History RoleAssociation / VideoGamesEnglishLToZ

[[WMG:[[center: [- ''Role Association - Video Games''\\
English ([[RoleAssociation/VideoGamesEnglishAToK 0-9 & A-K]] | '''L-Z''') | [[RoleAssociation/VideoGamesFrench French]] | [[RoleAssociation/VideoGamesItalian Italian]] | [[RoleAssociation/VideoGamesJapanese Japanese]] | [[RoleAssociation/VideoGamesKorean Korean]] | [[RoleAssociation/VideoGamesPolish Polish]] | [[RoleAssociation/VideoGamesSpanish Spanish]] \\
Individual Games: ''RoleAssociation/{{Danganronpa}}'' | ''RoleAssociation/FireEmblem'' (''[[RoleAssociation/FireEmblemAwakening Awakening]]'' | ''[[RoleAssociation/FireEmblemThreeHouses Three Houses]]'' | ''[[RoleAssociation/FireEmblemEngage Engage]]'' | ''[[RoleAssociation/FireEmblemHeroes Heroes]]'') | ''RoleAssociation/GenshinImpact'' | ''RoleAssociation/HonkaiStarRail'' | ''RoleAssociation/{{Persona}}'' | ''RoleAssociation/SuperSmashBros'' ]] -]]]
!!L
* ''VideoGame/LabyrinthOfRefrainCovenOfDusk'': [[Literature/FateApocrypha Atalanta]], a cold-hearted witch, and [[Anime/{{Charlotte}} Yusa Kurobane]], her cute and constantly put-upon assistant, send puppets down a well to gather magical artifacts from a dungeon. They were also briefly opposed by [[Anime/GundamBuildDiversReRise Hirito]].
* ''VideoGame/LANoire'': [[Series/MadMen Ken Cosgrove]] starts out as a patrolman who rises through the ranks and has [[Series/StarTrekEnterprise Corporal Hawkins]], [[Series/{{Southland}} Salinger]], and [[Series/{{Dexter}} Agent Walker]] as partners before he's demoted to arson where he works with [[VideoGame/MassEffect2 Harbinger]]. At least half the cast of ''Series/MadMen'' are interrogated, and other suspects include [[WesternAnimation/TransformersPrime Unicron]] and [[Series/{{Heroes}} Matt Parkman]]. [[spoiler: [[Franchise/TheLordOfTheRings Denethor]] and [[VideoGame/RedDeadRedemption2 Micah Bell]] are behind the overarching conspiracy.]]
* ''VideoGame/TheLastOfUs'': [[VideoGame/Persona4 Kanji Tatsumi]] is a rugged post-apocalyptic survivor, making his way past a zombie apocalypse, alongside his brother [[VideoGame/CallOfDutyWWII Joseph Turner]] and his partner [[Series/TwentyFour Renee Walker]]. Kanji's life changes when he is contracted by [[VideoGame/HalfLife2 Alyx Vance]] to escort [[WesternAnimation/Ben10AlienForce Gwen Tennyson]] to her group. Kanji and Gwen meet [[Franchise/AssassinsCreed Desmond Miles]] along the way.
* ''VideoGame/LeagueOfLegends'': After war wrecks the land of Runeterra, the nations decide to do diplomacy by making their greatest heroes and villains fight each other. These include [[Manga/FullmetalAlchemist Lust, Roy Mustang, Edward Elric]], [[WesternAnimation/EdEddNEddy Nazz]], [[WesternAnimation/TheGrimAdventuresOfBillyAndMandy Billy]], [[Anime/PuellaMagiMadokaMagica Kazuko Saotome, Mami Tomoe]], [[VideoGame/TwistedMetal Sweet Tooth]], [[Manga/AttackOnTitan Keith Shadis, Mitabi Jarnach, Levi]], [[Series/HawaiiFive0 Allie]], [[VideoGame/StarcraftII a Protoss Zealot]], [[Manga/InuYasha Koga]], [[VideoGame/{{Rift}} Kaliban, Kondraum]], [[WesternAnimation/Ben10AlienForce Ben Tennyson]], [[VideoGame/SamAndMaxTheDevilsPlayhouse Frankie the Rat]], [[Franchise/SonicTheHedgehog Rouge the Bat]], [[VideoGame/StreetFighterIV Guile, Fei Long, Rolento, Poison]], [[Anime/CodeGeass Kallen Kozuki, Charles zi Brittania]], [[Anime/{{Hellsing}} Heinkel Wolfe]], [[VideoGame/SoulSeries Astaroth]], [[VideoGame/BlazBlue Ragna the Bloodedge, Iron Tager, Noel Vermillion, Arakune, Bullet]], [[VideoGame/MortalKombat1992 Scorpion]], [[Anime/DragonballZ Teen Gohan, Cell, Broly]], [[Anime/TengenToppaGurrenLagann Kamina]], WesternAnimation/InvaderZim, [[WesternAnimation/TheAngryBeavers Daggett]], [[WesternAnimation/MegaManRubySpears Proton Man]], [[WesternAnimation/BeastWars Waspinator]], [[VideoGame/TheWalkingDeadTelltale Omid, Clementine, Hershel Greene, Tavia]], [[VideoGame/{{Neptunia}} Magiquone]], [[VideoGame/{{Dimension}} Ivan]], [[Series/Charmed1998 Jo Bennett]], [[Series/{{Entourage}} Megan]], [[Anime/{{Naruto}} Sakura Haruno, Tobi, Jiraiya]], the game's Audio Lead developer, [[VideoGame/BatmanArkhamOrigins Bane]], [[VideoGame/FalloutNewVegas Colonel Moore]], [[VideoGame/HeroesOfNewerth Abaddon, Syphon]], [[VideoGame/{{Strider}} General Mikiel]], [[VideoGame/KidIcarusUprising Pit]], [[VideoGame/{{Overwatch}} Roadhog]], [[Series/PowerRangersLostGalaxy Villamax]], [[VideoGame/FireEmblemAwakening Chrom and Female Corrin]], [[Anime/KillLaKill Maiko Ogure]] and [[Anime/PokemonOrigins Blue]], [[Film/ReturnToBabylon Josephine Baker]], [[VideoGame/FinalFantasyXV Ravus Nox Fleuret]], [[WesternAnimation/TimonAndPumbaa Timon]], [[WesternAnimation/TotalDramaPresentsTheRidonculousRace Stephanie]], [[VideoGame/{{Skullgirls}} Peacock]], [[WesternAnimation/UltimateSpiderMan2012 Aunt May]], Music/{{JORN}}, [[VideoGame/TheWolfAmongUs Bigby Wolf, Faith]], [[VideoGame/MinecraftStoryMode [=TorqueDawg=]]], [[VideoGame/MarvelVsCapcom3 Thor, Tron Bonne, Galactus]], [[Franchise/DotHack [=BlackRose=]]], [[WesternAnimation/TotallySpies Sam]], [[Anime/LoveLive Rin Hoshizora]], [[VideoGame/{{Commander}} Princess Leia]], [[VideoGame/StarlightInception Darkstar Three]], [[Anime/KOn Ritsu Tainaka, Aya]], [[VideoGame/DynastyWarriors Chen Gong]], [[WesternAnimation/BunsenIsABeast Darcy]], [[VideoGame/TheWolfAmongUs Colin]], [[VideoGame/{{Bakugan}} Ace]], [[Franchise/AssassinsCreed Armand Bouchart]], [[Anime/MobileSuitGundamSeedDestiny Amagi]], [[VideoGame/StreetFighterXTekken Bryan Fury]], [[VideoGame/WorldOfWarcraft Kuai the Brute]], [[VideoGame/TalesOfBerseria Magilou]], [[VideoGame/CryptOfTheNecrodancer Candence]], [[VideoGame/{{Smite}} Steel Scarab Khepri]], [[VideoGame/Bioshock2 Augustus Sinclair]], [[WesternAnimation/StarWarsTheCloneWars Asajj Ventress]], [[Manga/CaseClosed Harley Hartwell]], [[Anime/NeonGenesisEvangelion Shinji Ikari]], [[Anime/GhostInTheShell Batou]] and [[VideoGame/FinalFantasyIV Kain Highwind]].
** And guess what? ''This isn't even all of them!'' (It's roughly about three-quarters.)
** Out of interest, Waspinator used to be [[VideoGame/TheWalkingDeadTelltale Clyde]], Tavia used to be [[VideoGame/{{Skullgirls}} Painwheel]], JORN used to be [[VideoGame/TalesOfMonkeyIsland LeChuck]] and Roadhog used to be [[Anime/{{Bleach}} Kenpachi Zaraki]].
* ''VideoGame/Left4Dead'': [[Film/SawI Detective David Tapp]], [[VideoGame/HalfLife2 Father Grigori]], [[VideoGame/{{Halo}} Cortana]], and [[Series/{{Leverage}} Joey Cospito]] are four ordinary people who fight through hordes of zombies, which include the lead singer of Music/FaithNoMore, [[VideoGame/MarvelUltimateAlliance the Thing]], [[WesternAnimation/SpongeBobSquarePants Squilliam Fancyson]], and [[VideoGame/{{Portal}} GLaDOS]]. Along the way, they are helped by [[VideoGame/SpyFox William the Kid]] and [[VideoGame/TeamFortress2 Heavy, but Spy and Scout]] turn out to be infected.
** ''VideoGame/Left4Dead2'': [[Film/MondayNightMayhem O.J. Simpson]], [[Literature/GenerationKill Cpl. James Chaffin]], [[VideoGame/{{Infamous}} Cole McGrath]], and [[Series/TheForgotten Grace Russell]] are the new survivors.
* ''VideoGame/LegoCityUndercover'': [[VideoGame/XenobladeChronicles2 Perdido]] returns to LEGO City after a 2-year absence after exposing [[VideoGame/MirrorsEdge Faith]] as a secret witness in a trial against [[VideoGame/SpaceChannel5 Jaguar]] only to find out Jaguar has escaped and LEGO City is overrun with crime. With the aid of disguises and a police communicator provided by [[VideoGame/TheWitcher3WildHunt Triss]], Perdido must stop Jaguar's plan and bring him back to jail. [[VideoGame/MassEffectAndromeda Avitus Rix]] is an incompetent recruit, [[VideoGame/{{Deponia}} Rufus]] is the police chief, and [[VideoGame/LegoMarvelSuperheroes2 Kang the Conqueror]] is a billionaire [[spoiler:and Jaguar's boss]].
* ''VideoGame/LegoDCSuperVillains'': [[WesternAnimation/TangledTheSeries King Frederick]] breaks out of prison with the help of a mute and [[Literature/CliffordTheBigRedDog Cleo]]. Meanwhile, [[Franchise/StarWars Luke Skywalker]] and [[WesternAnimation/MyLittlePonyFriendshipIsMagic Twilight Sparkle]] team up with a bunch of other villains to rob the Gotham City Police Department. Things go pear shaped when a team of Super Villains masquerading as Heroes led by [[VideoGame/Portal2 A Defective Turret]] trap the local superheroes, led by [[Anime/FullmetalAlchemistBrotherhood Colonel Roy Mustang]], in an alternate dimension. Now King Frederick, Luke Skywalker, and a bunch of other villains must stop them before they bring [[VideoGame/CommandAndConquerTiberiumWars General Jack Granger]] to earth.
* ''VideoGame/LegoDimensions'': On his quest for Foundational Elements, the evil [[Film/TheDarkKnightTrilogy Commissioner Gordon]] merges the worlds in TheMultiverse into one. It's up to [[Film/ZackAndMiriMakeAPorno Miri]], [[Franchise/ThePowerpuffGirls Professor Utonium]], and [[Franchise/SonicTheHedgehog Espio the Chameleon]] to recruit other characters stop Gordon's plot. Among said characters are [[WesternAnimation/TheAdventuresOfJimmyNeutronBoyGenius Goddard]], [[Film/Scream1996 Stuart Macher]], [[WesternAnimation/FostersHomeForImaginaryFriends Frankie Foster]], [[WesternAnimation/{{Aladdin}} Abu]], [[Series/TheFactsOfLife Natalie]], [[WesternAnimation/APupNamedScoobyDoo Red Herring]], [[WesternAnimation/TheAvengersEarthsMightiestHeroes Captain America]], [[VideoGame/TeamFortress2 Merasmus]], [[VideoGame/StreetFighterIV Chun-Li]], [[WesternAnimation/AvengersAssemble Red Skull]], [[Franchise/ThePowerpuffGirls Mojo Jojo]], [[Anime/TengenToppaGurrenLagann Leeron Littner]], and [[VideoGame/SonicForces Infinite]].
* ''VideoGame/TheLegendOfZeldaBreathOfTheWild'': [[Film/TeenageMutantNinjaTurtles2014 The Japanese Donatello]] wakes up after a long sleep, beckoned by the voice of Princess [[VideoGame/RainbowSixSiege Ash]]. Now, Ash, with the help of Donatello, deceased Champions [[VideoGame/MobiusFinalFantasy a Moogle]], [[Anime/DragonBallSuper Caulifla]], [[WesternAnimation/TransformersWarForCybertronTrilogy Cheetor]] and [[Manga/JojosBizarreAdventureGoldenWind Guido Mista]], and new Champions [[Anime/KingsglaiveFinalFantasyXV a Kingsglaive]], [[VideoGame/Persona5 Sae Niijima]], [[Manga/JojosBizarreAdventureGoldenWind Pesci]] and [[WebAnimation/TheAmazingDigitalCircus Kinger]], must save Hyrule from an ancient evil. Aiding them are Sheikah elder [[WesternAnimation/TheJetsons Jane Jetson]], ghostly king [[Anime/PokemonTheSeries Brock]], Sheikah scientist turned child [[Manga/{{Naruto}} Sakura Haruno]], and Wise Tree [[VisualNovel/DanganRonpaTriggerHappyHavoc Kiyotaka Ishimaru]]. At some point, Donatello ends up fighting [[WesternAnimation/{{Amphibia}} the Japanese Hop Pop]].
** ''VideoGame/HyruleWarriorsAgeOfCalamity'': A small guardian named Terrako goes into the past to help Donatello and Princess Ash SetRightWhatOnceWentWrong, alongside a younger Jane. Along the way, they join forces with the Champions as well as the Korok [[Anime/LoveLive Kotori Minami]], and receive assistance from Sakura and her brother [[VideoGame/StarFoxZero Falco Lombardi]]. They end up fighting the evil sorcerer [[VideoGame/MultiVersus the Iron Giant]], while also dealing with Hop Pop, who is now [[VideoGame/FireEmblemEngage Sombron]], and his henchman [[VideoGame/StreetFighterIV M. Bison]]. [[spoiler:The new guardians also go back in time to help.]] [[VideoGame/BatmanTheTelltaleSeries Vicki Vale]], [[Anime/YoKaiWatchTheMovie Miradox]], [[WesternAnimation/OKKOLetsBeHeroes Wilhamena]] and [[Literature/KonoSuba Megumin]] are a group of Great Fairies, [[VideoGame/BlazBlue Ragna the Bloodedge]] is a horse god, and [[VideoGame/TacticsOgre Jeunan Avertif]] is a Sheikah monk.
** ''VideoGame/TheLegendOfZeldaTearsOfTheKingdom'': Years after ''Breath of the Wild'', Donatello and Ash discover the revival of Demon King [[Anime/DigimonFusion Beelzemon]], resulting in a weakened Donatello having his arm replaced with that of [[VideoGame/FireEmblemThreeHouses Dimitri Alexandre Blaiddyd]]. Donatello must now fight alongside the Sages, which consist of the Kingsglaive, Sae and Pesci from the last game, as well as [[Anime/PokemonJourneysTheSeries Riolu]], [[VideoGame/Persona3Reload Yukari Takeba]], and the aforementioned Dimitri. Meanwhile, Ash is sent into the past where she meets Dimitri and Yukari, as well as Queen [[Literature/SwordArtOnline Asuna Yuuki]]. [[VideoGame/{{Arknights}} Astgenne]] is Sakura's assistant.
* ''VideoGame/LegoMarvelSuperHeroes'': When cosmic bricks are scattered all across the Marvel Universe, [[VideoGame/RatchetAndClank Ratchet]], [[VideoGame/SonicColors Sonic the Hedgehog]], [[VideoGame/MassEffect1 Saren Arterius]], [[Manga/FullmetalAlchemist Roy Mustang]], [[WesternAnimation/MegasXLR Jamie]], [[VideoGame/TheLastOfUs Joel]], [[Manga/FruitsBasket Tohru Honda]], [[WesternAnimation/AmericanDad Klaus]], [[Franchise/KingdomHearts Lexaeus]], and [[Series/TheFlash2014 Cecile Horton]] are among the heroes assembled by [[Anime/SailorMoon Tiger's Eye]] to recover them before they fall into the hands of [[VideoGame/BatmanArkhamCity Solomon Grundy]] and [[VideoGame/TalesOfVesperia Yuri Lowell]]. Eventually, the heroes must [[EnemyMine join forces]] with Grundy and other supervillains to fight [[spoiler:[[WesternAnimation/{{Futurama}} Bender Bending Rodriguez]].]]
* ''VideoGame/LEGOIsland'': [[Franchise/ToyStory Andy Davis]], the adopted son of [[WesternAnimation/{{Mulan}} Grandmother Fa]] and [[Film/TheRock F.B.I. Agent Hunt]], competes in races with [[VideoGame/TYTheTasmanianTiger Lenny the Lyre Bird]] and [[VideoGame/BioShock2 Augustus Sinclair]], and then he helps the cops arrest [[Film/WhoFramedRogerRabbit Smart Ass]].
* ''VideoGame/LetItDie'': [[VideoGame/GrooveCoaster Linka]] operates an elevator for you.
* ''VideoGame/LifeIsStrange'': [[VideoGame/MurderedSoulSuspect Iris/Rose Campbell]] is a TimeMaster who saves [[VideoGame/HorizonZeroDawn Aloy]] from being gunned in the girls' bathroom by [[Series/GeneralHospital Tucker]]. The main Blackwell students include [[WebVideo/EmmaApproved Harriet Smith]], [[VideoGame/Fallout4 Emogene Cabot]], and [[Series/LadyDynamite Jaden]]. [[Film/RealityBites Damien]] is the principal of Blackwell. [[Film/{{Striptease}} Sabrina Hepburn]] is the chemistry teacher. Aloy's mother, [[VideoGame/TheWalkingDeadTelltale Katjaa]], is married to [[Film/TheShawshankRedemption Guard Wiley]], and her deceased father is [[VideoGame/RedDeadRedemption Professor Harold MacDougal]]. [[VideoGame/Fallout4 Elder Maxson]] is both a creepy janitor and a famous teacher [[spoiler:who owns the Dark Room]].
* ''VideoGame/LollipopChainsaw'': [[VideoGame/BatmanArkhamCity Harley Quinn]] is a chainsaw-wielding cheerleader who fights zombies while carrying the still-living (courtesy of some magic taught by [[Series/MortalKombatConquest Shang Tsung]]) severed head of her boyfriend [[WesternAnimation/JusticeLeague The Flash]] on her belt. Harley's sisters are [[Film/ScoobyDoo2002 Velma Dinkley]] and [[VideoGame/NoMoreHeroes Shinobu]], and her parents are [[Series/Castle2009 Winston Wellesley]] and [[VideoGame/MetalGearSolid2SonsOfLiberty Olga Gurlukovich]]. Together, Harley and The Flash must fight baddies such as [[Music/MindlessSelfIndulgence Jimmy Urine]], [[Series/TheWalkingDead2010 Merle Dixon]], [[Franchise/{{Saw}} Amanda Young]], [[WesternAnimation/StarWarsTheCloneWars Pong Krell]] and [[WesternAnimation/TheAvengersEarthsMightiestHeroes Thor]], in order to stop [[Series/GilmoreGirls Kirk Gleason]] from summoning [[spoiler:[[Manga/{{Naruto}} Kakuzu]]]].
* ''VideoGame/LooneyTunesBackInAction'': [[WesternAnimation/TinyToonAdventures Plucky Duck]] and [[WesternAnimation/{{Rugrats}} Grandpa Lou Pickles]] are sent on a mission to retrieve a blue monkey-shaped diamond from the nefarious Acme Corporation, led by the nearsighted [[WesternAnimation/TomAndJerryAndTheWizardOfOz Droopy]].
* ''VideoGame/LostDimension'': [[Anime/YuGiOh The Dark Magician]] leads a crack team of psychic-powered specialists, including [[VideoGame/DeadOrAlive Kasumi]], [[Manga/JojosBizarreAdventureBattleTendency Joseph Joestar]], [[VideoGame/BravelyDefault Agnès Oblige]], [[VideoGame/NierAutomata 2B]], [[Franchise/SonicTheHedgehog Shadow the Hedgehog]], and [[WesternAnimation/MyLifeAsATeenageRobot XJ-9]], to defeat terrorist [[Manga/AttackOnTitan Levi Ackerman]], but some of the Dark Magician's team may be traitors, and he must use his own abilities to discover whom.
* ''VideoGame/LostOdyssey'': [[WesternAnimation/FostersHomeForImaginaryFriends Bloo]], an anmnesiac immortal, was sent on a mission for the empire to check one of their magic engines by [[WesternAnimation/BeautyAndTheBeast LeFou]]. He is joined by [[WesternAnimation/MyLittlePonyFriendshipIsMagic Twilight Sparkle]] and [[VideoGame/SonicAdventure Knuckles the Echidna]]. On his way, he met up his grandchildren [[WesternAnimation/SonicTheHedgehogSatAM Sally Acorn]] and [[WesternAnimation/StarWarsTheCloneWars Asajj Ventress]], the immortal queen [[VideoGame/ResidentEvil4 Ingrid Hunnigan]] and his long forgotten wife [[VideoGame/JadeEmpire Dawn Star]]. Eventually, it turns out that [=LeFou=] was also an immortal and the reason behind the reactor's malfunction and their memories being lost.
* ''VideoGame/LoveNikkiDressUpQueen'': In a world where {{fashion show}}s are SeriousBusiness, [[Manga/CardcaptorSakuraClearCard Tomoyo Daidouji]] embarks on a quest to become the best [[TheFashionista fashionista]] in the land.
* ''VisualNovel/LuxPain'': After a traumatic accident that took his family, [[VideoGame/StreetFighterIV Abel]] becomes a telepath and joins an organisation created to hunt down mental parasites, led by [[Anime/OuranHighSchoolHostClub Kyoya Ohtori]] and co-ordinated by [[Manga/OnePiece Monkey D Luffy]]. He arrives in Kisaragi City with his colleague [[Manga/FruitsBasket Ayame Sohma]] and assisted psychic sensor [[FairyTale Mirajane]], who has a huge crush on him. Between his investigations he settles into the nearby school with his classmates, including [[WebVideo/StarTrekContinues Mr. Spock]], VideoGame/MsSplosionMan, [[Anime/OuranHighSchoolHostClub Kaoru Hitachiin]] and [[Webcomic/HetaliaAxisPowers Sweden]]. Eventually he confronts the strongest of the parasites, buried within the minds of an old man, [[Manga/FullmetalAlchemist Gelb]] and [[VideoGame/StreetFighterIV one of the Street Fighter announcers]].
** Another way of looking at it: Abel's fellow members of FORT are [[Anime/DragonBallZKai Zarbon, Young Gohan (who is also Android 18), Bulma]] and [[Anime/DragonBallZ Vegeta]].
!!M
* ''VideoGame/{{Madagascar}}'': [[Franchise/SonicTheHedgehog Cubot]], [[WesternAnimation/FostersHomeForImaginaryFriends Wilt]], [[WesternAnimation/{{Rugrats}} Alisa Carmichael]], and [[WesternAnimation/StarWarsRebels Wilhuff Tarkin]] are four zoo animals who end up stranded on the island of Madagascar, where they meet King [[VideoGame/{{Overwatch}} Reaper]] the lemur and his subjects [[WesternAnimation/TeenageMutantNinjaTurtles2012 Shredder]] and [[WesternAnimation/SpongeBobSquarePants Bubble Bass]]. The director of ''WesternAnimation/{{Megamind}}'' leads a group of secret agent penguins who help Wilt escape from the zoo. [[Franchise/KingdomHearts Axel]] is a cranky parrot, [[WesternAnimation/TheWildThornberrys Kip Biederman]] is a burly sailor, [[WesternAnimation/The7D Sleepy]] is a warthog with a crush on Alisa, [[WesternAnimation/ThunderCatsRoar Monkian]] is a Russian crocodile that Wilt runs afoul of, and [[VideoGame/MarvelVSCapcom3 Hulk]] is the leader of the fossa that constantly attack Reaper and his subjects.
* ''VideoGame/{{Madworld}}'': [[WesternAnimation/MegasXLR Jamie]], armed with a chainsaw, enters a very brutal and corrupt tournament orchestrated by [[Series/TheATeam "Howling Mad" Murdock]]. [[WesternAnimation/TinyToonAdventures Montana Max]] is caught in the crossfire and [[Manga/{{Naruto}} Killer Bee]] is amongst the mightiest of foes. Featuring hilarious commentary from [[WesternAnimation/TheSpectacularSpiderMan Sandman]] and WesternAnimation/BobTheBuilder.
* ''VideoGame/MadDashRacing'': A wacky foot racing game starring many characters including [[WesternAnimation/TheRenAndStimpyShow Ren and Stimpy]], [[Franchise/SuperMarioBros Mario]], [[VideoGame/CelDamage Fowl Mouth]], [[WesternAnimation/{{CatDog}} Rancid Rabbit]], [[WesternAnimation/{{Futurama}} Phillip J. Fry]], [[WesternAnimation/TheLooneyTunesShow Elmer Fudd]], [[WesternAnimation/{{Doug}} Doug Funnie]], [[WesternAnimation/WackyRaces2017 Muttley]], [[WesternAnimation/The7D Bashful]], [[WesternAnimation/TheAdventuresOfJimmyNeutronBoyGenius Sam Melvick]], [[WesternAnimation/DrawnTogether Popeye]], [[WesternAnimation/MyLifeAsATeenageRobot Principal Rizinski]], and [[VideoGame/TheCluefinders Ms. Rose]].
* ''VideoGame/MafiaII'': After getting back from World War II, [[VideoGame/MarvelVsCapcom3 Stephen Strange]] hooks up with his old friend, [[WesternAnimation/BatmanTheAnimatedSeries Harvey Bullock]] and ultimately joins of the Mafia. Among the bosses that rule the city are [[WesternAnimation/Thundercats1985 Lion-O]], [[VideoGame/XMenDestiny Colossus]], and [[WesternAnimation/YoungJustice2010 Superboy]]. [[Series/ThatsLife Lou Buttafucco]] is an associate of Strange and Bullock's. Stephen is sent to prison for six years by [[WesternAnimation/BatmanTheAnimatedSeries Commissioner Gordon]], where he meets [[VideoGame/DeadSpace3 Austin Buckell]], [[VideoGame/XMenLegends Iron Man]], and [[Anime/SamuraiChamploo Mugen]]. [[Series/LawAndOrder Rebecca Stein]] and [[WesternAnimation/TheOblongs Beth Oblong]] are Stephen's mother and sister respectively, [[VideoGame/TheDarkness Jackie Estacado]] is Stephen's brother-in-law, and WesternAnimation/{{Jackie Chan|Adventures}} is a Triad member. During a break-in Stephen and Harvey have a run-in with [[WesternAnimation/WolverineAndTheXMen2009 Nightcrawler]].
* ''VideoGame/MakaiKingdom'': [[Literature/HaruhiSuzumiya Kyon]], the most badass overlord in the Netherworld, destroys it when he gets enraged by [[Anime/NeonGenesisEvangelion Rei Ayanami]] insulting him through the Sacred Tome. In order to get his body back after confining his soul to the Tome [[spoiler:and pushing out [[VideoGame/TalesOfSymphonia Mithos Yggdrasil]] in the process]], he has to take over Rei's netherworld, along with those of such other Netherworld luminaries as [[VideoGame/DisgaeaHourOfDarkness Vulcanus]], [[VideoGame/BlazBlue Iron Tager]] and [[VideoGame/Disgaea2CursedMemories Axel]].
* ''TabletopGame/MagicTheGathering Arena'': Dimension-hopping wizards fight each other. The closest thing to protagonists are the group known as the Gatewatch, including the Living Guildpact [[VideoGame/MarvelVsCapcom3 Deadpool]], warrior of justice [[VideoGame/LeagueOfLegends Azir]] and ghost-hunter [[VideoGame/FinalFantasyX2 Leblanc]]. One of the main settings is run by guilds, whose guildmasters include Leblanc, the mysterious shapeshifter [[Anime/{{Hellsing}} Alucard]], Grand Arbiter [[VideoGame/TeamFortress2 Medic]], the anarchist [[VideoGame/ValkyriaChroniclesII Avan Hardins]] and the demonic showstopper [[VideoGame/{{Overwatch}} Reinhardt]], as well as one that is ''de facto'' run by [[VideoGame/CallOfDutyGhosts David Walker]] on behalf of a dragon. Other dimensional travellers include the CoolOldLady pyromancer [[VideoGame/DirgeOfCerberus Lucrecia Crescent]], the vampire [[Anime/CodeGeass Jeremiah Gottwald]], the dragon mage [[Anime/CowboyBebop Spike Spiegal]], the beast-summoning mermaid [[VideoGame/TheElderScrollsVSkyrim Vex]], the nightmare sculptor [[Anime/{{Naruto}} Orochimaru]], the artifice master [[VideoGame/MortalKombat11 Geras]] and his boss, the evil elder dragon [[VideoGame/{{Overwatch}} Wrecking Ball]].
* ''VideoGame/ManaKhemiaAlchemistsOfAlRevis'': [[VideoGame/FinalFantasyIV Kain Highwind]] is a young man [[RaisedByWolves raised by a cat]]. One day, he was invited to an alchemy school. His friends in the school's workshop include [[VisualNovel/FateStayNight Saber]], [[Manga/KOn Yui Hirasawa]], [[VideoGame/TalesOfSymphonia Mithos Yggdrasil]], [[VideoGame/KingdomHeartsI Ansem, Seeker of Darkness]], [[VideoGame/TalesOfTheWorld Widdershin]], [[VideoGame/TalesOfVesperia Estelle]], and an alien named [[Manga/{{InuYasha}} Jaken]].
* ''VideoGame/MarvelHeroes'': When [[Series/PowerRangersInSpace Ecliptor]] gets his hands on a very powerful cube, ComicBook/{{SHIELD}} agents [[WesternAnimation/{{Gargoyles}} Goliath]] and [[Series/GeneralHospital Reese Marshall]] gather a bunch of superheroes, including [[VideoGame/TheDarkness Jackie Estacado]], [[WesternAnimation/TeenTitans2003 Killer Moth]], [[VideoGame/BatmanArkhamCity Clayface]], [[WesternAnimation/JLAAdventuresTrappedInTime Lex Luthor]], [[Series/DrakeAndJosh Drake Parker]][[TheOtherDarrin /]][[WesternAnimation/TheLittleMermaid1989 Prince Eric]], and [[Anime/TengenToppaGurrenLagann Leeron]] to stop Ecliptor and his allies, as well as other villains including Clayface's adopted brother [[Anime/EurekaSeven Holland]] and the master of magnetism [[WesternAnimation/StarWarsTheCloneWars Obi-Wan Kenobi]].
* ''VideoGame/MarvelUltimateAlliance 2'': [[WesternAnimation/TransformersAnimated Optimus Prime]] and [[VideoGame/TransformersWarForCybertron Breakdown]] have [[ComicBook/CivilWar2006 a political quarrel]] [[spoiler: that's interrupted by {{nanomachines}} who end up turning [[Manga/InuYasha Sesshoumaru]] into an evil cyborg]].
* ''VideoGame/MarvelVSCapcom3'': [[Manga/InuYasha Naraku]] and [[VideoGame/MassEffect2 Legion]] team-up to conquer their respective universes. Unfortunately for them, their plans have unleashed another threat from Naraku's universe: the PlanetEater known as [[WesternAnimation/GreenLanternTheAnimatedSeries Atrocitus]].
** From the same universe as Naraku and Atrocitus: The shield-wielding SuperSoldier [[WesternAnimation/GIJoeRenegades Zartan]], the PoweredArmor-clad [[Anime/CrayonShinChan Hiro Hohara]], the God of Thunder [[VideoGame/DragonAgeII Arishok]], the savage [[Franchise/MassEffect Saren Arterius]], and his cousin [[Series/WizardsOfWaverlyPlace Theresa Russo]] are part of a team of superheroes who have to deal with enemies like the move-copying [[WesternAnimation/Ben10 Vilgax]] and A.I.M., led by [[WesternAnimation/TheGarfieldShow Jon Arbuckle]]. The telepathic and telekinetic [[VideoGame/TalesOfSymphonia Sheena Fujibayashi]], the feral [[Anime/DigimonTamers Guilmon]] and his OppositeSexClone [[WesternAnimation/TeenTitans2003 Raven]], and the weather controlling [[Franchise/{{Naruto}} Haku]] are part of another team of superheroes who regularly deal with enemies like [[WesternAnimation/TheWildThornberrys Darwin]], the Master of Magnetism, the mutant-hunting robot series [[WesternAnimation/DannyPhantom Bertrand]], and [[WesternAnimation/TransformersPrime Smokescreen]], the Merc with a Mouth. WesternAnimation/{{Hercules}} is a young man with spider-like superpowers, [[Series/ThePretender Jarod]] is an EldritchAbomination, and [[WesternAnimation/CowAndChicken the Red Guy]] is an alien with the powers of the Fantastic Four (whom regularly oppose Naraku, Red Guy, and Atrocitus). For DLC, [[Manga/RanmaOneHalf Happosai]] is another EldritchAbomination.
** From Legion's universe: [[Manga/{{Bleach}} Shinji Hirako]] is a member of the BSAA and opposes Legion, [[Anime/TengenToppaGurrenLagann Kamina]] is a wandering martial artist, [[Manga/SoulEater Maka Albarn]] is an Interpol agent, [[Manga/{{Monster}} Petr Capek]] is Kamina's EvilCounterpart, [[Anime/LupinIII Fuijko Mine]] is a spy, [[Series/BigTimeRush Arthur Griffin]] is the mayor of Metro City, [[Manga/TriGun Vash the Stampede]] is Dr. Wily's final creation, [[VideoGame/{{Tekken}} Anna Williams]] is a genius pirate, [[VideoGame/StreetFighterIV Ken Masters]] is a demon hunter, [[ArtificialHuman Artificial Demon]] [[Series/TheWalkingDead2010 Judy]] is Ken's lover, [[Anime/DragonBallZ Cell]] is a cyborg commando, [[Literature/{{Durarara}} Mikado Ryugamine]] is an AscendedFanboy, [[Manga/SpaceAdventureCobra Cobra]] is a knight, [[Anime/RODTheTV Wendy Earhart]] is a [[SuccubiAndIncubi succubus]], [[VideoGame/StreetFighterXTekken Asuka Kazama]] is a CatGirl, [[Manga/GirlsBravo Lisa Fukuyama]] is a [[ChineseVampire jiang-shi]]. There's also a sun goddess wolf and for DLC, [[Anime/EurekaSeven Anemone]] is an ally of Shinji's who is BrainwashedAndCrazy by Legion.
** ''Ultimate Marvel vs. Capcom 3'': All of the above (including Happosai and Anemone) are joined by...
*** From Naraku and Atrocitus's universe: Archer [[WesternAnimation/JusticeLeague Captain Atom]] (who's a teammate of Zartan, Hiro, Arishok, Saren, and Theresa), Sorcerer Supreme [[VideoGame/MafiaII Vito Scaletta]] (who regularly deals with creatures like, ''and'' including, Jarod and Happosai), the motorcycle-riding Spirit of Vengeance [[Series/TwentyOneJumpStreet Dennis Booker]], Heroes for Hire founder [[WesternAnimation/BatmanTheAnimatedSeries Nightwing]], [[SpacePolice Nova Corps]] member [[WesternAnimation/GeneratorRex Van Kleiss]], and alien raccoon SpacePolice officer [[WesternAnimation/TeenTitans2003 Malchior]].
*** From Legion's universe: Ken's twin brother [[Series/PowerRangersTimeForce Eric Myers]], photojournalist [[Series/PowerRangersInSpace Dark Specter]], ninja [[VideoGame/DeadRising Brad Garrison]], and lawyer [[WesternAnimation/TeenageMutantNinjaTurtles2003 Donatello]]. There's also a mutant zombie who's crossed paths with Shinji and Anemone and a gargoyle who's crossed paths with Cobra.
* ''VideoGame/MarvelVsCapcomInfinite'': The genocidal androids [[ComicBook/DCTheNewFrontier Slam Bradley]] and [[WebComic/OnePunchMan Tank-Top Tiger]] team up, even [[TwoBeingsOneBody fusing into one]]. To stop them, the heroes of the universes must turn to [[WesternAnimation/JusticeLeagueCrisisOnTwoEarths Wonder Woman]]'s adopted father, [[VideoGame/TransformersWarForCybertron Soundwave]] (who's obsessed with [[Manga/YoKaiWatch Jibanyan]]), for help. Zartan, Hiro, Saren, Kamina, Shinji, Ken, Wendy, Brad, Vash, Captain Atom, Dark Specter, Cobra, Arthur, and Cell remain the same, but now Arishok is [[VideoGame/BatmanTheTelltaleSeries Two-Face]], Malchior is [[Manga/BlackLagoon Mr. Chang]], Hercules is now [[WesternAnimation/{{Breadwinners}} SwaySway]], Vito is [[Manga/{{Naruto}} Gaara]], Maka is now [[Manga/AttackOnTitan Sasha Braus]], Van Kleiss is now [[WesternAnimation/HeyArnold Eugene Horowitz]], Dennis is now [[WesternAnimation/MarvelsSpiderMan Max Modell]], and Jarod is now WesternAnimation/SamuraiJack. In addition to Wonder Woman, they're joined by [[VideoGame/MetalGearSolid Sigint]], [[WesternAnimation/GIJoeResolute the Baroness]], [[Manga/IkkiTousen Koukin Shuuyu]], [[WesternAnimation/Ben10Omniverse Khyber]], [[VideoGame/TheWalkingDeadTelltale Clementine]], Zartan's former sidekick [[VideoGame/Injustice2 Robin]], spy (and teammate of Zartan, Hiro, Two-Face, Saren, Captain Atom, and Signit) [[VideoGame/BloodRayne Rayne]], and the symbiotic [[Series/{{Grimm}} Zerstörer]]. Additionally, the gargoyle is [[WesternAnimation/BeastWars Cheetor]], the mutant zombie is now [[Series/{{Stitchers}} Quincy Fisher]], and [[WesternAnimation/TransformersPrime Bulkhead]] is a plant creature that helps Wonder Woman and Mr. Chang.
