History Tearjerker / ThePowerpuffGirls2016

This show may be a DenserAndWackier version of ''WesternAnimation/ThePowerpuffGirls'', but it is sure to have at least a few sad moments here and there.
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* Whenever Blossom cries is slightly sad. Whenever her bow droops due to sadness is is a bit poignant too.

This is not only depressing to longtime fans of the original series for having Ms. Bellum PutOnABus, but it's also hard not to feel sorry for the Mayor when he's shown to break down over realizing how dependent he's been on Ms. Bellum.

-->'''Buttercup''': So what if she doesn't have her new powers yet! And might never get them! ''Never get them!'' '''Never get them!''' ''[Each time she says "Never get them", the camera zooms closer in on Blossom's sad face]''
-->'''Blossom''':''[Feelings hurt]'' I gotta go. I'll see you guys at home.

-->'''Blossom''': Geez, I get it! ''[Sobbing]''

* [[spoiler:Sapna Nehru breaks up with the Professor to protect him from her Spider Transformations]]. While the Professor seemed to get over it, [[spoiler: the episode ends with him trying to find a cure for her]].

* After getting a bad school photo, bad haircut, a bad reaction to defective makeup and getting her teeth knocked out after flying into a fan, Bubbles ends up looking deformed feels ugly. She teams up with Mojo and fights her sisters.

* Blossom running away crying after [[spoiler:Princess betrays her.]]

Bubbles feeling useless after finding no momentos. Even the newspapers mistake her for an annoying pigtailed fan.

* Blossom telling President Dinosaur that there’s to much for her to juggle as a leader.

* Although he is a perpetual jerkass, it is at least a little bit sad to see Manboy getting kicked out of his home, and reduced to a babyfaced coward.

* Morbucks falls in love with Barry but soon mistakes him for having a crush on Blossom
** Morbucks attacks Blossom for revenge but when Barry witnesses the fight, she leaves much to everyone’s confusion.

-->'''Morbucks''': Take good care of him Blossom, I have many reasons to hate you but this isn’t one of them. (Flies off.)

* Toy Ploy. Blossom telling President Dinosaur that there’s to much for her to juggle as a leader.

* Morbucks falls in love with Barry but soon mistakes him for having a crush on Blossom.

[[folder: Show]]

* The Professor being ''heartbroken'' after he finds out the Girls blabbed about his secrets in "Secret Swapper Of Doom".

* Blossom running away crying in "Poorbucks" after [[spoiler:Princess betrays her.]]
* Somewhere over the Swingset, The Girls finding the Professor in the real world through the bathroom mirror reflection worrying about them while the Girls unsuccessfully gets his attention.

* The ending song in “Home Sweet Homesick”.

* “Memory Lane of Pain” Bubbles feeling useless after finding no momentos. Even the newspapers mistake her for an annoying pigtailed fan.

* “Bridezilla”. Bianca tricks the Girls into destroying Barbarus’s wedding with Mojo. When that failed, Bianca reveals she’s lonely for Barbarus.

* Although he is a perpetual jerkass, it is at least a little bit sad to see Manboy getting kicked out of his home, and reduced to a babyfaced coward in ''Man Up 3: the Good, the Bad, and the Manly''.

[[folder: Meta]]

* Creator/TaraStrong not even being contacted by the network if she wanted to reprise her role as Bubbles or not, going on to say that it felt like [[https://twitter.com/tarastrong/status/608033768264318977 a stab in the heart]].
** To sweeten the pill, she ''did'' wish the best of luck to Kristen Li, the new Bubbles.
** Similarly, Catherine Cavadini and E.G. Daily voiced their disappointment while wishing the new voice actresses well.
* The sheer amount of ''vitriol'' triggered by the controversial changes made to the show. Many fans who grew up with the Powerpuff Girls in their childhood were excited to see them return to Cartoon Network after so many years, but instead, the changes left many more people angry, confused, or upset than satisfied. It's gotten so ridiculous that some are even questioning whether or not the show truly deserves it.
** As stated above, the Girls' original voice actresses were disappointed when they weren't even asked if they wanted to reprise their roles. Many fans were saddened, too, and some were angry, beleving the network replaced them on account of their age (even though all three are still active and, as the ''Dance Pantsed'' special proved, are still able to do the voices the same way they did in 1998).
** The removal of Ms. Bellum was an unpleasant surprise, considering that she was a prominent role model to the Girls in the original series and a reflection of the show's most important message--that a woman can be as intelligent, capable, and strong as a man. The producers attempted to rationalize her removal by saying she didn't send the right message, and fans didn't believe them, believing that MoralGuardians demanded that she be removed simply because of her busty appearance, character traits be damned.
* Creator/TomKane (The voice of Professor Utonium and HIM) suffered a stroke in 2020 that impaired his right side and ultimately retired from voice acting. So this series is pretty much the last time you'll hear the two characters with their original voices.
* “Viral Spiral", also has a meta example, as it was the last time Creator/ChuckMcCann voiced the Amoeba Boys before he died on April 9, 2018.

[[/folder]]

* Bubbles saying goodbye to Cheepy in "Cheep Thrills".

* Tiara Trouble, Bubbles running away crying after Blossom and Buttercup pressure her into winning.
* In "Arachno-Romance" [[spoiler:Sapna Nehru breaks up with the Professor to protect him from her Spider Transformations]]. While the Professor seemed to get over it, [[spoiler: the episode ends with him trying to find a cure for her]].
* “Bubbles of the Opera”, after getting a bad school photo, bad haircut, a bad reaction to defective makeup and getting her teeth knocked out after flying into a fan, Bubbles ends up looking deformed feels ugly. She teams up with Mojo and fights her sisters.

* "Princess Buttercup"
** Bubbles and Blossom feeling abandoned by Buttercup after she hangs out with the Derby-Tantes more than them.

* "Bye Bye Bellum" is not only depressing to longtime fans of the original series for having Ms. Bellum PutOnABus, but it's also hard not to feel sorry for the Mayor when he's shown to break down over realizing how dependent he's been on Ms. Bellum.
* Bubbles crying over [[spoiler:Buttercup's DisneyDeath]] in "Little Octi Lost", saying that if [[ItsAllMyFault she had forgiven her,]] [[spoiler: Buttercup wouldn't have gotten caught in the garbage crusher trying to save Octi]].

* "Power-Up Puff" is one big [[TheWoobie Blossom]] torture porn.
** The scene where Buttercup and Bubbles showing off their aura powers to other kids. Another kid asks Blossom if she has aura powers too, but before Blossom can answer, Buttercup says this: