Given the nature of the show, these moments are bound to happen frequently.
- Any time that the EMT's are unable to save a patient for whatever reason.
- In one fatal shooting case, Keeley went and attended the patient's memorial service the next day.
- Episodes where emergency service workers are killed in the line of duty:
- One episode featured the cast attending the funeral of Daryle Holloway, a New Orleans Police Department officer who was killed by gunfire.
- In another episode, police officer Natasha Hunter was killed in a car accident during the episode's filming.
- Being set in New Orleans, Hurricane Katrina is mentioned a few times:
- One episode took place on the 10th anniversary of the hurricane.
- In another episode, a patient tells Holly about how he lost his three-year-old daughter to the hurricane. To make matters worse, the day the episode was filmed was his daughter's birthday.
- One episode of S3 is set during Pride Week 2016, which occurred immediately after the Orlando nightclub shooting. Keeley (who is openly LGBT) breaks down crying when talking about it.
