History DelicateAndSickly / VideoGames

* ''VideoGame/EldenRing'' plays with this trope in regards to Malenia, a demigod infected with [[MysticalPlague Scarlet Rot]] from birth. When you meet her in-game, three of her limbs have been replaced with prosthetics, her remaining arm does not look long for this world, her [[EyeScream eyes are gone]], and her body is scarred all over by the Rot. Her introductory cutscene emphasizes her vulnerability, as she comes out of a long coma and slowly puts on her prosthetic arm while recounting the nightmares she's had while unconscious. The fact that she's ''still'' [[{{Superboss}} the hardest boss in the game]] says ''a lot'' about [[{{Determinator}} Malenia]]. Her frailty still makes her vulnerable to the Bleed and Frostbite status effects though.

* In ''VideoGame/LikeADragonInfiniteWealth'', Kiryu is revealed to have cancer.

* [[spoiler: The playable Elektrosoldat]] turns out to be this in ''VideoGame/AkatsukiBlitzkampf''. [[spoiler: The consequences of being both [[CloningBlues a clone]] and a member of the MechaMooks "club" include [[BloodFromTheMouth coughing up blood]] (as he does in his ending) and [[WoundThatWillNotHeal being unable to heal properly from any injuries he sustains]].]]

* ''VideoGame/EldenRing'' plays with this trope in the character of Malenia. A demigod infected with Scarlet Rot from birth, when you meet her in-game three of her limbs are prosthetic (and her remaining arm does not look long for this world), her eyes are gone, and her body is scarred all over by the Rot. Her introductory cutscene emphasizes her vulnerability, as she comes out of a long coma and slowly puts on her prosthetic arm while recounting the nightmares she had while unconscious. The fact that she's ''still'' [[{{Superboss}} the hardest boss in the game]] says a ''lot'' about [[{{Determinator}} Malenia]].

* Ellen from ''VideoGame/TheWitchsHouse'' is [[TheHeroine Viola]]'s 7-year-old friend who lives in a house near the woods, and is also terminally ill. The disease gradually eats away at her body, making her look uglier, and her parents are [[ParentalNeglect basically absent from her life]], but Viola cares for her anyway. The plot happens because Viola, on the way to visit her, gets lost and wanders into the titular house. [[spoiler:The sympathetic aspect is subverted, however, when Ellen is revealed as the [[WickedWitch witch]], and a cruel {{sadist}} who screwed over Viola in the backstory in addition to killing [[SelfMadeOrphan her parents]] and hundreds of innocents over the course of her [[ReallySevenHundredYearsOld immortal life]].]]

* Subverted: Ukyo Tachibana from ''VideoGame/SamuraiShodown'' has tuberculosis (IncurableCoughOfDeath and BloodFromTheMouth included), but he remains quite a badass fighter. [[spoiler: Further subverted as the second game implies that he dies of it, but he reappears in the third.]] Amusingly, his [[PressXToDie Seppuku]] sees him cough and then collapse, as the TB finally finishes the job.

* VideoGame/GranblueFantasy: Ferry's [[TheCutie little sister Firra]]. During their childhood (long before the start of the plot), Firra suffered from a chronic disease that left her bedridden for days on end, which is why she eventually (but reluctantly) left her family behind on their [[WorldInTheSky small island]] to seek treatment elsewhere. She never returned. Much of Ferry's story is about finding out what happened to her little sister.

* In both ''VideoGame/ArtOfFighting'' and ''VideoGame/TheKingOfFighters'', we have [[{{Bifauxnen}} King]]'s [[PromotionToParent ward and younger brother]] [[CuteShotaroBoy Jean]]. His illness is never specified but it's mentioned that he's very delicate and can only walk short distances, so his older sister's main goal is [[HealthcareMotivation to pay for his surgery and later for his treatment]]. He gets noticeably better around ''[[http://www.vgmuseum.com/end/neogeo/a/aof2king.htm AOF 2]]'' ([[spoiler: Robert and Ryo paid for his operation as thanks for King's help when Yuri was kidnapped]]) /[[http://www.vgmuseum.com/end/neogeo/b/kof96gor.htm KOF' 96]] ([[spoiler: he was hospitalized and in treatment as his sister, Mai and Kasumi fought around the world, and the other two girls brought him to King's presence in the end]]).

