These are what we call the 'YMMV items.' Things that some people find in this work. We call them 'your mileage might vary' because not everyone sees these things in the same way. This starts discussions in the trope lists, a thing we don't want. Please use the discussion page if you'd like to discuss any of these items.
Squick - Caroline, after vomiting, drops her gum in the (filthy, New York City bus station) toilet. She then proceeds to fish it out and put it back in her mouth. And that's just the start; the same gum ends up traveling to both Norah's and Nick's mouths at separate points. (Neither of them knows it's been in a toilet, but they do know it's been in someone else's mouth, which is gross enough as it is.)
The Woobie - While their romantic dilemmas are partly of their own making, the titular couple can be considered candidates for partial Woobie status (at least until the final third of the film). Their respective exes are simply that awful.