Seriously, has anyone thought of an Orion's Arm
RPG. It might be a little difficult considering that the thoughts of even an S:1 transapient are supposed to be completely alien to a modosophont but I have a couple ideas.
In one the players are modosphonts who for some reason or another have taken up adventuring and found a transapient patron.
The other is a wargame type where the players are transapients from the different Sephirotic Empires trying to convert a newly discovered (but already colonized
) system to their side.