* ''Franchise/MassEffect'':
** ''VideoGame/MassEffect1'': [[VideoGame/DragonAgeII Jethann]] (or [[VideoGame/KnightsOfTheOldRepublic Bastila]], depending on your gender) is asked by [[VideoGame/ModernWarfare Sgt. Foley]] and [[WesternAnimation/TransformersAnimated Lockdown]] to defeat [[Manga/{{Naruto}} Kakuzu]], a rouge Citadel agent who is assisted by [[WesternAnimation/{{Gargoyles}} Demona]], before he ends humanity. To accomplish this, Jethann/Bastila creates a team consisting of [[WesternAnimation/AtlantisTheLostEmpire Cookie]], [[VideoGame/BatmanArkhamSeries Oracle]], [[Film/AustinPowers Scott Evil]], [[Manga/{{Naruto}} Karin]], [[Series/BuffyTheVampireSlayer Lance Brooks]], [[Anime/BloodPlus Anna-Marie]], and [[VideoGame/StarWarsRepublicCommando Scorch]].
*** And Bastila can have sex with [[VideoGame/KnightsOfTheOldRepublic Carth Onasi]]. Curious implications, there.
** ''VideoGame/MassEffect2'': After dying in an ambush from a species known as the Collectors, Jethann/Bastila is revived by [[Series/TheWestWing President Josiah Bartlet]]'s organization to investigate themi and their connection with the Reapers. Accompanied by [[Series/TwentyFourLiveAnotherDay Kate Morgan]] and [[Series/TheYoungAndTheRestless Nathan Hastings]], Jethann/Bastila puts together a team of specialists including Lance, Anna, [[WesternAnimation/OKKOLetsBeHeroes KO]], [[Anime/TengenToppaGurrenLagann Leeron Littner]], [[WesternAnimation/CareBearsNutcrackerSuite the Nutcracker]], and [[VideoGame/{{Skylanders}} Eruptor]] to stop their threat. In the process, the team gets a surprising additional membber in the form of [[VideoGame/ResidentEvil Albert Wesker]]. Jethann/Bastila also gets a new ship with [[WesternAnimation/TheSpectacularSpiderMan Black Cat]] as a helpful AI.
** ''VideoGame/MassEffect3'': With Earth under invasion by the Reapers, Sgt. Foley has Jethann/Bastila reinstated under alliance miltary to put a stop to the threat. He/she [[PuttingTheBandBackTogether reunites the old team]] of Carth/Oracle, Anna, Lance, Karin, and newcomer [[WesternAnimation/StarWarsRebels Kanan Jarrus]], while Black Cat gains an artifical body to begin assisting the team on assignments. [[VideoGame/Injustice2 Atrocitus]] also can join the team. However, President Bartlet has employed [[VideoGame/LegoBatman Batman]] as his new enforcer to get in the team's way.
* ''VideoGame/MasterDetectiveArchivesRainCode'': [[VisualNovel/DanganronpaV3KillingHarmony [=K1=]-[=B0=]]] is an amnesiac Master Detective for the World Detective Organization who solves seemingly impossible mysteries alongside his ghostly partner [[VideoGame/GenshinImpact Dori]]. They work with the Nocturnal Detective Agency under the guidance of [[VideoGame/YakuzaLikeADragon Ichiban Kasuga]], whose members include fellow Master Detectives [[Franchise/StreetFighter Luke]], [[VideoGame/FireEmblemEngage Kagetsu]], [[Manga/{{Keijo}} Nozomi Kaminashi]], and [[VideoGame/Persona5 Haru Okumura]], each of whom have special detective fortes that help them solve mysteries around the world. In their way however is the shady MegaCorp that runs Kanai Ward known as Amaterasu Corporation, whose peacekeepers are headed by [[VideoGame/OctopathTravelerII Hikari Ku]] and his second-in-command [[VideoGame/TokyoMirageSessionsFE Eleonora Yumizuru]]
* ''VideoGame/MegaMan11'': [[WesternAnimation/CodenameKidsNextDoor Numbuh One]], helped by his creator [[VideoGame/FireEmblemGaiden Mycen]], his sister [[WebAnimation/HelluvaBoss Loona]], his dog [[WebVideo/HonestTrailers the Honest Trailers epic voice guy]] and the goofy robot [[VideoGame/FireEmblemGaiden Boey]], must stop [[WesternAnimation/OKKOLetsBeHeroes Ted Viking]]'s new plan to use Mycen's robots [[VideoGame/StreetFighterV Necalli]], [[Manga/FairyTail Natsu Dragneel]], [[Manga/HunterXHunter 2011 Illumi Zoldyck]], [[WebAnimation/TheTransformersCombinerWars Optimus Prime]], [[VideoGame/StreetFighterV F.A.N.G]], [[VideoGame/FireEmblemGaiden Silque]], [[Manga/OnePiece Spandam]] and [[Franchise/StreetFighter Cody]] to conquer the world thanks to an old grudge.
* ''VideoGame/MegaManX7'': [[VideoGame/TheKingOfFighters Kyo Kusanagi and Iori Yagami]] must team up with newbie [[VideoGame/{{Tekken}} Anna Williams]] to stop their new foe [[VideoGame/ResidentEvil Barry Burton]] and their old enemy [[VideoGame/BloodyRoar Xion]]. They are lead by [[VideoGame/CastlevaniaSymphonyOfTheNight Alucard]] and have the support of [[VideoGame/BloodyRoar Alice Nonomura]].
* ''VideoGame/MegaManX8'': [[Anime/MobileFighterGGundam Domon Kasshu]], [[Manga/FlameOfRecca Kashamura]], and [[Manga/DokiDokiSchoolHours Kenta Suetake]] team up to save [[Manga/HunterXHunter 1999 Gon Freecss]] from [[Anime/MobileFighterGGundam Chibodee Crockett]], who was last seen exploding in ''X3''. It turns out that [[Anime/MobileFighterGGundam Master Asia]] is pulling the strings once more and trying to get Mavericks to migrate to the Moon and abandon Earth. The trio is led by [[Anime/MobileFighterGGundam Chibodee]] and supported once more by [[Manga/CeresCelestialLegend Aya]], who is now joined by two more navigators: [[Anime/MobileSuitZetaGundam Reccoa Londe]] (who is [[HopelessSuitor hopelessly smitten]] with Kashamura) and a less loli [[Anime/DiGiCharat Dejiko]].
* ''VideoGame/MetalGearSolid'': [[Manga/{{Guyver}} Sean Barker]] is deployed to a remote island in Alaska, where he meets up with his old friend, [[WesternAnimation/TheGrimAdventuresOfBillyAndMandy Grim]] ([[WesternAnimation/DannyPhantom Jack Fenton]] in the Gamecube remake) and fights with his brother, [[Manga/{{Bleach}} Yasochika Iemura]], whose underlings include [[Anime/DigimonDataSquad Director Hashima]], [[VideoGame/DissidiaFinalFantasy Ultimecia]], and [[VideoGame/XMenLegends Sabretooth]]. Along the way, [[Manga/{{Naruto}} Tsunade]] falls in love with him. He's guided by [[WesternAnimation/Ben10 Max Tennyson]], with help from [[WesternAnimation/TotallySpies Sam]], [[Series/GuidingLight ER Doctor Tompkins]] and [[Franchise/DotHack Subaru]].
** ''VideoGame/MetalGearSolid2SonsOfLiberty'': After Sean's mission aboard a tanker commanded by [[WesternAnimation/ThunderCats2011 Panthro]], he is replaced by [[Manga/{{Naruto}} Iruka Umino]], who flies out to the site of an oil spill, where he has to make contact with [[WesternAnimation/Ben10UltimateAlien Old George]], gets his crotch grabbed by [[VideoGame/LegacyOfKain Vorador]], and has to save [[VideoGame/BrutalLegend Ophelia]], who is Tompkins' sister. There, he is helped by [[VideoGame/CrashBandicoot Aku Aku]], who killed his soul, and fights villains including [[Film/PulpFiction Marvin]] and [[VideoGame/PrinceOfPersia Vizier]]. It turns out that [[WesternAnimation/TheJetsons Elroy Jetson]] was behind everything. Or possibly [[WesternAnimation/TeenageMutantNinjaTurtles1987 Leonardo]]. Or was it [[Series/StarTrekTheNextGeneration Loquel]]?
** ''VideoGame/MetalGearSolid3SnakeEater'': Sean's father, [[WesternAnimation/SpiderManTheAnimatedSeries Captain America]], guided by [[WesternAnimation/TheLionKing1994 Zazu]], goes to the Soviet Union to kill [[Franchise/SpyroTheDragon Moneybags]] and his former mentor, [[WesternAnimation/SpongebobSquarepants Pearl Krabs]]. He also gets into a fight with Major WesternAnimation/{{Hercules}} and rescues [[WesternAnimation/BeautyAndTheBeast a stove]].
** ''VideoGame/MetalGearSolid4GunsOfThePatriots'': Sean, now an old man assisted by a cyborg Iruka, his adoptive daughter [[VideoGame/ViewtifulJoe Silvia]], and Tsunade, accepts a mission from Max to terminate his brother/rival Elroy, who commands Marvin and four mentally disturbed women: [[VideoGame/NoMoreHeroes Silvia Christel]], [[WesternAnimation/GIJoeRenegades Lady Jaye]], [[WesternAnimation/TheProudFamily Oprah Winfrey]], and [[VideoGame/SaintsRow1 Luz Avalos]], [[spoiler:the last of whom is controlled by [[Series/BeetleborgsMetallix the Dragonborg]]]]. Along the way, [[spoiler:Sean meets his mother [[Series/AllMyChildren Ruth Martin]], Ophelia turns out to have nanomachines that stop her cancer from killing her, and Tsunade marries [[VideoGame/GodHand Gene]]. In the end, Sean tries to commit suicide, but is stopped by [[WesternAnimation/WolverineAndTheXMen2009 Senator Kelly]]]].
** ''VideoGame/MetalGearSolidPortableOps'': Captain America travels to South America to confront the super soldier, [[WesternAnimation/TheAvengersEarthsMightiestHeroes Red Skull]] and his psychic underling, [[WesternAnimation/TransformersAnimated Sari Sumdac]]. Along the way, he learns that the stove isn't dead and encounters his old comrade, [[VideoGame/CrashBandicoot Dingodile]].
** ''VideoGame/MetalGearSolidPeaceWalker'': Captain America is back in South America, accompanied by [[VideoGame/JakAndDaxter Captain Phoenix]], where they encounter the KGB agent [[WesternAnimation/TheSpectacularSpiderMan Green Goblin]]. They get involved in a conflict between [[Franchise/TombRaider Natla]] and mechanical monsters created by [[WesternAnimation/YoungJustice2010 Black Canary]]. The final boss fight is against [[spoiler:[[WesternAnimation/TheFairlyOddParents Timmy Turner]] piloting a Metal Gear]].
** ''VideoGame/MetalGearRisingRevengeance'': Iruka goes up against a corporation backed by the corrupt senator [[Franchise/MassEffect Councilor Sparatus]], who's subordinates include Iruka's rival [[VideoGame/HaloReach Noble 6]], Sparatus' second-in-command [[VideoGame/BatmanArkhamOrigins Firefly]], the magnetic [[WesternAnimation/Ben10 Zombozo]], and FemmeFatale [[VideoGame/SpiderManWebOfShadows Black Widow]]. Iruka's also assisted by allies such computer specialist [[WesternAnimation/WolverineAndTheXMen2009 Emma Frost]], pointman [[WesternAnimation/BewareTheBatman Alfred Pennyworth]], military advisor [[WesternAnimation/YoungJustice2010 Aquaman]], and cybernetics expert [[VideoGame/TransformersFallOfCybertron Perceptor]].
** ''[[VideoGame/MetalGearSolidVThePhantomPain Metal Gear Solid V: Ground Zeroes]]'': One year after ''Peace Walker'', Captain America -- [[TheOtherDarrin who has suddenly aged into]] [[Series/TwentyFour Jack Bauer]] -- must rescue [[VideoGame/GodOfWar young Kratos]], [[WesternAnimation/SuperMarioWorld Hip and Hop]] from [[WesternAnimation/TransformersPrime Wheeljack]]. [[spoiler:Bauer performs a messy emergency surgery on Hip and Hop, who then explode violently, sending Bauer into a coma.]]
** ''VideoGame/MetalGearSolidVThePhantomPain'': After waking up from a coma, Jack Bauer travels to Africa with [[CelebrityVoiceActor a model]] to deal with Hercules (who is now [[VideoGame/Persona4 Kanji Tatsumi]]), [[WesternAnimation/TransformersPrime Wheeljack]], [[WesternAnimation/TheGrimAdventuresOfBillyAndMandy Yogi Bear]], and [[WesternAnimation/LittleEinsteins Leo]]. [[spoiler: Leo turns out to be [[LukeYouAreMyFather Jack's son/clone]] and the future Yasochika. Also a young Dragonborg is there]].
* ''VideoGame/MetroidPrime'': [[WesternAnimation/ThePowerpuffGirls1998 Princess Morbucks]] is an intergalactic bounty hunter on a mission to save the galaxy from a group of rouges known as the Space Pirates who killed her entire family.
* ''VideoGame/MinecraftStoryMode'': [[WesternAnimation/WeBareBears Nom Nom]] (or alternatively [[WesternAnimation/StarWarsCloneWars Padme Amidala]]), along with his pet pig [[WesternAnimation/PhineasAndFerb Perry]] and their best friends; [[https://en.wikipedia.org/wiki/Hair_High Crumbles]], [[WesternAnimation/StevenUniverse Sour Cream]], and [[VideoGame/TheLastOfUs Ellie]] go on an adventure to destroy an EldritchAbomination created by [[Film/PeeWeesBigAdventure Pee-wee Herman]] while searching for the members of a group of heroes, consisting of [[VideoGame/TheWalkingDeadTelltale Lee Everett]] and [[WesternAnimation/AvatarTheLastAirbender Azula]].
* ''VideoGame/MirrorsEdge'': [[WesternAnimation/ThomasAndFriends Alicia Botti]] is a parkour messenger who is ordered around by [[Film/SavingPrivateRyan Doyle]]. When her sister is framed for a crime, Alicia searches the city for her.
* ''VideoGame/MonkeyIsland'': [[WesternAnimation/HeyArnold The Stoop Kid]] is a mighty pirate who fights against the evil Ghost Pirate [[Series/WhosTheBoss Jim Peterson]].
** ''VideoGame/TalesOfMonkeyIsland'': The Stoop Kid seeks a cure from Peterson's pox spreading around the Caribbean. He finds a first mate in [[Franchise/ThePowerpuffGirls Mojo Jojo]], while MadScientist [[VideoGame/SamAndMaxFreelancePolice Bluster Blaster]] hires pirate assassin [[VideoGame/{{Psychonauts}} Lili Zanotto]] to exterminate him.
* ''VideoGame/MonsterHunter World'': The player character, assisted by their handler, [[VideoGame/ShinMegamiTenseiIV Isabeau]], the commander, [[Literature/FateZero Alexander The Great]], his son and field officer [[Literature/FateZero Kiritsugu Emiya]] and the admiral [[Manga/JojosBizarreAdventure Joseph Joestar]] explores the new world fighting unique monster and discovering why an elder dragon is going there.
* ''VideoGame/MonsterHunterRise'':
** A hunter [[note]] who is either [[VideoGame/FireEmblemThreeHouses Ferdinand Von Aegir]], [[Manga/DemonSlayerKimetsuNoYaiba Zenitsu Agatsuma]], [[VideoGame/Persona5 Ren Amamiya]], [[Literature/SwordArtOnline Kirito]], [[Manga/JoJosBizarreAdventureGoldenWind Giorno Giovanna, Diavolo]], [[VideoGame/MortalKombatX Johnny Cage]], [[VideoGame/CrisTales Lucio]], [[VideoGame/WarioWare 5-Volt]], [[VideoGame/Persona3 Aigis]], [[Anime/DevilmanCrybaby Sirene]], [[VideoGame/MonsterHunterWorld The Handler]], [[Anime/DragonBallSuper Kale]], [[VideoGame/Persona5Strikers Sophia]], [[VideoGame/ThereIsNoGameWrongDimension Gigi]], [[Anime/LittleWitchAcademia2017 Croix Meridies]] or [[WesternAnimation/TransformersWarForCybertronTrilogy Elita-One]][[/note]] has to hunt monsters and investigate why they are on a rampage. They are helped by the Village Elder [[VideoGame/MarvelVSCapcomInfinite Sigma]], the twin Wyverian sisters [[Literature/SwordArtOnline Quinella]] and [[VideoGame/FireEmblemHeroes Elincia]], Dango cook and princess of a destroyed kingdom [[Manga/DemonSlayerKimetsuNoYaiba Shinobu Kocho]], mysterious salesman [[Manga/FairyTail Natsu Dragneel]], TotallyRadical ninja [[Literature/SwordArtOnline Eugeo]], cat and dog handler [[Manga/DemonSlayerKimetsuNoYaiba Yushiro]] and master weaponsmith [[VideoGame/DragonBallZKakarot Frieza]].
** ''Monster Hunter Rise: Sunbreak'': At the request of the travelling foreinger [[Manga/JojosBizarreAdventure Aya Tsuji]], the hunter travels to the land of Elgado where they are helped by Aya's sister and knight of the kingdom [[Anime/MobileSuitGundamSeedDestiny Talia Gladys]] to investigate a mysterious creature called the Qurio. They are assisted with the admiral [[VideoGame/ArenaOfValor Tachi]], Wyverian scientist [[WesternAnimation/SealTeam Benji]], kingdom's princess [[VisualNovel/HigurashiWhenTheyCry Hanyuu]], weaponsmith with a smile [[Manga/{{Boruto}} Sarada Uchiha]], shopkeeper with a love for money puns [[VideoGame/ShinMegamiTenseiV Aogami]], Arena Master [[Manga/HunterXHunter Hisoka]], young excitable hunter [[Manga/DemonSlayerKimetsuNoYaiba Muichiro Tokito]] and firm lady who is secretly a BloodKnight [[Anime/Berserk2016 Casca]]. After Talia got infected by a virus thanks to the Qurio, the hunter must find Wverian doctor [[Manga/JujutsuKaisen Megumi Fushiguro]] in order to find an antidote.
* ''VideoGame/MonstersIncScreamTeam'': [[WesternAnimation/DuckTales1987 Doofus Drake]] and [[WesternAnimation/RockosModernLife Rocko]] are chosen by [[Film/HudsonHawk George Kaplan]] to go to the mysterious Scare Island in order to train to become Top Scarers. [[WesternAnimation/FindingNemo Mr. Ray]] shows the two the basics of their training.
* ''Franchise/MortalKombat'':
** ''VideoGame/MortalKombatVsDCUniverse'':
*** [[Manga/{{Hellsing}} Luke Valentine]] and a supervillain merge into one being, then spread a HatePlague among both of their universes in an attempt to make them destroy each other.
*** The warriors of Luke's universe are [[Manga/{{Bleach}} Zangetsu]], [[VideoGame/{{Diablo}} the Necromancer]], [[Webcomic/HetaliaAxisPowers Germany]], [[VideoGame/MortalKombat9 Skarlet]], a BruceLeeClone, an EvilSorcerer, a fanged guy with dual wristblades, AnIcePerson, a ScaryBlackMan with mechanical arms, and [[Anime/{{Pokemon}} Delia Ketchum]].
*** The warriors of the supervillain's universe are [[Manga/{{Bleach}} Wonderweiss Margera]], a certain Caped Crusader, [[VideoGame/TransformersWarForCybertron Skywarp]], [[Manga/{{Naruto}} Temari]], [[Manga/OnePiece Franky]], [[VideoGame/WorldOfWarcraft Varos Cloudstrider]], [[VideoGame/MarvelUltimateAlliance Namor the Sub-Mariner]], [[Manga/IkkiTousen Genjou Kakouton]], [[VideoGame/StreetFighterIV Adon]], and [[VideoGame/WorldOfWarcraft Sylvanas]].