** Marlin from ''VideoGame/HarvestMoonAWonderfulLife'' and ''VideoGame/HarvestMoonDS'' was an IllBoy in his youth. He was moved out into the mountains in the hope that the HealthyCountryAir would cure him. It did help quite a bit, but he's still kinda sickly.

* ''VideoGame/SilentHill2'' has Mary, a rare adult example. Naturally, she has the IncurableCoughOfDeath, too. The real rarity is the fact that she dies before the start of the game and is only seen and heard in flashbacks [[spoiler:or maybe not.]]

* ''VideoGame/LufiaIIRiseOfTheSinistrals'' has Leefa, an orphan who sells flowers for a living. (In [[VideoGame/LufiaCurseOfTheSinistrals the remake]], she has siblings.) The party ends up climbing a dangerous mountain to get her a special rare flower—[[ContinuityNod a flower that ends up being named "priphea"]].

* ''Growlanser II: The Sense of Justice'' has a female character whose younger brother is an ill boy. And yes, there is a mysterious "operation" that can cure him, and this provides that character's main motivation. In a slight variation on the usual plot, the character's family is very wealthy and can easily afford the operation, but the Ill Boy is afraid to go through with it because it is reputed to be extremely painful. (Maybe the MagiTek of the setting doesn't include anesthetic?)

* Subverted: Ukyo Tachibana from ''VideoGame/SamuraiShodown'' has tuberculosis (IncurableCoughOfDeath and BloodFromTheMouth included), but he remains quite a badass fighter. [[spoiler: Further subverted as the second game implies that he dies of it, but he reappears in the third.]] Amusingly, his [[PressXToDie Seppuku]] sees him cough and then collapse, as the TB finally finishes the job.
* ''VideoGame/HarvestMoon'':
** Marlin from ''VideoGame/HarvestMoonAWonderfulLife'' and ''VideoGame/HarvestMoonDS'' was an IllBoy in his youth. He was moved out into the mountains in the hope that the HealthyCountryAir would cure him. It did help quite a bit, but he's still kinda sickly.
** In stark contrast with his boisterous and muscular adult self, Dean from ''VideoGame/HarvestMoonLightOfHope'' was a sickly child who spent much of his time indoors. He loved reading books about flowers so he begged his dad to take him hiking with him. Over time, the frequent hikes helped Dean become healthier.
* [[WhiteHairBlackHeart Hanbe Takenaka]] from ''VideoGame/SengokuBasara'' is a villainous version of this, as he spends most of his time proving just how [[EvilerThanThou evil he is]] through sheer [[MagnificentBastard manipulation]] and [[KickTheDog dog-kicking]] despite his [[IncurableCoughOfDeath tuberculosis]].
* Similar to the above, Hanbei from ''VideoGame/PokemonConquest'' suffers from tuberculosis (not like the game will state that). Unlike the above example, he keeps it to himself and does what Hideyoshi tells him to do, so at the end of his episode, he starts coughing. When asked what's wrong, Hanbei responds that he got too excited; Kanbei doesn't believe it one bit. In both cases, the disease eventually killed the real-life Hanbe Takenaka.
* Akinari Kamiki, the Sun Arcana from ''VideoGame/Persona3'', is a prospective writer who was born ill, thus his days have been numbered ever since birth. Developing his S-Link is about having him learn to enjoy his last days of life. [[spoiler: He will die before the game is over, leaving the children's book he wrote with the MC's help and encouragement as a TragicKeepsake, and if his link is maxed his soul will cheer on you before you take on Nyx.]]
** From the same game is party member [[HiddenHeartOfGold Shinjiro Aragaki]], who is slowly dying courtesy of suppressants that he's taking to suppress his Persona. It has degraded his immune system to the point that he gains a nasty IncurableCoughOfDeath and, according to WordOfGod, his body cannot regulate its body temperature properly anymore (this was given as an explanation as to why he always wears winter clothing during Spring and Summer.)
* Wally/Mitsuru, TheRival from ''VideoGame/PokemonRubyAndSapphire'', is mentioned to be rather sickly and weak-bodied as well. Apparently, he has asthma.
* In both ''VideoGame/ArtOfFighting'' and ''VideoGame/TheKingOfFighters'', we have [[{{Bifauxnen}} King]]'s [[PromotionToParent ward and younger brother]] [[CuteShotaroBoy Jean]]. His illness is never specified but it's mentioned that he's very delicate and can only walk short distances, so his older sister's main goal is [[HealthcareMotivation to pay for his surgery and later for his treatment]]. He gets noticeably better around ''[[http://www.vgmuseum.com/end/neogeo/a/aof2king.htm AOF 2]]'' ([[spoiler: Robert and Ryo paid for his operation as thanks for King's help when Yuri was kidnapped]]) /[[http://www.vgmuseum.com/end/neogeo/b/kof96gor.htm KOF' 96]] ([[spoiler: he was hospitalized and in treatment as his sister, Mai and Kasumi fought around the world, and the other two girls brought him to King's presence in the end]]).
* Daniel Curien, son of Dr. Roy Curien (an antagonist in the ''VideoGame/HouseOfTheDead'' series) was overcome with an illness during his childhood days. Dr. Curien stepped beyond the boundaries, just to save his son's life.
* [[spoiler: The playable Elektrosoldat]] turns out to be this in ''VideoGame/AkatsukiBlitzkampf''. [[spoiler: The consequences of being both [[CloningBlues a clone]] and a member of the MechaMooks "club" include [[BloodFromTheMouth coughing up blood]] (as he does in his ending) and [[WoundThatWillNotHeal being unable to heal properly from any injuries he sustains]].]]

* John Cassidy from ''VideoGame/Fallout2'' suffers from a heart condition, necessitating regular injections of cardio-boosters to keep from having a heart attack. If you give him a chem like Psycho, Buffout, or Jet, it will aggravate the condition to the point of giving him an instant, and fatal, heart attack.
* In ''VideoGame/DarkElfHistoria'', Ruse has always been a bit sickly as a result of the time he spent alone after his parents were killed, but if Fraylia manages to defeat Danny the Orc without failing any previous missions, Ruse will suddenly fall ill with "Neysterbey Syndrome", which requires Fraylia to immediately abandon paid questing in order to go find a cure.
* In ''VideoGame/TheLegendOfZeldaTwilightPrincess'', Prince Ralis of the [[FishPeople Zora]] is first encountered gravely ill due both to being attacked by Zant's forces on his way to seeking help from Princess Zelda and to being dehydrated from being away from water too long. Link must escort Telma and Ilia as they take Ralis to Kakariko Village to be healed by the shaman there.
* After regaining the memories of their true identity in ''VideoGame/SuperRobotWarsX'', [[spoiler:Iori]] revealed to X-Cross members that they were originally somone who was physically weak, and prone to sickness. Which greatly surprised the X-Cross members.
* ''VideoGame/EnsembleStars'' has Eichi, who has all the apparent theming for it, having pale blonde hair, a kindly disposition, and constant angel motifs. However, in a total deviation from the trope's usual implications, Eichi is actually a BitchInSheepsClothing who presents an image as a kind BigGood type to the public while secretly sabotaging anyone standing in his way. To a lesser extent, there is also Chiaki who was sickly in his youth and spent a lot of time in hospital (crossing paths with Eichi several times), but who mostly overcame that illness as he grew up. However, he's still very accident prone, and so ends up in the hospital for injuries fairly often.
* From what little we see of [[spoiler: Hugo]] in ''VideoGame/{{OFF}}'', he seems to be this. His [[VoiceGrunting voice grunting]] is a cough, and exploring The Room shows writing that mentions having to take pills. There's also all the brain and coma imagery in the battles, items, and game over screen, but that's going into WMG territory.

* The quarians from ''Franchise/MassEffect'' are a ''species'' of Ill People. Since their forced exile from their homeworld 300 years before the events of the games, quarian immune systems (which were already weaker than those other species) have deteriorated to the point that all quarians must wear [[LatexSpaceSuit environmental suits]] at all times just so they don't die. ''Every'' quarian Shepard meets in the games--from WrenchWench party member Tali'Zorah to badass marine Kal'Reegar to the valley girl complaining about her boyfriend on Illium--is one suit breach away from potentially deadly sickness. That said, [[DontyouDarePityMe they don't appreciate the stereotype:]]
--> "I'm not gonna die from an infection in the middle of a battle. That's just insulting!”
* The main characters of ''VisualNovel/{{Narcissu}}'' are a terminally ill boy and girl. The prequel adds two more ill girls to the cast, one of them an [[LittlestCancerPatient 8-year-old orphan.]] And the third game... just say the whole series revolves around this trope.

** Male Example: Bedman, a comatose young boy piloting a sort of hybrid between a MiniMecha and a bed. He's been subjected to horrible experiments that allow him to trap people in nightmare worlds of his own creation. [[spoiler: Subverted in that he is actually a ''villain'' - more exactly an agent of the Senate, the driving force behind Ky's appointment as a PuppetKing, amongst other things.]]

* Throughout the ''VideoGame/GodOfWar'' series, both of Kratos's children were ill.
** Calliope was a rather sickly child and Kratos went on a quest for Ambrosia to help her condition.
** In ''VideoGame/GodOfWarPS4'', Atreus suffers from some kind of debilitating condition that manifests as IncurableCoughOfDeath for most of his life. Mimir suggests that the illness is [[spoiler: psychosomatic, a result of Atreus' struggle to reconcile his divine nature and emerging abilities.]]
* ''VideoGame/DragonQuestV'': Mr. Whitaker is always sick, recovering from being sick or coming down with a new sickness. Taking care of him is the reason that his daughter Bianca can't be an adventurer, as much as she'd like to. Before the Hero comes along at least.

%%%* Castille from ''VideoGame/PhantomBrave''.
* ''VideoGame/LufiaIIRiseOfTheSinistrals'' has Leefa, an orphan who sells flowers for a living. (In [[VideoGame/LufiaCurseOfTheSinistrals the remake]], she has siblings.) The party ends up climbing a dangerous mountain to get her a special rare flower—[[ContinuityNod a flower that ends up being named "priphea"]].
* Muse from ''VideoGame/RomancingSaGa3''. Surprisingly enough, she is one of the better characters to recruit after [[spoiler:she is cured of her sickness]].
* Subverted in ''VideoGame/SuperRobotWarsOriginalGeneration'': Ryusei's mother is an adult Ill Girl, but it's due to a military project she used to work on as a psychic destroying her body. Her son has ended up being "recruited" by the same project in exchange for paying for her hospital bills.
* ''VideoGame/SilentHill2'' has Mary, a rare adult example. Naturally, she has the IncurableCoughOfDeath, too. The real rarity is the fact that she dies before the start of the game and is only seen and heard in flashbacks [[spoiler:or maybe not.]]
* ''VideoGame/BreathOfFireIII'' subverts this during the [[InevitableTournament Contest of Champions]]. Emitai, one of the competitors, visits the heroes before their bout (which is weighed against a spellcaster like him because the arena has AntiMagic) and introduces them to his daughter; he claims to be in the contest to earn her an operation that will cure her disease, and asks them to throw the fight. As one of the heroes is being held hostage, they refuse. After the match, however, if you visit Emitai's dressing room, you learn that it was a giant fraud on his part to get his opponents to forfeit. Just to make this clear, after the TimeSkip, you can find Emitai again (and recruit him as a master); his daughter has grown up and is rather embarrassed with him.

* Heather the Ghoul from the ''VideoGame/VampireTheMasqueradeBloodlines'' game practically embodies this trope. First, you have to save her life when she lies dying in a hospital. Then, when she finds you again, she acts so cute and affectionate, you just have to have a heart of stone to send her away. Then, she starts making you small presents and other pleasant things, like letting you feed on her blood, free of charge, etc. Most of her behavior is determined by her condition (by turning her into your ghoul, you bind her to yourself and your blood becomes a powerful, addictive drug for her) but that doesn't diminish her cuteness even one bit. That she is a {{Meganekko}} and a potential CosplayOtakuGirl doesn't exactly help, either... [[spoiler: if you ''don't'' send her away, at some point she is gonna be kidnapped and murdered as an act of [[PlayerPunch revenge upon you]].]]
* Subverted by Raquel in ''VideoGame/{{Wild ARMs 4}}''. While she's [[spoiler: slowly dying of an unknown disease in her body that's greatly implied to be radiation poisoning]], it doesn't stop her from becoming a badass swordswoman and one of the most powerful characters in the game.
* ''Franchise/FireEmblem'' has three cases:
** In ''VideoGame/FireEmblemTheBlazingBlade'', [[GentleGiant Dorcas]]'s wife and VictoriousChildhoodFriend in an ill girl named Natalie, who has had problems in her leg ever since she was a little girl. One of the earlier missions is to keep her safe her inside of some abandoned ruins, and if Lyn talks to her husband who is in the enemy group, you can make him defect and [[HeelFaceTurn join your group]].
** In ''VideoGame/FireEmblemTheSacredStones'', [[spoiler: Orson's wife Monica]] was an ill girl who died prior to the story. [[spoiler: Her husband loved her so much that [[DespairEventHorizon he fell into utter and complete despair]], [[LoveMakesYouEvil and defected to Grado when given the chance to have her revived]].]]
** In ''VideoGame/FireEmblemAwakening'':
*** ShrinkingViolet Noire says she's anemic, and some of her lines have her saying she gets tired much easier than the other characters.
*** Subverted with [[CuteClumsyGirl Sumia]]. In a support with Henry, he notices [[spoiler: after their FreakyFridayFlip]] that her heartbeat is faster than normal and believes she has a heart murmur. It turns out that since this is [[RelationshipUpgrade their S level support]], the super fast heartbeat happens because [[LoveTropes Sumia has fallen in love with Henry and is nervous around him]]; when she gives him her LoveConfession, he realizes [[LoveEpiphany that the same thing happens to him]] and then he asks her to marry him-
* VideoGame/GranblueFantasy: Ferry's [[TheCutie little sister Firra]]. During their childhood (long before the start of the plot), Firra suffered from a chronic disease that left her bedridden for days on end, which is why she eventually (but reluctantly) left her family behind on their [[WorldInTheSky small island]] to seek treatment elsewhere. She never returned. Much of Ferry's story is about finding out what happened to her little sister.
* Tyler Chase's little sister Amy is infected with the Deftera GUILT two years prior to the first ''VideoGame/TraumaCenter'', and [[spoiler: eventually goes into critical condition in Chapter 3. Derek operates on her and cures her, thus removing her status as Ill Girl.]]
* ''VideoGame/TalesSeries'':
** Colette from ''VideoGame/TalesOfSymphonia'', who ends up suffering from a couple various ailments, the first being Angel Toxicosis [[spoiler:Actually is pain from her soul being consumed by the Cruxis Crystal, as part of the World Regeneration Journey]], and the second Chronic Angeleus Crystallius Inofficium actually ''does'' disfigure her (In the one cutscene where it's visible) and you spend a while (half of disc 2) getting the cure for her.
** Hilda from ''VideoGame/TalesOfRebirth'' was one as a child. [[HalfHumanHybrid Huma/Gajuma hybrids]] in general tend to have frail bodies, and many don't survive infancy because of this.
** Cheria starts ''VideoGame/TalesOfGraces'' like this, but she gets better when Asbel returns.
* Tomoki in ''VisualNovel/Canvas2''. However, the surgery she needs is actually quite easy and not that expensive. Not even that risky. She's actually afraid it will work and she'll be lonely.
* Mary/Maki Sonomura in ''VideoGame/Persona1'' is introduced as an Ill Girl, but when demons arrive to the scene, she suddenly got back up. [[spoiler:Turns out this healthy Mary is the 'Ideal Mary', imagined by the real, ill Mary, who dreamed of her own world where one of the aspects there is that she's healthy, and by some complicated means, it's coming to take over reality.]]

* Jessica from ''VideoGame/ManaKhemiaAlchemistsOfAlRevis''. One alchemist, [[spoiler:who turns out to be TheHero's "father", sort of]], cured her ... at the cost of her life energy. In short, she got better, but her life was cut in half ''at least''.

* Ameena from ''VideoGame/StarOceanTillTheEndOfTime'', who's also an Expy of [[VideoGame/FinalFantasyVII another flower-selling girl]]. It ends [[DiabolusExMachina even worse than this implies]].
* In the ''VisualNovel/TokimekiMemorial'' series, there's [[{{Meganekko}} Mio]] [[CuteBookworm Kisaragi]] of Tokimemo 1, who suffers from anemia and thus and can't handle violent physical activities and emotions, and Hotaru Izumi of Tokimemo 3, who had to stay for a long time at the hospital, and still suffers from some aftereffects, due to a car accident a few years prior the game's proper, which also [[spoiler: [[TheMourningAfter cost the life of her dear boyfriend]]]].
* In ''VideoGame/MitsumeteKnight'', the SpiritualSuccessor of ''Tokimeki Memorial'', the resident Ill Girl is [[{{Meganekko}} Sarah]] [[HotForStudent Pixis]] ; she suffers from a heart disease that prevents her to go outside, and the Asian (the player avatar) gets to meet her as his private teacher. Other Ill Girls are [[TheWoobie Sophia's]] [[TheUnfavourite estranged mother]] and little brother, Dolphan's Queen, as well as [[spoiler:[[HospitalHottie Teddie Adelaide]], Sarah's nurse and friend, who suffers from the same heart disease as her and thus why the two are close]].
* Yonah from ''VideoGame/{{NieR}}'', who is infected with the Black Scrawl Virus, prompting her [[PapaWolf father]]/[[KnightTemplarBigBrother brother]] (depending on which version you buy) to go out and fight his way to finding a cure. Later on, it is revealed that [[spoiler:Kaine]] is also infected.
* Patchouli Knowledge from ''Franchise/TouhouProject'' is really sick. She suffers from asthma, anemia, and Vitamin A deficiency because of her refusal to leave the library she lives in for ''centuries''[[note]]and also because of all the poisonous chemicals, such as mercury and arsenic, that she uses for her magic[[/note]]. This is used to justify her inconsistent power level; when she's the midboss of the Extra Level in ''VideoGame/TouhouKoumakyouTheEmbodimentOfScarletDevil'', she explains beforehand that her asthma has cleared up.
* In the JRPG ''VideoGame/LostOdyssey'' the player can acquire an ingame codex entry of the maincharacters past experiences. One in particular centers around an Ill Girl whom liked to hear his stories of far off places when ever he stopped by. The codex ends with the last encounter with this Ill Girl has her comatosed and on the brink of dying when he arrives to tell her one last final story.
* Occurs a couple of times in the ''VideoGame/{{Growlanser}}'' series:
** ''Growlanser II: The Sense of Justice'' includes Charlone's younger brother in this role.
** ''Growlanser 3'' has this as part of [[spoiler: TheDragon's motivation to side with the BigBad]].
* ''VideoGame/ProfessorLaytonAndTheLastSpecter'' has [[spoiler: Arianna; she is cured a year after the events of the story.]]
* ''VideoGame/SakuraWarsSoLongMyLove'' has Diana Caprice, the niece of the New York Combat Revue's commander. When she is introduced, she is wheelchair-bound and all but convinced that she will die in the very near future. The chapter that sees her inducted into the Revue as a STAR pilot revolves around helping her find the will to live. She eventually ditches the wheelchair when she resolves to survive. [[spoiler:At the end of the game, she reveals that she will undergo surgery in the hopes of extending her life.]]
* ''VideoGame/HarvestMoonMagicalMelody'' features Dia, a girl you can romance who is incredibly ill from some vague disease. As such she spends every waking hour in the hospital and you have to come visit her. You could always just woo her nurse instead.
* Kaoru Watabe from ''VideoGame/TheKingOfFighters'', who is in a wheelchair at the start of KOF'97. She has only started to take her first steps out of it by the time she meets her idols, the Psycho Soldiers. [[spoiler: Around KOF 99 her health has improved dramatically, atleast enough to have her [[BigDamnHeroes help the group out of the NESTS base]].]]
* In the ''VideoGame/YumeNikki'' fangame ''[[VideoGame/DotFlow .flow]]'', through the game's symbolism, [[spoiler:it is heavily implied that Sabitsuki, the player character, is dying from some sort of illness]]. This isn't just an EpilepticTree, but almost ''canon''. [[MindScrew Maybe]].
* Maria Robotnik of the ''Franchise/SonicTheHedgehog'' series had NIDS. In fact, Gerald Robotnik's creation of Shadow the Hedgehog was his attempt to save Maria's life.
* Miyuki Tanaka from ''VisualNovel/TrueLoveJunaiMonogatari'' is, like Mio, anemic and prone to dizzy spells. She even collapses at some point and [[spoiler: her friend Mikae]] has to take care of her.
* Victoria F. Stein from ''VideoGame/BravelyDefault'' is a dark twist on this trope; while she was subjected to an incurable disease, she was treated by Victor and his father Vincent. The treatment was imperfect, however, and while Victoria can move freely, not only did it stunt her growth, but she is subjected to [[spoiler:increasingly frequent]] seizures, and the continued trauma has made her [[AxCrazy a different kind of sick]].
* Taimi of ''VideoGame/GuildWars2'' is an Asuran child who suffers from a disease similar to multiple sclerosis, rendering it painful to walk for significant distances. She gets around this by riding in a [[HandicappedBadass combat-ready golem chassis]].

* Claudia, the main character in ''VideoGame/LegendOfFae'' has a leg brace due to contracting polio as a child. Fortunately, she can still kick butt using her affinities with the elemental spirits.
* ''VideoGame/DotHackGU'' has Aina, Oban's sister who plays [[ShowWithinAShow The World]] because it's the only way for her to communicate with her brother (He's in Japan, she's receiving treatment in Germany). She would've received a crucial treatment long ago... but unfortunately she became a Lost One (a victim of the [[PlayerKilling PKer]] Tri-Edge. [[spoiler: This greatly eats away at Oban's consciousness because ''he'' is Tri-Edge due to the AIDA infection. His plans throughout the series are so that he can free her mind from the game.]]
* Em in ''VideoGame/{{Prelude}}'' is another adult example. She has an unspecified ailment which makes her tire easily and start coughing when she's been outside for too long and which prompted her father to discourage her from singing due to the vocal strain.
* ''VideoGame/AVeryLongRopeToTheTopOfTheSky'': Mint, although, unlike more conventional examples, this doesn't stop her from adventuring with the rest, to the noticeable detriment of her health. Her condition is strongly implied to be genetic (or at least congenital), and the major way it manifests is that she will occasionally just ''collapse'' from too much excitement, strain, or some other strong emotion. [[spoiler:[[KillTheCutie She dies]] [[TearJerker because of this.]]]]
-->'''Mint''': ''[to Ivy]'' [[DontYouDarePityMe I told you to stop using me as an excuse!]]

* ''VideoGame/LoveNikkiDressUpQueen'' has two of these:
** The BigGood of the game, Queen Nanari of the Lilith Kingdom, has such a weak health that she hasn't been seen in public for years and her NumberTwo, Sir Nidhogg, has to handle almost everything. Even her members of her own family (like [[spoiler: her younger brother, Prince Royce]]) can only visit with her on a limited basis. The Nanari that spirits the titular Nikki and her cat Momo to the world of Miraland is actually a product of AstralProjection, and disappears few later.
** While not as frail as Queen Nanari, Nikki's IdenticalStranger Bai Jinjin appears to have a weak constitution. When she and her boyfriend Zhong Lizi headed towards the frigid North Kingdom [[spoiler: after the attempted kidnapping at the Designer's Tea Party]], her health deteriorated to the point that they were forced to return to their homeland, the Cloud Empire.
-->'''Zhong Lizi:''' "The further north we went, the worse Bai Jinjin's condition would get. Maybe she just can't bear the freezing weather."

* Ellen from ''VideoGame/TheWitchsHouse'' is [[TheHeroine Viola]]'s seven-year-old friend who lives in a house near the woods, and is also terminally ill. The disease gradually eats away at her body, making her look uglier, and her parents are [[ParentalNeglect basically absent from her life]], but Viola cares for her anyway. The plot happens because Viola, on the way to visit her, gets lost and wanders into the titular house. [[spoiler:The sympathetic aspect is subverted, however, when Ellen is revealed as the [[WickedWitch witch]], and a cruel {{sadist}} who screwed over Viola in the backstory in addition to killing [[SelfMadeOrphan her parents]] and hundreds of innocents over the course of her [[ReallySevenHundredYearsOld immortal life]].]]

