These are what we call the 'YMMV items.' Things that some people find in this work. We call them 'your mileage might vary' because not everyone sees these things in the same way. This starts discussions in the trope lists, a thing we don't want. Please use the discussion page if you'd like to discuss any of these items.
Crowning Moment of Heartwarming: When Cooper finds out that Charlotte was raped, he sits down with her, tells her he loves her (no matter what), vows to protect her, and ultimately helps her find the strength to identify her rapist. May also be a Tear Jerker for some. It was just that good.
Ensemble Darkhorse: Charlotte, for many fans, once she was defrosted. Probably helps that KaDee Strickland pulls off the whole Southern-Belle Texas-accented charm with perfect ease.
Fan-Preferred Couple: Pete and Violet as of now, Cooper and Violet in season 1, later Cooper and Charlotte until recently (see Jerkass example below).
Addison and Sam. ADDISON AND SAM, until recently when he started getting indecisive.
Also, Naomi and Gabriel.
Addison and Jake, on the grounds he actually likes kids and her.
Sheldon and Amelia have a pretty passionate fan base, although Ryan and James don't often get the Die for Our Ship treatment ( although that may be because Ryan did).
"Funny Aneurysm" Moment: Early in Season 3, in order to get some perspective on one of her patients, Violet poses Cooper a hypothetical: Charlotte is raped, falls pregnant by the rapist, and decides to keep it. Cooper responds with "Don't hypothetically rape my girlfriend!". A year later, Charlotte being raped is no longer a hypothetical.
Growing the Beard: Every fan will have a different answer to "When did the show completely step out of the shadow of Grey's Anatomy and become its own entity?", but they can all agree that "Did You Hear What Happened to Charlotte King?" is a contender.