
** Cobra "Synthoids" could perfectly mimic real people and were key to several episodes where a FakedRipVanWinkle or BodySnatcher plot was in effect. They were apparently organic in nature, being constructed of a grey goopy matter called "Pseudoplasm" which they would terrifyingly revert back into by ''[[ImMelting melting]]'' if killed or self-destructed.
** The Synthoid technology was also put into use in a crossover episode of ''Franchise/{{Transformers}}'', in which Rodimus Prime, Arcee and Ultra Magnus had their minds transferred into synthetic human bodies (by Cobra Commander no less). Luckily for the MoralGuardians, these came with automatic underwear.

* ''Manga/{{Bleach}}'': The Bounts in the anime's FillerArc are artificially-created humans who accidentally came into being during a botched Shinigami experiment originally meant to create immortal beings . The scientists, led by Ran'Tao, used the slow-aging souls of Shinigami as a base for Artificial Souls (as using human souls would be ethically questionable regardless of the results). However, one of the Jokaisho melted and exploded, releasing a large quantity of energy that made it into the circle of rebirth and affected a number of souls which were reincarnating into the human world. The Bount gained immortality by feasting on human souls.

* The Thirds of ''Anime/ArmitageIII'' seem to have been heavily inspired by replicants. They appear indistinguishable from humans and, on the emotional scale, are actually ''more'' emotional than many humans [[spoiler: due to having been created for the purpose of motherhood.]]
* In ''Manga/BirdyTheMighty'', [[spoiler:it is revealed that the Federation used [[HumanAlien Altirran]] DNA to [[GeneticEngineeringIsTheNewNuke bioengineer]] {{Super Soldier}}s to their [[SpaceMarine military]] and [[SpacePolice law enforcement]] divisions. One of the ones used for law enforcement is the title character herself.]]

* In ''Manga/DGrayMan'' you have the second Exorcists, [[spoiler: brains of dead exorcists transplanted into artificial bodies]] which include [[spoiler: Yu Kanda and Alma Karma]]

* In ''Anime/Metropolis2001'', [[spoiler:Tima states "I'm an artificial human"]] after being shot by Rock and [[spoiler:noticing that the bruise she got was not blood or flesh, but her "inner skeleton"]].

* In ''Anime/MobileSuitGundam00'', it is initially hinted that the Innovators, along with [[spoiler:Tieria Erde and Nena Trinity]], may be like this due to their innate ability to interact with the supercomputer VEDA. Hinted no more in Season 2 and outright confirmed in TheMovie where [[spoiler:Tieria himself]] confirms that Innovades are basically a VirtualGhost uploaded into organic hardware. If the hardware in question suffers fatal damage, they simply BodySurf [[BodyBackupDrive back into Veda]] and optionally create themselves a new body, or just stay uploaded and play DeusEstMachina, [[spoiler:as Tieria did between the series finale and the movie]].

** And let's not forget that [[spoiler: the majority of the inhabitants of the Magical World are actually sentient illusions.]]
* ''Anime/NeonGenesisEvangelion'': [[spoiler: Rei Ayanami and Kaworu Nagisa]] are human/Angel clones, and the Evangelions qualify at some level, as they have [[spoiler:biological bodies similar to huge human organisms (actually copied from Adam, but Angels in ''Evangelion'' are basically what humans would be if they rejected their "humanity"), a human soul, and are literally called "jinzouningen", meaning "artificial humans"]].

* Most of the [[spoiler: Mibu Clan]] in ''Manga/SamuraiDeeperKyo'', with the exclusion of [[spoiler: Kyo himself]].

* ''Manga/{{Trigun}}'''s [[spoiler: Vash, Knives, Tessla, Chronica, Domina, and all the other plants]] are genetically modified alien creatures with some astonishingly human characteristics.

* The last guardians of the Pyramid in ''Manga/{{Yaiba}}'', namely Ruby, Sapphire, Diamond [[spoiler: and Emerald]]. The Platina Company is also apparently working on building the Ultimate Fighter.

