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* In ''Manga/TwentiethCenturyBoys'', approximately 2/3 of the people who complete Friend's VR, which purportedly reveals [[TheFaceless his face]], are DrivenToSuicide. [[spoiler: It's not his face, it's Sadakiyo's--specifically it's his adult face on a ''child's'' body. In a simulation that is otherwise completely indistinguishable from reality, it drives people crazy simply because of how ''wrong'' it looks.]]
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* In ''Manga/TwentiethCenturyBoys'', approximately 2/3 of the people who complete Friend's VR, which purportedly reveals [[TheFaceless his face]], are DrivenToSuicide. [[spoiler: It's not his face, it's Sadakiyo's--specifically it's his adult face on a ''child's'' body. In a simulation that is otherwise completely indistinguishable from reality, it drives people crazy simply because of how ''wrong'' ''[[UncannyValley wrong]]'' it looks.]]
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* In ''Anime/DanganRonpa3: Future Chapter'', Kazuo's [[TheReveal reveal]] of the attacker being [[spoiler:technically everybody]] has this effect on Kyousuke, [[spoiler:causing him to become singularly obsessed with ending the game by any means necessary... even if it means killing everybody.]]
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* ''Anime/Danganronpa3TheEndOfHopesPeakHighSchool'': In ''Anime/DanganRonpa3: Future ''Future Chapter'', Kazuo's [[TheReveal reveal]] of the attacker being [[spoiler:technically everybody]] has this effect on Kyousuke, [[spoiler:causing him to become singularly obsessed with ending the game by any means necessary... even if it means killing everybody.]]
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moving to GoMadFromTheRevelation.Literature
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* ''Literature/InstantDeath'': When Aoi used her ability to see fate in [[ApocalypseMaiden Yogiri]], she ended up losing her sanity when the only thing she saw was [[TheEndoftheWorldasWeKnowIt the end of everything that exists.]]
-->'''Aoi''': "It was a dead end. The inevitable destination of all fates, beyond which there was nothing. The end of all things in human form. An embodiment of nonexistence that would overcome all others, something that no one could ever hope to surpass. Before this thing, the machinations of Fate were nothing more than a crude joke."
-->'''Aoi''': "It was a dead end. The inevitable destination of all fates, beyond which there was nothing. The end of all things in human form. An embodiment of nonexistence that would overcome all others, something that no one could ever hope to surpass. Before this thing, the machinations of Fate were nothing more than a crude joke."
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* ''LightNovel/{{Instant Death}}: When Aoi used her ability to see fate in [[ApocalypseMaiden Yogiri]], she ended up losing her sanity when the only thing she saw was [[TheEndoftheWorldasWeKnowIt the end of everything that exists.]]
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* The events of the Eclipse in ''Manga/{{Berserk}}'' took a horrible toll on the mind of Casca, who not only [[spoiler:lost every one of her men, including Judeau, to things out of nightmare, but was raped by the very essence of evil itself in the form of the fifth member of the Godhand, Femto -- who used to be Griffith, one of the two most important men in her life -- right in front of Guts, the man she loved]]. The trauma of the experience rendered her [[CuteMute mute]], [[TraumaInducedAmnesia amnesiac]] and insane, and it was not helped one bit by [[spoiler:Guts leaving her for two years to pursue vengeance against Griffith]].
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* The events of the Eclipse in ''Manga/{{Berserk}}'' took a horrible toll on the mind of Casca, who not only [[spoiler:lost every one of her men, including Judeau, to things out of nightmare, but was raped by the very essence of evil itself in the form of the fifth member of the Godhand, Femto -- who used to be Griffith, one of the two most important men in her life -- right in front of Guts, the man she loved]]. The trauma of the experience rendered her [[CuteMute mute]], [[TraumaInducedAmnesia amnesiac]] and insane, and it was not helped [[TheOphelia insane]], essentially turning her into an EmptyShell of her former self. It doesn't help one bit by that [[spoiler:Guts leaving left her for two years to pursue vengeance against Griffith]].
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** [[spoiler: Mutsuki breaks down into hysterical laughter and undergoes serious SanitySlippage, after seeing Torso's mutilated body done at his hands and realizing the full scale of his past crimes that he had long tried to bury in his mind.]]
** [[spoiler: Kaneki breaks down laughing after Yamori duck taped his head once he put a centipede into his ear during a long torture session in which he also repeatedly cut off his toes and fingers. He also snapped after Yamori did a SadisticChoice in front of him where he killed two people after ordering him to choose who would live and would die. He breaks down crying and begs Yamori to kill him instead and later it's the torture which led him to become a ruthless AntiHero.]]
** [[spoiler: Kaneki breaks down laughing after Yamori duck taped his head once he put a centipede into his ear during a long torture session in which he also repeatedly cut off his toes and fingers. He also snapped after Yamori did a SadisticChoice in front of him where he killed two people after ordering him to choose who would live and would die. He breaks down crying and begs Yamori to kill him instead and later it's the torture which led him to become a ruthless AntiHero.]]
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** [[spoiler: Mutsuki breaks down into hysterical laughter and undergoes serious SanitySlippage, SanitySlippage after seeing Torso's mutilated body done at his hands and realizing the full scale of his past crimes that he had long tried to bury in his mind.]]
