- Most of the last half hour or so of the episode "Catherine" can prompt a bout of the old lacrimation.
- The quiet despair of Margaret Scully, after she's just been told that a) she's never had an orgasm; and b) as such, she can't participate in the study. Allison Janney is just incredible.
- "No. There's only one person who gets to be sickened by me. And that's me." This entire scene sends a skewer straight through the cardiac muscles.
- The insensitive treatment of an intersex newborn in the episode "Fight" and how Masters is completely powerless about acting on the child's behalf.
- Helen dying in childbirth, and Betty losing custody of the baby to Helen's homophobic parents, in "Family Only".
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