* The [[SelfInsert SI]] from the ''[[Franchise/LyricalNanoha Nanoha]]'' fanfic ''FanFic/TheNewMath'' counts as this after [[spoiler:he gets a new form from a mad scientist in the Nanoha multiverse.]]
* ''Fanfic/ChildOfTheStorm'' twists expectations with this in the sequel, with the general assumption InUniverse and out being that [[spoiler: Maddie Pryor]] is this trope (the character in question believes it, having been raised as a SympatheticSentientWeapon), and that [[spoiler: Gambit]] isn't. In fact, the former was replaced at birth and stolen in a kind of ChangelingTale, while the latter is an altered clone who managed to escape captivity as a child, but isn't aware of it until much later. For added {{Irony}}, the latter was helping the former come to terms with the fact that despite they were artificial (or believed that they were), they had free will and the rights that came with it. When they find out the truth, the former more or less collapses, thanks to TomatoInTheMirror, while the latter has a more subdued freak out and leaves to rebuild their life.

* Ashley from ''FanFic/PrettyCurePerfumePreppy'', who was presumably created from biological materials and rapidly grown in a tank. She even has the atypical eye color and coldness to go with it.
* [[Literature/SwordArtOnline Yui]] gets an artificial body created by RECT in ''[[FanFic/IWillNotBow Blazing Generations]]'', allowing her to have a normal life in the real world. [[spoiler:Luna later gains a new body through that same process]].
* ''Fanfic/PokemonMysteryDungeonHandsOfCreation'' has synthetic Pokémon, including [[spoiler: the main character, Owen, and the rest of Team Alloy.]]

* The now-dead Death Note fanfic "L, Robot" has L as one of these, with a variable amount of human traits adjustable with a switch.

* ''Literature/Area51'': It's revealed that the Airlia created many people, partly with their DNA, to serve as agents. [[spoiler:It's eventually revealed that humanity in ''general'' were created by the Airlia.]] However, later on in the series it's revealed that [[spoiler: the Martians created them.]]

* Creator/PoulAnderson's "Literature/CallMeJoe": The titular character is the pseudojovian lifeform artificially constructed by humans to live on the surface of {{UsefulNotes/Jupiter}} and act as a [[TelepathicSpacemen puppet controlled by a human on Ganymede]]. Joe specifically is controlled by Edward Anglesey, [[NotDisabledInVR a cripple]]. They created dozens of others, as well, for teams of esmen to control and conduct experiments on Jupiter's surface.

** One of the main intrigues of the series is that [[spoiler: the biological sister of the protagonist, Miyuki Shiba, was created as a perfect improved magikan. Although she is his real sibling, their genes are different enough (how much is never said, but it is implied that they are technically only half-siblings) that [[RoyalInbreeding their]] [[BrotherSisterIncest mating]] will not be dangerous to their offspring, and the head of the clan announces the engagement of Miyuki with her brother. After it becomes known, the whole second half of the series is devoted to how Miyuki and her brother Tatsuya will try to understand their feelings for each other and the apparent immorality of their new status of "lovers".]]

* In ''Literature/TheCampHalfBloodSeries'', all Children of Athena are technically this; like Artemis, Athena pleged to never marry, so Athena instead forms her children from divine thoughts and has them conveyed to mortal parents that she falls in love with as gifts.

* In the last arc, the Newmark arc, of ''VideoGame/CriminalCaseTheConspiracy'', it's revealed that the [[spoiler:head of S.A.R.A., Denise Daniels]], created a race of artificial superhumans [[spoiler: so she can use them to take over Grimsborough]].

* ''VideoGame/FateGrandOrder''

** Okita Alter is one, in a sense. Though summoned by the Counter Force, she was created without a fully functioning Saint Graph. [[spoiler: As she's supposed to be detonated like a bomb and be annihilated from existence, this makes her not necessarily an ArtificialHuman, but an ''Artificial Servant''.]]
** Played with for Ashiya Douman. He used to create shikigami duplicates of himself that he could control and use in his place, making it so he'd never fully be in danger. [[spoiler: This ability gets cut short by Pepe in Olympus, making it so he can't use it anymore. No word on whether it hits his Servant Incarnation however.]]