** [[spoiler: Yamori inflicts a series of brutal tortures on Kaneki: first cutting off his fingers and toes (they grow back) over and over for ''days'', then stuffing a live centipede in his ear and duct-taping his head so that it tunnels into his brain. Kaneki starts to laugh hysterically, but what truly shatters him is Yamori giving him a SadisticChoice: choose one of a mother and child pair (two lovers in the anime) for Yamori to kill in front of him. Kaneki breaks downlaughing after Yamori duck taped his head once he put a centipede into his ear during a long torture session in which he also repeatedly cut off his toes and fingers. He also snapped after Yamori did a SadisticChoice in front of him where he killed two people after ordering him to choose who would live and would die. He breaks down crying weeping and begs Yamori to kill him instead ''him'' instead, but Yamori loses his temper and later it's the torture which led kills both victims. One after another, these tortures snap Kaneki's already rather fragile mental state like a twig, causing him to become assume the role of a ruthless AntiHero.AntiHero and suffer further mental issues throughout the series.]]
** [[spoiler: Yamori inflicts a series of brutal tortures on Kaneki: first cutting off his fingers and toes (they grow back) over and over for ''days'', then stuffing a live centipede in his ear and duct-taping his head so that it tunnels into his brain. Kaneki starts to laugh hysterically, but what truly shatters him is Yamori giving him a SadisticChoice: choose one of a mother and child pair (two lovers in the anime) for Yamori to kill in front of him. Kaneki breaks down
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* Occurs to one of the astronomers in ''Manga/HellstarRemina'' when he realizes that [[spoiler: Remina's a sentient PlanetEater...and it's headed for Earth.]]
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* Occurs to one of the astronomers in ''Manga/{{Remina}}'' when he realizes that [[spoiler: Remina's a sentient PlanetEater...and it's headed for Earth.]]
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* Russia from ''Webcomic/AxisPowersHetalia'' during the Bloody Sunday strip, in which he snaps and starts to mow down his own people on the grounds that "they're not really Russians if they don't love me."
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* Russia from ''Webcomic/HetaliaAxisPowers'' during the Bloody Sunday strip, in which he snaps and starts to mow down his own people on the grounds that "they're not really Russians if they don't love me."
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* ''LightNovel/{{Instant Death}}: When Aoi used her ability to see fate in [[ApocalypseMaiden Yogiri]], she ended up losing her sanity when the only thing she saw was [[TheEndoftheWorldasWeKnowIt the end of everything that exists.]]
-->'''Aoi''': "It was a dead end. The inevitable destination of all fates, beyond which there was nothing. The end of all things in human form. An embodiment of nonexistence that would overcome all others, something that no one could ever hope to surpass. Before this thing, the machinations of Fate were nothing more than a crude joke."
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* ''Anime/DigimonAdventure02'': Certainly not the only factor in his descent, but his visit to the [[CosmicHorrorStory Dark Ocean]] a perpetually dark realm, populated by various Lovecraftian horrors and where Love and Hope are a foreign concept, was definitely the Straw that Broke the Camel's Back for Ken Ichijoji. One look at his [[http://www.alltrees.org/anime/basetwo/images/ken.chibi.evil.jpg expression]] in that [[{{Flashback}} scene]] is enough to convince you that this kid just went off the deep end.
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* ''Anime/DigimonAdventure02'': Certainly not the only factor in his descent, but his visit to the [[CosmicHorrorStory Dark Ocean]] a perpetually dark realm, populated by various Lovecraftian horrors and where Love and Hope are a foreign concept, was definitely the Straw that Broke the Camel's Back for Ken Ichijoji. One look at his [[http://www.alltrees.org/anime/basetwo/images/ken.chibi.evil.jpg expression]] in that [[{{Flashback}} scene]] is enough to convince you that this kid just went off the deep end.
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* ''Anime/YuYuHakusho'', of all series, has this happen to Sensui in his backstory. Not from any eldritch lore, though, but from simply [[spoiler:seeing how horrible people can be--shattering his belief in black and white morality by witnessing the torments sadistic humans inflicted on demons for fun, leaving him an omnicidal maniac]]. Chapter Black is also noted to be able to force people to go mad from the revelation. It's a compilation of every terrible thing humanity has ever done in loving detail. This is implied to be partly a supernatural effect. It should be noted this is a case where a ''partial'' revelation has this effect: there's a Chapter White, a compilation of every ''good'' [[spoiler:thing humanity has ever done in equal detail]]. The two are meant to be viewed simultaneously, never seperately.
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* ''Anime/YuYuHakusho'', of all series, has this happen to Sensui in his backstory. Not from any eldritch lore, though, but from simply [[spoiler:seeing how horrible people can be--shattering his belief in black and white morality by witnessing the torments sadistic humans inflicted on demons for fun, leaving him an omnicidal maniac]]. Chapter Black is also noted to be able to force people to go mad from the revelation. It's a compilation of every terrible thing humanity has ever done in loving detail. This is implied to be partly a supernatural effect. It should be noted this is a case where a ''partial'' revelation has this effect: there's a Chapter White, a compilation of every ''good'' [[spoiler:thing thing humanity has ever done in equal detail]].detail. The two are meant to be viewed simultaneously, never seperately.
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** Notably, if you didn't already know who was going to grow up to be the villain, it would ''look'' like Knives handled it better than Vash. They both locked themselves in and attempted to starve to death together, but after Rem broke in and saved them it was ''[[MessianicArchetype Vash]]'' who did the CreepyLaugh and HumansAreBastards and hysteria, and Knives seemed...perfectly okay. He saved his freak-out until after he'd set up all the colony ships to crash.
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** Notably, if you didn't already know who was going to grow up to be the villain, it would ''look'' like Knives handled it better than Vash. They both locked themselves in and attempted to starve to death together, but after Rem broke in and saved them it was ''[[MessianicArchetype Vash]]'' who did the CreepyLaugh LaughingMad and HumansAreBastards and hysteria, and Knives seemed...perfectly okay. He saved his freak-out until after he'd set up all the colony ships to crash.
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Changed line(s) 51,52 (click to see context) from:
* ''Anime/YuYuHakusho'', of all series, has this happen to Sensui in his backstory. Not from any eldritch lore, though, but from simply [[spoiler:seeing how horrible people can be--shattering his belief in black and white morality by witnessing the torments sadistic humans inflicted on demons for fun, leaving him an omnicidal maniac]]. Chapter Black is also noted to be able to force people to go mad from the revelation. It's a compilation of every terrible thing humanity has ever done in loving detail. This is implied to be partly a supernatural effect. It should be noted this is a case where a ''partial'' revelation has this effect: there's a Chapter White, a compilation of every ''good'' thing humanity has ever done in equal detail. The two are meant to be viewed simultaneously, never seperately.
to:
* ''Anime/YuYuHakusho'', of all series, has this happen to Sensui in his backstory. Not from any eldritch lore, though, but from simply [[spoiler:seeing how horrible people can be--shattering his belief in black and white morality by witnessing the torments sadistic humans inflicted on demons for fun, leaving him an omnicidal maniac]]. Chapter Black is also noted to be able to force people to go mad from the revelation. It's a compilation of every terrible thing humanity has ever done in loving detail. This is implied to be partly a supernatural effect. It should be noted this is a case where a ''partial'' revelation has this effect: there's a Chapter White, a compilation of every ''good'' thing [[spoiler:thing humanity has ever done in equal detail.detail]]. The two are meant to be viewed simultaneously, never seperately.
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People [[GoMadFromTheRevelation going mad from the revelation]] in anime and manga.
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* In ''Manga/TwentiethCenturyBoys'', approximately 2/3 of the people who complete Friend's VR, which purportedly reveals [[TheFaceless his face]], are DrivenToSuicide. [[spoiler: It's not his face, it's Sadakiyo's--specifically it's his adult face on a ''child's'' body. In a simulation that is otherwise completely indistinguishable from reality, it drives people crazy simply because of how ''wrong'' it looks.]]
* Russia from ''Webcomic/AxisPowersHetalia'' during the Bloody Sunday strip, in which he snaps and starts to mow down his own people on the grounds that "they're not really Russians if they don't love me."
* More or less every single Tipharian in ''Manga/BattleAngelAlita'' that learns ''"the secret of Tiphares"'' ([[spoiler:Tipharians undergo a special ceremony at the age of nineteen. During this ceremony, the brain of the Tipharian is replaced with a computer chip]]) is driven insane. Most commit suicide.
** [[spoiler: Alita is a citizen of Tiphares thanks to Desty Nova. HeroicBSOD time!]]
* The events of the Eclipse in ''Manga/{{Berserk}}'' took a horrible toll on the mind of Casca, who not only [[spoiler:lost every one of her men, including Judeau, to things out of nightmare, but was raped by the very essence of evil itself in the form of the fifth member of the Godhand, Femto -- who used to be Griffith, one of the two most important men in her life -- right in front of Guts, the man she loved]]. The trauma of the experience rendered her [[CuteMute mute]], [[TraumaInducedAmnesia amnesiac]] and insane, and it was not helped one bit by [[spoiler:Guts leaving her for two years to pursue vengeance against Griffith]].
** The poor mother who gets put to the torture by Mozgus to "expiate her sins" during the Conviction Arc is later seen back among the refugees having gone completely insane and clutching the corpse of the baby she had gone through hell for.
* The reason Schwarzwald from ''Anime/TheBigO'' goes mad and decides to destroy Paradigm City is because he figures out the show's OntologicalMystery (or at least part of it... it's a [[JigsawPuzzlePlot big mystery]]).
* In ''Manga/ChronoCrusade'', Aion has a tenuous grasp on his sanity after he's MindRaped by Pandaemonium and discovers the AwfulTruth of his origins.
* Jeremy has one of these in ''Manga/ACruelGodReigns'' after he [[spoiler: finds his mother's diary detailing that she knew Greg was raping Jeremy, but did nothing. This leads to his DrivenToSuicide BungledSuicide just as he is going to confess to killing Greg to Ian.]]
* In ''Anime/DanganRonpa3: Future Chapter'', Kazuo's [[TheReveal reveal]] of the attacker being [[spoiler:technically everybody]] has this effect on Kyousuke, [[spoiler:causing him to become singularly obsessed with ending the game by any means necessary... even if it means killing everybody.]]
* ''Anime/DigimonAdventure02'': Certainly not the only factor in his descent, but his visit to the [[CosmicHorrorStory Dark Ocean]] a perpetually dark realm, populated by various Lovecraftian horrors and where Love and Hope are a foreign concept, was definitely the Straw that Broke the Camel's Back for Ken Ichijoji. One look at his [[http://www.alltrees.org/anime/basetwo/images/ken.chibi.evil.jpg expression]] in that [[{{Flashback}} scene]] is enough to convince you that this kid just went off the deep end.
* In ''Anime/FantasticChildren'', scientist Dr. Radcliffe became obsessed with unraveling the mystery of the Children of Befort. Needless to say, the more he found out, the madder he went. He could have been saved a lot of suffering if he knew that his theory was actually [[spoiler:as far from the truth as you could get]].
* In ''Manga/FullmetalAlchemist'', it's strongly implied, and possibly outright stated, that the experience of going through the Gate is so "awful" that even if you did manage to survive through the pain of whatever it took from you, you could wind up a vegetable.
** Isaac [=McDougal=], a.k.a. The Freezing Alchemist, from Episode 1 of ''Brotherhood'' went totally off his rocker when [[spoiler:he uncovered the country-wide transmutation circle conspiracy]], and decided to remedy the problem by attempting to reduce Central to a frozen pile of rubble.
* Towards the end of ''Anime/{{Gankutsuou}}'' Heloïse Villefort, who seems perfectly normal in her first appearances, is revealed to actually be a murderous woman who's out of touch with reality. When her husband tells her to her face that she's just a murderous BitchInSheepsClothing, and reveals that he knows she's been trying to kill him and their daughter Heloise collapses to the floor, finally giving into her insanity. Her husband then has her committed to an insane asylum for the rest of her life.
* Every so often ''Anime/GhostInTheShellStandAloneComplex'' uses this trope to great (chilling) effect. For example, in the episode entitled "Not Equal" an American Special Ops soldier is reduced to a gibbering, suicidal shell of a man after seeing [[spoiler: the memories of the experiences that aged a young girl into an old woman in the span of 16 years during her time as a prisoner of a paramilitary group.]]
* In the ''Anime/HaloLegends'' segment ''Homecoming'', a few of the escaped Spartans find out they've been replaced with clones, [[spoiler: leading a few to commit suicide]].
* What happens to [[spoiler:Kurumi's friend Kaafai]] from ''Manga/HaouAiren'' when [[spoiler:he's ForcedToWatch as Hakuron rapes Kurumi.]] This is why he [[spoiler:shoots Hakuron to death in the end.]]
* Occurs to one of the astronomers in ''Manga/HellstarRemina'' when he realizes that [[spoiler: Remina's a sentient PlanetEater...and it's headed for Earth.]]
* In ''Manga/HunterXHunter'', the sheer intensity and strength of Neferpitou’s and Meruem’s auras can be so overwhelming for a regular Nen-user, that even a momentary exposure to it can have severe permanent psychological and physiological consequences. Knov, for instance, who was specifically picked up for the highest-threat and highest-difficulty level mission against Chimera Ants, became almost completely demoralised after seeing just the brink of Neferpitou’s aura at close range and soon after lost almost all hair on his head. Similarly, Welfin rapidly aged and his fur fell out when he felt the King’s KillingIntent focused on him.
* In ''Anime/{{Monster}}'' after [[TraumaCongaLine Nina recovers all of her memories]] and realizes that the memories her evil twin brother Johan thinks are his are really hers ([[ItMakesSenseInContext it's complicated]]), she nearly commits suicide. Thankfully [[AllLovingHero Dr. Tenma]] intervenes just in time to avert a potentially HUGE TearJerker.
* ''Manga/{{Naruto}}'':
** Sasuke, understandably, [[MyGodWhatHaveIDone does not react well]] when he finds out the truth about Itachi. Thankfully, after 200 or so chapters, he gets better ([[BaitTheDog well, or so it seems]]).
** [[spoiler: Likewise, [[BigBad Madara Uchiha]] went mad after reading deeply into the Uchiha Tablet and discovering [[TheseAreThingsManWasNotMeantToKnow that their war-torn world has always been such and that it only became worse once a princess sought to end all conflict by stealing Chakra from a God/Eldritch Abomination and becoming a goddess herself.]] Which was exactly what Black Zetsu intended when he rewrote the tablet. Madara was driven mad by a lie.]]
* Towards the end of ''Anime/NeonGenesisEvangelion'', Shinji Ikari finds out that [[spoiler:Rei Ayanami, [[TheConfidant one of his closest confidants]], has died and been replaced by a clone]], and later still he deduces that [[spoiler:there is definitely a connection between her, his dead mother, and the weird presence in Eva Unit 01]], and these revelations does indeed shake his already fragile psychological stability quite a bit. It finally comes to a head in ''The End of Evangelion'' when the ritual to [[spoiler:awaken [[EldritchAbomination Lilith]]/Rei Ayanami]] reduces him to a fit of shrieking omnicidal insanity. It didn't help that he had just seen [[spoiler: Asuka's torn-apart remains]] only about a minute earlier.
* Suzu in ''Manga/PeacemakerKurogane'' becomes AxCrazy and a DepravedHomosexual after [[spoiler:finding his beloved master dead, and being raped by an old man]].
* ''Anime/PerfectBlue'': In the anime's denouement, [[spoiler: Rumi]] is permanently delusional and institutionalized.
* Mewtwo from ''Anime/PokemonTheFirstMovie'' goes off his gourd when he's basically told that his purpose in life is just to be a science experiment and/or a weapon and nothing more to those who created him. As a result, he psychically nukes a lab and a Team Rocket base, kills the scientists who brought him into being, almost kills Giovanni, and decides to make himself judge, jury and executioner to every human and Pokémon on the planet. [[spoiler: Ash's desperate attempt to stop the fighting between the clones and original Pokémon is enough to bring Mewtwo back to Earth and question his initial belief on humans.]]
