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* Many criticize the fact that Thrax couldn't remove himself from the false eyelash, despite his ability to burn things. However, it stance to reason his ability works differently with artificial stuff than organic. It would make sense organic beings are in danger against him because he's a virus and he can kill them with ease, but artificial objects are essentially lifeless things, at least something a virus can't really destroy as easy.

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* Many criticize the fact that Thrax couldn't remove himself from the false eyelash, despite his ability to burn things. However, it stance stands to reason his ability works differently with artificial stuff than organic. It would make sense organic beings are in danger against him because he's a virus and he can kill them with ease, but artificial objects are essentially lifeless things, at least something a virus can't really destroy as easy.
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* According to Wiki/TheOtherWiki, bacillus anthracis is a soil-borne bacteria that can be contracted via ingestion and causes death by invoking cold or flu-like symptoms, such as, say, a fever. Bacillus anthracis. Otherwise known as an'''thrax'''. What's even more disturbing? How anthrax was even exposed to the monkey cage at the zoo in the first placed, and how many cases of Thrax are now just waiting to happen...

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* According to Wiki/TheOtherWiki, Website/TheOtherWiki, bacillus anthracis is a soil-borne bacteria that can be contracted via ingestion and causes death by invoking cold or flu-like symptoms, such as, say, a fever. Bacillus anthracis. Otherwise known as an'''thrax'''. What's even more disturbing? How anthrax was even exposed to the monkey cage at the zoo in the first placed, and how many cases of Thrax are now just waiting to happen...
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* Frank's poor health may be (at least partially) due to depression. People with depression sometimes turn to overeating and other other self-destructive habits in order to cope with sadness and other negative emotions. Frank is a widower and the incident with Shane's teacher humiliated him and his daughter, cost him his job and stuck him with a restraining order, as well as getting a job at the zoo which he clearly doesn't like. Granted, Shane implies that Frank's poor health habits had started long before losing his wife, but losing her possibly just made his habits get ''worse'' and Mayor Phlemming wasn't doing him any favors either due to his incompetence and negligence.

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* Frank's poor health may be (at least partially) due to depression. People with depression sometimes turn to overeating and other or other self-destructive habits in order to cope with sadness and other negative emotions. Frank is a widower and the incident with Shane's teacher humiliated him and his daughter, cost him his job and stuck him with a restraining order, as well as getting a job at the zoo which he clearly doesn't like. Granted, Shane implies that Frank's poor health habits had started long before losing his wife, but losing her possibly just made his habits get ''worse'' and Mayor Phlemming wasn't doing him any favors either due to his incompetence and negligence.
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!! FridgeSadness
* Frank's poor health may be (at least partially) due to depression. People with depression sometimes turn to overeating and other other self-destructive habits in order to cope with sadness and other negative emotions. Frank is a widower and the incident with Shane's teacher humiliated him and his daughter, cost him his job and stuck him with a restraining order, as well as getting a job at the zoo which he clearly doesn't like. Granted, Shane implies that Frank's poor health habits had started long before losing his wife, but losing her possibly just made his habits get ''worse'' and Mayor Phlemming wasn't doing him any favors either due to his incompetence and negligence.
** However, Thrax's visit to his subconscious also hints that Frank may have a low view of himself for a long time and may have gone through some trauma's in the past, which may have lead to his less than ideal lifestyle in the first place.
** After Frank had his nightmare, he is clearly shaken and his first reaction is to eat something.
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* Thrax claims that, once he breaks his record by killing Frank in two days, he plans to go after Shane and kill her in one day. We see from her initial reaction when Frank flatlines that Shane would not be taking Frank's death well at all. Considering grief can weaken the immune system(which, in the context of the movie, could have been represented as the police becoming increasingly apathetic according to Shane's ongoing mood), Shane would have been a very easy target if Thrax attacked straight away.