* ''VideoGame/GenshinImpact'' has two flavors of this trope, both hinted to be LostTechnology from the lost nation of Khaenri'ah. The more straightforward example is the homunculus [[spoiler: Albedo, and his failed "brothers"]], all creations of an alchemist that survived the destruction of Khaenri'ah. The other version are Puppets, ambiguously mechanical beings that are nearly identical to living beings but [[SuperToughness essentially immortal]] and vary in their degree of individuality and emotional capacity. [[spoiler: Scaramouche is a PsychoPrototype with a fully-developed sense of self and was deemed ''too'' emotional, while his "sister" the Raiden Shogun is much closer to an emotionless machine that strictly follows her programming]]. In comparison to them, the mass-produced [[spoiler: Kathrynes]] are much more fragile and can interact normally with people but apparently lack of true individuality or sense of self.
* From ''VideoGame/GirlsFrontline'', we have [[spoiler: the Nytos. Devised by Dr. William as a controllable way to access precursor Relic sites, Nytos are essentially vat-grown clones augmented with advanced cybernetics. While the Nytos aren't able to reach that goal yet, it turns out they make excellent combat units, and are frequently given authority over lesser Paradeus forces. Despite that, it is noted that their brain waves exhibit close similarities to a Doll's Digi-Mind, to the point that they can be remotely hacked like any other machine.]]
* [[spoiler: Sylvari]] in ''[[VideoGame/GuildWars2 Guild Wars 2]]'' and its novels [[spoiler: were created by the forest dragon to serve as his minions]].

* ''VideoGame/TalesOfTheAbyss'' has a plot that centers around replicas (basically clones created by magic), and a few important characters are eventually [[TheReveal revealed]] to be replicas. [[spoiler: Namely, Ion, Sync, and the protagonist himself, Luke.]]

** In ''VideoGame/WildArms1'' (original and ACF version), [[spoiler:the protagonist Rudy is an android/artificial human made from technology similar to that of the Metal Demons. He is a "Holmcross", given the alchemy refs, is clearly a transliteration for "Homunculus".]]
** ''VideoGame/WildArms3'' had [[spoiler:Jet, who was similar to the first game's example, only he was created to test the theory of Filgaia as a lifeform]], and ''VideoGame/WildArms2'' and ''[[VideoGame/WildArms4 4]]'' had Cyborgs in the characters of Kanon and Balgaine.
* ''VideoGame/WitchHunterIzana'': [[spoiler: Izana. She was created as part of a program to create effective witch hunters who were programmed to serve without question. The game is spent exploring the island where the process was developed.]]

** [[spoiler:Rubedo, Albedo, Nigredo, and Citrine]] from the ''VideoGame/{{Xenosaga}}'' videogame series are all variant clones of their creator, [[spoiler:Dr. Dmitri Yuriev]]. There were others created that collectively formed a sort of "hive mind", but [[spoiler: they were all destroyed during the Miltia Incident.]]

* In ''{{VisualNovel/Nameless}}'', the potential love interests are all dolls that have been magically brought to life.

** Touko of ''Literature/TheGardenOfSinners'' created a number of perfect copies of herself (physically and mentally) using her skill as a ''dollmaker''. She uses them as [[BodyBackupDrive backup copies of herself]], in the sense of "it doesn't matter if I die because my other bodies will live on and do what I would've done." She doesn't seem to care which one is the original or whether its still alive. [[spoiler: As usual -- with Kinoko Nasu, that is -- the 'truth' is more complex. Touko achieved a level of sophistry in "copying" herself, that the copy is no longer distinguishable from the original hence it ceases to be a copy and Touko can no longer tell which self is really "her".]]

* All furniture in ''VisualNovel/UminekoWhenTheyCry'' is supposed to be some variant of this, [[spoiler:although with Shannon, Kanon and Genji, this turns out not to be the case]]. In fact, the person who created the term "furniture" in-universe was [[spoiler: Yasu, the original personality of Shannon, Kanon and Beatrice (III), who sees [[AmbiguousGender him/herself]] as less than human due to his/her mutilated sexual organs and inability to have sex as a result.]]

* [[spoiler:Eric]] in ''WesternAnimation/KimPossible'' is such a realistic drone that everyone expects him to be human until the RoboticReveal. [[MadeOfPlasticine And he is killed by a bite from a rodent....]]

** ''ComicBook/{{Guardian}}'': Cadmus got permission to clone the original Guardian on his deathbead, though it's unlikely he knew just how many clones, DesignerBabies, and other genetically engineered [=DNAliens=]/Genomorphs would be created by the project using his DNA. His most prominent "clone" used the Guardian title for a while himself as the head of security at Cadmus, and adopted a young opposite gender clone of himself when he left.