* ''Anime/PuellaMagiMadokaMagica'': Happens to [[spoiler:Sayaka Miki, and Mami Tomoe from the third alternate timeline]]. [[spoiler:Sayaka]] starts losing it as she realizes that [[spoiler:not only does [[NoGoodDeedGoesUnpunished no good deed go unpunished]], but being a Magical Girl is NOT sunshine and rainbows]]. She ends up becoming the witch known as Oktavia Von Seckendorff since among other things, she brought hope to others only to lose herself to despair ''and'' her wishes weren't as selfless as she believed; [[spoiler:the third Mami]] goes insane with grief after [[spoiler:the Sayaka of her continuity also becomes Oktavia (probably in similar circumstances) and is killed by Homura, since she cannot handle the AwfulTruth that being a Puella Magi means she will eventually become a witch; she kills Kyouko and gets ready to kill Homura, so Madoka has to MercyKill her.]]
** And in the backstory of [[spoiler: Kyoko Sakura]], this happened to [[spoiler: her father, when he found out that Kyoko used her SelflessWish to brainwash people into following him. His mind splintered so badly that he went the PaterFamilicide route, with Kyoko as the SoleSurvivor of the Sakura clan.]]
* In ''Manga/RurouniKenshin'' Soujiro goes temporarily insane when he realizes that he did regret killing people despite clinging to the words of his EvilMentor: -> "If you're strong you live. If you're weak, you die." It doesn't help that the people he regretted killing were his AbusiveParents or that he'd been a StepfordSmiler so long that every other emotion was completely suppressed until then. To top it all off it was Kenshin's words that caused this. It eventually leads to Soujiro's VillainousBSOD.
* ''VisualNovel/SchoolDays''' Kotonoha and Sekai. Both are dumped by a JerkAss Makoto Ito and have realized that he's also screwed around with their best friends. [[DullEyesOfUnhappiness Kotonoha's eyes turn dark]] around the later half of the anime, especially after it's implied that Makoto's friend raped her.
* ''Anime/SpacePirateMito'': Masatsuki Nenga goes insane when [[spoiler: he comes to the realisation that his "Justice" is nothing more than a tool of oppression (one that has no issue shooting down a "mob" of villagers, men, women and children) used by a pretender to the throne]]. This leads to about two episodes worth of him screaming "I AM JUSTICE!" at the top of his lungs whilst firing his gun like the lunatic he is. This would be fine all in all, but the guy doesn't look older than 12.
* Ralph Werec of ''Anime/StrainStrategicArmoredInfantry'' went from perfect soldier to traitorous OmnicidalManiac [[spoiler:when he saw that his people had created the HumongousMecha he was piloting by [[{{Aesoptinum}} killing harmless little alien girls]] for their PsychicPowers]]. However, though his reaction is understandable, [[spoiler:when one of the [[FateWorseThanDeath sort-of-survivors]] shows Sara the story in a vision, she keeps her own sanity. Ralph also got sucked into a dimensional rift that gave him terminal cancer directly ''after'' said vision.]]
* ''Manga/TokyoGhoul'':
** [[spoiler: Mutsuki breaks down into hysterical laughter and undergoes serious SanitySlippage, after seeing Torso's mutilated body done at his hands and realizing the full scale of his past crimes that he had long tried to bury in his mind.]]
** [[spoiler: Kaneki breaks down laughing after Yamori duck taped his head once he put a centipede into his ear during a long torture session in which he also repeatedly cut off his toes and fingers. He also snapped after Yamori did a SadisticChoice in front of him where he killed two people after ordering him to choose who would live and would die. He breaks down crying and begs Yamori to kill him instead and later it's the torture which led him to become a ruthless AntiHero.]]
** [[spoiler: During Itsuki Marude's confrontation with Yoshitoki, Matsuri heard the gunshot from another part of the ship. When he went to investigate, he came across the aftermath of the battle and discovered his father's corpse.]] Barely maintaining his composure, he radioed Urie to report the commander's death at the hands of an "unknown assailant." He falsely reported that Marude had committed suicide, and then collapsed to the ground after ending the transmission. [[spoiler: Weeping hysterically, he spoke in an effeminate manner and swore revenge against Marude for his father's murder. His insanity is further shown in chapter 100 where he tears his clothes off until he's naked in front of a window in his office and flamboyantly declares his love for Urie. This occurring not too long after his despair at having lost his father.]]
* BigBad [[KillAllHumans Millions]] [[EvilTwin Knives]] from ''Manga/{{Trigun}}'' has this as his manga origin story. (In the anime he just decided HumansAreTheRealMonsters for semi-logical if not terribly extreme reasons, and then went EvilPlan on them and his brother. In the manga, he [[UsedToBeASweetKid was a sweet boy]] who snapped after discovering the AwfulTruth--that there had been an 'Independent Plant' born before him and his brother, and the crew had [[ForScience studied her right to death]].
** Notably, if you didn't already know who was going to grow up to be the villain, it would ''look'' like Knives handled it better than Vash. They both locked themselves in and attempted to starve to death together, but after Rem broke in and saved them it was ''[[MessianicArchetype Vash]]'' who did the CreepyLaugh and HumansAreBastards and hysteria, and Knives seemed...perfectly okay. He saved his freak-out until after he'd set up all the colony ships to crash.
* On ''Anime/TsukuyomiMoonPhase'', Kouhei experiences temporary madness after his new power lets him see [[spoiler:Hazuki]]'s true form, after which he temporarily becomes a trembling wreck who screams like a madman every time he sees her, he eventually gets over it though.
