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HIV Vaccine Trials Approved by FDA
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HIV Vaccine Trials Approved by FDA:

Science is awesome.

A vaccine that prevents HIV has been given the green light by the U.S. Food and Drug Administration to begin clinical trials in humans, according to Canadian researchers.

The announcement was made on the campus of the University of Western Ontario in London, Ont.

"We have gone through so many different challenges to come to this point, " said Dr. Chil-Yong Kang, a researcher and professor at Western's Schulich School of Medicine and Dentistry. "This is the first time that I feel very happy and comfortable to initiate this human clinical trial."

Scientists at the University of Western Ontario, financially backed by the pharmaceutical venture company Sumagen, developed the vaccine, which is based on a genetically modified killed whole virus. The vaccine stimulated a strong immune response in early testing and appears to have no adverse effects, according to the researchers.

"FDA approval for human clinical trials is an extremely significant milestone for our vaccine, which has the potential to save the lives of millions of people around the world by preventing HIV infection, " said Kang.

He said there have been three clinical trials for the HIV vaccine in the past using live viruses. "None of the researchers in the past have used this approach, " he says of his use of a killed virus.

The vaccine, SAV 001, will now have to undergo three phases of human clinical trials;

  • Phase 1. Beginning in January 2012, this phase will involve 30 HIV-positive people on whom safety will be retested.
  • Phase 2. This phase will examine immune responses in humans and will involve 600 HIV-negative people who are at high risk of contracting the AIDS virus.
  • Phase 3. This phase will determine the efficacy of the vaccine and will involve 6, 000 HIV-negative volunteers at high risk of contracting the virus.

HIV was never that big of a problem.

Like... when are they gonna make a vaccine for tuberculosis??? The I will be impressed.
I will always cherish the chance of a new beggining.
 3 Drunk Girlfriend, Tue, 20th Dec '11 9:11:22 AM from Castle Geekhaven
[up][up] Awesome. I hope it works. grin

[up] What? They already have a TB vaccine, and HIV is a gigantic global problem currently.
"I don't know how I do it. I'm like the Mr. Bean of sex." -Drunkscriblerian
 4 Inhopelessguy, Tue, 20th Dec '11 9:11:23 AM from Birmingham, Greater Europe Relationship Status: Less than three
Psych Lad
TB is a bitch to inoculate against. Damn thing keeps mutating every year.

Sorry, thinking of a different (but similar) pathogen. TB has a vaccine.

Well, I guess this is good news. If the FDA can do it, I'm sure the NHS will have in 5-10 years.

edited 20th Dec '11 9:12:11 AM by Inhopelessguy

Its difficult to explain it. But why use words when I can touch you and make you feel it...?

^^^ Aside from us already having a vaccine for that, a few people might disagree with you on this being a big deal.

EDIT: Ninja'd

edited 20th Dec '11 9:12:23 AM by Pentadragon

 6 Meeble, Tue, 20th Dec '11 9:12:58 AM from the ruins of Granseal
likes the cheeses.
HIV was never that big of a problem.

A disease that has killed over 25 million people, with another 20 million or so currently infected, and kills about a quarter of a million children each year is not that big of a problem? Since when?
Visit my contributor page to assist with the "I Like The Cheeses" project!
[up][up] Ill be surprise when they find a cure. Those people will die eventually from AIDS or its complications... should something else not kill them first. A vaccine will not do one damn thing to help them. [up] That is relatively little compared to Malaria. But since Malaria is a disease for poor people and so not even half the resuorces devoted to HIV have been alocated to its investigation.

Also if TB vaccine exist... then why havent we vaccinated the whole world like we did with polio????

edited 20th Dec '11 9:18:04 AM by Baff

I will always cherish the chance of a new beggining.
 8 Inhopelessguy, Tue, 20th Dec '11 9:13:33 AM from Birmingham, Greater Europe Relationship Status: Less than three
Psych Lad
Hmmm, I'm not too keen on that graph. Absolute figures are good, but as a % of the population would be better.

e.g. India has above 1mn, but it's population is close to about 1.25bn.

[up]Money, politics, transport, and greedy pharma.

edited 20th Dec '11 9:14:02 AM by Inhopelessguy

Its difficult to explain it. But why use words when I can touch you and make you feel it...?

 9 Drunk Girlfriend, Tue, 20th Dec '11 9:17:40 AM from Castle Geekhaven
@Baff: Here's the graph for TB. Compared to the graph for HIV infection, I'd say that it's not as big of a problem.

Also, we didn't vaccinate the world for polio. It's still a large problem in India, China, and the Middle East.

edited 20th Dec '11 9:19:06 AM by DrunkGirlfriend

"I don't know how I do it. I'm like the Mr. Bean of sex." -Drunkscriblerian
^^ Better?

edited 20th Dec '11 9:17:56 AM by Pentadragon

[up][up] one-third of the world's population is currently infected with the TB

Also it might be worthwile to point out that people who die of AIDS usually do as a result of TB.

EDIT: I look at the data and it seems that AIDS is actually a much greater problem that I thought. So nevermind my past statements.

I still think TB is potentially more dangerous do.

edited 20th Dec '11 9:26:52 AM by Baff

I will always cherish the chance of a new beggining.
 12 Drunk Girlfriend, Tue, 20th Dec '11 9:28:27 AM from Castle Geekhaven
@Baff: Yes, but we have a vaccine for TB. Quite a few of the countries that still have a rate of infection are either a) not willing to innoculate their citizens or b) have populations living in remote locations (for example: China and Russia).

edited 20th Dec '11 9:29:02 AM by DrunkGirlfriend

"I don't know how I do it. I'm like the Mr. Bean of sex." -Drunkscriblerian
 13 Chalkos, Tue, 20th Dec '11 9:28:28 AM from The Internets
Sidequest Proliferator
Which is why it's great there's already a TB vaccine.

Glad to see this. Been keeping an eye on a few promising trials and it's lovely to hear that one has made it to major clinical trials.

 14 Inhopelessguy, Tue, 20th Dec '11 9:31:17 AM from Birmingham, Greater Europe Relationship Status: Less than three
Psych Lad
@ % chart.

HOLY. CRAP.

Britain is green!

GREEN!

Its difficult to explain it. But why use words when I can touch you and make you feel it...?

[up][up][up] The potentail of TB to mutate is what is worrysome. There already some cases of Super TB. Besides... back with Polio, everyone in the world was vaccinated more or less... and that was 30 years ago.

Meanwhile the cure for AIDS and Cancer remain the holly grails of medicine. Hopefully this goals will be achieved but not to the detriment of investigation on other diseases that are just a serious but commonly overlooked.

edited 20th Dec '11 9:32:19 AM by Baff

I will always cherish the chance of a new beggining.
 16 Chalkos, Tue, 20th Dec '11 9:36:27 AM from The Internets
Sidequest Proliferator
[up][up]Yup. The Western world has benefited greatly from easy access to and education about contraceptives and other practices which reduce risk of contracting HIV.

The West cannot compare to Best Korea though. Look at dat green.

edited 20th Dec '11 9:42:00 AM by Pentadragon

 18 3of 4, Tue, 20th Dec '11 9:50:31 AM from Five Seconds in the Future. Relationship Status: GAR for Archer
Feeble Turtle Duck
The problem with TB is not in the medicine. Its in the people who are stupid.

To cure TB fully you have to make the treatment until the end. Now people (who, as I mentioned are stupid) do feel better after some time STOP the treatment short, which lets the TB survive somewhat and the little buggers who didn't get killed of do mutate because that what evolution does.

For god's sake TB is a BACTERIA! Its killable by ANTIBIOTICS (while HIV as a virus is not.)

(we have a Professor of Molecular Biology who made a full lecture about TB and such fun...she hates those bacterias.)

Seriously, most resistant bacteria are created by humans.

About HIV...a Cure would be awesome for those infected, but a Vaccine is equally good news. If it works and is distributed well enough it will only be a matter of time until HIV goes the way smallpox went and dies.

edited 20th Dec '11 9:55:12 AM by 3of4

LMage: NO ONE ASKED FOR YOUR WITCHCRAFT THREE
HIV was never that big of a problem.
This is a great start to this topic.

Seriously: this is great; lets hope the results are good.
 
 20 Major Tom, Tue, 20th Dec '11 9:53:59 AM Relationship Status: Barbecuing
Eye'm the cutest!
^ Indeed.

Let's hope the trials go well. An HIV vaccine means only one thing in the long run: There is nothing that science cannot overcome!
Endless Conflict: Every war ends in time, even supposedly this one.
 21 3of 4, Tue, 20th Dec '11 10:03:00 AM from Five Seconds in the Future. Relationship Status: GAR for Archer
Feeble Turtle Duck
Additional TB Fun Fact: HIV raises the chance that latent TB infections goes to full out active TB because it weakens the immune system. Kill HIV and the number of active TB patients will go down. (And its easier to kill in latent form, too.)

(also for the record, the 1/3 of the world describes those who have the bacteria, and not the active TB)

edited 20th Dec '11 10:05:02 AM by 3of4

LMage: NO ONE ASKED FOR YOUR WITCHCRAFT THREE
 22 Blue Ninja 0, Tue, 20th Dec '11 11:26:19 AM from The Middle of Nowhere Relationship Status: She's holding a very large knife
Slowly dying on the inside
This is good news.

My paranoia compels me to doubt the low reported rates in northern Africa, given how overwhelming it is in the nations they share borders with.
Once the avalanche has started, it is too late for the pebbles to cast their vote. - Ambassador Kosh
 23 USAF713, Tue, 20th Dec '11 12:01:06 PM from the United States
I changed accounts.
Cool, but I'll be actually impressed when they release a detailed and realistic plan to start distributing it en masse throughout Africa and Asia, too...
I am now known as Flyboy.
If the could eradicate Polio... they can eradicate anything if they put their mind to it.

Except of course that Super virus that could kill half of the planetīs population.

edited 20th Dec '11 4:26:00 PM by Baff

I will always cherish the chance of a new beggining.
 25 Drunk Girlfriend, Tue, 20th Dec '11 4:28:55 PM from Castle Geekhaven
[up] Actually, they've yet to eradicate polio. It's still a problem in some developing nations.
"I don't know how I do it. I'm like the Mr. Bean of sex." -Drunkscriblerian
Total posts: 57
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