History Main / AcquiredPoisonImmunity

* Killua from ''Manga/HunterXHunter'' is immune to virtually all forms of poison due to his family's TrainingFromHell, and is seen happily downing five cans of laxative-laced juice before the Hunter Exam starts.

** In "Intersections in Real Time", Sheridan is being held prisoner by [=EarthGov=] and subjected to interrogation. At one point, the interrogator is eating a sandwich with delight and offers it to Sheridan, pointing out that he's eating it with no ill effects. And he assures Sheridan [[FalseReassurance they have no desire to kill him until after he's been broken]]. It's only after Sheridan finishes eating that the interrogator mentions that it contained a powerful toxin that the latter has built an immunity to. The toxin doesn't kill Sheridan but makes him ''very'' sick, as intended.
** When Mollari becomes Emperor but ends up a Drakh thrall, he eventually discovers that the parasite the Drakh implanted in him to keep him under control CantHoldHisLiquor, something Londo himself can, having indulged in wine, women and song regularly for decades. This allows him to act against his controllers if he first drinks the Keeper into a stupor first. Unfortunately, over the course of nearly twenty years together, the Keeper gradually develops a tolerance, eventually reaching a point where the amount of privari needed to incapacitate the Keeper is close to the amount needed to incapacitate Londo himself, reducing his ability to act when he's finally free.

* ''Series/ForeverKnight''. Dr. Natalie Lambert tries to wean Nick Knight off his vampirism (which she thinks is mostly psychological) by encouraging him to eat small amounts of food, take garlic pills and use a sunbed. He's also shown touching candle flames and exposing himself to religious symbols to deal with his fear of them. In the past just trying to touch a cross caused Nick's hand to burst into flame, whereas now he only gets a minor burn. This proves useful when he's able to ward off his sire [=LaCroix=] by holding a cross; even though it should effect Nick just as much, [=LaCroix=] breaks and flees before he does.

* ''Fanfic/TheRigelBlackChronicles'': Harry doesn't exactly build up ''immunity'' to poisons, but in preparation for the Fifth Triwizard Task, and under Professor Snape's careful supervision, she trains herself to flush them out of her system with magic, after allowing them to progress to varying degrees. [[spoiler:The Draught of Delirium still leaves her confused, weak, and struggling, but she wins the Task.]]

* "Literature/RappaccinisDaughter": Rappaccini's lifelong obsession with poison inspired him to nourish his daughter with poison from birth. The result is that Beatrice is poisonous herself and also immune to the vegetable poisons she's been fed on. A short but promising romantic interaction between Beatrice and the student Giovanni prompts Rappaccini to lure Giovanni to his garden repeatedly so that he becomes like Beatrice and can stay with her.

* Franchise/{{Batman}}:
** One issue revealed that the title character regularly devises antidotes and methods of controlled exposure to Scarecrow's fear gas. However, every time Scarecrow attacks Batman with gas, he changes the formula afterwards so that immunizing against the previous has no effect. Batman does it [[CrazyPrepared simply on the off chance that Scarecrow didn't change it this one time]]. In ''Batman RIP'', Batman reveals that he is immune to many toxins and poisons, [[ProperlyParanoid and carries antidotes for all the ones he isn't immune to]].
** On the topic of Dr. Crane, [[Comicbook/BlackestNight apparently]] he's gassed himself so often he's become unable to fear ''anything''...except Batman.

* ComicBook/{{Blade}} once fought with [[HeroKiller Draconis]], a [[SinisterMinister vampire priest]] that developed immunity to all traditional weaknesses like holy symbols and sunlight with small gradual exposures to it, in addition to his unshakable faith turning him into a "[[ReligiousVampire Holy Vampire]]".
* In ''ComicBook/TheBoys'' the Russian mob attempts to kill the team with poison but while most of them were knocked out but kept alive by the [[SuperSerum Compound V]] in their system, Hughie and Love Sausage are completely unaffected due to them drinking Love Sausage's [[VodkaDrunkenski brake fluid cocktail]] which happened to build up their tolerance for poison.
* In one issue of the ''ComicBook/HarleyQuinn'' solo series, Harley rapidly throws off an attempt by Dr. Hugo Strange to drug her and explains to him that it's a bit silly to try to poison someone who's had long-term sexual relationships with both the Joker and Ivy.

