Tear Jerker / Onimusha 2: Samurai's Destiny

• Takajo's last moments as she dies in Jubei's arms. Made even worse due to The Reveal that she is his mother.
• The death of Gogandantess. Alas, Poor Villain indeed.
  Gogandantess: Magnificent. You've become so strong...
  Jubei: Dantess…
  Gogandantess: So impressive... Now please do one thing for me, Jubei? Tell me my name.
  Jubei: Your name is... Gogandantess. The greatest swordsman of all demons.
  Gogandantess: Thank you, Jubei…
• If Jubei's friendship with Kotaro is high enough, then the latter will burst in during Jubei's final battle against Ginghamphatts and end up on the sharp end of said demon's weapon for his efforts. His death scene is extremely sad.
• As Jubei and Oyu attempt to leap off the falling Genma airship Oyu stumbles and falls inside as it goes down and all Jubei can do is scream her name.
• If Jubei has a low friendship level with Ekei, the latter will do a Face–Heel Turn and Jubei is forced to fight him. His death is also heartbreaking.
• The scene where Ekei freaks out after rescuing a baby and refuses to hand it over to his comrades, because it reminds him of the child and wife he lost.