Anvilicious: The effects of the wrong political party taking control end up turning America into a Death World within a few decades, to the point where the main character is eaten alive by dogs.
Harsher in Hindsight: One of the headlines on the Dakota Online Magazine feelie is Queen Di at 70. Princess Diana died in a car crash in 1997.
Hilarious in Hindsight: It is stated in one of the articles in Library Mode that Muammar al-Gaddafi was killed during a nuclear accident in 1998. al-Gaddafi did not meet his demise until 2011.
Steve Meretzky said that the game is a Take That! to then-President Ronald Reagan, which was "so successful that we’ve never had another President like that!" Well, Meretzky, if your game were made today in the continuing Donald Trump era, it would show people what a "war-mongering, Christian-Right-pandering, environment-trashing, rights-trampling asshole" President Trump is. (Although given the time the interview took place, it's likely that the statement was a Self-Deprecation regarding how the game, unsurprisingly, did nothing to prevent the election of GWB.)
Just Here for Godzilla: The liberal politics of the game are overshadowed by the sci-fi elements of PRISM. Unless you go digging through menus, it's easy to play most of the game without knowing what the Plan for Renewed National Purpose involves. You can see its effects, as the police state gets worse and worse, but the plan behind it isn't as visible.
Paranoia Fuel: "You have spent twenty years living a normal, unsuspecting life. You are YOU. Then suddenly, one day, the universe around you is torn away, and you learn that your whole life has been a charade, a carefully calculated scientific experiment. Perhaps, at this very moment, you are a normal human being, sitting in some comfortable armchair reading this story. But - perhaps you are not."
Tear Jerker: The short story prologue describes what are probably the most painful moments in Perry Sim's/PRISM's life.
Additionally, several events in the future simulations (especially regarding his son) are soul-crushingly depressing.