*** S-13, alias Superboy and later named [[ComicBook/Superboy1994 Kon-El]] and Conner Kent, a version of whom is pictured above, [[spoiler:is a clone created by the Cadmus organisation in secret, as they knew that at some point, Superman would either die or otherwise become incapacitated in his current role. He's technically not a perfect clone, however; they had to splice in some Lex Luthor DNA to stabilize him, making him... slightly different in powers and personality -- though, peculiarly, the New 52 version was actually a clone of the future son of Clark and Lois, with hints at a relation to Lex being nothing more than a RedHerring.]] Oh, and [[BerserkButton don't call him Superboy.]]

* [[spoiler:Quote]] in ''VideoGame/CaveStory'', sort of.

* The ''VideoGame/PhantasyStar'' series is rife with artificial humans, the best example of this being the Newmans, starting with Nei in ''VideoGame/PhantasyStarII'' (described as a result of combining human and biomonster DNA), continuing with Rika in ''VideoGame/PhantasyStarIV'', and eventually becoming an entire race in ''VideoGame/PhantasyStarOnline''. The series also has various androids and cyborgs, such as Wren, Mieu, and Demi in the original series, and a race of humanoid robots called [=CASTs=] introduced in PSO. ''VideoGame/PhantasyStarUniverse'' also introduced yet another race of artificial humans called [[BeastMan Beasts]].

** As we find out in ''VideoGame/MegamanZX'' however, "Original Human" is a rather loose term, as long before then, both humanity and Reploids had been modified to the point that the differences between the two were pretty much superficial.

* ''ComicBook/AstroCity'': One story has several civilians secretly kidnapped and replaced with plant-based copies. The doppelgängers are sufficiently human-like to give false testimony as [[ClearMyName part of a frame-up]] and evaporate into mist when cornered.

** [[spoiler:Turns out, [[TheHero Ragna]], Saya, and [[AnnoyingYoungerBrother Jin]] are all "children" of the 5th Prime Field (implied to be based off Saya Terumi). They were found in an abandoned lab by The Six Heroes and promptly put in Celica's orphanage. [[ForegoneConclusion At least]], until it all went to shit because of [[ManipulativeBastard a certain snake]]...]]

* ''VideoGame/{{BlazBlue}}'':

Artificial Humans often have cognitive traits similar to TheSpock, such as [[GoodWithNumbers mathematical skill]] and a [[PhotographicMemory perfect memory]] on the positive side, they may be [[TheStoic unemotional]] and on the negative side they may suffer from [[CreativeSterility uncreativity]] and [[BluntMetaphorsTrauma excessive literal-mindedness]]. Being organic, however, allows some Artificial Humans to have some emotional similarity to humans, often in [[CloningBlues angst]] that leads to bonding with the kind-hearted hero(ine) or KillAllHumans.

* In ''VideoGame/HauntingGround'', [[spoiler:the first three antagonists ([[AndCallHimGeorge Debilitas]], [[AxCrazy Daniella]] and [[EvilUncle Riccardo]]), and even Fiona's ''father'' are all Artificial Humans created by the BigBad. The latter two are his ''[[CloningBlues clones]]''.]]

* ''WebOriginal/{{Mortasheen}}'' plays with this with the creature [[http://www.bogleech.com/mortasheen/lester.htm Lester]]. These creatures were designed by the monstrous citizens of Mortasheen city to be able to perfectly mimic and infiltrate humans to monitor their natural behavior and harvest them for "research". Unfortunately, they weren't very good at making convincing humans, and it landed so far in the UncannyValley that, though the monsters thought it looked like a normal human, the humans were too freaked out for it to be of any use at infiltration. So, now it's only used for infiltrating monsters.

* The Presger Ambassadors from ''Literature/AncillaryJustice'', which [[HeWhoMustNotBeSeen the Presger]] created to communicate with humanity after having learned, through trial and error, how to pull humans apart and put them back together again. Though they look human at first glance, their internals and especially their psychology are anything but, and most humans tend to give them a wide berth as a result.

* Despite their name, Bioroids in ''Manga/{{Appleseed}}'' are actually genetically modified human clones. They are identical to humans except for reduced capabilities to feel strong emotions and the lack of their cells ability to freely perform cell division. As a result they require regular injections to regenerate cells and lack the capacity to reproduce. Which is a good idea, as they are far more numerous than regular humans in Olympus. However Hitomi and Yoshi seem to be at least in a romantic relationship, though it's unclear if it is also sexual.
** Also, Athena seems perfectly capable of governing Olympus with a very strong fist and by intimidating the human politicians into compliance. [[NobleTopEnforcer Nike]] is really the only bioroid who shows limited emotions, but that makes her appear even more dangerous and intimidating.