%%** ''VideoGame/MortalKombat9'':
%%** ''VideoGame/MortalKombatX'':
** ''VideoGame/MortalKombat11'': [[Manga/{{Naruto}} Kurenai Yuhi]] seeks balance in all realms by working with [[WesternAnimation/WolverineandtheXMen2009 Phoenix]], causing a merger of the timelines. Thunder God [[Manga/JojosBizarreADVENTUREStardustCrusaders Joseph Joestar]] and [[Series/CsiNY Bryce Sweet]] must stop her before she can make everyone her slaves, enlisting help from [[VideoGame/SOulCaliburVI Sophitia]] the Shinnok Slayer, the WesternAnimation/{{Wolverine|AndTheXMen2009}}, they must also erase the present-day revenants of [[VideoGame/BlazBlue Rachel Alucard]], [[VideoGame/Injustice2 the Atom]], [[Anime/WitchHunterRobin Robin Sena]], among others...but [[VideoGame/TeamFortress2 Saxton Hale]] is only interested in money and so started a fight club to do so. Meanwhile, [[VideoGame/TeamSonicRacing Knuckles the Echidna]] is a fixed point in time and cannot die, ever, so he had to sink in the bottomless Sea of Blood. Fast forward to ''Aftermath'', [[VideoGame/Injustice2 Atrocitus]] wants to take the Hourglass' power for himself, making love with a revived [[VideoGame/FOrtNite Luna]]...but they all die at the hands of Evil Sorcerer [[Film/LicencetoKill Kwang]], who seeks to rule even time itself.
* ''VideoGame/MugenSouls'': [[VideoGame/{{Skullgirls}} Bloody Marie]], a tiny tyrant overlord, declares her plans to conquer seven rainbow-colored worlds by turning all of its inhabitants into bunny people. Aiding her in her quest are [[VideoGame/Disgaea3AbsenceOfJustice Almaz]], her fiercely loyal but easily-flustered vassal, and [[Anime/HaibaneRenmei Rakka]], an angel who desperately wants to be a demon. [[VideoGame/InjusticeGodsAmongUs Joker]] is a noble village guardian.
** ''Mugen Souls Z'': Thanks to a mishap involving a cursed coffin, Marie becomes ''even tinier'', leaving her to ride around atop the head of dimwitted heroine [[Anime/FairyTail Lucy Heartfilia]] as they quest to undo the effects with the help of Lucy's more intelligent companion [[WesternAnimation/HiHiPuffyAmiYumi Ami Onuki]].
* ''VideoGame/{{MultiVersus}}'': A MascotFighter starring various characters from Creator/WarnerBros and Creator/CartoonNetwork properties, including the youngest daughter of a family of lords [[Film/TheNewMutants Wolfsbane]], the wacky cat and mouse duo [[WesternAnimation/RiseOfTheTeenageMutantNinjaTurtles Splinter]] and [[WesternAnimation/{{Breadwinners}} Buhdeuce]], RascallyRabbit [[WesternAnimation/{{Unikitty}} Master Frown]], destructive Tasmanian Devil [[WesternAnimation/SonicTheHedgehogSatAM Dr. Robotnik]], Martian invader [[WesternAnimation/MuppetBabies2018 Fozzie Bear]], vigilante superhero [[WesternAnimation/TheVentureBrothers Captain Sunshine]], good-natured superhero [[VideoGame/DissidiaFinalFantasy Sephiroth]], AmazonianBeauty [[Manga/DemonSlayerKimetsuNoYaiba Nezuko Kamado]], mischievous harlequin [[WesternAnimation/MyLittlePonyFriendshipIsMagic Twilight Sparkle]], corrupt antihero [[VideoGame/StreetFighterIV Balrog]], superpowered teenager [[Film/Scream1996 Stuart Macher]] and his billionaire uncle [[WesternAnimation/MickeyAndTheRoadsterRacers Donald Duck]], bespectacled genius [[WesternAnimation/{{Unikitty}} Dr. Fox]], rubbery adventuring human [[VideoGame/CookieRunKingdom GingerBrave]] and his equally rubbery dog [[WesternAnimation/{{Futurama}} Bender]], kindhearted robot [[VideoGame/HyruleWarriorsAgeOfCalamity Astor]], gem-powered boy [[WesternAnimation/SpiritRidingFree Pete]], gem-powered alien [[Series/{{Empire}} Delphine]], reindeer-dog hybrid [[WesternAnimation/{{Jellystone}} Fancy-Fancy]], real-life basketball player [[VideoGame/FireEmblemWarriorsThreeHopes Rufus Thierry Blaiddyd]], mad scientist [[WesternAnimation/FishHooks Oscar Fishtooth]] and his dimwitted grandson [[WesternAnimation/Invincible2021 Doug Cheston]], and small gremlin [[VideoGame/TransformersTheGameConsole Starscream]].
* ''VideoGame/MySims'': [[WesternAnimation/TeenTitans2003 Beast Boy and Robin]] are a bellhop and an extreme daredevil respectively. In other games, we also get to hear [[Franchise/ThePowerpuffGirls Mojo Jojo, a different Robin]] and ''[[Series/TalesFromTheCrypt the Crypt Keeper!]]''
!!N
* ''VideoGame/NeoContra'': [[Manga/OutlawStar Gene Starwind]] and his partner [[Anime/CowboyBebop Jet Black]] must fight a terrorist organization led by [[Anime/CowboyBebop Spike Spiegel]]. The members of said terrorist organization includes [[VideoGame/DynastyWarriors Zhang Fei]], [[Anime/DigimonAdventure Gabumon]], and [[Anime/CowboyBebop Faye Valentine]]. [[Franchise/BlazBlue Valkenhayn R. Hellsing]] is Gene's mentor.
* ''VideoGame/NeonWhite'': [[Anime/CowboyBebop Spike Spiegel]] is an amnesiac sent to heaven to dispose of various demons plaguing the afterlife for a chance to gain eternal peace. Along the way, he encounters other Neons like him fighting for a chance at redemption, including [[Anime/YoKaiWatch Jibanyan]], [[VideoGame/CookieRunKingdom Squid Ink Cookie]], [[WesternAnimation/OKKOLetsBeHeroes Radicles]], and [[VideoGame/ThirteenSentinelsAegisRim Renya Gouto]], all of whom have some connection to Spike from when he was alive. In Heaven, they meet various angels, including [[VideoGame/GodOfWarRagnarok Ratatoskr]], [[VideoGame/FireEmblemThreeHouses Hilda Valentine Goneril]], and [[Anime/PokemonJourneysTheSeries Goh]].
* ''VideoGame/NewPokemonSnap'': Professor [[VideoGame/FireEmblemThreeHouses Dedue]] and his apprentice [[WebAnimation/PokemonTwilightWings Nessa]] want you to take pictures of wild (and sometimes [[PowerGlows glowing]]) Pokémon. Later on, [[VideoGame/PacManAndTheGhostlyAdventures Pac-Man]] joins the team, along with his mentor [[{{Manga/Kakegurui}} Ryota Suzui]], who was also the protagonist of the previous game.
* ''VideoGame/NickelodeonAllStarBrawl'' (Post-June 6, 2022): In this MascotFighter starring various Creator/{{Nickelodeon}} and Creator/{{Viacom}} properties, players can take control of cheerful frycook [[WesternAnimation/WanderOverYonder Commander Peepers]], dim-witted starfish [[WesternAnimation/TransformersAnimated Bulkhead]], karate-loving Texan [[VideoGame/SpyroYearOfTheDragon Zoe the Fairy]], a cheery Airbender[[note]]Dustin Sardella, Aang's voice actor in this game, doesn't have any works with pages on TV Tropes at the moment[[/note]], talented blind girl [[WesternAnimation/TangledTheSeries Angry]], hot-headed Avatar [[WesternAnimation/Injustice2021 Wonder Woman]], down-to-earth youth [[Anime/Belle2021 Angel]], depressing goth girl [[WesternAnimation/AdventureTime Flame Princess]], focused leader [[Manga/{{Akira}} Shotaro Kaneda]], pizza-loving party dude WesternAnimation/TheTick, intrepid news reporter [[VisualNovel/PhoenixWrightAceAttorneySpiritOfJustice Maya Fey]], ill-tempered dog and bumbling cat duo [[Film/SpaceJam Bugs Bunny]] and [[WesternAnimation/{{Futurama}} Phillip J. Fry]], powdered toast mascot [[WesternAnimation/BeastWars Megatron]], incompetent alien invader [[WebAnimation/HelluvaBoss Moxxie]], conjoined twins WesternAnimation/DarkwingDuck and [[WesternAnimation/TheSuperHeroSquadShow Captain America]], multi-media {{Notzilla}} [[VideoGame/TheIncredibleHulkUltimateDestruction The Hulk]], nature documentary producer and father [[WesternAnimation/AvengersAssemble Ultron]], LovingBully [[WesternAnimation/{{Recess}} Ashley B]], half-ghost superhero [[WesternAnimation/{{Freakazoid}} Dexter Douglas]] and scaring prodigy [[VideoGame/WarioWare Lulu]] to beat the stuffing out of each other. Added to the roster via free updates are lasagna-loving fat cat [[WesternAnimation/WhatsNewScoobyDoo Scooby-Doo]] and ruthless ninja [[WesternAnimation/OKKOLetsBeHeroes Lord Boxman]]. Paid DLC includes teenage robot [[VideoGame/FireEmblemThreeHouses Lysithea Von Ordelia]], BumblingDad [[Series/WizardsOfWaverlyPlace Cupid]], and mild-mannered wallaby [[WesternAnimation/CampLazlo Lazlo]].
** ''Nickelodeon All-Star Brawl 2'': Joining the roster this time around are cynical clarinet player [[WesternAnimation/TeenTitans2003 Doctor Light]], evil fast food rival [[WebAnimation/MightyMagiswords Ralphio]], boy genius and Cupid's son [[Manga/ZatchBell Zatch Bell]], hot-headed ninja [[WesternAnimation/CodenameKidsNextDoor Robin Food]], calculating inventor [[WesternAnimation/PacMan Inky]], tiger-themed superhero/supervillain [[WesternAnimation/OzzyAndDrix Mayor Spryman]], spectral metalhead [[VideoGame/BatmanArkhamCity Harley Quinn]], eccentric grandmother [[WesternAnimation/TheSimpsons Agnes Skinner]], Agnes' grandson's BlackBestFriend [[WesternAnimation/TheEpicTalesOfCaptainUnderpants George Beard]], beaver siblings [[WesternAnimation/SquirrelBoy Rodney J. Squirrel]] and [[WesternAnimation/SabrinaTheAnimatedSeries Salem Saberhagen]], and sadistic Firebender [[Anime/LoveLiveNijigasakiHighSchoolIdolClub Ayumu Uehara]]. Additionally, Wonder Woman is now [[Series/TrueLies Eva]], while the cheery Airbender has a different voice[[note]]Caz Inghram, Aang's new voice actor, also doesn't have any other credits[[/note]].
* ''VideoGame/NicktoonsBasketball'': Cheerful sea sponge [[WesternAnimation/KidCosmic Chuck]], dimwitted starfish [[WesternAnimation/WanderOverYonder Prince Cashmere]], Texan squirrel [[WesternAnimation/MoralOrel Orel Puppington]], grouchy octopus [[WesternAnimation/WhereOnEarthIsCarmenSandiego the Chief]], boy genius Manga/ZatchBell, Zatch's rival [[VideoGame/ResidentEvil4 Ashley Graham]], Zatch's friend [[WesternAnimation/CloneHigh Jesus Cristo]], Zatch's RobotDog [[WesternAnimation/{{Futurama}} Nibbler]], buck-toothed kid [[WesternAnimation/Ben10 Ben Tennyson]], fairies [[WesternAnimation/TheSpectacularSpiderMan J. Jonah Jameson]] and [[WesternAnimation/HouseOfMouse Maleficent]], Ben's friend [[Series/TheCosbyShow Nelson Tibideaux]], paranormal superhero [[WesternAnimation/{{Freakazoid}} Dexter Douglas]], adventurous teenager [[WesternAnimation/ThePowerpuffGirls1998 Buttercup]], teenage robot [[Anime/LoveLive Cocoa Yazawa]], sports-obssessed girl [[WesternAnimation/AllGrownUp Savannah Shane]], and shaman-in-training [[WesternAnimation/AGoofyMovie Max Goof]] play basketball with each other.
* ''Nickelodeon Extreme Tennis'': Happy-go-lucky frycook [[WesternAnimation/TheSuperHeroSquadShow Iron Man]], pizza-obsessed ninja [[WesternAnimation/TeenTitans2003 Beast Boy]], BrattyHalfPint [[Anime/MyNeighborTotoro Mei Kusakabe]], conjoined twins [[WesternAnimation/ScoobyDooMysteryIncorporated Captain Caveman]] and [[WesternAnimation/CodenameKidsNextDoor Knightbrace]], a boy with a football-shaped head,[[note]]Zane [=VanWicklyn=], Arnold's voice actor in this game, doesn't have any other notable credits.[[/note]] lasagna-loving fat cat Literature/CuriousGeorge, LovingBully [[WesternAnimation/{{Recess}} Ashley B]], ineffectual alien invader [[WesternAnimation/Ben10 Grey Matter]], timid wallaby [[WesternAnimation/MuchaLucha Ricochet]], and teenage half-ghost [[WesternAnimation/TheBuzzOnMaggie Aldrin Pesky]] play tennis with each other. Free updates add dimwitted starfish [[WesternAnimation/LloydInSpace Kurt Blobberts]], animal-speaking girl [[VideoGame/SonicTheHedgehog2006 Princess Elise]], Mei's rival [[VideoGame/KidIcarusUprising Medusa]], and buck-toothed kid [[WesternAnimation/XiaolinShowdown Omi]] to the mix.
* ''VideoGame/NickelodeonKartRacers 3: Slime Speedway'': In this MascotRacer consisting of Creator/{{Nickelodeon}} and Creator/{{Viacom}} icons, you can race with cheerful sea sponge [[WesternAnimation/XiaolinShowdown Raimundo Pedrosa]], dumb starfish [[WesternAnimation/{{Gargoyles}} Broadway]], Texan squirrel [[VideoGame/ResidentEvil4 Ashley Graham]], cranky octopus [[WesternAnimation/TeenTitans2003 Doctor Light]], Broadway's adopted squid sister [[WesternAnimation/TheBoondocks Sarah Dubois]], younger versions of Raimundo and Broadway called [[WesternAnimation/RickAndMorty Mr. Jellybean]] and [[WesternAnimation/BatmanBeyond Payback]], ninja turtles [[WesternAnimation/HeManAndTheMastersOfTheUniverse2002 He-Man]], [[WesternAnimation/{{Animaniacs}} Yakko Warner]], [[WesternAnimation/PacMan Inky]] and WesternAnimation/TheTick, a monochrome clone of Yakko named [[WesternAnimation/CoconutFredsFruitSaladIsland Coconut Fred]], news reporter [[VideoGame/Persona5 Tae Takemi]], toddlers [[WesternAnimation/AdventureTime Flame Princess]] and [[WesternAnimation/CodenameKidsNextDoor Numbuh 5]], multi-media NotZilla [[VideoGame/CrashBandicoot Dingodile]] and his purple clone [[Franchise/RatchetAndClank Neftin Prog]], a football-headed boy[[note]]Zane [=VanWicklyn=] does not have any other voice-acting credits[[/note]] and his best friend [[WesternAnimation/TheEpicTalesOfCaptainUnderpants George Beard]], the football-headed boy's LovingBully [[WesternAnimation/BatmanTheAnimatedSeries Annie]], cheery airbender [[WesternAnimation/CraigOfTheCreek Jerry]], blind earthbender [[WesternAnimation/TangledTheSeries Angry]], honor-obsessed firebender [[WesternAnimation/MyLittlePonyFriendshipIsMagic Garble]], hot-headed waterbender [[WesternAnimation/Injustice2021 Wonder Woman]], white-haired boy [[Anime/Belle2021 Angel]], cynical goth girl [[WesternAnimation/TheBuzzOnMaggie Maggie Pesky]], Angel's BlackBestFriend[[note]]Jaedan White does not have any other voice-acting credits[[/note]], incompetent alien invader [[VideoGame/DestroyAllHumans Orthopox]], insane robot assistant [[VideoGame/Psychonauts2 Raz's Archetype]], psychotic chihuahua [[WesternAnimation/{{Futurama}} Dr. Zoidberg]], cheerful dimwitted cat [[WesternAnimation/JungleJunction Ellyvan]], powdered-toast mascot [[WesternAnimation/BeastWars Megatron]], young inventor [[VideoGame/CrashBandicoot Coco Bandicoot]], Coco's academic rival [[VideoGame/SpyroYearOfTheDragon Greta]], lasagna-loving cat WesternAnimation/{{Jabberjaw}}, dimwitted dog [[VideoGame/Spyro2RiptosRage Ripto]], conjoined cat-and-dog mix [[WesternAnimation/SonicTheHedgehogSatAM Dr. Robotnik]] and [[WesternAnimation/StarWarsTheCloneWars Nute Gunray]], an internet celebrity[[note]][=JoJo=] Siwa doesn't have voice acting[[/note]], timid wallaby [[VideoGame/KingdomHeartsIII Mike Wazowski]], scaring student [[Anime/CyberpunkEdgerunners Rebecca]], half-ghost superhero [[VideoGame/MarvelUltimateAlliance the Human Torch]], and teenage robot [[WesternAnimation/HiHiPuffyAmiYumi Ami Onuki]].
* ''VideoGame/NickelodeonPartyBlast'': Upbeat sponge [[WesternAnimation/StarWarsTheCloneWars Nute Gunray]], alien invader [[VideoGame/{{Psychonauts}} Raz]], animal-speaking girl [[WesternAnimation/TheSpectacularSpiderMan Gwen Stacy]], bratty toddler [[WesternAnimation/TheMrMenShow Little Miss Bossy]], Bossy's cousin [[Franchise/SonicTheHedgehog Miles "Tails" Prower]], big-headed inventor [[Anime/DigimonAdventure Kari Kamiya]], and a pair of extreme sports-loving siblings[[note]]It is unknown who Otto and Reggie's voice actors in this game are.[[/note]] compete against each other in various minigames. Commentary is provided by conjoined twins [[WesternAnimation/FostersHomeForImaginaryFriends Eduardo]] and [[WesternAnimation/{{Stanley}} Harry]].
* ''VideoGame/NicktoonsRacing'': Sponge frycook [[WesternAnimation/MyGymPartnersAMonkey Jake Spidermonkey]], idiotic starfish [[WesternAnimation/{{Gargoyles}} Broadway]], villainous protozoan [[WesternAnimation/CampLazlo Edward Q. Platypus]], adventurous infant [[VideoGame/FireEmblemFates Hinoka]], Hinoka's cousin [[Film/AddamsFamilyValues Pubert Addams]], conjoined twins [[WesternAnimation/SonicTheHedgehogSatAM Dr. Robotnik]] and [[WesternAnimation/TransformersAnimated Starscream]], scaring student [[WesternAnimation/IAmWeasel IR Baboon]], football-headed kid [[WesternAnimation/OneHundredAndOneDalmatiansTheSeries Tripod]], LovingBully [[WesternAnimation/{{Recess}} Ashley B.]], grotesque cat [[WesternAnimation/{{Futurama}} Phillip J. Fry]], animal-speaking girl [[Film/MeanGirls Gretchen Weiners]], chimpanzee [[Franchise/ThePowerpuffGirls Professor Utonium]], and beavers [[VideoGame/{{Skylanders}} Kaos]] and [[WesternAnimation/SabrinaTheAnimatedSeries Salem Saberhagen]] participate in a kart racing tournament.
