This is based on opinion. Please don't list it on a work's trope example list.
Tear Jerker / The Asylum for Wayward Victorian Girls
Emilie's accounts of her life are heart breaking to read, but most upsetting of all, even more than her time in a psyche ward, are her accounts of her thoughts and feelings while on a variety of prescription drugs. What really stands out is just a few brief paragraphs where she, while on a drug used to suppress memories, mused whether she had ever really been happy. She concludes that she can't remember genuinely feeling good even once but would like to think she has because maybe then people won't find it so hard to deal with her and to love her. It's especially bad for readers who suffer from manic depression themselves.