Deep Space Nine is going to be destroyedJust saw the DS9-centric two-parter (Plagues of Night / Raise the Dawn) which is coming out in May/June 2012, the second of which shows a Starbase being constructed in front of the Bajoran wormhole and referencing "catastrophic events" in the Bajor system. So either they build a sister base on the Gamma Side of the Wormhole or ol' Terok Nor is going to be Terok Ex shortly.
Ultimately the Typhon Pact will blow up in the face of the more aggressive races.Once the Tholians and Tzenkethi, with their scheming and all such, play their hand too far the pact will collapse. Afterwards the moderates, the Breen, the Gorn and the Romulans, seeing as they have seen the advantages of working together but figuring out that said Typhon Pact allies are never going to be willing to not simply use their "allies" as pawns they decide to either make a more neutral alliance with just themselves or outright sign on the Khitomer Accords. And as such reaffirm Star Treks Utopian outlook and that things CAN be solved by working together instead of just another star war.