VIDEOS:
"Take that ya dumb squirrel!"
An example of a Take That! happening in-universe.
Marge's protests against the Itchy & Scratchy cartoon inspires an animator to caricaturize Marge as a squirrel who angrily objects to Itchy and Scratchy's violent antics only to then get it's head whacked off by Itchy.
Example of:
Take That!