- California Doubling: While the baseball game in Chapter 5 takes place in Boston, the background image used in the chapter is a shot of Oracle Park in San Francisco, home of the Giants. The mistake can be put down to Pixelberry's tendency to reuse assets; the same photo was used in #LoveHacks, which did take place in San Francisco.
- Distanced from Current Events: In the wake of both the Coronavirus pandemic and the Black Lives Matter protest, Book 2 was put on hiatus halfway through to accommodate for the storyline to be rewritten (and because of the unfortunate timing). It's hard not to see why, given that Chapters 10 and 11 involve a biological weapon attack which infects several people (including Casey), causing them to be put under quarantine, references to political corruption, and the near-death of Rafael, a person of color (especially since he's supposed to be a love interest).
- Meaningful Release Date: All three books were released in February (Book 1 in 2019, Book 2 in 2020, and Book 3 in 2021). Fittingly, February is the month of Valentine's Day, and the series is called "Open Heart".
- Release Date Change: Book 2 was originally slated to be released in late 2019, before being delayed to February 2020.
- Series Hiatus: In Book 2, this happened twice. The first one started after Chapter 8, lasting from mid-April until near the end of May 2020, due to the Coronavirus pandemic. The second one started after Chapter 9 (just one chapter after the book came back from hiatus). This time, it was due to real life events that happened around the time the book returned from hiatus that caused the writers to rewrite the second half of the book (since they felt that the storyline they had planned would have been untimely in the wake of the recent events).
- What Could Have Been: Rafael Aveiro was originally meant to die at the biological weapon attack in Book 2, Chapters 10 and 11, but public outcry over it due to Rafael's Out of Focus status and the Black Lives Matter movement caused the writers to rewrite the scene and have him live.
- You All Look Familiar: Even by Choices standards, this series does a ton of portrait recycling, especially for patients.
Book 1
- The woman who collapses at the beginning of Chapter 1 is President Vera Thompson.
- Annie, Casey's first patient, is Whitney. One of the girls at the bar in Chapter 2 is Sierra.
- Mrs. Martinez, one of the elderly patients, is Ms. Harlenay.
- The manager of the Boston Nighthawks is Chief Walsh, Senator Lucius, and Ulrich Ziegler.
- Reggie, the bartender at Donahue's, is Tommy Phelps.
- If you play darts in a premium scene with Bryce in Chapter 2, one of the surgical interns is Percy Mendoza.
- Mike Knoblauch is Lucanus Flavius and Professor Englund.
- Dolores Hudson is Eliana Vera.
- Jake Sandburg is Kyle Garza.
- In a premium scene in Chapter 5, two of the executives in the VIP section are Mac Hornby and Loretta Crandall.
- Shonda Turner is Samantha Winters and The Broker.
- Phoebe is Mirasol Bautista and Lucilla Nazario.
- Rowan and Willow, the fraternal twins, are Tony Rez and Yvette.
- Dr. Tanaka is Agent Michael Kim.
- Orchid Montague is Theresa Sutton.
- A premium scene in Chapter 8 has Casey and Bryce attending a bachelorette party with Grace Liao, Claire Pierce (post-haircut), and Scarlett Emerson.
- Nigel Platt is Bryce Sterling.
- One of the vendors at the convention in Chapter 10 is Reyna Mercado.
- Declan Nash is Carson Stewart.
- Dr. Ryan is Julia Hawkins.
- Kima is Aiyana Midthunder.
- An unnamed patient in Chapter 12 is Alexis Davenport.
- Tommy Liu is one of the male options for the child version of Devon.
- Sharon Liu is Bridget Zhou.
- Tamara, a patient from the train crash, is Kailani Keawe.
- Dr. Calais is Rodger Crandall.
- Dr. Cyrus is Mr. Olsen.
- Dr. Rosario is Tino Thompson.
- Luis Martinez is the truck driver.
Book 2
- Dr. Sothy Yoeun is Andy Kang.
- Evelyn de la Vega is Evelyn Swan.
- Senator Ed Farrugia is Ned Mallory.
- Two reporters in Book 2 Chapter 10 are Vanessa Blackwood and Dorian Delacroix.
- Wayne is Brad. Travis Perry in Book 2 is the same sprite with a different hairstyle.
- Bob Gunderson and the priest at the funeral are Gabriel Amarne recycling the same sprite with different hair and beards.
- Mr. and Mrs. Coates are Martin Silva and Faith Park.
- A random woman that Jackie helps in Book 2 Chapter 13 is Autumn Brooks.
- Rodney Marsh is Alan Park.
- Paula is Anna-Marie Mendoza.
- Timothy is Graham.
- Charlotte St. Yves is Aiko Nakamura.
- Benicia Valdez is Principal Rivera.
- Ms. Thompson is Penny Chen.
- Marisa Flores is Miranda Moreau.
- Wally is Robert Tennyson.
- The insurance agent in Book 2 Chapter 18 is Mr. Gallagher.
- Evan, Sophie Ortega, and Peter Liao appear as patients in Book 2 Chapter 18.
Book 3
- James Llewellyn is Khaan Mousavi.
- John is Lucas Thomas.
- Michael is Josh Morello.
- Naomi is Carmen.
- Armaan is Keo Parata.
- Nick is Frank Walter.
- Mrs. Timmet is Mitzi Montjoy.
- Becca is Savannah Walker.
- Mac's parents are Reyna Mercado and Yousef.