* Eve in ''VideoGame/BlasterMasterZero2'' plays this role due to the mutant infection [[HappyEndingOverride not quite having gone away]] and the plot involves racing to her home planet to find a cure. Unlike most examples, her disease shows a clear sign of BodyHorror.

* ''VideoGame/BreathOfFire3'' subverts this during the [[InevitableTournament Contest of Champions]]. Emitai, one of the competitors, visits the heroes before their bout (which is weighed against him due to its rules) and introduces them to his daughter; he claims to be in the contest to earn her an operation that will cure her disease, and asks them to throw the fight. As one of the heroes is being held hostage, they refuse. After the match, however, if you visit Emitai's dressing room, you learn that it was a giant fraud on his part to get his opponents to forfeit. Just to make this clear, after the midgame time skip, you can find Emitai again (and recruit him as a master); his daughter has grown up and is rather embarrassed with him.

* Tomoki in ''VisualNovel/{{Canvas 2}}''. However, the surgery she needs is actually quite easy and not that expensive. Not even that risky. She's actually afraid it will work and she'll be lonely.
* Mary/Maki Sonomura in ''VideoGame/{{Persona 1}}'' is introduced as an Ill Girl, but when demons arrive to the scene, she suddenly got back up. [[spoiler:Turns out this healthy Mary is the 'Ideal Mary', imagined by the real, ill Mary, who dreamed of her own world where one of the aspects there is that she's healthy, and by some complicated means, it's coming to take over reality.]]

* Patchouli Knowledge from ''VideoGame/{{Touhou}}'' is really sick. She suffers from asthma, anemia, and Vitamin A deficiency because of her refusal to leave the library she lives in for ''centuries''[[note]]and also because of all the poisonous chemicals, such as mercury and arsenic, that she uses for her magic[[/note]]. This is used to justify her inconsistent power level; when she's the midboss of the Extra Level in ''Embodiment of Scarlet Devil'', she explains beforehand that her asthma has cleared up.

* In the ''VideoGame/YumeNikki'' fangame [[VideoGame/DotFlow .flow]], through the game's symbolism, [[spoiler:it is heavily implied that Sabitsuki, the player character, is dying from some sort of illness]]. This isn't just an EpilepticTree, but almost ''canon''. [[MindScrew Maybe]].

* Akinari Kamiki, the Sun Arcana from ''VideoGame/{{Persona 3}}'', is a prospective writer who was born ill, thus his days have been numbered ever since birth. Developing his S-Link is about having him learn to enjoy his last days of life. [[spoiler: He will die before the game is over, leaving the children's book he wrote with the MC's help and encouragement as a TragicKeepsake, and if his link is maxed his soul will cheer on you before you take on Nyx.]]

* John Cassidy from ''VideoGame/{{Fallout 2}}'' suffers from a heart condition, necessitating regular injections of cardio-boosters to keep from having a heart attack. If you give him a chem like Psycho, Buffout, or Jet, it will aggravate the condition to the point of giving him an instant, and fatal, heart attack.

* Eve in ''VideoGame/BlasterMasterZero2'' plays this role due to the mutant infection [[GoodEndingOverride not quite having gone away]] and the plot involves racing to her home planet to find a cure. Unlike most examples, her disease shows a clear sign of BodyHorror.

* Beatrix from ''VideoGame/{{Battleborn}}'' was born with a terminal disease that gave her a very weak body, a thing that is looked down upon by Jennerit society which greatly values strength. Because of this, she originally didn't have long to live. However thanks to her mother's lobbying to have Beatrix sustained for her genius, Beatrix became something akin to ''SelfDemonstrating/{{Deadpool}}'', an immortal stuck with an otherwise sickly body. Excerpts from her diary from the lore in [[https://forums.gearboxsoftware.com/t/battleplan-32-12-22-16/1552633 Battleplan 32]] reveal her thoughts about her illness.

* Mary/Maki Sonomura in ''VideoGame/{{Persona}}'' is introduced as an Ill Girl, but when demons arrive to the scene, she suddenly got back up. [[spoiler:Turns out this healthy Mary is the 'Ideal Mary', imagined by the real, ill Mary, who dreamed of her own world where one of the aspects there is that she's healthy, and by some complicated means, it's coming to take over reality.]]