* In one comic, ComicBook/{{Superboy}} deliberately exposes himself to pieces of kryptonite, to build up an immunity to those particular pieces, so he can later use them against Kryptonian criminals without being affected himself.
* Franchise/{{Superman}}

* Spoofed in ''WesternAnimation/TheTick'', with a minor character [[ItRunsOnNonsenseoleum who claims to have been building up an immunity to bullets this way.]] The character was an expy of ComicStrip/DickTracy, who has been shot an absurd number of times over the decades.
* [[{{Ninja}} Chizu]] in ''ComicBook/UsagiYojimbo'' takes a small dose of poison every day for this reason.
* ComicBook/{{Venom}}'s symbiote has been stated to have become increasingly resilient to flames and sonics through repeated exposure. How much more resilient it's become depends on the writer.
* ''ComicBook/{{Wolverine}}'' has assassin Reiko invoke this trope with blowfish toxin, which Jubilee learns while dodging attacks.
* Implicitly in DC's ''Electric Warriors'', which is set somewhere in the post-apocalyptic world of ComicBook/{{Kamandi}} where humanity has somewhat recovered and is coexisting with uplifted animals. The Earth has settled into a galactic community that avoids war over scarce resources through a hunger games kind of ritual where they [[SuperEmpowering empower]] champions to battle on their civilization's behalf. The food stocks from Earth are stuff known to be highly toxic like [[ComicBook/ElongatedMan Gingold]] or the Joker's [[Recap/BatmanTheAnimatedSeriesE34TheLaughingFish laughing fish]].
* Franchise/TheDCU rogue [[Characters/TeenTitansCheshire Cheshire]] is a MasterPoisoner who has made herself immune to countless types of toxins and poisons in this fashion. In one ''ComicBook/BirdsOfPrey'' storyline, shot took down ComicBook/LadyShiva by simply flooding the room with an odorless and [[TheParalyzer paralyzing toxin]]. Shiva soon fell to the floor while Cheshire herself was immune to the effects.

* ComicBook/SpiderMan seems to be developing an immunity to the gas used by the Green Goblin to nullify his Spider-Sense. Originally, the stuff rendered him unconscious and would make him unable to use the power for several days. Most recently, when the Hobgoblin used it in the "Revenge of the Sinister Six" story, he was able to stay conscious and recover in little over ''one'' day.
** In ''ComicBook/SpiderIsland'', Mary-Jane is one of the last people to be infected with Spider Flu. [[ComicBook/FantasticFour Reed Richards]] theorizes that the delay was due to her having been sleeping with [[Franchise/SpiderMan Peter Parker]] for years.

* In ''[[Literature/BofuriIDontWantToGetHurtSoIllMaxOutMyDefense BOFURI: I Don't Want to Get Hurt, so I'll Max Out My Defense]]'' (seen on the Video Examples page for this trope), the main character Maple uses this to maximize her skill (via using potions when she's about to die) to develop a higher level of immunity and to have a chance to defeat a poison dragon.

* ''Literature/SoImASpiderSoWhat'':
** The heroine gets a rather high poison resistance (and Corrosion resistance, too) from being forced to hunt for prey in a dungeon where every creature is poisonous to various degrees. She even ups this by creating globules of Poison that she uses ''on herself'' to build it up further: something that many other Magic Users thought was impossible to accomplish.
** Turns out in this RPGMechanicsVerse, you can build resistance to ''anything'' this way. Including building resistance to the Earth element by flinging boulders at yourself.
* ''Literature/TheStoryOfSaiunkoku'':
** Ryuuki built up a resistance to various poisons mostly thanks to growing up as TheUnFavorite at the bottom of a pecking order of six princes and their mothers. He once realized that [[TamperingWithFoodAndDrink Shuurei had been handed a poisoned drink]] and drank it himself before she gulped it down, counting on the trope to work; it did and he lived to tell, but it still made him rather sick.
** Sa Sakujun in the same series built up a similar resistance through bored experimentation, not that it does him a lot of good in the end.