* In ''Anime/YukiYunaIsAHero'', after [[spoiler:Togo learns what the world is like beyond the barrier created by the Shinju-sama, and that the heroes fight against the Vertex will never end, Togo decides it would be better to end the world on the spot rather than continuing to fight an uphill battle that would inevitably end in the remaining humans of Shikoku dying anyway.]]
* ''Anime/YuYuHakusho'', of all series, has this happen to Sensui in his backstory. Not from any eldritch lore, though, but from simply [[spoiler:seeing how horrible people can be--shattering his belief in black and white morality by witnessing the torments sadistic humans inflicted on demons for fun, leaving him an omnicidal maniac]]. Chapter Black is also noted to be able to force people to go mad from the revelation. It's a compilation of every terrible thing humanity has ever done in loving detail. This is implied to be partly a supernatural effect. It should be noted this is a case where a ''partial'' revelation has this effect: there's a Chapter White, a compilation of every ''good'' thing humanity has ever done in equal detail. The two are meant to be viewed simultaneously, never seperately.
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People [[GoMadFromTheRevelation going mad from the revelation]] in anime and manga.
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* In ''Manga/TwentiethCenturyBoys'', approximately 2/3 of the people who complete Friend's VR, which purportedly reveals [[TheFaceless his face]], are DrivenToSuicide. [[spoiler: It's not his face, it's Sadakiyo's--specifically it's his adult face on a ''child's'' body. In a simulation that is otherwise completely indistinguishable from reality, it drives people crazy simply because of how ''wrong'' it looks.]]
* Russia from ''Webcomic/AxisPowersHetalia'' during the Bloody Sunday strip, in which he snaps and starts to mow down his own people on the grounds that "they're not really Russians if they don't love me."
* More or less every single Tipharian in ''Manga/BattleAngelAlita'' that learns ''"the secret of Tiphares"'' ([[spoiler:Tipharians undergo a special ceremony at the age of nineteen. During this ceremony, the brain of the Tipharian is replaced with a computer chip]]) is driven insane. Most commit suicide.
** [[spoiler: Alita is a citizen of Tiphares thanks to Desty Nova. HeroicBSOD time!]]
* The events of the Eclipse in ''Manga/{{Berserk}}'' took a horrible toll on the mind of Casca, who not only [[spoiler:lost every one of her men, including Judeau, to things out of nightmare, but was raped by the very essence of evil itself in the form of the fifth member of the Godhand, Femto -- who used to be Griffith, one of the two most important men in her life -- right in front of Guts, the man she loved]]. The trauma of the experience rendered her [[CuteMute mute]], [[TraumaInducedAmnesia amnesiac]] and insane, and it was not helped one bit by [[spoiler:Guts leaving her for two years to pursue vengeance against Griffith]].
** The poor mother who gets put to the torture by Mozgus to "expiate her sins" during the Conviction Arc is later seen back among the refugees having gone completely insane and clutching the corpse of the baby she had gone through hell for.
* The reason Schwarzwald from ''Anime/TheBigO'' goes mad and decides to destroy Paradigm City is because he figures out the show's OntologicalMystery (or at least part of it... it's a [[JigsawPuzzlePlot big mystery]]).
* In ''Manga/ChronoCrusade'', Aion has a tenuous grasp on his sanity after he's MindRaped by Pandaemonium and discovers the AwfulTruth of his origins.
* Jeremy has one of these in ''Manga/ACruelGodReigns'' after he [[spoiler: finds his mother's diary detailing that she knew Greg was raping Jeremy, but did nothing. This leads to his DrivenToSuicide BungledSuicide just as he is going to confess to killing Greg to Ian.]]
* In ''Anime/DanganRonpa3: Future Chapter'', Kazuo's [[TheReveal reveal]] of the attacker being [[spoiler:technically everybody]] has this effect on Kyousuke, [[spoiler:causing him to become singularly obsessed with ending the game by any means necessary... even if it means killing everybody.]]
* ''Anime/DigimonAdventure02'': Certainly not the only factor in his descent, but his visit to the [[CosmicHorrorStory Dark Ocean]] a perpetually dark realm, populated by various Lovecraftian horrors and where Love and Hope are a foreign concept, was definitely the Straw that Broke the Camel's Back for Ken Ichijoji. One look at his [[http://www.alltrees.org/anime/basetwo/images/ken.chibi.evil.jpg expression]] in that [[{{Flashback}} scene]] is enough to convince you that this kid just went off the deep end.
* In ''Anime/FantasticChildren'', scientist Dr. Radcliffe became obsessed with unraveling the mystery of the Children of Befort. Needless to say, the more he found out, the madder he went. He could have been saved a lot of suffering if he knew that his theory was actually [[spoiler:as far from the truth as you could get]].
* In ''Manga/FullmetalAlchemist'', it's strongly implied, and possibly outright stated, that the experience of going through the Gate is so "awful" that even if you did manage to survive through the pain of whatever it took from you, you could wind up a vegetable.
** Isaac [=McDougal=], a.k.a. The Freezing Alchemist, from Episode 1 of ''Brotherhood'' went totally off his rocker when [[spoiler:he uncovered the country-wide transmutation circle conspiracy]], and decided to remedy the problem by attempting to reduce Central to a frozen pile of rubble.
* Towards the end of ''Anime/{{Gankutsuou}}'' Heloïse Villefort, who seems perfectly normal in her first appearances, is revealed to actually be a murderous woman who's out of touch with reality. When her husband tells her to her face that she's just a murderous BitchInSheepsClothing, and reveals that he knows she's been trying to kill him and their daughter Heloise collapses to the floor, finally giving into her insanity. Her husband then has her committed to an insane asylum for the rest of her life.