** ''Nicktoons Winner's Cup Racing'': Jake and Edward return for another round of racing, and joining them are genius inventor [[VideoGame/CrashBandicoot Coco Bandicoot]], buck-toothed kid [[WesternAnimation/TeenTitans2003 Raven]], ghostly teenager [[WesternAnimation/TheAvengersEarthsMightiestHeroes Human Torch]], Raven's teacher [[WesternAnimation/MuchaLucha Ricochet]], mad scientist [[Film/TheRockyHorrorPictureShow Dr. Frank N. Furter]], and vampire [[WesternAnimation/TeamoSupremo Governor Kevin]].
** ''Nicktoons Nitro'': Jake, Coco, Raven, and Human Torch are now joined by alien invader [[Series/MightyMorphinPowerRangers Alpha 5]] and youthful Airbender [[WesternAnimation/LittleBill Andrew]], and together they must race against the wicked [[WesternAnimation/WinnieThePooh2011 Rabbit]].
* ''VideoGame/NicktoonsUnite'': The nefarious [[Film/HomeAlone2LostInNewYork Mr. Hector]] has stolen the plans for WesternAnimation/JayJayTheJetPlane’s latest invention, allowing him to go to other dimensions, where he recruits an alliance of villains including [[{{Film/Clue}} Colonel Mustard]], [[Series/Reno911 Deputy Garcia]], and [[WesternAnimation/RockosModernLife Filburt Turtle]]. To counter this evil syndicate, Jay Jay recruits his own band of heroes from the same dimensions including [[WesternAnimation/BackToTheFutureTheAnimatedSeries Marty McFly]], [[WesternAnimation/TheAdventuresOfRockyAndBullwinkle Rocky]] (accompanied by [[Series/NedsDeclassifiedSchoolSurvivalGuide Gordy]] and [[Franchise/KingdomHearts Maleficent]]), and Franchise/SpyroTheDragon.
** ''Nicktoons: Battle For Volcano Island'': An ancient evil named [[VideoGame/KidIcarusUprising Magnus]] has awoken and is taking over an island, so {{WesternAnimation/Goofy}} summons Spyro, Marty, and Rocky to save him and the other inhabitants of the island. Jay Jay continues to help out behind the scenes. Spyro's friends [[WesternAnimation/TheLegendOfFrostyTheSnowman Frosty the Snowman]] and [[VideoGame/ResidentEvil4 Ashley Graham]] join the action this time, as does Marty’s friend [[WesternAnimation/TheCupheadShow Ms. Chalice]]. [[WesternAnimation/ABugsLife Harry Mosquito]] and [[{{WesternAnimation/Recess}} Vince LaSalle]] are also there to offer support.
** ''Nicktoons: Attack of the Toybots'': Mr. Hector is back, and this time, he plans to win a game show by creating an army of evil toys and sending them to capture heroes from across the multiverse. Spyro, Frosty, Marty, Ms. Chalice, Rocky, and Jay Jay all return, and this time, they are joined by a new friend, [[Series/LabRats Donald Davenport]]. [[VideoGame/RatchetAndClank Captain Qwark]] is a minion of Mr. Hector’s who defects and helps the heroes. [[WesternAnimation/CaptainPlanetAndThePlaneteers Gi]], [[{{WesternAnimation/Futurama}} Phillip J. Fry]], [[VideoGame/Psychonauts2 Raz's Archetype]], and [[WesternAnimation/ElTigre Puma Loco]] appear as guest characters, with [[WesternAnimation/TheGrimAdventuresOfBillyAndMandy Billy]], [[WesternAnimation/ToyStory2 Al McWhiggin]], and [[WesternAnimation/TheLegendOfVoxMachina Osysa]] joining them in the UsefulNotes/NintendoDS version.
** ''[=SpongeBob SquarePants=] featuring the Nicktoons: Globs of Doom'': The worlds are all being invaded by orange slime aliens called the Morphoids, so Spyro, Marty, Jay Jay, and Donald must join forces with their enemies in order to defeat them (Rocky and company are [[ChuckCunninghamSyndrome MIA]]). Filburt Turtle returns, along with a new villain team including [[WesternAnimation/BojackHorseman Beatrice Horseman]], [[WesternAnimation/TeenageMutantNinjaTurtles1987 Raphael]], and [[{{WesternAnimation/Animaniacs}} Yakko Warner]]. Billy and his archenemy [[Series/TheWonderYears Chuck Coleman]] also show up, and join the teams as well. Goofy also returns, though since his last appearance, he has turned into [[WesternAnimation/GreenEggsAndHam2019 Mr. Jenkins]]. The Morphoids’ leader, [[WesternAnimation/TheWackyAdventuresOfRonaldMcDonald Sundae]], occasionally uses Spyro as a vessel to communicate with the team. Also appearing are Spyro's pet snail [[Anime/RaveMaster Griffon Kato]], Jay Jay's friends [[WesternAnimation/SonicTheHedgehogSatAM Antoine D'Coolette]], [[WesternAnimation/{{Barnyard}} Pip]], and [[WesternAnimation/MoralOrel Orel Puppington]], Donald's friends [[WesternAnimation/Cars2 Fillmore]], [[Anime/{{FLCL}} Haruko Haruhara]] and [[WesternAnimation/{{Futurama}} Bender]] as well as his rival [[WesternAnimation/TheEmperorsNewGroove Kronk]], Marty's sister [[Anime/DigimonAdventure02 Sora Takenouchi]] and his bully [[VideoGame/KidIcarusUprising Hades]], Billy's teacher [[WesternAnimation/MuchaLucha Headmistress]], and Chuck's father [[WesternAnimation/MonsterFarm Frankenswine]] and sister [[Franchise/{{Neptunia}} Neptune]].
* ''VideoGame/NicktoonsMLB'': Happy-go-lucky sponge [[WesternAnimation/ThePowerpuffGirls1998 The Mayor of Townsville]], dimwitted starfish [[WesternAnimation/LloydInSpace Kurt Blobberts]], Texan squirrel [[WesternAnimation/MoralOrel Orel Puppington]], muscular lobster [[WesternAnimation/CampLazlo Edward Q. Platypus]], ghostly pirate [[WesternAnimation/TheMarvelousMisadventuresOfFlapjack Cap'n Knuckles]], secret agent dog [[WesternAnimation/TheBatman Jimmy Olsen]], feline secret agent [[VideoGame/{{Bayonetta}} Jeanne]], inventor [[Anime/GlitterForce Candy]], Candy's friend [[WesternAnimation/CloneHigh Jesus Cristo]], chimpanzee [[WesternAnimation/BigCityGreens Bill Green]], superhero [[WesternAnimation/TaleSpin King Louie]], action-obsessed adolescents [[WesternAnimation/KungFuPandaLegendsOfAwesomeness Shengqi]] and [[VideoGame/SonicBoom Sticks the Badger]], Airbender [[Series/DebtCollectors Tyler Sneed]], Waterbender [[WesternAnimation/JohnnyBravo Lil' Suzy]], Earthbender [[WesternAnimation/MeetTheRobinsons Young Franny]], Firebender [[Film/{{Hook}} Rufio]], half-ghost teenager [[WesternAnimation/FostersHomeForImaginaryFriends Bloo]], alien [[WebAnimation/HelluvaBoss Moxxie]], cynical goth girl [[Franchise/{{Neptunia}} Neptune]], psychotic Chihuahua [[WesternAnimation/HarveyBirdmanAttorneyAtLaw Peter Potamus]], dimwitted cat [[Film/SpaceJamANewLegacy Porky Pig]], toast-themed superhero [[WesternAnimation/SpiderMan1981 Lizard]], and yak [[VideoGame/CrashNitroKart Nash]] play baseball with real-life UsefulNotes/MajorLeagueBaseball players. Commentary is provided by news reporter [[VideoGame/Cyberpunk2077 Kerry Eurodyne]] and hyperactive robot [[WebAnimation/MightyMagiswords the Electric Eel Magisword]].
* ''VideoGame/NieR (Gestalt version)'': In order to save his daughter [[VideoGame/SoulSeries Amy Sorel]], [[VideoGame/TransformersWarForCybertron Warpath]] acquires the power of the dark book of [[Manga/{{Naruto}} Gaara]]. He is challenged and later assisted by hot-tempered swordswoman [[VideoGame/Disgaea3AbsenceOfJustice Raspberyl]] and child turned weapon [[VideoGame/TalesOfVesperia Karol Capel]]. Twins [[VideoGame/FireEmblemAwakening Sumia]] and [[VideoGame/Persona4 Marie]] are the bartenders in the village Warpath lives in, and are also [[spoiler: the main antagonists]].
** ''Nier Replicant'' ([=PS4=] version): The same but with [[VideoGame/FireEmblemThreeHouses Byleth]] (later [[VideoGame/FinalFantasyXV Noctis Lucis Caelum]]) instead of Warpath and him being Amy Sorel's brother instead of her father.
** ''VideoGame/NierAutomata'': Eight thousand years later, Earth is being invaded by aliens using "machine lifeforms" they control. Androids are built and dispatched to combat those machines. [[Franchise/LoveLive Umi Sonoda]] and [[Anime/MobileSuitGundamIronBloodedOrphans Mikazuki Augus]] are some of these androids. [[Franchise/MassEffect Legion]] is Umi's support unit, whereas [[Manga/DemonSlayerKimetsuNoYaiba Nezuko Kamado]] is Mikazuki's support unit, and [[Literature/SwordArtOnline Asuna]] is a prototype to both Umi and Mikazuki. Umi and Mikazuki fight the machine siblings [[Manga/DemonSlayerKimetsuNoYaiba Muzan Kibutsuji]] and [[Manga/JoJosBizarreAdventureGoldenWind Bruno Bucciarati]] to bring peace upon Earth and to safely bring back humans from the Moon.
* ''VisualNovel/NineHoursNinePersonsNineDoors'': [[WesternAnimation/MonsterHigh Deuce Gorgon]] wakes up in a ship not knowing how he arrives there. After nearly escaping with his life, he met other people who are in the same predicament as him; like his childhood friend [[VideoGame/FireEmblemFates Azura]], a blind man named [[Webcomic/HetaliaAxisPowers England]] and his younger sister [[VisualNovel/AceAttorney Athena Cykes]], a white haired man named [[VisualNovel/DanganronpaTriggerHappyHavoc Kiyotaka Ishimaru]], an old gentleman called [[Anime/DigimonAdventure Etemon]] a black man called [[WebComic/OnePunchMan Hammerhead]], a woman called [[VideoGame/Persona4DancingAllNight Naoto Shirogane]] and a bespectacled man named [[VideoGame/MetalGearSolid Liquid Snake]]. Together, they must survive the nonary games or they will die.
* ''VideoGame/NinjaGaiden'': [[WesternAnimation/UltimateAvengers Captain America]] is a ninja who seeks to avenge his village after it's destroyed by [[VideoGame/KnightsOfTheOldRepublic Davik Kang]]. He has help from [[WesternAnimation/TeenTitans2003 Raven]], [[WesternAnimation/CaptainPlanetAndThePlaneteers Gi]], and [[WesternAnimation/TheTransformers Sideswipe]]. [[WesternAnimation/SwatKats Mac Mange]] is Cap's uncle [[spoiler:and the true villain]].
** ''Ninja Gaiden II'': Cap is now [[WesternAnimation/TheSpectacularSpiderMan Spider-Man]] and Sideswipe is now [[Franchise/Ben10 Max Tennyson]]. Spidey must deal with [[WesternAnimation/BatmanTheDarkKnightReturns Sarah Essen]], [[WesternAnimation/TheAvengersEarthsMightiestHeroes Baron Zemo]], [[WesternAnimation/TheFairlyOddparents Cosmo]], [[WesternAnimation/GIJoeResolute Duke]], and [[VideoGame/MarvelUltimateAlliance Odin]] with the help of Gi, [[WesternAnimation/JusticeLeagueVsTeenTitans Starfire]], and [[Anime/SailorMoon Sailor Mercury]]. Spidey's father [[WesternAnimation/WolverineAndTheXMen2009 Silver Samurai]] has a history with [[WesternAnimation/VoltronLegendaryDefender Emperor Zarkon]].
** ''Ninja Gaiden III'': Spidey is now [[VideoGame/MarvelVsCapcom3 Nova]] and has to deal with [[VideoGame/TransformersDarkOfTheMoon Wheeljack]] and [[VideoGame/FullSpectrumWarrior Brian Sims]] with the help of Max, [[Franchise/MassEffect Liara T'Soni]], Gi and her sister [[VideoGame/BlazBlue Litchi Faye-Ling]], [[Anime/CodeGeass Emperor Charles zi Britannia]] and Starfire, who's now [[WesternAnimation/AdventuresInOdyssey Eva Parker]]. [[Anime/ViewtifulJoe Fire Leo]] is MissionControl and [[WebAnimation/DCSuperHeroGirls Katana]] is a little girl.
* ''VideoGame/NoMoreHeroes'': Loser otaku [[WesternAnimation/TheAvengersEarthsMightiestHeroes Baron Zemo]] tries to worm his way into [[VideoGame/FinalFantasyX Lulu's]] pants by battling [[Series/LegendsOfTheHiddenTemple Olmec]], [[WesternAnimation/StarWarsCloneWars General Grievous]], [[Anime/{{Pokemon}} Hunter J]], [[WesternAnimation/TheSpectacularSpiderMan Spider-Man]], [[VideoGame/MetalGearSolid Mei Ling]], [[WesternAnimation/StarWarsTheCloneWars Captain Rex]], [[Film/TheGoldenCompass Lee Scoresby]], [[WesternAnimation/HeyArnold Pearl]], [[VideoGame/MetalGearAcid2 Venus]], and [[VideoGame/SpiderManShatteredDimensions Hobgoblin]] with a lightsaber. Then he finds out that [[VideoGame/FinalFantasyTactics Ovelia]] is his half-sister and [[Franchise/KingdomHearts Axel]] is his twin brother. [[WesternAnimation/CarmenSandiego Shadowsan]] is a gym instructor, [[WesternAnimation/JusticeLeagueCrisisOnTwoEarths Wonder Woman]] makes Zemo's lightsabers, [[VideoGame/SlyCooperThievesInTime The Grizz]] is an ex-wrestler, and [[Manga/JojosBizarreAdventureStardustCrusaders Jotaro Kujo]] is a video store owner and Zemo's best friend.
** ''VideoGame/NoMoreHeroes2DesperateStruggle'': In retaliation for Jotaro's murder, Zemo goes on a RoaringRampageOfRevenge against [[Anime/DigimonFusion Beelzemon]], [[WesternAnimation/TeenTitans2003 Cyborg]], [[Manga/{{Naruto}} Sasuke Uchiha]], [[WesternAnimation/TheAdventuresOfJimmyNeutronBoyGenius Jimmy Neutron]], [[WesternAnimation/BatmanTheAnimatedSeries Batgirl]], a returning Rex (who is now ComicBook/TheIncredibleHulk), [[VideoGame/MetalGearSolid Roy Campbell]], ''[[DualBoss two]]'' Spider-Men, [[WesternAnimation/FamilyGuy Mr. Washee-Washee]], [[WesternAnimation/MyLittlePonyFriendshipIsMagic Twilight Sparkle]], [[Franchise/Ben10 Max Tennyson]], [[WesternAnimation/CinderellaIIDreamsComeTrue Cinderella]], and finally [[Anime/TengenToppaGurrenLagann Simon]]. Hunter J also returns to deal with Campbell and the Spider-Men on Zemo's behalf. [[VideoGame/RatchetAndClankRiftApart Rivet]] is an assassin in training, and [[VideoGame/CrashBandicoot Coco Bandicoot]] is a foe that Axel fights in a dream. Creator/TakashiMiike appears as a friend of Jotaro.
!!O
* ''VideoGame/OctopathTraveler'': Eight heroes wander the land of Orsterra in search of finding their own purpose in life:
** [[VideoGame/TalesOfBerseria Velvet Crowe]], a priestess on a pilgrimage to restore light to the world;
** [[VideoGame/TheOrder1886 Sir Galahad]], a teacher in pursuit of a book that had long gone missing from the royal library;
** [[VideoGame/MassEffectAndromeda Sara Ryder]], a merchant traveling the world for the best bargains and the rarest items;
** [[VideoGame/Disgaea4APromiseUnforgotten Fenrich]], a retired knight searching for the reasons behind his former partner's betrayal;
** [[WebAnimation/PokemonGenerations Diantha]], a dancer seeking revenge on the criminal gang who murdered her father;
** [[VideoGame/FireEmblemGaiden Lukas]], a medicine man on a journey to heal the sick;
** [[Literature/FateApocrypha Karna]], a thief ordered to steal a set of rare gemstones; and
** [[Literature/MoribitoGuardianOfTheSpirit Balsa]], a huntress looking for her master, who suddenly disappeared during a hunt for a highly dangerous beast.
* The [[VideoGame/OctopathTravelerII sequel]] brings eight new heroes in the world of Solistia, where a new era awaits.
** [[VideoGame/FinalFantasyVIIRemake Yuffie Kisaragi]], a beastling accompanied by her choice of animal companion, either [[Anime/SK8TheInfinity Kaoru Sakurayashiki]] the jackal or {{VideoGame/Shantae}} the owl, who journeys to find three legendary beasts to save her island;
** [[Manga/MissKobayashisDragonMaid Tohru]], a healer with no memories to speak of, yet is associated with controversial healers;
** [[Literature/TrappedInADatingSimTheWorldOfOtomeGamesIsToughForMobs Leon Fou Bartfort]], a man of religion, with doubts, who wishes to learn more about the happenings in the church;
** [[VideoGame/GenshinImpact Cyno]], a scholar framed for the murder of his wife and child, who busted out of prison to find the real murderer;
** [[Animation/ScissorSeven Dai Bo]], a merchant who was exposed to a life of a beggar, who then vows to rid of all poverty;
** [[Literature/SwordArtOnline Sachi]], a young dancer who has always wanted to be just like her mother and rise to stardom;
** [[VisualNovel/DanganronpaV3KillingHarmony Maki Harukawa]], a thief who no longer wants to be one, and wishes to end of lives of her abusive "parents" to escape said lifestyle; and
** [[Manga/JojosBizarreAdventureStoneOcean Narciso Anasui]], a samurai and young prince of his clan who wishes to grow stronger and gain allies to fight off his tyrannical older brother.
* ''VideoGame/OdinSphere'': [[Literature/{{Toradora}} Sumire Kano]] reads about the stories of Valkyrie [[Manga/{{Monster}} Nina Fortner]], rabbit prince [[Anime/CodeGeass Suzaku Kururugi]], fairy princess [[Manga/{{Naruto}} Hinata Hyuga]], dark knight [[Manga/{{Bleach}} Uryu Ishida]], and forest witch [[VideoGame/StreetFighterIV Crimson Viper]] who fight over a giant magical cauldron [[spoiler:that eventually tries to destroy their world]].
* ''VideoGame/OpenSeason'': Woodland animals [[VideoGame/CrashTagTeamRacing Crunch Bandicoot]] and [[WesternAnimation/TUFFPuppy Verminous Snaptrap]] must survive open season and get back to Crunch's owner [[VisualNovel/FateStayNight Altria Pendragon]] while avoiding crazed hunter [[VideoGame/LikeADragon Kazuma Kiryu]].