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* Thrax claims that, once he breaks his record by killing Frank in two days, he plans to go after Shane and kill her in one day. We see from her initial reaction when Frank flatlines that Shane would not be taking Frank's death well at all. Considering grief can weaken the immune system(which, system (which, in the context of the movie, could have been represented as the police becoming increasingly apathetic according to Shane's ongoing mood), Shane would have been a very easy target if Thrax attacked straight away.
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* The song "Hot-Blooded" just seems like a jab at how the movie is taking place in a human body, and our protagonist is a white blood cell who happens to be [[{{Pun}} hot-blooded]]. But it takes a whole new [[{{Foreshadowing}} prophetic]] level when one takes this lyric into account: "I got a ''fever'' of a hundred and three"... Fun fact: Fevers of a hundred and four (and over) are dangerous. Not only is Thrax's plan to create a deadly fever, but the climax revolves around keeping Frank from hitting the tipping point where [[BodyHorror his body starts to cook him alive]]...
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* Many criticize the fact that Thrax couldn't remove himself from the false eyelash, despite his ability to burn things. However, it stance to reason his ability works differently with artificial stuff than organic. It would make sense organic beings are in danger against him because he's a virus and he can kill them with ease, but artificial objects are essentially lifeless things, at least something a virus can't really destroy as easy.
* It was quite convenient that Shane ran back for Osmosis to make it back to save Frank. Who's to say those running Shane weren't witnessing what's happening right in front of them and decided to give Jones some much needed help. What's best for Shane is for Frank to live.
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* Frank says that the reason monkeys eat so many fruits and vegetables is that they're not smart enough to butcher a cow. It's meant to make him look like an unhealthy slob, but he's more or less right...monkeys and chimps in particular ''love'' meat, will go to scary lengths to procure it, and if they were strong enough and numerous enough to take down a cow, probably would.
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* Thrax mentions that one of his earlier victims was a little girl, and that it took him three whole weeks. He says he's getting better as he goes along, and this is undoubtedly true, but children have robust immune systems and less space for a sentient virus to move around in. Of course she would have given him more trouble than the old man in Philly.
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* Jones' ability to shapeshift is actually a reference to [[https://en.wikipedia.org/wiki/Leukocyte_extravasation leukocyte extravasation]], or the ability of white blood cells to move through intact blood vessels to reach pathogens quicker.
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* The designs of the different microorganisms and cells are distinct from one another that you can tell which of the characters are human cells based on how anthropomorphic they are. Human cells as depicted in the movie are not only more visibly anthropomorphic (i.e., they are the most [[ShapedLikeItself human-shaped]]) but are also uniquely colored to appear to have a translucent outline to their bodies while having a solid internal color, which vary between cell types (for instance, red for red blood cells, blue-purple for neurons, and cyan for white blood cells). Humans, as animals, do not have cell walls. Microorganisms, meanwhile, have [[CartoonCreature more variety to their appearances]]--with multiple legs, eyes, and mouths--and are opaque with darker outlines.

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* The designs of the different microorganisms and cells are distinct from one another that you can tell which of the characters are human cells based on how anthropomorphic they are. Human cells as depicted in the movie are not only more visibly anthropomorphic (i.e., they are the most [[ShapedLikeItself human-shaped]]) but are also uniquely colored to appear to have a translucent outline to their bodies while having a solid internal color, which vary between cell types (for instance, red for red blood cells, blue-purple for neurons, and cyan for white blood cells). Humans, as animals, Humans cells, like all animal cells, do not have rigid cell walls. Microorganisms, meanwhile, have [[CartoonCreature more variety to their appearances]]--with multiple legs, eyes, and mouths--and are opaque with darker outlines.
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*** However, the villain in that episode was directly identified as Scarlet Fever, which is real and is a disease, not a virus. That said, the similarities suggest that Red Death may be a fictitious "cousin" to Scarlet Fever.

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*** However, the villain in that episode was directly identified as Scarlet Fever, which is real and is a bacterial disease, not a virus. That said, the similarities suggest that Red Death may be a fictitious "cousin" to Scarlet Fever.

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* In light of the above point, Thrax doesn't seem like a natural virus. But he could be [[OhCrap an engineered bioweapon that escaped containment or was unleashed]]. If Thrax is not this, he's a case of ArtMajorBiology. If he was ''designed'' for killing, whoever created him (terrorists, the military, take your pick) would likely have more samples stored away...