* The entire Agriche family in ''Literature/TheWayToProtectTheFemaleLeadsOlderBrother'' practices this due to their rather [[ChronicBackstabbingDisorder unorthodox]] [[TheSpartanWay way]] of raising children. {{Exaggerated|Trope}} by Roxana, who consumes so much poison (albeit it has less to do with acquiring immunity and more with feeding her [[TheSwarm butterflies]]) she eventually becomes a PoisonousPerson.

-->-- '''Jude Duarte''', ''Literature/TheFolkOfTheAir: The Cruel Prince''

* ''LightNovel/SoImASpiderSoWhat'':

* ''LightNovel/TheStoryOfSaiunkoku'':

* The entire Agriche family in ''Lightnovel/TheWayToProtectTheFemaleLeadsOlderBrother'' practices this due to their rather [[ChronicBackstabbingDisorder unorthodox]] [[TheSpartanWay way]] of raising children. {{Exaggerated|Trope}} by Roxana, who consumes so much poison (albeit it has less to do with acquiring immunity and more with feeding her [[TheSwarm butterflies]]) she eventually becomes a PoisonousPerson.

* The ''Franchise/{{Disgaea}}'' [[LightNovel/DisgaeaNovels novels]] gives an explanation as to why [[Characters/DisgaeaHourOfDarkness Laharl]] survived being poisoned by [[Characters/DisgaeaHourOfDarkness Etna]] in the [[VideoGame/DisgaeaHourOfDarkness game]], the reason was that his crazy aunt [[Characters/DisgaeaNovels Yasurl]] gave him the same poison when he was little and in her care.

* One version of [[Franchise/GIJoe Cobra Commander]] was given treatments against cobra and other snake venom. (This particular version [[CompositeCharacter was previously]] Baron Ironblood, the main villain of the European ''Joe'' equivalent, ''[[Franchise/ActionMan Action Force]]''. When Hasbro bought out Palitoy, they proceeded to [[CanonImmigrant bring in various characters and concepts]] from the US ''GI Joe'' line, resulting in Ironblood becoming [[YouHaveOutlivedYourUsefulness fed up with the Red Shadows' failures]] and intentionally leaking info about their bases, while he went to Southeast Asia to form this continuity's version of Cobra.]])

* In ''VideoGame/TheLegendOfZeldaBreathOfTheWild'', the [[FishPeople Zora]] are portrayed as being especially vulnerable to [[ShockAndAwe electricity]], which is inconvenient because Shock Arrows are needed to incapacitate the [[HumongousMecha Divine Beast Vah Ruta]] that has been causing havoc for the Lanayru Province. King Dorephan and Prince Sidon decide to seek help from [[HumansAreAverage Hylians]], who lack said vulnerability, but one Zora named Seggin instead tries to develop an immunity to electricity by repeatedly touching a Shock Arrow. He is apparently making some progress, as it's mentioned that he can hold it far longer than any other Zora, but it's still excruciatingly painful.

* In ''[[LightNovel/BOFURIIDontWantToGetHurtSoIllMaxOutMyDefense BOFURI: I Don't Want to Get Hurt, so I'll Max Out My Defense]]'' (seen on the Video Examples page for this trope), the main character Maple uses this to maximize her skill (via using potions when she's about to die) to develop a higher level of immunity and to have a chance to defeat a poison dragon.

* ''VideoGame/EtrianOdyssey'' has a mechanic where inflicting a status ailment or bind on an enemy or ally will increase that character's resistance to that effect for the remainder of the battle. In the fourth game, Arcanists have a skill called "Release Spell" that undoes this.

Here's a typical scenario: The hero has finally appeared at his confrontation with the BigBad, who's seated at his big table, just about to take his evening meal. "There's no reason to be uncivil," the villain says. [[NoMisterBondIExpectYouToDine Would the hero like some wine]]? The hero takes a drink and immediately starts choking. The villain laughs -- that fool, the hero, should have known that the villain would poison the wine with the dreaded juice of the [[NamesToRunAwayFromReallyFast Ultramurder]] fruit!

* ''Webcomic/LatchkeyKingdom'' has princess Rosaline Lannistark, though her parents were [[http://latchkeykingdom.smackjeeves.com/comics/2261667/minion-11/ a bit mean-spirited]] in teaching her.