* Every so often ''Anime/GhostInTheShellStandAloneComplex'' uses this trope to great (chilling) effect. For example, in the episode entitled "Not Equal" an American Special Ops soldier is reduced to a gibbering, suicidal shell of a man after seeing [[spoiler: the memories of the experiences that aged a young girl into an old woman in the span of 16 years during her time as a prisoner of a paramilitary group.]]
* In the ''Anime/HaloLegends'' segment ''Homecoming'', a few of the escaped Spartans find out they've been replaced with clones, [[spoiler: leading a few to commit suicide]].
* What happens to [[spoiler:Kurumi's friend Kaafai]] from ''Manga/HaouAiren'' when [[spoiler:he's ForcedToWatch as Hakuron rapes Kurumi.]] This is why he [[spoiler:shoots Hakuron to death in the end.]]
* Occurs to one of the astronomers in ''Manga/HellstarRemina'' when he realizes that [[spoiler: Remina's a sentient PlanetEater...and it's headed for Earth.]]
* In ''Manga/HunterXHunter'', the sheer intensity and strength of Neferpitou’s and Meruem’s auras can be so overwhelming for a regular Nen-user, that even a momentary exposure to it can have severe permanent psychological and physiological consequences. Knov, for instance, who was specifically picked up for the highest-threat and highest-difficulty level mission against Chimera Ants, became almost completely demoralised after seeing just the brink of Neferpitou’s aura at close range and soon after lost almost all hair on his head. Similarly, Welfin rapidly aged and his fur fell out when he felt the King’s KillingIntent focused on him.
* In ''Anime/{{Monster}}'' after [[TraumaCongaLine Nina recovers all of her memories]] and realizes that the memories her evil twin brother Johan thinks are his are really hers ([[ItMakesSenseInContext it's complicated]]), she nearly commits suicide. Thankfully [[AllLovingHero Dr. Tenma]] intervenes just in time to avert a potentially HUGE TearJerker.
* ''Manga/{{Naruto}}'':
** Sasuke, understandably, [[MyGodWhatHaveIDone does not react well]] when he finds out the truth about Itachi. Thankfully, after 200 or so chapters, he gets better ([[BaitTheDog well, or so it seems]]).
** [[spoiler: Likewise, [[BigBad Madara Uchiha]] went mad after reading deeply into the Uchiha Tablet and discovering [[TheseAreThingsManWasNotMeantToKnow that their war-torn world has always been such and that it only became worse once a princess sought to end all conflict by stealing Chakra from a God/Eldritch Abomination and becoming a goddess herself.]] Which was exactly what Black Zetsu intended when he rewrote the tablet. Madara was driven mad by a lie.]]
* Towards the end of ''Anime/NeonGenesisEvangelion'', Shinji Ikari finds out that [[spoiler:Rei Ayanami, [[TheConfidant one of his closest confidants]], has died and been replaced by a clone]], and later still he deduces that [[spoiler:there is definitely a connection between her, his dead mother, and the weird presence in Eva Unit 01]], and these revelations does indeed shake his already fragile psychological stability quite a bit. It finally comes to a head in ''The End of Evangelion'' when the ritual to [[spoiler:awaken [[EldritchAbomination Lilith]]/Rei Ayanami]] reduces him to a fit of shrieking omnicidal insanity. It didn't help that he had just seen [[spoiler: Asuka's torn-apart remains]] only about a minute earlier.
* Suzu in ''Manga/PeacemakerKurogane'' becomes AxCrazy and a DepravedHomosexual after [[spoiler:finding his beloved master dead, and being raped by an old man]].
* ''Anime/PerfectBlue'': In the anime's denouement, [[spoiler: Rumi]] is permanently delusional and institutionalized.
* Mewtwo from ''Anime/PokemonTheFirstMovie'' goes off his gourd when he's basically told that his purpose in life is just to be a science experiment and/or a weapon and nothing more to those who created him. As a result, he psychically nukes a lab and a Team Rocket base, kills the scientists who brought him into being, almost kills Giovanni, and decides to make himself judge, jury and executioner to every human and Pokémon on the planet. [[spoiler: Ash's desperate attempt to stop the fighting between the clones and original Pokémon is enough to bring Mewtwo back to Earth and question his initial belief on humans.]]
* ''Anime/PuellaMagiMadokaMagica'': Happens to [[spoiler:Sayaka Miki, and Mami Tomoe from the third alternate timeline]]. [[spoiler:Sayaka]] starts losing it as she realizes that [[spoiler:not only does [[NoGoodDeedGoesUnpunished no good deed go unpunished]], but being a Magical Girl is NOT sunshine and rainbows]]. She ends up becoming the witch known as Oktavia Von Seckendorff since among other things, she brought hope to others only to lose herself to despair ''and'' her wishes weren't as selfless as she believed; [[spoiler:the third Mami]] goes insane with grief after [[spoiler:the Sayaka of her continuity also becomes Oktavia (probably in similar circumstances) and is killed by Homura, since she cannot handle the AwfulTruth that being a Puella Magi means she will eventually become a witch; she kills Kyouko and gets ready to kill Homura, so Madoka has to MercyKill her.]]
** And in the backstory of [[spoiler: Kyoko Sakura]], this happened to [[spoiler: her father, when he found out that Kyoko used her SelflessWish to brainwash people into following him. His mind splintered so badly that he went the PaterFamilicide route, with Kyoko as the SoleSurvivor of the Sakura clan.]]