* ''VideoGame/OverTheHedge'': [[VideoGame/{{Madagascar}} Melman]] the raccoon and [[Film/MuppetsFromSpace Fast Eddie]] the turtle must reclaim their forest from humans such as [[WesternAnimation/RoverDangerfield Daisy]] and [[WesternAnimation/{{Breadwinners}} the Bread Maker]], with help from their animal friends [[WesternAnimation/KungFuPandaSecretsOfTheFuriousFive Ladybug]], [[WesternAnimation/BikerMiceFromMars Tanisha]], [[VideoGame/ToyStory3 Stinky Pete]], [[WesternAnimation/GoofTroop Goofy]], [[VideoGame/{{Yakuza}} Yayoi Dojima]], and [[WesternAnimation/MarvelsSpiderMan Liz Allan]]. Melman also has a run-in with a loan shark bear named [[WesternAnimation/PetAlien Swanky]].
* ''VideoGame/{{Overwatch}}'': [[VideoGame/FireEmblemAwakening Chrom]] is a 21st-century cowboy who would like to tell you that ''IT'S HIGH NOON''. [[VideoGame/ShinMegamiTenseiIV Flynn]] is a Swedish dwarf who builds turrets. [[Anime/{{Hellsing}} Alucard]] is a gorilla from the moon in charge of bringing a multinational group of heroes back together. [[VideoGame/StreetFighterIV Guile]] is a B-movie director who wants you to move the damn payload already, and [[WesternAnimation/WanderOverYonder Lord Hater]] is [[GrimReaper Death himself]].
** Alternatively, [[Series/DowntonAbbey Ivy Stuart]], [[WebVideo/StreetFighterAssassinsFist Akuma]], [[VideoGame/NoMoreHeroes Thunder Ryu]], [[ComicBook/TheIncredibleHulk The Hulk]], [[WesternAnimation/AvatarTheLastAirbender Ursa]], [[VideoGame/Persona5 Yusuke Kitagawa]], [[WesternAnimation/FostersHomeForImaginaryFriends Bloo]], [[Manga/{{Monster}} Johan Liebert]], [[VideoGame/Fallout4 Nisha]], [[VideoGame/FinalFantasyXV Ardyn Izunia]], [[VideoGame/Hitman2016 Jordan Cross]], [[Manga/{{Hellsing}} Alucard]], [[VideoGame/GrandTheftAutoV Taliana Martinez]], and a lot of others are members of a peace-keeping organization.
!!P
* ''VideoGame/PacManAndTheGhostlyAdventures'': [[Literature/KonoSuba Megumin]] has to use a variety of superpowers to stop the evil [[WesternAnimation/PhineasAndFerbStarWars Luke Skywalker]] from using a giant FreezeRay to take over the city. She also has to rescue her best friends [[Manga/SailorMoon Chibi-Usa]] and [[Manga/OuranHighSchoolHostClub Tamaki Suoh]], while a kooky scientist named [[VideoGame/Persona5 Igor]] provides assistance. [[Manga/JujutsuKaisen Mahito]], [[Manga/AttackOnTitan Eren Jeager]], [[VideoGame/AtelierRoronaTheAlchemistOfArland Rorona Frixell]] and [[VisualNovel/PhoenixWrightAceAttorneyDualDestinies Apollo Justice]] are four ghosts that are henchmen of Luke, but are secretly helping Megumin out.
* ''VideoGame/{{Pepsiman}}'': [[Film/SawI Paul]] is a superhero who does nothing but chug on Pepsi.
* ''VideoGame/PhantomBrave'': [[WesternAnimation/MyLifeAsATeenageRobot Melody]] is a girl who lives on an island and is rejected by society at large because of her ability to see spirits. Her only friend is a dead boy named [[Series/PowerRangersInSpace Ecliptor]]. During a couple of jobs, they run into [[Manga/{{Naruto}} Orochimaru]], who is trying to take their reward so he can support his sister [[Anime/DigimonAdventure Kari]].
* ''VideoGame/PigletsBigGame'': [[WesternAnimation/TheEmperorsNewGroove Rudy]] feels like he isn't appreciated, so he ventures into the dreams of his friends WesternAnimation/{{Cat|Dog}}, [[WesternAnimation/CourageTheCowardlyDog the Great Fussili]], [[Franchise/{{Transformers}} Optimus Prime]], [[WesternAnimation/TheLittles Dr. Hunter]], [[WesternAnimation/TheGrimAdventuresOfBillyAndMandy Basil the Druid]], and [[WesternAnimation/HouseOfMouse Chip the Teacup]] to help them with various tasks. Chip's mother [[WesternAnimation/HeyArnold Miriam Pataki]] and [[VideoGame/{{Diablo}} Deckard Cain]] assist Rudy on his quest.
** In the PC version, Rudy goes around collecting ingredients to make a soup, and Optimus Prime is instead [[Franchise/SpyroTheDragon Ripto]].
* ''VideoGame/PlanescapeTorment'': Series/ThePretender goes on a quest to discover his identity and the nature of his immortality, aided by [[WesternAnimation/TeenageMutantNinjaTurtles1987 Raphael]], [[Series/TheXFiles Assistant Director Skinner]], [[WesternAnimation/RockosModernLife Bev Bighead]], [[WesternAnimation/TheSimpsons Homer Simpson]], [[VideoGame/KnightsOfTheOldRepublic Bastila Shan]], [[WesternAnimation/{{Gargoyles}} Goliath]], and Sheena Easton. Along the way, he has run-ins with [[WesternAnimation/TheBatman Alfred Pennyworth]], [[WesternAnimation/MyLittlePonyFriendshipIsMagic Discord]], and [[WesternAnimation/SpongebobSquarepants Squidward Tentacles]].
* ''VideoGame/PokemonMasters'': A DreamMatchGame featuring [[Anime/AttackOnTitan Eren Jaeger]], [[VideoGame/SonicLostWorld Zazz]], [[Franchise/{{Tekken}} Bob]], VideoGame/{{Shantae}}, [[VideoGame/MugenSouls Chou Chou]], [[VisualNovel/PhoenixWrightAceAttorneySpiritOfJustice Trucy Wright]], [[VideoGame/PuyoPuyo Amitie]], [[WesternAnimation/HiHiPuffyAmiYumi Ami Onuki]], [[Anime/HunterXHunter Shizuku]], [[Franchise/StreetFighter Ryu]], [[VideoGame/FireEmblemThreeHouses Marianne]], [[VideoGame/{{Skullgirls}} Valentine]], [[Anime/LoveLive Nico Yazawa]], [[Franchise/MortalKombat Scorpion]], [[Manga/KOn Ui Hirasawa]], [[Manga/JojosBizarreAdventureDiamondIsUnbreakable Josuke Higashikata]] and many others.
* ''VideoGame/PokerNightAtTheInventory'': [[VideoGame/SamAndMaxFreelancePolice Jurgen]], [[Series/TheAquabatsSuperShow Carl]], [[VideoGame/Dota2 Shadow Shaman]] and [[VideoGame/AmericanMcGeesAlice the Mad Hatter]] walk into a bar hosted by [[Franchise/ThePowerpuffGirls Mojo Jojo]] to play a round of poker.
** ''VIdeoGame/PokerNight2'': [[WesternAnimation/FamilyGuy Joe Swanson]], a Gearbox Software employee, [[Film/{{Birdemic}} Rick]] ([[TheOtherDarrin pretending to be]] [[Series/BurnNotice Sam Axe]]) and [[ComicBook/{{Bone}} Fone Bone]] (accompanied by [[Franchise/KingdomHearts Lexaeus]], [[TheOtherDarrin who used to be]] Jurgen in the previous poker round) walk into the same bar to play a round of poker now dealt by [[Film/PacificRim a Jaeger AI]].
* ''VideoGame/{{Portal}}'': A [[VideoGame/HalfLife2 City 17 citizen]] (disguising herself with the face of [[VideoGame/FirstEncounterAssaultRecon Alma]]) is forced to cure [[VideoGame/TeamFortress2 the Administrator's]] OCD and ADHD, while cleansing ''VideoGame/TheDarkness'' from her soul, to boot. All it seems to do is make the Admin stronger. NiceJobBreakingItHero.
* ''VideoGame/Portal2'': A man with experience in [[Series/{{The Office|UK}} incompetent corporate leadership]] wakes [[VideoGame/StarFox Krystal]] ([[HeroicMime her face, anyway]]) up to escape a facility once owned by [[WesternAnimation/GeneratorRex White Knight]]. However, [[VideoGame/HalfLife2 the Combine Overwatch]] goes online, and she can only stop it is by harnessing the power of [[VideoGame/{{Uncharted}} Nathan Drake]]. Meanwhile, [[WesternAnimation/AmericanDad Klaus]] and [[WesternAnimation/StarWarsTheCloneWars Captain Rex]] work together '''TO SAVE SCIENCE'''.
* ''VideoGame/PrinnyCanIReallyBeTheHero'': [[Manga/{{Bleach}} Rukia]] sends 1000 of her [[VideoGame/Persona4 Teddies]] on pretty much a suicide mission to get the Ultra Dessert. Along the way, they run into various bosses such as [[Manga/{{Chobits}} Sumomo]] the {{Yandere}} Cat Witch and [[Manga/{{Naruto}} Sasuke Uchiha]] of the Phoenix Clan. Meanwhile, [[Manga/{{Bleach}} Yoruichi]] gets tired of not having her own game and attempts a HostileShowTakeover.
** ''Prinny 2: Dawn of Operation Panties, Dood'': The 1000 Teddies have reincarnated and have been [[TheOtherDarrin replaced]] by 1000 [[VideoGame/DissidiaFinalFantasy Warriors of Light]] who are tasked with finding Rukia's missing panties. Meanwhile, Yoruichi tries to fight her way through look-a-likes to be a main character, especially her EvilCounterpart [[VideoGame/TalesOfGraces Pascal]].
* ''VideoGame/ProfessorLaytonAndTheMiracleMask'': After receiving a letter from his old friend [[Manga/SoulEater Maka Albarn]], the Professor, along with his assistants [[VideoGame/FireEmblemRadiantDawn Mia and Micaiah]], head to the desert casino town of Monte d'Or, run by Maka's husband [[Manga/AttackOnTitan Levi]]. While there they encounter a mysterious masked man with a mask similar to that found by the Professor and Maka's old friend [[VideoGame/SaintsRowTheThird Matt Miller]] who disappeared during an expedition. Meanwhile they are caught in a business feud between Levi and another old acquaintance, businessman [[Manga/FullmetalAlchemist [=Greed!Ling=]]] who suspects Akihiko is up to no good.
* ''VideoGame/{{Prototype}}'': [[Film/SavingPrivateRyan Pvt. Daniel Jackson]] wakes up in a morgue with no memories of his past actions. With the help of his sister [[Series/ChildrensHospital Dr. Cat Black]] and his ex-girlfriend [[WesternAnimation/TheGrimAdventuresOfBillyAndMandy Irwin]], Daniel tears through New York to get answers to his past from [[Series/{{CSI}} Captain Jim Brass]] and [[Series/CheckItOut Viker]].
* ''VideoGame/{{Psychonauts}}'': [[WesternAnimation/InvaderZim Zim]] goes to a camp for psychics, where he has to stop [[WesternAnimation/GIJoeResolute Cobra Commander]] and [[WesternAnimation/SpiderManTheAnimatedSeries Morbius]] from stealing kids' brains. [[WesternAnimation/MyLittlePonyFriendshipIsMagic Twilight Sparkle]] is Zim's [[TheIgor loyal assistant]].
* ''VideoGame/PuyoPuyo'':
** ''VideoGame/PuyoPuyoTetris'': [[Anime/OnePunchMan Saitama]] and [[WesternAnimation/TheLionGuard Kiara]] discover [[Recap/WelcomeToMonsterHigh Frankie Stein]] and her friends [[Anime/KillLaKill Ryuko and Mako]], who are from other universes, aboard their space vessel. When Frankie and Saitama's universes begin merging thanks to [[VideoGame/ResidentEvil6 Leon S. Kennedy]], the key to everything may be [[VideoGame/BlazBlueCalamityTrigger Arakune]] and [[VideoGame/AHatInTime the Conductor]], whom [[VideoGame/StreetFighterV Falke]] is madly in love with. Also starring bully [[VisualNovel/PhoenixWrightAceAttorneySpiritOfJustice Ema Skye]], scholar [[Anime/HunterXHunter Franklin]], chemist [[VideoGame/StreetFighterIV Ryu]], lolita [[WesternAnimation/EdEddNEddy May Kanker]], dog-man [[VideoGame/MortalKombatVsDCUniverse Lex Luthor]], robot [[VideoGame/MarvelUltimateAlliance Namor]], witch [[VideoGame/BlazBlueCalamityTrigger Litchi Faye-Ling]], twins [[Literature/HaruhiSuzumiya Haruhi]] and [[Anime/LuckyStar Konata]], dragon woman [[Anime/CowboyBebop Faye Valentine]], [[WesternAnimation/CodenameKidsNextDoor Numbuhs One and Two]], fish-man [[VideoGame/WarioWare 18-Volt]], ghost [[Anime/DragonBallSuper Maijin Buu]], swordsman [[VideoGame/FireEmblemThreeHouses Dedue]], and small round creature [[Franchise/SonicTheHedgehog Amy Rose]]. [[WesternAnimation/EdEddNEddy Nazz]] is Ryuko's rabbit companion, and Mako's teacher [[VisualNovel/PhoenixWrightAceAttorneyDualDestinies Athena Cykes]] appears briefly, as do the twin ghosts [[VideoGame/BlazBlue Makoto Nanaya]] and [[VideoGame/Persona5 Labrys]].
** ''Champions'': Frankie, Ryuko, Mako, Arakune, the Conductor, Falke, Ema, Ryu, Litchi, Faye, Numbuh One, 18-Volt, and Dedue all return and are now joined by several new competitors, including demon [[WesternAnimation/HeyArnold Eugene Horowitz]], sultan [[VideoGame/SuperSmashBrosUltimate Female Robin]], angel [[Anime/LoveLive Eli Ayase]], harpy [[Literature/BludgeoningAngelDokuroChan Dokuro Mitsukai]], mermaid [[Manga/SquidGirl Ika Musume]], another swordsman named [[Anime/NeonGenesisEvangelion Shinji Ikari]], dancer [[VideoGame/DetectivePikachu Frederick Hartfield]], warriors [[Franchise/SonicTheHedgehog Big the Cat]] and [[VideoGame/SoulCaliburIV Hildegard von Krone]], and [[Anime/{{Charlotte}} Ayumi Otosaka]] and her dark counterpart [[VideoGame/NierAutomata 2B]], as well as a [[TheUnintelligible gibberish-speaking squirrel]]. Additionally, Nazz is now [[VideoGame/FireEmblemHeroes Cordelia]].
** ''VideoGame/PuyoPuyoTetris2'': Frankie and the gang reunite with Saitama's gang, and together they must help a corrupted girl named [[VideoGame/Persona5Strikers Sophia]] and her older brother [[WesternAnimation/Ben10AlienForce Alan Albright]] discover the true meaning of fun. Amongst the cast, Cordelia is back to being Nazz, and the roster is now joined by frog prince [[VideoGame/HyperdimensionNeptunia Black Heart/Noire]], shy girl [[Anime/PuellaMagiMadokaMagica Kyoko Sakura]], and GuestFighter [[VideoGame/ResidentEvil5 Chris Redfield]]. Later updates add Athena, Makoto, Labrys, Ika, Dokuro, Shinji, 2B, heavenly knight [[VideoGame/PokemonMasters Archer]], and a teacher of apprentice warlocks[[note]]It is unknown who Rozatte's English voice actor is.[[/note]] to the mix.
!!Q
* ''VideoGame/QuestForGloryIV'': A HeroicMime must stop [[VideoGame/MassEffect Female Shepard]] and WesternAnimation/JohnnyBravo from releasing an EldritchAbomination while [[Film/TheLordOfTheRings Gimli]] provides snarky narration.
!!R
* ''VideoGame/RadiantHistoria: Perfect Chronology'': [[VideoGame/SoulcaliburVI Grøh]] is a member of a secret intelligence agency who watches his companions [[Manga/AttackOnTitan Annie Leonhart]] and [[VideoGame/FireEmblemThreeHouses Caspar]] die when a routine mission to escort a spy back to base goes horribly wrong. He is saved from a premature death when a [[ItMayHelpYouOnYourQuest seemingly-useless white book]] given to him by his commanding officer transports him to a PlaceBeyondTime, where [[Manga/{{Naruto}} Shisui Uchiha]] and [[VideoGame/{{Neptunia}} Neptune]] give him a mission to save his world from being covered in sand by [[SetRightWhatOnceWentWrong setting history on its correct course]].
* ''VideoGame/RaidenV'': [[VideoGame/StreetFighterV Abigail]] is the coffee-addicted captain of an AirborneAircraftCarrier, [[Anime/KillLaKill Ragyo Kiryuin]] is part of the global military council, [[Anime/PuellaMagiMadokaMagica Sayaka Miki]] has turned to piracy, [[Anime/OnePunchMan Speed o' Sound Sonic]] works with an underground organization, and [[VideoGame/MondayNightCombat Megabeth]] has now become Bellwether's MissionControl.
* ''VideoGame/{{Ratatouille}}'': [[WesternAnimation/MyLittlePonyFriendshipIsMagic Quibble Pants]], with spiritual guidance from Chef [[WesternAnimation/SupermanTheAnimatedSeries Lobo]], helps the young [[WesternAnimation/TheIncredibles Bernie Kropp]] try his hand at cooking while avoiding the sinister head chef [[Film/TheLordOfTheRings Bilbo Baggins]] and winning the heart of fellow cook [[Anime/KikisDeliveryService Ursula]]. Quibble Pants' brother [[WesternAnimation/ToyStoryToons Recycle Ben]] guides him through the tutorial.
* ''[[VideoGame/RatchetAndClank2002 Ratchet & Clank]]'': [[WesternAnimation/{{TMNT}} Michelangelo]] and his sidekick [[WesternAnimation/BeastWars Megatron]] track down [[Franchise/ResidentEvil Jack Krauser]] and fight [[VideoGame/MetalGearSolid Scott Dolph]] with [[{{BFG}} the biggest]] and most unconventional guns money can buy. They also cross paths with [[Series/TheMiddle Mike Heck]] and [[Series/{{Scrubs}} the Janitor]].
** ''VideoGame/RatchetAndClankGoingCommando'': Michelangelo [[TheOtherDarrin is now]] [[WesternAnimation/StarWarsTheCloneWars Obi-Wan]]; working for [[spoiler:Krauser impersonating]] [[VideoGame/MarvelVsCapcom3 Sentinel]], he and Megatron do the same with [[WesternAnimation/TheCrampTwins Lucien Cramp]] and [[WesternAnimation/TheSpectacularSpiderMan Green Goblin]]. [[WesternAnimation/CodenameKidsNextDoor Nigel Uno]] idolizes Krauser.
** ''VideoGame/RatchetAndClankUpYourArsenal'': As above, except now it's [[Series/StarTrekDeepSpaceNine Quark the Ferengi]], [[VideoGame/MetalGearSolid3SnakeEater The Fear]], and [[WesternAnimation/BatmanBeyond Blade Sommer]]. Mike Heck and [[Series/SesameStreet Abby Cadabby]] assist Obi-Wan and Megatron.
** ''VideoGame/RatchetDeadlocked'': [[Series/{{Dallas}} Les Crowley]] captures Obi-Wan and Megatron for his gladiator arena, where Obi-Wan has to fight [[WesternAnimation/TheFairlyOddParents Doug Dimmadome]], [[WesternAnimation/TheSecretSaturdays Doc Saturday]], [[TheVoiceless their silent comrade]], and [[VideoGame/SpyroYearOfTheDragon Sparx the Dragonfly]] as [[WesternAnimation/TuffPuppy Chief Dumbrowski]] and [[WesternAnimation/FanboyAndChumChum Chum Chum]] mock him.