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* In light of the above point, Thrax doesn't seem like a natural virus. But he could be [[OhCrap an engineered bioweapon that escaped containment or was unleashed]]. If Thrax is not this, he's a case of ArtMajorBiology.ArtisticLicenseBiology. If he was ''designed'' for killing, whoever created him (terrorists, the military, take your pick) would likely have more samples stored away...
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* One of the nightmares playing in the movieplex in Franks's brain? Frank's brother marries Shane--his ''own niece''. Since nightmares are basically subconscious fears given imagery, there must be ''something'' about his brother that Frank doesn't trust, especially when his daughter is concerned.
** Frank knows he's unhealthy. His wife died due to a similar lifestyle, and his brother looks to be the only other adult who's really around in Shane's life--if anything happens to Frank, his daughter would most likely be put in his brother's custody. That, coupled with the above point, carries some very UnfortunateImplications about that particular nightmare...

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Fridge subpages are Spoilers Off pages. Also removed a reason that didn't seem like it fit the Fridge category (felt more like Trivia)


'''As a Moments subpage, all spoilers are unmarked [[Administrivia/SpoilersOff as per policy.]] Administrivia/YouHaveBeenWarned.'''



* All the white blood cells are voiced by black actors.
** For bonus brilliance, they're white blood cells in a white person (Frank is Caucasian).



** When [[spoiler: Thrax]] died in the beaker of alcohol, that's what happens to ''every germ on your hands'' whenever you use hand sanitizer. Yikes.

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** When [[spoiler: Thrax]] Thrax died in the beaker of alcohol, that's what happens to ''every germ on your hands'' whenever you use hand sanitizer. Yikes.
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* Jones' boss is six times his size. Macrophagei, a type of white blood cell responsible for attacking bigger pathogens ("macro-" means "can be seen with the eye" and "-phage" means "I eat it"), and teaching other leukocytes about them, are six times the size of regular white corpuscles. They can also metamorphocize into dendrites, which is more or less a white cell's desk job.

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* Jones' boss is six times his size. Macrophagei, a type of white blood cell responsible for attacking bigger pathogens ("macro-" means "can be seen with the eye" and "-phage" means "I eat it"), and teaching other leukocytes about them, are six times the size of regular white corpuscles. They can also metamorphocize into dendritic cells (not to be confused with dendrites, which are a type of nerve), which is more or less a white cell's cell who's got a desk job.
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* Jones' boss is six times his size. Macrophagei, a type of white blood cell responsible for attacking bigger bacteria and viri, and teaching other leukocytes about them, are six times the size of regular white corpuscles. They can also metamorphocize into dendrites, which is more or less a white cell's desk job.

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* Jones' boss is six times his size. Macrophagei, a type of white blood cell responsible for attacking bigger bacteria pathogens ("macro-" means "can be seen with the eye" and viri, "-phage" means "I eat it"), and teaching other leukocytes about them, are six times the size of regular white corpuscles. They can also metamorphocize into dendrites, which is more or less a white cell's desk job.
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to:

* Jones' boss is six times his size. Macrophagei, a type of white blood cell responsible for attacking bigger bacteria and viri, and teaching other leukocytes about them, are six times the size of regular white corpuscles. They can also metamorphocize into dendrites, which is more or less a white cell's desk job.
Is there an issue? Send a MessageReason:
None


* The designs of the different microorganisms and cells are distinctly different from one another. Human cells as depicted in the movie are not only more visibly anthropomorphic (i.e., they are the most [[ShapedLikeItself human-shaped]]) but are also uniquely colored to appear to have a translucent outline to their bodies while having a solid internal color, which vary between cell types (for instance, red for red blood cells, blue-purple for neurons, and cyan for white blood cells). Various microorganisms have [[CartoonCreature more variety to their appearances]]--with multiple legs, eyes, and mouths--and are opaque with darker outlines.

to:

* The designs of the different microorganisms and cells are distinctly different distinct from one another.another that you can tell which of the characters are human cells based on how anthropomorphic they are. Human cells as depicted in the movie are not only more visibly anthropomorphic (i.e., they are the most [[ShapedLikeItself human-shaped]]) but are also uniquely colored to appear to have a translucent outline to their bodies while having a solid internal color, which vary between cell types (for instance, red for red blood cells, blue-purple for neurons, and cyan for white blood cells). Various microorganisms Humans, as animals, do not have cell walls. Microorganisms, meanwhile, have [[CartoonCreature more variety to their appearances]]--with multiple legs, eyes, and mouths--and are opaque with darker outlines.
Is there an issue? Send a MessageReason:
None


* The designs of the different microorganisms and cells are distinctly different from one another. Human cells as depicted in the movie are not only more visibly anthropomorphic (i.e., they are the most [[ShapedLikeItself human-shaped]]) but are also uniquely colored to appear to have a translucent outline to their bodies while having a solid colors, which vary between cell types (for instance, red for red blood cells, blue-purple for neurons, and cyan for white blood cells). Various microorganisms have [[CartoonCreature more variety to their appearances]]--with multiple legs, eyes, and mouths--and are opaque with darker outlines.

to:

* The designs of the different microorganisms and cells are distinctly different from one another. Human cells as depicted in the movie are not only more visibly anthropomorphic (i.e., they are the most [[ShapedLikeItself human-shaped]]) but are also uniquely colored to appear to have a translucent outline to their bodies while having a solid colors, internal color, which vary between cell types (for instance, red for red blood cells, blue-purple for neurons, and cyan for white blood cells). Various microorganisms have [[CartoonCreature more variety to their appearances]]--with multiple legs, eyes, and mouths--and are opaque with darker outlines.
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None



to:

* The designs of the different microorganisms and cells are distinctly different from one another. Human cells as depicted in the movie are not only more visibly anthropomorphic (i.e., they are the most [[ShapedLikeItself human-shaped]]) but are also uniquely colored to appear to have a translucent outline to their bodies while having a solid colors, which vary between cell types (for instance, red for red blood cells, blue-purple for neurons, and cyan for white blood cells). Various microorganisms have [[CartoonCreature more variety to their appearances]]--with multiple legs, eyes, and mouths--and are opaque with darker outlines.
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None

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*** However, the villain in that episode was directly identified as Scarlet Fever, which is real and is a disease, not a virus. That said, the similarities suggest that Red Death may be a fictitious "cousin" to Scarlet Fever.
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Who spreads hand sanitizer all over their entire body?


** When [[spoiler: Thrax]] died in the beaker of alcohol, that's what happens to ''every germ on your body'' whenever you use hand sanitizer. Yikes.

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** When [[spoiler: Thrax]] died in the beaker of alcohol, that's what happens to ''every germ on your body'' hands'' whenever you use hand sanitizer. Yikes.
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* If every cell in your body is alive and sentient, minor injuries in the world of Osmosis Jones become horrifying. Not to mention the fate of the poor blood cells carried off by mosquitoes and other biting bugs...
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* Thrax claims that, once he breaks his record by killing Frank in two days, he plans to go after Shane and kill her in one day. We see from her initial reaction when Frank flatlines that Shane would not be taking Frank's death well at all. Considering grief can weaken the immune system(which, in the context of the movie, could have been represented as the police becoming increasingly apathetic according to Shane's ongoing mood), Shane would have been a very easy target if Thrax attacked straight away.

to:

* Thrax claims that, once he breaks his record by killing Frank in two days, he plans to go after Shane and kill her in one day. We see from her initial reaction when Frank flatlines that Shane would not be taking Frank's death well at all. Considering grief can weaken the immune system(which, in the context of the movie, could have been represented as the police becoming increasingly apathetic according to Shane's ongoing mood), Shane would have been a very easy target if Thrax attacked straight away.away.
* The DNA beads Thrax carries around are each trophies from his earlier successful infections; each representative of a person he's killed. There are over ''twenty beads'' in that chain. Now, figure in that Thrax killing the human also kills every single cell inside them -- which are established as sentient in this universe -- and that factors into possibly one of the highest body counts of an animated villain period.
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* Thrax claims that, once he breaks his record by killing Frank in two days, he plans to go after Shane and kill her in one day. We see from her initial reaction when Frank flatlines that Shane would not be taking Frank's death well at all. Considering grief can weaken the immune system, Shane would have been a very easy target if Thrax attacked straight away.

