Of the sisters, Prue seems the most fond of baby Matthew, and has expressed she wants kids before. Prue becomes the only one of the sisters not to have children since she dies young.
Phoebe is called the best with kids, but her first pregnancy ends up being an ordeal due to the father being the Source of All Evil at the time.
The fact that the sisters bond so well with Matthew here is this, considering Phoebe and Piper will bond with another "Matthews" in the future...
Piper ends up giving her firstborn son the middle name "Matthew". While it was meant to honor his Aunt Paige's adoptive surname, it doubles as a callback to how much the sisters bonded with baby Matthew here.