** ''VideoGame/RatchetAndClankFutureToolsOfDestruction'': [[VideoGame/{{Psychonauts}} Clem Foote]] attacks, claiming to be from Obi-Wan's past. [[VideoGame/BatmanArkhamCity Harley Quinn]] and her caretakers [[WesternAnimation/JusticeLeagueGodsAndMonsters Sivana]] and [[WesternAnimation/Incredibles2 Reflux]] help fight him as well as [[SpacePirate space pirates]] [[Film/BatmanVSupermanDawnOfJustice Doomsday]] and [[VideoGame/BatmanArkhamSeries Riddler]]. The Janitor is now VideoGame/CrashBandicoot.
** ''VideoGame/RatchetAndClankFutureACrackInTime'': Quark and The Fear are back, this time with [[VideoGame/CallOfDutyBlackOpsII Samuel Stuhlinger]], [[WesternAnimation/PhineasAndFerb Suzie Johnson]], [[WesternAnimation/DextersLaboratory Dee Dee]], and [[VideoGame/GodOfWarI Ares]] helping them. Obi-Wan and Megatron have to protect time from him (filling in for [[Franchise/SuperMarioBros Mario and Luigi]]) with assistance from Krauser, the [[VideoGame/Portal2 Space Core]], and [[WesternAnimation/TheMrMenShow Mr. Persnickety]]. [[VideoGame/HotelMario Weegie]] gets to blow stuff up. [[FridgeHorror Frightening]] and [[FridgeBrilliance hilarious]] all at the same time.
*** Alternatively, [[VideoGame/{{Psychonauts}} Augustus Aquato]] wishes to MakeWrongWhatOnceWentRight, and later [[WesternAnimation/TheFairlyOddParents Chet Ubetcha]] gets stranded in space.
** ''VideoGame/RatchetAndClankFullFrontalAssault'': Nigel Uno, now [[WesternAnimation/TheGrimAdventuresOfBillyAndMandy Billy]], takes up arms against his former idol Krauser (and Obi-Wan and Megatron by association), spouting Internet memes all the while.
** ''VideoGame/RatchetAndClankIntoTheNexus'': Obi-Wan and Megatron battle [[WesternAnimation/StarWarsTheCloneWars Asajj Ventress]] and [[WesternAnimation/StarWarsCloneWars Qui-Gon Jinn]]. [[VideoGame/KidIcarusUprising Palutena and Pandora]] assist Weegie in blowing stuff up. Harley Quinn is now [[VideoGame/FinalFantasyXIII Lightning]].
** ''VideoGame/RatchetAndClank2016'': [[VideoGame/MarvelvsCapcom3 Hulk]] listens to Krauser's story of Obi-Wan and Megatron's first adventure, in which they met heroes [[Series/DirtySexyMoney Margaux Darling]], [[WesternAnimation/KungFuPandaLegendsOfAwesomeness Po]], and [[Series/Daredevil2015 Claire Temple]], and rescued [[WesternAnimation/TheAngryBeavers Daggett Beaver]]. WesternAnimation/InvaderZim harvests brains, and VideoGame/HotelMario is the CEO of Gadgetron. Scott Dolph is now [[Film/CinderellaMan Joe Gould]] and [[WesternAnimation/{{Breadwinners}} Buhdeuce]], Pandora is [[VideoGame/MarvelvsCapcom3 Phoenix Wright]], and Mike Heck is [[WesternAnimation/{{Animaniacs}} Wakko]] and Daggett's nephew.
* ''VideoGame/{{Rayman}}'':
** ''VideoGame/Rayman2TheGreatEscape'': [[Anime/DragonBallZ Goku]][[note]]Big Green dub version[[/note]], with aid from [[VideoGame/DetroitBecomeHuman Dan]] and [[VideoGame/FreddiFish Luther]], faces off against the evil forces of [[VideoGame/{{XIII}} Colonel Amos]].
** ''VideoGame/Rayman3HoodlumHavoc'': Goku and Dan (now [[WesternAnimation/IceAge Sid the Sloth]]) must save the world from a Black Lum and his army of Hoodlums (among them [[WesternAnimation/TheLooneyTunesShow Marvin the Martian]] and [[WesternAnimation/SharkTale Ernie]]), with partial help from [[WesternAnimation/{{Futurama}} Phillip J. Fry]].
* ''Franchise/ResidentEvil''
** ''VideoGame/ResidentEvil2'': [[WesternAnimation/XMenTheAnimatedSeries Nightcrawler and Jubilee]] find themselves trapped in a zombie-infested city. All the while, they must tend to [[WesternAnimation/XMenTheAnimatedSeries Mystique]]'s daughter [[VideoGame/DinoCrisis Paula Morton]] as her mutated father tries to abduct her for his own purposes. Nightcrawler falls in love with the announcer from ''[[VideoGame/MarvelVsCapcomClashOfSuperheroes Marvel vs. Capcom]]''.
** ''VideoGame/ResidentEvil3Nemesis'': [[WesternAnimation/XMenTheAnimatedSeries Jean Grey]], having survived [[VideoGame/ResidentEvil "the Mansion incident"]], finds herself stuck in Raccoon City during the same ZombieApocalypse that Nightcrawler and Jubilee found themselves in. She later teams up with [[VideoGame/KingdomHeartsChainOfMemories Zexion]] to escape the necropolis, all the while fending off an [[ImplacableMan Implacable Zombie]] named [[WesternAnimation/TheAdventuresOfSuperMarioBros3 Luigi]].
** ''VideoGame/ResidentEvil4'': U.S. Secret Agent [[VideoGame/SOCOMUSNavySeals Specter]] has been tasked with rescuing the President's daughter [[WesternAnimation/TheAdventuresOfJimmyNeutronBoyGenius Cindy Vortex]] from a mysterious European cult led by [[VideoGame/{{Xenosaga}} Jin Uzuki]]. He runs into [[WesternAnimation/TheBatman Batman]] early on and from there on, it becomes apparent that this isn't some simple rescue mission. Specter is soon caught up with (among other things) a new breed of zombie-esque monsters, the return of [[DatingCatwoman his love interest]] [[VideoGame/CastlevaniaRondoOfBlood Annette Renard]], and his thought-to-be-dead partner [[WesternAnimation/TheAvengersEarthsMightiestHeroes Baron Strucker]].
** ''VideoGame/ResidentEvil5'': [[Manga/{{Bleach}} Shinji Hirako]] continues the fight against the zombies and heads to Africa, where he discovers that his MIA partner [[Series/PowerRangersTurbo Cassie]] [[Series/PowerRangersInSpace Chan]] may not be dead and that [[VideoGame/MassEffect2 Legion]] is once again pulling the strings.
** ''VideoGame/ResidentEvil6'': The fight against zombies and global bio-terrorism continues fifteen years after the Raccoon City Incident. Shinji partners with [[Series/WokeUpDead the Mystery Pill Guy]] to investigate an outbreak in China; [[VideoGame/TalesOfXillia Alvin]] (standing in for Specter) partners with [[VideoGame/TalesOfGraces Cheria Barnes]] to investigate an outbreak in Tall Oaks that infected the President himself; and [[VideoGame/TheLastOfUs Joel]], a mercenary, partners with [[Series/AllMyChildren Bianca Montgomery]] (standing in for Paula). [[VideoGame/MassEffect3 Jack]] (standing in for Annette) becomes heavily involved in the stories of the three aforementioned pairs.
* ''VideoGame/{{Resistance}}'': [[Anime/UnicronTrilogy Megatron]], [[WesternAnimation/TheSuperHeroSquadShow Thor]] (later [[VideoGame/{{Uncharted}} Talbot]]) and [[Series/TwentyFour Michael Amador]] are all humans battling an alien race of [[VideoGame/TeamFortress2 Medics]].
* ''VideoGame/ResonanceOfFate'': [[VideoGame/KingdomHeartsII Olette]] attempts to kill herself, only to by saved by [[WesternAnimation/CaptainPlanetAndThePlaneteers Ma-Ti]] and put to work for a small group of bounty hunters led by [[VideoGame/BatmanArkhamCity the Penguin]].
* ''VideoGame/RiverCityGirls'': [[Literature/KonoSuba Yunyun and Chris]] fight their way through the six regions of River City to rescue their kidnapped boyfriends, [[VideoGame/{{Judgment}} Takayuki Yagami]] and VideoGame/DetectivePikachu.
* ''VideoGame/RogueGalaxy'': [[WesternAnimation/BatmanBeyond Terry McGinnis]] is mistaken for [[VideoGame/{{Doom}} Jack Campbell]] by [[Franchise/TombRaider Alister Fletcher]] and [[VideoGame/FinalFantasyXII Reks]] thanks to his CoolSword. [[VideoGame/GodOfWarIII Pandora]] brings them aboard her father [[VideoGame/MassEffect1 Saren's]] pirate ship, and they sail the stars in search of treasure. The crew's ranks grows to include [[Manga/{{Naruto}} Orochimaru]], [[WesternAnimation/Ben10 Charmcaster]], [[Manga/{{Bleach}} Szayel Apporo Granz]], and [[WesternAnimation/BeastWars Depth Charge]].
* ''VideoGame/RuneFactory4'': A courier (either [[VideoGame/TalesOfGraces Asbel Lhant]] or [[VideoGame/FireEmblemAwakening Maribelle]]) is found amnesiac and mistaken as royalty by the dragon [[VideoGame/DotHackR1Games BlackRose]] until the real prince [[VideoGame/TalesOfXillia Jude Mathis]] arrives. Despite the misunderstanding, they keep up the act and must work for the improvement of Sylvaria. They can also romance some of the bachelors/bachelorettes like [[VideoGame/TalesOfSymphonia Collete Brunel, Presea Combatir]], [[VideoGame/EternalSonata Polka]], [[Manga/{{Naruto}} Hinata Hyuga]], [[VideoGame/TalesOfGraces Sophie and Cheria Barnes]] for Asbel or [[VideoGame/Disgaea3AbsenceOfJustice Mao]] ([[VideoGame/TalesOfBerseria Oscar Dragonia]] in the Switch version), the aforementioned Jude, [[VideoGame/TalesOfTheAbyss Luke Fon Fabre]], [[WesternAnimation/CodenameKidsNextDoor Numbuh One]], [[VideoGame/ResidentEvil5 Albert Wesker]] and [[VideoGame/ShinMegamiTenseiIV Walter]] for Maribelle.
!!S
* ''VideoGame/SaintsRow2'': The PlayerCharacter wakes up from a coma that they were put into by being on a boat with [[VideoGame/CrashBandicoot Dr. Neo Cortex]] that was blown up by [[WesternAnimation/ThePrincessAndTheFrog Dr. Facilier]]. The player saves their friend [[Series/{{Lost}} Jin Sun Kwon]] from going to prison, then soon starts up a new group of Saints consisting of [[VideoGame/{{WET}} Rubi Malone]] and an actor in Dominos Pizza commercials. They also have to rid the city of three gangs consisting of:
** The Brotherhood: [[WesternAnimation/IAmWeasel IM Weasel]], [[Series/MyNameIsEarl Joy Turner]] and (from the first game) [[WesternAnimation/GiJoeRenegades Storm Shadow]].
** The Sons of Samedi: [[VideoGame/MetalGearSolid Grey Fox]], WesternAnimation/SamuraiJack, and [[Series/HowIMetYourMother Barney Stinson]].
** The Ronin: [[Anime/CowboyBebop Spike Spiegel]], [[WesternAnimation/WolverineAndTheXMen2009 Iceman]], and [[WebVideo/MortalKombatLegacy Liu Kang]].
*** The head of business group Ultor, [[Series/GaryUnmarried Gary Brooks]], later attempts to have them killed.
** ''VideoGame/SaintsRowTheThird'': The player (now voiced by either [[Manga/{{Naruto}} Pain]], [[VideoGame/TeamFortress2 The Medic]], [[Manga/FullMetalAlchemist Lust]], [[VideoGame/Drakengard3 Zero]], or [[Creator/{{Toonami}} TOM]] spouting gibberish) and their homies, including newcomers [[VideoGame/GodOfWarIII Pandora]], a porn star, and [[Film/SuburbanCommando Shep Ramsey]], go fight a criminal syndicate which consists of a Belgian, the hacker [[VideoGame/AceCombatZeroTheBelkanWar Pixy]], and the Luchadore [[VideoGame/BatmanArkhamCity Clayface]].
** ''VideoGame/SaintsRowIV'': The player (TOM is replaced by [[VideoGame/MarvelVsCapcom3 Deadpool]]) goes up against [[VideoGame/SpyroReignitedTrilogy Moneybags]]. [[Film/TheyLive Nada and Frank]] are among the new homies.
* ''[[VideoGame/SakuraWarsSoLongMyLove Sakura Wars: So Long, My Love]]'': [[VideoGame/TalesOfTheAbyss Guy Cecil]] is sent to New York City to lead the New York Combat Revue, which consists of [[VideoGame/{{Skullgirls}} Parasoul]], [[VideoGame/TalesOfXillia Agria]], [[VisualNovel/FateStayNight Rider]], [[VideoGame/Persona4 Rise Kujikawa]], and [[WesternAnimation/InvaderZim Gaz]].
* ''[[VideoGame/SamAndMaxFreelancePolice Sam & Max Hit the Road]]'': [[WesternAnimation/AGoofyMovie Goofy]], a dog detective, tries to solve the mystery of a missing bigfoot with the help of his unhinged partner [[WesternAnimation/TheCritic Vlada]].
** ''VideoGame/SamAndMaxFreelancePolice'': In an episode followup, Goofy becomes [[VideoGame/HouseOfTheDead Thomas Rogan]] and Vlada becomes [[Manga/JoJosBizarreAdventure Dio Brando]], then [[WesternAnimation/HiddenSide Douglas]]. Thomas and Dio[=/=]Douglas investigate all sorts of threats, including a wave of mind control crimes, an attempt to purchase Hell, and race to collect cursed toys that grant the user psychic powers.
* ''VideoGame/SEGASuperstars''
** ''Sonic & SEGA All-Stars Racing'': [[Manga/OnePiece Usopp]] (4Kids dub), [[WesternAnimation/WinxClub Mirta]], [[Literature/{{Slayers}} Lina Inverse]], and [[Anime/{{Pokemon}} Mewtwo]] hold a kart racing tournament with characters from a wide variety of SEGA franchises. Amongst the various competitors are [[Anime/UltimateMuscle Meat]], [[Anime/YuGiOhGX Atticus Rhodes]], [[Anime/ShamanKing Morty Oyamada]], [[Manga/{{Bleach}} Mizuho Asano]], [[WesternAnimation/MegasXLR Nova]], [[Series/IronChef Chairman Kaga]], [[Manga/MagiLabyrinthOfMagic Ithnan]], [[VideoGame/TimeCrisis Marc Godart]], and [[Series/LAForensics Dennis Brown]]. [[VideoGame/DonkeyKong64 Diddy Kong]] and [[VideoGame/PerfectDark Daniel Carrington]] appear as special guest racers in the Xbox 360 version.
* ''VideoGame/SengokuBasara: Samurai Heroes'': [[VideoGame/GuiltyGear Ky Kiske]] defeated his mentor and now aims to unite the land, but he is opposed by his former friend [[VideoGame/Persona4 Kanji Tatsumi]]. In the meantime Ky had aligned with [[VideoGame/DevilMayCry Dante]], assisted by [[VideoGame/BlazBlue Relius Clover]], who wished vengeance on Kanji. On the other side, Kanji sought the assistance of [[Anime/CodeGeass Lelouch Lamperouge]], assisted by [[Anime/GaoGaiGar Guy Shishioh]], who swore vengeance upon Ky for defeating '''[[VideoGame/DisgaeaHourOfDarkness CAPTAIN GORDON, DEFENDER OF EARTH!]]'''. Other war participants include locked-up convict [[VideoGame/MortalKombatVsDCUniverse Raiden]], sexy mercenary [[VisualNovel/FateStayNight Rider]], and pirate [[VideoGame/WorldOfWarcraft Arthas Menethil]]. And somewhere else, the evil [[Manga/FullmetalAlchemist Edward Elric]] is out to revive a Demon King using his sister [[VideoGame/ValkyriaChronicles Isara Gunther]].
* ''VideoGame/{{Shantae}}'' (series): [[VideoGame/{{Paladins}} Ying]] is a half-human, half-genie tasked with defending a town from the constant raids of pirate queen [[VideoGame/{{Skullgirls}} Cerebella]].
** ''Shantae and the Seven Sirens'': Ying, joined by her friends [[Anime/HellsingUltimate Heinkel Wolfe]], [[Anime/BNABrandNewAnimal Michiru Kagemori]], and [[VideoGame/RiverCityGirls Shinji]] (formerly [[VideoGame/RiverCityGirls Naritaka]]), and her uncle [[VideoGame/Persona5 Joker]], must investigate the kidnapping of several Half-Genies on a distant island. These missing Half-Genies include [[Manga/TheSevenDeadlySins Hawk]], [[VideoGame/PokemonMasters Rosa]], and [[VideoGame/FireEmblemHeroes Loki]]. Meanwhile, Cerebella seeks a treasure beneath the island’s surface.
* ''VideoGame/SharkTale'': WesternAnimation/SamuraiJack crosses paths with [[WesternAnimation/MonstersVsAliens Advisor Ortega]] in a freak accident that makes Jack famous and Ortega's father [[VideoGame/DisneyInfinity Ultron]] ''very'' angry. He also has to deal with his competing love interests [[VideoGame/Spyro2RiptosRage Elora the Faun]] and [[Series/LawAndOrderSpecialVictimsUnit Lois Green]]. Also starring [[Series/{{NCIS}} Leon Vance]] and [[WesternAnimation/HeyArnold Gerald Johannsen]] as two jellyfish.
* ''VideoGame/ShinMegamiTenseiIIINocturne'' (HD Remastered version): [[VideoGame/FireEmblemThreeHouses Ignatz]] and his friends [[VideoGame/Cyberpunk2077 Judy Alvarez]] and [[VideoGame/Persona5 Goro Akechi]] are going in a hospital to search for their teacher [[VideoGame/ThirteenSentinelsAegisRim Yuki Takiyama]]. Ignatz met mysterious reporter [[VideoGame/MonsterHunterRise Fugen]] who told him of the end of the world. He became a half-demon thanks to [[VideoGame/HyperdimensionNeptuniaMK2 Uni]] who is, in reality, [[VideoGame/MetalGearSolid Colonel Roy Campbell]]. Depending of the version, he is either confronted by [[Manga/JojosBizarreAdventureDiamondIsUnbreakable Josuke Higashikata]] or [[VideoGame/SengokuBasara Masamune Date]].
* ''VideoGame/ShinMegamiTenseiIV'': [[VisualNovel/DanganronpaTriggerHappyHavoc Mondo Ohwada]] is a new samurai from the eastern kingdom of Mikado which, alongside [[VideoGame/FireEmblemAwakening Kellam]], [[VideoGame/TalesOfXillia Alvin]] and [[VideoGame/Persona4 Marie]] who travels in Naraku. He is accompanied by his AI partner, [[VideoGame/KidIcarusUprising Palutena]] and can have contact with demons. After [[Manga/{{Naruto}} Temari]] has corrupt Kirito's best friend, [[VisualNovel/DanganronpaTriggerHappyHavoc Makoto Naegi]] he and his friends are ordered by [[Franchise/GhostInTheShell Batou]] and [[Manga/{{Bleach}} Uryu Ishida]] to find Temari in the depths of Naraku who is, in actuality Tokyo. Eventually, Kirito has to choose between joining Kellam in a crusade against Lucifer [[spoiler: who took human form as [[VideoGame/BlazBlueContinuumShift Tsubaki Yayoi]]]], Alvin and [[VideoGame/EternalSonata Claves]] to fight God or assist Marie, [[VideoGame/DynastyWarriors Lu Bu]] and [[VisualNovel/PhoenixWrightAceAttorneyDualDestinies Miles Edgeworth]] to fight both Kellam and Alvin to make sure mankind is safe.