to:

* Thrax claims that, once he breaks his record by killing Frank in two days, he plans to go after Shane and kill her in one day. We see from her initial reaction when Frank flatlines that Shane would not be taking Frank's death well at all. Considering grief can weaken the immune system, system(which, in the context of the movie, could have been represented as the police becoming increasingly apathetic according to Shane's ongoing mood), Shane would have been a very easy target if Thrax attacked straight away.
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** There is another more grim explanation for Frank's declining health. Frank's internal temperature nearly reached 108 during the events of the film, which is deadly. However, if one's internal temperature reaches 104, which Frank's surpassed, that can result in permanent brain damage. This puts a dark contrast on the situation; Frank tried to get healthy but resulting brain damage from his brush with death meant he kept forgetting (from the anthropmorphised cell POV, the brain cell in charge of memory could've been killed and the records or information cataloguing system destroyed) to maintain his new healthy lifestyle or he just discarded the attempts.

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** There is another more grim explanation for Frank's declining health. Frank's internal temperature nearly reached 108 during the events of the film, which is deadly. However, if one's internal temperature reaches 104, which Frank's surpassed, that can result in permanent brain damage. This puts a dark contrast on the situation; Frank tried to get healthy but resulting brain damage from his brush with death meant he kept forgetting (from the anthropmorphised cell POV, the brain cell in charge of memory could've been killed and the records or information cataloguing system destroyed) to maintain his new healthy lifestyle or he just discarded the attempts.attempts.
* Thrax claims that, once he breaks his record by killing Frank in two days, he plans to go after Shane and kill her in one day. We see from her initial reaction when Frank flatlines that Shane would not be taking Frank's death well at all. Considering grief can weaken the immune system, Shane would have been a very easy target if Thrax attacked straight away.
Is there an issue? Send a MessageReason:
None


* According to {{The Other Wiki}}, bacillus anthracis is a soil-borne bacteria that can be contracted via ingestion and causes death by invoking cold or flu-like symptoms, such as, say, a fever. Bacillus anthracis. Otherwise known as an'''thrax'''. What's even more disturbing? How anthrax was even exposed to the monkey cage at the zoo in the first placed, and how many cases of Thrax are now just waiting to happen...

to:

* According to {{The Other Wiki}}, Wiki/TheOtherWiki, bacillus anthracis is a soil-borne bacteria that can be contracted via ingestion and causes death by invoking cold or flu-like symptoms, such as, say, a fever. Bacillus anthracis. Otherwise known as an'''thrax'''. What's even more disturbing? How anthrax was even exposed to the monkey cage at the zoo in the first placed, and how many cases of Thrax are now just waiting to happen...
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** Probably but cells don't live too long (except for brain cells) so it'ss more like the end of the world after many,many generations. The more dramatic case would be the death of an infant causing a newly formed world to expire too soon.

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** Probably Probably, but cells don't live too long (except for brain cells) so it'ss it's more like the end of the world after many,many many, many generations. The more dramatic case would be the death of an infant causing a newly formed world to expire too soon.



** Not really. Viruses in the Real World evolve for two things: to make more of themselves and spread to other hosts. A virus that quickly killed its host would severely hamper its own spread (see: Ebola).

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** Not really. Viruses in the Real World real world evolve for two things: to make more of themselves and spread to other hosts. A virus that quickly killed its host would severely hamper its own spread (see: Ebola).
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** Probably but cells don't live too long (except for brain cells) so is more like the end of the world after many many generations. The more dramatic case will be the death of an infant causing a newley form world to expire too soon.

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** Probably but cells don't live too long (except for brain cells) so is it'ss more like the end of the world after many many many,many generations. The more dramatic case will would be the death of an infant causing a newley form newly formed world to expire too soon.



* When you think about it, a sentient virus would pride themselves on killing everything, so slowly but surely Thrax aims to try and kill every living thing on Earth.

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* When you think about it, a sentient virus would pride themselves on killing everything, so slowly but surely surely, Thrax aims to try and kill every living thing on Earth.

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