* In ''Manga/RurouniKenshin'' Soujiro goes temporarily insane when he realizes that he did regret killing people despite clinging to the words of his EvilMentor: -> "If you're strong you live. If you're weak, you die." It doesn't help that the people he regretted killing were his AbusiveParents or that he'd been a StepfordSmiler so long that every other emotion was completely suppressed until then. To top it all off it was Kenshin's words that caused this. It eventually leads to Soujiro's VillainousBSOD.
* ''VisualNovel/SchoolDays''' Kotonoha and Sekai. Both are dumped by a JerkAss Makoto Ito and have realized that he's also screwed around with their best friends. [[DullEyesOfUnhappiness Kotonoha's eyes turn dark]] around the later half of the anime, especially after it's implied that Makoto's friend raped her.
* ''Anime/SpacePirateMito'': Masatsuki Nenga goes insane when [[spoiler: he comes to the realisation that his "Justice" is nothing more than a tool of oppression (one that has no issue shooting down a "mob" of villagers, men, women and children) used by a pretender to the throne]]. This leads to about two episodes worth of him screaming "I AM JUSTICE!" at the top of his lungs whilst firing his gun like the lunatic he is. This would be fine all in all, but the guy doesn't look older than 12.
* Ralph Werec of ''Anime/StrainStrategicArmoredInfantry'' went from perfect soldier to traitorous OmnicidalManiac [[spoiler:when he saw that his people had created the HumongousMecha he was piloting by [[{{Aesoptinum}} killing harmless little alien girls]] for their PsychicPowers]]. However, though his reaction is understandable, [[spoiler:when one of the [[FateWorseThanDeath sort-of-survivors]] shows Sara the story in a vision, she keeps her own sanity. Ralph also got sucked into a dimensional rift that gave him terminal cancer directly ''after'' said vision.]]
* ''Manga/TokyoGhoul'':
** [[spoiler: Mutsuki breaks down into hysterical laughter and undergoes serious SanitySlippage, after seeing Torso's mutilated body done at his hands and realizing the full scale of his past crimes that he had long tried to bury in his mind.]]
** [[spoiler: Kaneki breaks down laughing after Yamori duck taped his head once he put a centipede into his ear during a long torture session in which he also repeatedly cut off his toes and fingers. He also snapped after Yamori did a SadisticChoice in front of him where he killed two people after ordering him to choose who would live and would die. He breaks down crying and begs Yamori to kill him instead and later it's the torture which led him to become a ruthless AntiHero.]]
** [[spoiler: During Itsuki Marude's confrontation with Yoshitoki, Matsuri heard the gunshot from another part of the ship. When he went to investigate, he came across the aftermath of the battle and discovered his father's corpse.]] Barely maintaining his composure, he radioed Urie to report the commander's death at the hands of an "unknown assailant." He falsely reported that Marude had committed suicide, and then collapsed to the ground after ending the transmission. [[spoiler: Weeping hysterically, he spoke in an effeminate manner and swore revenge against Marude for his father's murder. His insanity is further shown in chapter 100 where he tears his clothes off until he's naked in front of a window in his office and flamboyantly declares his love for Urie. This occurring not too long after his despair at having lost his father.]]
* BigBad [[KillAllHumans Millions]] [[EvilTwin Knives]] from ''Manga/{{Trigun}}'' has this as his manga origin story. (In the anime he just decided HumansAreTheRealMonsters for semi-logical if not terribly extreme reasons, and then went EvilPlan on them and his brother. In the manga, he [[UsedToBeASweetKid was a sweet boy]] who snapped after discovering the AwfulTruth--that there had been an 'Independent Plant' born before him and his brother, and the crew had [[ForScience studied her right to death]].
** Notably, if you didn't already know who was going to grow up to be the villain, it would ''look'' like Knives handled it better than Vash. They both locked themselves in and attempted to starve to death together, but after Rem broke in and saved them it was ''[[MessianicArchetype Vash]]'' who did the CreepyLaugh and HumansAreBastards and hysteria, and Knives seemed...perfectly okay. He saved his freak-out until after he'd set up all the colony ships to crash.
* On ''Anime/TsukuyomiMoonPhase'', Kouhei experiences temporary madness after his new power lets him see [[spoiler:Hazuki]]'s true form, after which he temporarily becomes a trembling wreck who screams like a madman every time he sees her, he eventually gets over it though.
* In ''Anime/YukiYunaIsAHero'', after [[spoiler:Togo learns what the world is like beyond the barrier created by the Shinju-sama, and that the heroes fight against the Vertex will never end, Togo decides it would be better to end the world on the spot rather than continuing to fight an uphill battle that would inevitably end in the remaining humans of Shikoku dying anyway.]]
* ''Anime/YuYuHakusho'', of all series, has this happen to Sensui in his backstory. Not from any eldritch lore, though, but from simply [[spoiler:seeing how horrible people can be--shattering his belief in black and white morality by witnessing the torments sadistic humans inflicted on demons for fun, leaving him an omnicidal maniac]]. Chapter Black is also noted to be able to force people to go mad from the revelation. It's a compilation of every terrible thing humanity has ever done in loving detail. This is implied to be partly a supernatural effect. It should be noted this is a case where a ''partial'' revelation has this effect: there's a Chapter White, a compilation of every ''good'' thing humanity has ever done in equal detail. The two are meant to be viewed simultaneously, never seperately.
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