* It is harder to find people who ''weren't'' artificially created in the ''Manga/{{Blame}}'' [[TheVerse 'verse]].

** A straighter example would be the series of Artificial Humans Gero created/developed before Cell. However, #17 and #18 were normal human twins until Gero messed with them (hence why #18 and Krillin have a kid later on), while #20 (Gero himself) is an entirely robotic construct, except with Gero's {{brain in a jar}} in its head, making those three {{cyborg}}s.
*** #17 and #18's cyborg status isn't obvious in the English dub because the Japanese word Jinzōningen (人造人間) meaning "artificial human", used for both Gero's robots and Gero's cyborgs, was translated as "Android", giving the false impression that #17 and #18 were robots like #16 and #19 (and #8 all the way back in the original ''Manga/DragonBall''). Vegeta even has a line in the dub where he says that #18 moves fast "for someone who's made of metal".

* [[OurHomunculiAreDifferent The homunculi]] from ''Manga/FullmetalAlchemist''. Their creation method differs between the manga/''Brotherhood'' and ''Anime/FullmetalAlchemist2003'', with the manga's being made from scratch and the 2003 anime's being closer to a Frankenstein's monster.
** Also, the [[spoiler:Philosopher's Stone-infused dummies]]. Although, since they [[spoiler:contain Philosopher's Stones, they might technically count as a type of homunculus anyway]].

* [[spoiler:Fate Testarossa]], the Wolkenritter, [[spoiler:Erio Mondial]], the members of the Numbers (including [[spoiler:Subaru and Ginga]]), [[spoiler:Vivio]], [[spoiler:Jail Scaglietti]], [[spoiler:Zest Grangaitz]] and all familiars from ''Franchise/LyricalNanoha''. Notable in that they're all three kinds; clones, living programs, ''and'' cyborgs.

* In the manga ''Minimum'', [[spoiler:the main [[LittlePeople tiny girl]], as well as the main antagonist, turn out be data people]].
* In ''Anime/MobileSuitGundam00'', it is heavily hinted that the Innovators, along with [[spoiler:Tieria Erde and Nena Trinity]], may be like this due to their innate ability to interact with the supercomputer VEDA.
** Hinted no more in Season 2 and outright confirmed in TheMovie where [[spoiler:Tieria himself]] confirms that Innovades are basically a VirtualGhost uploaded into organic hardware. If the hardware in question suffers fatal damage, they simply BodySurf [[BodyBackupDrive back into Veda]] and optionally create themselves a new body, or just stay uploaded and play DeusEstMachina, [[spoiler:as Tieria did between the series finale and the movie]].

* In ''Manga/{{Naruto}}'', [[spoiler:Zetsu]] and his various clones are the results of a failed experiment by [[spoiler:Madara using Hashirama's DNA and the Juubi's sealed body]]. They are sapient but completely subservient to their creator.

* The titular ''Manga/Dolls2005'' are living dolls.

** ''ComicBook/TheAvengers'': The Vision's body is a {{temporal duplicat|ion}}e of the android Human Torch's body, with some modifications and a different personality. Whatever those modifications were, the Vision is usually depicted as having a lot more inorganic bits than the Torch does.
*** ''ComicBook/TheVision2015'': Vision creates three other synthezoids -- Virginia, Viv, and Vin -- using brain patterns from [[spoiler:the Scarlet Witch]].

* [[Literature/SwordArtOnline Yui]] gets an artificial body created by RECT in ''[[FanFic/IWillNotBow Blazing Generations]], allowing her to have a normal life in the real world. [[spoiler:Luna later gains a new body through that same process]].

* Walter M. Miller's novella ''Conditionally Human'' is about this. TwentyMinutesIntoTheFuture people are organized into eugenic classes. Class C, not allowed to have children at all, is a niche market for the "neutroids" -- genetically modified chimpanzees who look like human children. But they are legally pets. They are bought and sold, stored in kennels and quite frequently euthanized. [[http://stepheneshort.com/other/library/_fiction/_Science%20Fiction%20&%20Fantasy/Miller,Walter%20M/Miller,%20Walter%20M%20-%20Conditionally%20Human.pdf The original story]] is not for the squeamish.

* The song "Coin Operated Boy" by The Dresden Dolls:

* The Mr. Bungle songs "Golem II: The Bionic Vapour Boy" and "None of Them Knew They Were Robots".

