YMMV / Isaac Survivors

• Game-Breaker:
  • A few of the penny trinkets that trigger from collecting coins (aside from those that are more detrimental or useless) are all kinds of busted in the context of this game-mode where Money Is Experience Points. In particular:
    • Bloody Penny and Blessed Penny, which can spawns red hearts and soul hearts respectively. While the former trinket can help max out whatever heart containers you have, with the latter you're likely to max out your health limit to ensure your death is miles away.
    • Rotten Penny, which spawns Blue Flies for each coin obtained. At a certain point with this trinket, it can be self-sustaining with the enemies they kill, thus dropping a coin that'll spawn another.
  • If you get the Sigil of Baphomet trinket, with its ability to give Isaac a one second shield per enemy killed, you pretty much win the endgame. With the right amount of offense, Isaac can go Leeroy Jenkins into the foes to collect all the coins they drop while avoiding damage effortlessly.