Crosses the Line Twice: More like doing the Macarena all over it. For one such example, consider his "Three Cheese Baby" routine.
He once called himself "three times better than Jesus" because of a medical procedure that effectively killed him and brought him back to life three times to fix an issue with his heart.
Moral Event Horizon: He has a tendency to see suicide as cowardly, including mocking a dead girl who killed herself over online harassment, and outright telling suicidal people to kill themselves in a rant because he found suicidal people whiny. Needless to say, this has not sat well with many. 2 has clarified that his stance is "the only one who gives your life meaning is you, ad you don't give it meaning by killing yourself," but it's still a very bitter pill to swallow.
His mockery of the swine flu outbreak might have qualified had it not been made years after the fact.