* TabletopGame/EclipsePhase:

* The bioroids -- "biological androids" -- in ''TabletopGame/{{GURPS}} TabletopGame/TranshumanSpace''.
** Guidelines for designing your own bioroids -- and infinite other forms of [[GeneticEngineeringIsTheNewNuke gengineered]] life -- reappear in ''GURPS: Bio Tech''.

* In ''[[TabletopGame/MutantYearZero Mutant: Year Zero]]'' The core race of [[{{Mutant}} Mutants]] are genetically grown humans who were designed from the get go to survive the hostile Zone of The Dawnworld.

* [[TabletopGame/PrometheanTheCreated Prometheans]] are born of alchemical rituals designed to create life from corpses. [[CameBackWrong It... doesn't exactly work right]]; a new consciousness is born inside the body, powered by the very force the moves the universe. Said force makes humans batshit crazy through continued exposure, which means Prometheans have to stick to their own kind. Since they were born of an imperfect alchemical ritual, though, [[ToBecomeHuman they always have the means to finish the transmutation...]]
** And from the same universe, we have the fetches of ''TabletopGame/ChangelingTheLost'', fake humans made by TheFairFolk to cover up their abductions. They're usually made from whatever stray garbage seems appropriate and a piece of the abductee's soul. Many of them, though not all, believe themselves to be the person they're meant to replace, but always seem to lack at least one feature (positive or negative) that went into the character of their template. Occasionally they are complete psychos.

* ''VideoGame/{{BlazBlue}}'': The various Murakumo units, of which [[TheWoobie Lambda-11]], [[BrainwashedAndCrazy Mu-12]] ([[spoiler:otherwise known as Noel Vermillion]]), [[AxCrazy Nu-13]] [[spoiler:and their genetic template Saya]] count among them.

* Interestingly, ''VideoGame/DissidiaFinalFantasy'' reveals that the very first ''[[VideoGame/FinalFantasyI Final Fantasy]]'' protagonist [[spoiler:started life as a Manikin (a being born artificially from living crystal infused with the memories of the very first Cid, via a Lufenian memory-passing ritual)]]. The [[spoiler:Gods Chaos and Cosmos were created in a similar manner]].
** Turns out to be the origin of [[BlackMage Vivi]] and his fellow Black Mages, as well as their enhanced [[EliteMook Black Waltz]] commanders that are being sold as weapons to Queen Brahne. This actually comes full circle when it is revealed [[spoiler:[[BigBad Kuja]] the one selling the black mages]] is also an artificial humanoid from an alien world trying to take over Gaia, albeit a defective one if [[TheManBehindTheMan Garland]] is to be believed. As is [[spoiler:Zidane Tribal]].

* ''VideoGame/HarukanaruTokiNoNakaDe'''s Abe no Yasuaki was created by his teacher [[UsefulNotes/{{Onmyodo}} Abe no Seimei]] to assist the main character. In the manga version, Yasuaki occasionally explains just how, [[MagiBabble because he wasn't born from a woman, he is "incomplete"]] [[OurSoulsAreDifferent and doesn't possess a heart]] [[TheStoic or emotions]], even after [[CharacterDevelopment certain events that proved otherwise]]; of course, there's always the main character to help with such cases...

* In the ''VideoGame/MegaManLegends'' games, it's revealed that [[spoiler:all the humans you see in the game are Artificial Humans made by the main character's creator, and the main character himself is either an Artificial Human or a {{Ridiculously Human Robot|s}} created by the leader of the original humans]]. Then the game stops being serious and gets nice and zany again for the post-credits ending.

* [[TheRival Shadow]] from the ''VideoGame/SonicTheHedgehog'' games is stated several times to be the "{{ultimate life form}}" and was engineered (at least in part) from alien DNA. He's more of an artificial [[FunnyAnimal hedgehog]], though...

* In ''VideoGame/SuperRobotWarsAdvance'', the [[WarForFunAndProfit Shadow-Mirror]] employs troops of android {{mooks}} called the W-Series. The W-Numbers are a particular group of W-Series built to follow this trope, with female protagonist Lamia "W17" Loveless being a cyborg, who is apparently half and half. Her brain contains several computers, and parts of her limbs, sometimes entire limbs, are mechanical. She is made to [[TheMole infiltrate military organizations]], and [[RidiculouslyHumanRobots looks and acts so human, nearly no one can tell the difference]]. One event in ''Advance'' puts her in harm's way when she's struck by [[{{Anime/Daimos}} Kazuya Ryuuzaki]] and [[Anime/MobileFighterGGundam Domom Kasshu]] and simply shrugs it off. Both men, who're exceptional martial artists, state they hit her vitals, which would outright kill a person.

