History Main / AdaptationOriginConnection

** Its version of ''ComicBook/IronMan'' has Bruce Banner as a Stark Industries scientist and one of Tony's closest friends from college. When ComicBook/{{HYDRA}} attacks the Stark facility where the Gamma Bomb is housed, the blast mutates Bruce into ComicBook/TheIncredibleHulk, and it's the Hulk's subsequent rampage that badly wounds Tony and forces him to don the prototype Iron Man armor to save his own life.

* In ''WesternAnimation/TeenageMutantNinjaTurtlesMutantMayhem'', Baxter Stockman is the one who created the Ooze and dumped it into the sewers, meaning he is directly responsible for the mutation of the Turtles, Splinter, Bebop, Rocksteady, Leatherhead and the other mutants. In [[ComicBok/TeenageMutantNinjaTurtlesMirage the original Mirage comics]], Stockman was not involved with the Turtles' origin story, but he was April O'Neil's employer.

In ''WesternAnimation/TurtlesForever'', Hun mutates into Slash after he accidentally spilled the 80s mutagen on himself and got kicked by the 2003 Raph twice.

** In [[WesternAnimation/TeenageMutantNinjaTurtles1987 the 1987 animated series]], the Shredder tracked down Yoshi in the sewers of New York City and dumped the experimental mutagen there, in an attempt to kill him, hoping the mutagen would be poisonous and fatal, but the Turtles, who were adopted by Yoshi, got affected by it and mutated.

*** [[PsychoForHire Barry the Chopper]] as well. In the manga, the Elrics have no idea who he is by the time they meet him in the Fifth Laboratory. In the anime, they ''do'' know of him because they encountered him on his killing spree, with Ed and Winry being his next victims.

* The UDON ''Comicbook/StreetFighter'' comics had Rose be the one to free Cammy from M. Bison's brainwashing, despite no such connection between the two existing in [[Franchise/StreetFighter the games]]. Cammy is also revealed to be the one who killed Chun-Li's father back when she was still a Shadaloo assassin.

* The UDON ''Comicbook/StreetFighter'' comics had Rose be the one to free Cammy from M. Bison's brainwashing, despite no such connection between the two existing in [[Franchise/StreetFighter the games]].

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''Franchise/DCAnimatedUniverse'':

* ''WesternAnimation/HarleyQuinn2019'' - in Batman: The Animated Series (the first medium in which Harley Quinn appears) she runs into Ivy on a random heist and they are both already villainesses; Harley thinks the other woman is named "Poison Oakey." But in this as in other later adaptations that focus on Harley and Ivy's relationship, Harleen Quinzell was Ivy's therapist at Arkham and they became close there before their escape.
* In ''WesternAnimation/TheNewBatmanAdventures'', reporter Jack Ryder is transformed into the Creeper after [[Characters/BatmanTheJoker the Joker]] exposes him to Joker Venom and then pushes him into a vat of chemicals.
* ''WesternAnimation/SupermanTheAnimatedSeries'':
** The show blames the failure to evacuate Krypton on [[Characters/SupermanBrainiacCharacter Brainiac]]'s deliberate suppression of Jor-El's theories, making the comic-book Coluan robot into a Kryptonian example of AIIsACrapshoot. As such, Brainiac is responsible for Superman's status as (initially) the LastOfHisKind. Brainiac goes on to be one of the series' {{Big Bad}}s alongside [[Characters/SupermanLexLuthor Lex Luthor]] and [[Characters/NewGodsDarkseid Darkseid]].
** In "Monkey Fun," [[KillerGorilla Titano the Super-Ape]] is made [[Characters/SupermanLoisLane Lois Lane]]'s former pet from when she was a child.
** The episode "In Brightest Day" makes it so that Kyle Rayner is a co-worker of Clark Kent to explain his presence in Metropolis and also has him become a Green Lantern from inheriting Abin Sur's ring due to being a CompositeCharacter with Hal Jordan in addition to Sinestro being responsible for Abin Sur's death in the first place. In the comics, Kyle Rayner was given a ring by Ganthet during a time when the Green Lantern Corps was disbanded and Sinestro had no involvement whatsoever in Abin Sur's death (even established later on to consider Abin Sur a friend).
* ''WesternAnimation/JusticeLeague'':
** Prior to becoming ComicBook/{{Metamorpho}}, Rex Mason was the ComicBook/GreenLantern John Stewart's close friend from back during their time as Marines. In the comics, the two have no real connection.
** Gorilla Grodd was inadvertently given his trademark psychic powers when Wally West foiled his first attempt to brainwash the human race. Grodd was subsequently responsible for granting Giganta a human body and SizeShifter abilities.
** [[Characters/SupermanDoomsdayCharacter Doomsday]] was cloned from Superman's DNA by Project Cadmus as a contingency plan in case the former ever went rogue again.

** ''ComicBook/UltimateSpiderMan'': The Ultimate reimagining of [[Characters/MarvelComicsPeterParker Spider-Man]] does this three times over. First, [[Characters/MarvelComicsNormanOsborn Norman Osborn]] becomes the Green Goblin thanks to the same AppliedPhlebotinum that affected the spider that empowered Peter Parker; and another recurring BigBad candidate, [[Characters/MarvelComicsTheKingpin The Kingpin]], is connected to Spider-Man's origin in that the burglar who killed Uncle Ben is one of his lower-level thugs. Finally, [[Characters/MarvelComicsEddieBrock Eddie Brock]] is Peter's childhood best friend, and [[Characters/MarvelComicsVenom the Venom symbiote]] is the result of an experiment their parents worked on together for Bolivar Trask. Also, the explosion caused by the Green Goblin created [[Characters/MarvelComicsOttoOctavius Doctor Octopus]] and [[spoiler:turned Harry into the Hobgoblin]].

** ''ComicBook/UltimateXMen'': Regular-verse Yuriko is obsessed with Wolverine and only cares about the other X-Men through their relationship with him. This Yuriko is obsessed with Storm and doesn't give two hoots about Wolverine. However, as he's her boyfriend, if she goes after her she must be ready to fight with him as well.