** Aschen Brodel in ''[[VideoGame/EndlessFrontier Super Robot Wars OG Saga: Endless Frontier]]''. KOS-MOS and T-ELOS appear in the game as well.
*** And as it later turns out, [[spoiler:Haken is one, too]].

* ''VideoGame/{{Tangledeep}}'': [[TheHero Mirai]] can choose to be one if her starting class is the [[{{Cyborg}} HuSyn]]. Notably, the opening narration -- where Mirai explains her backstory and worldview -- changes to accommodate this; she notes that she was built, not born. She does further note that [[HappilyAdopted she has always been welcomed by friends and family]] despite being a RobotGirl, but that she also knows nothing about her own nature, and that is what propels her to investigate the titular [[DeathWorld Tangledeep]].
** Later revelations [[spoiler:make it clear that ''every'' version of Mirai is this, to some extent, being that they are all avatars of the Supervisor.]]
* In ''VideoGame/WildArms1'' (original and ACF version), [[spoiler:the protagonist Rudy is an android/artificial human made from technology similar to that of the Metal Demons. He is a "Holmcross", given the alchemy refs, is clearly a transliteration for "Homunculus".]]
** The other games had their share of Artificial Humans too. ''VideoGame/WildArms3'' had [[spoiler:Jet, who was similar to the first game's example, only he was created to test the theory of Filgaia as a lifeform]], and ''VideoGame/WildArms2'' and ''[[VideoGame/WildArms4 4]]'' had Cyborgs in the characters of Kanon and Balgaine.
* The Realians from the ''VideoGame/{{Xenosaga}}'' TV and game series. In addition, Ziggy is a Cyborg relic from the past.

* In ''VideoGame/{{Xenogears}}'', the heroes find out that they -- the whole humanity, actually -- are not humans. Original humans died out 10,000 years ago (well, humanity's fate in ''VideoGame/{{Xenogears}}'' is ambiguous at best), and what looked like humanity are actually [[spoiler:[[HumanResources replacement parts]] made by [[AIIsACrapshoot Deus]]]].

* Belphoebe of the ''Literature/WhateleyUniverse'', a cloned body based on Jobe's secret drow transformation serum. A mental copy of Belphegor is (accidentally) imprinted onto the body, and it wakes up. It's adapting quite nicely so far.

* Cobra "synthoids" in ''WesternAnimation/GIJoeARealAmericanHero'' could perfectly mimic real people and were key to several episodes where a FakedRipVanWinkle or BodySnatcher plot was in effect. They were apparently organic in nature, being constructed of a grey goopy matter called "Pseudoplasm" which they would terrifyingly revert back into by ''[[ImMelting melting]]'' if killed or self-destructed.
** The Synthoid technology was also put into use in an episode of ''Franchise/{{Transformers}}'', in which Rodimus Prime, Arcee and Ultra Magnus had their minds transferred into synthetic human bodies (by Cobra Commander no less). Luckily for the MoralGuardians, these came with automatic underwear.

* ''Franchise/ThePowerpuffGirls'' were created by Professor Utonium with "Sugar and Spice and Everything Nice" mixed into a vat; when he accidentally spilled in Chemical X.
** Similarly, The [[EvilCounterpart Rowdyruff]] [[SpearCounterpart Boys]], by Mojo Jojo, only with "Snips, Snails and Puppy Dog Tails", again, with the Chemical X.

* Some ''Franchise/{{Transformers}}'' late in the original line made use of Pretender technology, which involved fleshy outer shells. Those with human shells, therefore, could shrink down and blend in with humans. This skips the BecomeARealBoy step, though, as Transformers are MechanicalLifeforms, and thus start off sentient and sapient.

* From ''WesternAnimation/YoungJustice2010'', Red Tornado and his siblings, Red Torpedo, Red Inferno, and Red Volcano. Red Torpedo and Red Inferno forgot they were androids, leading to their destruction in the line of hero work. Red Tornado was subsequently programmed to remember he was an android, but he eventually begins to develop human emotions such as caring for others anyways.