* ''VideoGame/ShinMegamiTenseiIVApocalypse'': [[VideoGame/Persona5 Ren Amamiya]] offers to bring [[Manga/JojosBizarreAdventureGoldenWind Giorno Giovanna]] back from the dead in exchange for becoming his personal god killer.
* ''VideoGame/Shrek2'': [[VideoGame/SpyroTheDragon1998 Gnasty Gnorc]], [[VideoGame/SpiderMan2 Black Cat]], and [[VideoGame/GodOfWar3 King Minos]] are invited to the kingdom of Far Far Away to meet Black Cat's father [[Franchise/WinnieThePooh Gopher]], who sends the nefarious ogre killer [[VideoGame/CrashNitroKart Zem]] to deal with Gnasty. Meanwhile, [[VideoGame/Fallout4 Mrs. Whitfield]] plans to have her son [[WesternAnimation/{{TMNT}} Leonardo]] marry Black Cat. Other characters include [[WesternAnimation/DrawnTogether Wooldor Sockbat]] the gingerbread man, [[WesternAnimation/TheBookOfLife Thomas]] the wolf, [[WesternAnimation/MyLittlePonyFriendshipIsMagic Twilight Sparkle]] the human girl, and [[WesternAnimation/ThePowerpuffGirls1998 Bubbles]] the fairy.
** ''VideoGame/ShrekSuperSlam'': Gnasty Gnorc, Black Cat, King Minos, Zem, Leonardo, Wooldor (now [[WesternAnimation/{{Madagascar}} Mason]]), Twilight Sparkle and Thomas (now [[WesternAnimation/TheNewAdventuresOfSpeedRacer Speed Racer]]) return to duke it out across numerous arenas. Joining them are living puppet [[WesternAnimation/OpenSeason Mr. Weenie]], dark knight [[WesternAnimation/KungFuPandaLegendsOfAwesomeness Mantis]], angry gnome Chester Cheetah, cyclops [[WesternAnimation/TheEpicTalesOfCaptainUnderpants Hank]], sentient egg [[Franchise/RatchetAndClank Ratchet]], magical unicorn [[WesternAnimation/TeenTitans2003 Raven]], sneezing witch [[WesternAnimation/Ben10 Ben Tennyson]], donkey-dragon hybrid [[WesternAnimation/SamuraiJack Ashi]], archer [[WesternAnimation/AvatarTheLastAirbender Bumi]], metalhead hunchback [[VideoGame/MarvelVsCapcom3 Deadpool]] and pirate captain [[VideoGame/NickelodeonAllStarBrawl Nigel Thornberry]].
** ''VideoGame/ShrekSmashNCrashRacing'': Gnasty Gnorc decides to hold a kart racing tournament with Black Cat, King Minos, and Mason (who is back to being Wooldor). Joining them are Zem, Leonardo, Mr. Weenie, Ratchet, Twilight, little girl [[WesternAnimation/{{Rugrats}} Dil Pickles]], pig trio [[WesternAnimation/CloudyWithAChanceOfMeatballs2 Barry the Strawberry and the Dill Pickles]], and [[Series/ThirdRockFromTheSun Dick Solomon]]'s henchman [[WesternAnimation/{{Madagascar}} Private]].
* ''Franchise/SilentHill'':
** ''VideoGame/SilentHill1'': After getting into a car crash, [[VideoGame/CastlevaniaSymphonyOfTheNight Dracula]] must search a mysterious town in search of his missing daughter. Along the way he encounters the likes of [[VideoGame/PuyoPuyo Klug]] and [[VideoGame/TheSecretOfMonkeyIsland Mancomb Seepgood]].
** ''Silent Hill HD Collection'': Due to the lack of any notable credits for the original cast members, we'll use the cast from the recording for the following.
*** ''VideoGame/SilentHill2'': After receiving a letter from his dead wife [[Anime/GhostInTheShell Motoko Kusanagi]], [[VideoGame/BioshockInfinite Booker DeWitt]] travels to a mysterious town where he encounters monsters, a woman resembling his wife named [[Anime/WolfsRain Jagara]], [[Manga/SoulEater Maka Albarn]], [[Manga/{{Naruto}} Ga'ara]], and the most unspeakable horror of all....[[PortingDisaster game breaking bugs]].
*** ''VideoGame/SilentHill3'': After Dracula's daughter grows up to be [[Anime/NeonGenesisEvangelion Rei Ayanami]], she gets trapped in Silent Hill where she encounters more monsters, a cult led by [[Manga/FullmetalAlchemist Lust]], Manga/BlackJack, [[Manga/{{Naruto}} Sasuke]], and more bugs.
** ''VideoGame/SilentHills'': [[Series/TheWalkingDead2010 Daryl Dixon]] would have explored a mysterious town and/or his own tortured psyche if this project [[WhatCouldHaveBeen hadn't been cancelled]].
* ''VideoGame/TheSimpsonsHitAndRun'': When the citizens of Springfield become corrupted by the brand new Buzz Cola, [[WesternAnimation/{{Rugrats}} Jonathan]], [[WesternAnimation/TheLionKingOneAndAHalf Timon's Ma]], [[WesternAnimation/PinkyElmyraAndTheBrain Rudy Mookich]], [[WesternAnimation/WereBackADinosaursStory Cecilia]], and [[Film/TheSmurfs Gargamel]] get caught up in a conspiracy plot by aliens [[WesternAnimation/OliveTheOtherReindeer the Postman]] and [[Film/Godzilla1998 Charles Caiman]] to boost ratings for their intergalactic reality show "Foolish Earthlings".
* ''VideoGame/{{Skullgirls}}'': Several girls compete for possession of the Skull Heart, an artifact which can bestow wishes on the victor but could potentially cost her soul. The combatants are [[Anime/PuellaMagiMadokaMagica Madoka Kaname, Homura Akemi and Sayaka Miki]], respectively an amnesiac schooligirl who fights with the help of [[VideoGame/BlazBlue Ragna the Bloodedge]] (a parasite that forms PrehensileHair), a circus performer in the employ of the mafia whose weapon is a hat with two giant muscular arms and a young girl [[BloodKnight with a damaged psyche]] who has been experimented to effectively become a living cartoon, [[Franchise/{{Neptunia}} Noire]], a Princess with a napalm-tossing umbrella and a unit of crack troops at her command, [[WebVideo/DragonBallAbridged Chi-Chi]], a catwoman with an undying body whose attacks involve throwing her head at her enemies, [[VideoGame/LeagueOfLegends Pre-rework Karma and Ahri]], respectively a ChildSoldier who has been tortured and mindraped into being a LivingWeapon and the psychotic nurse who did the experiments on the former, and an EldritchAbomination. DLC characters so far include the undead opera singer [[VideoGame/BlazBlue Litchi Faye-Ling]] and her benevolent parasite [[VideoGame/FinalFantasyIV Kain Highwind]], the Game Trailers countdown guy who received an iron lung and assortment of musical instrument-shaped weaponry to take back his policeman job, Madoka Kaname's sinister dream-clone, an Egyptian-themed lounge singer [[VideoGame/MarvelVsCapcom3 Crimson Viper]] who secretly harbours a LovecraftianSuperpower that uses her own blood, a god complex and a psychotic parasite [[Franchise/DotHack BlackRose]] who lives inside her skin, [[Manga/HunterXHunter Gon Freeccs]], a TV star cursed with eternal youth, [[VideoGame/FireEmblemThreeHouses Sothis]], Noire's younger sister, and [[Anime/CowboyBebop Faye Valentine]], the Medici family's deadliest assassin. Chi-Chi also appears as a robotic double of herself, [[ActingForTwo despite being the same person]].
* ''Franchise/SonicTheHedgehog:''
** ''VideoGame/SonicAdventure:'' [[VideoGame/BlueStinger Eliot G. Ballade]] is an energetic hedgehog who, with the help of his longtime friends, genius fox and best friend [[VideoGame/BackyardSports Bobby Higginson]], bruiser echidna rival [[VideoGame/LostOdyssey Jansen Friedh]], and a pink hedgehog with a crush on Eliot[[note]]Jennifer Douillard, Amy's original voice actress, doesn't have any other notable roles unless one counts the San Diego County Fair[[/note]], thwart the nefarious scientist [[Anime/ParanoiaAgent Masami Hirukawa's]] latest plan to take over the world. Joining them are newcomers VideoGame/DukeNukem, a dim-witted cat searching for his frog friend, and [[Creator/CriterionGames Clayton (AirBlade)]], a creation of Masami's. The group is frequently assisted by [[VideoGame/{{Frogger}} Princess Dar]].
** ''VideoGame/SonicShuffle:'' Jansen is now [[VideoGame/TheGodfather Bill Bardi]], and the gang has to thwart [[VideoGame/ProfessorLayton Luke Triton]].
** ''VideoGame/SonicAdventure2:'' Bobby and Bill are now [[VideoGame/BackyardSports Jerry Rice]] and [[VideoGame/Runaway2TheDreamOfTheTurtle Paco]], respectively. Masami's latest plan involves releasing VideoGame/JackKeane, a black hedgehog with a strong resemblance to Eliot who wants revenge for the death of his friend, [[VideoGame/EvilZone Setsuna Saizuki]], and his creator, [[VideoGame/TonyToughAndTheNightOfRoastedMoths Dudley]]. Masami and Jack are joined by [[Franchise/SuperMarioBros Wendy O. Koopa]], a jewel thief hired by President [[VideoGame/EvilDeadHailToTheKing Allard]] to look into Jack. [[VideoGame/SuperSmashBros Lucas]] is a robot that [[AnnoyingVideoGameHelper gives obvious advice]].
** ''VideoGame/SonicHeroes:'' Jerry is now [[VideoGame/BackyardSports Reese Worthington]]. After Masami's latest plot to take over the world begins, Eliot, Reese and Paco team up to stop him. Meanwhile, Wendy discovers that Jack is alive, and teams up with him and renegade robot [[VideoGame/Postal4NoRegerts The Postal Dude]] to help Jack recover his memories. The pink hedgehog teams up with Duke Nukem, a rabbit and her pet Chao[[note]]Sarah Wulfeck, Cream's original voice actress, doesn't have any further notable roles[[/note]] to find Duke's frog friend (again) and the rabbit's other Chao. Finally, a detective agency consisting of [[VideoGame/Strider2014 Strider Hiryu]], [[VideoGame/AmnesiaTheDarkDescent Agrippa and Justine]] are hired by a mysterious benefactor, who turns out to be the real Masami as [[VideoGame/TwistedMetal Pizza Boy]], his creation and Eliot's EvilKnockoff, had been impersonating him.
** ''VideoGame/ShadowTheHedgehog:'' Jack, who is now [[Anime/PokemonTheSeriesBlackAndWhite Cilan]], is confronted by alien leader [[Anime/UltimateMuscle Kid Muscle]] and must choose whether to side with him or military commander [[Anime/YuGiOhGX Chazz Princeton]]. Eliot, Reese, Paco, the pink hedgehog, Masami, Wendy, the Postal Dude, Strider, Agrippa, Justine, the rabbit, Allard, Setsuna and Dudley are now respectively [[Manga/OnePiece Usopp]], [[Anime/OjamajoDoremi Dorie Goodwyn]], [[Manga/YuGiOh Yugi Muto]], [[Literature/{{Slayers}} Lina Inverse]], [[Webcomic/{{Lackadaisy}} Church]], [[Manga/YuGiOh Mai Valentine]], [[VideoGame/NightsJourneyOfDreams an owl]], [[WesternAnimation/TeenageMutantNinjaTurtles2003 Raz]], [[Anime/FZeroGPLegend Captain Falcon]], [[Anime/PokemonTheSeriesRubyAndSapphire Max]], [[Manga/ArcadeGamerFubuki Ruriko Sakuragasaki]], [[Anime/PokemonTheOriginalSeries Meowth]], [[Manga/IchiTheKiller Midori]] and [[Anime/PokemonTheSeriesBlackAndWhite Drayden]]. In [[Anime/SonicX a different continuity]], Duke Nukem and Clayton are now [[Anime/YuGiOhGX Aster Phoenix]] and [[Anime/KirbyRightBackAtya Chief Bookem]].
** ''VideoGame/SonicRush'': Usopp helps [[Anime/ShamanKing Lyserg Diethel]], the princess of the Sol Dimension, open up by showing her ThePowerOfFriendship and the duo take down Church and his alternate dimension counterpart [[Anime/UltimateMuscle Meat]]. [[VideoGame/SonicRushAdventure Sometime later]], Usopp and Dorie end up in the Sol Dimension to take down an even bigger threat in the form of a pirate named Captain Whisker.
** ''VideoGame/SonicRiders'': Usopp, Dorie and Yugi race against their new rivals, [[WesternAnimation/TeenageMutantNinjaTurtles2003 Usagi Yojimbo]], [[Anime/YuGiOh5Ds Akiza Izinski]] and [[Anime/KirbyRightBackAtYa NME Customer Service]]. Lucas is now [[WesternAnimation/WinxClub Princess Bloom]].
** ''VideoGame/SonicTheHedgehog2006:'' When the princess of Soleanna, [[WesternAnimation/TheWildThornberrys Eliza Thornberry]], is under attack by Church's robots, Usopp has to save her. Along the way, he has to deal with [[Anime/YuGiOh5Ds Dexter]], a hedgehog from the future who is manipulated by [[Anime/PokemonMewtwoReturns Mewtwo]] into trying to kill Usopp. The owl is now [[Anime/PokemonTheOriginalSeries Lt. Surge]], and Eliza's father was [[WesternAnimation/TurtlesForever 1987 Splinter]].
** ''VideoGame/SonicStorybookSeries:'' Usopp is brought into different book worlds to put a stop to their respective villains. In [[VideoGame/SonicAndTheSecretRings the first]], he's brought to the world of the ''Literature/ArabianNights'' by the [[Manga/YuGiOh Dark Magician Girl]], and must deal with an evil genie.[[note]]Peter Cormican, Erazor Djinn's voice actor, doesn't have any noteworthy roles on this site.[[/note]] In [[VideoGame/SonicAndTheBlackKnight the second]], he's brought into the Myth/ArthurianLegend by [[Franchise/YokaiWatch Katie Forester]] and wields the legendary blade [[VideoGame/NightsJourneyOfDreams Reala]] against the corrupt king [[VideoGame/TheWalkingDead Kenny]].
** ''VideoGame/SonicUnleashed:'' After Greg's latest ploy turns Usopp into a [[OurWerebeastsAreDifferent werebeast]], he meets [[Anime/PokemonTheSeriesXY Ramos]] and receives assistance from [[Anime/YuGiOh5Ds Tetsu Trudge]].
** ''VideoGame/SonicFreeRiders:'' Usopp, Dorie, Yugi, Lina, Ruriko, Raz, Cilan, Mai, Usagi, Akiza, Customer Service, Dexter, Lyserg, Bloom and a disguised Pizza Boy are now [[VideoGame/ResidentEvil5 Chris Redfield]], [[Anime/CodeGeass C.C.]], [[Manga/FullmetalAlchemist Roy Mustang]], [[Manga/{{Bleach}} Kukaku Shiba]], [[Anime/LuckyStar Tsukasa Hiiragi]], [[Manga/JoJosBizarreAdventure Robert E.O. Speedwagon]], [[Manga/BoboboboBobobo Don Patch]], [[VideoGame/Persona4 Nanako Dojima]], [[Manga/{{Naruto}} Obito Uchiha]], [[VideoGame/SuperMarioOdyssey Pauline]], [[VideoGame/StreetFighterIV Guile]], [[WesternAnimation/MyLifeAsATeenageRobot Sheldon Lee]], [[Manga/SoulEater Maka Albarn]], [[VideoGame/{{Klonoa}} Huepow]] and [[VideoGame/BatmanArkhamAsylum the Riddler]], respectively.
** ''VideoGame/SonicColors:'' Chris and C.C. discover a plot by Church to harness aliens using an interstellar amusement park, with help from his robotic minions [[Anime/DigimonAdventure Gabumon]] and [[WesternAnimation/TheGarfieldShow Jon Arbuckle]]. In the Nintendo DS version, Aster, Lt. Surge, Captain Falcon and Max are now [[Anime/TengenToppaGurrenLagann Kamina]], [[Franchise/DragonBall Broly]], [[VideoGame/TheLastOfUs Joel]] and [[WesternAnimation/DannyPhantom Jazz Fenton]] respectively.
** ''VideoGame/SonicGenerations:'' In this MilestoneCelebration, the [[DependingOnTheWriter past/alternate versions]] of Chris and C.C, TheVoiceless and [[Manga/{{Naruto}} Sakura Haruno]] respectively, team up to stop Greg and ''his'' past/alternate self, [[Anime/{{Berserk}} Adon]].
** ''VideoGame/SonicLostWorld:'' Chris, C.C. and Church reluctantly team up against the Deadly Six, consisting of [[WesternAnimation/AvengersAssemble Thor]], [[Manga/{{Naruto}} Gaara]], [[Manga/MyHeroAcademia Endeavor]], [[Franchise/KingdomHearts Saix]], Manga/SailorMoon and [[VisualNovel/AceAttorney Phoenix Wright]].
** ''VideoGame/SonicBoom:'' In this spinoff series, C.C. is now [[Anime/DigimonAdventure Sora Takenouchi]]. Chris, Sora, Roy and Kukaku, along with new character [[WesternAnimation/TheLoudHouse Luna Loud]], team up to thwart Greg on many occasions. In the first two games, they have to deal with the ancient evil [[Manga/OnePiece Franky]], while receiving assistance from [[WesternAnimation/CodenameKidsNextDoor Nigel Uno]]. [[VideoGame/Persona4 Chie Satonaka]] is a notable [=NPC=].
** ''VideoGame/SonicForces:'' Church's newest creation, the reality-warping [[VideoGame/Persona3 Akihiko Sanada]], defeats Chris and causes the others to form a resistance against them, with a [[PlayerCharacter new face]] (either [[Anime/TigerAndBunny Chopman]] or [[Anime/PuellaMagiMadokaMagica Madoka Kaname]][[note]]Japanese; the Avatar has no English voice actor[[/note]]) joining the fight. Joel is now [[VideoGame/FireEmblemAwakening Chrom]].
** ''VideoGame/TeamSonicRacing:'' Roy, Huepow, Maka, Sheldon, Broly and Thor are now [[VideoGame/MortalKombat11 Geras]], [[VideoGame/Persona5 Futaba Sakura]], [[Anime/LoveLive Eli Ayase]], [[Manga/BlueExorcist Rin Okumura]], [[WesternAnimation/{{Primal}} Spear]] and [[Manga/JojosBizarreAdventure Dio Brando]], respectively. They all enter a racing tournament held by [[VideoGame/StreetFighterIV Ryu]].
** ''VideoGame/SonicFrontiers:'' Chris finds himself in the Starfall Islands and ends up clashing against a mysterious girl named [[Anime/NeonGenesisEvangelion Rei Ayanami]] who keeps telling him to leave the islands.
* ''VideoGame/SpaceInvaders Extreme 2'': [[VideoGame/FZero Black Shadow]] tries his hand at commentating shootouts against multi-colored aliens.
* ''VideoGame/SpecOpsTheLine'': [[Franchise/AssassinsCreed Desmond Miles]] and his team members, [[Film/HouseParty Chris Reid]] and [[Series/AmericanGods Salim]] infiltrate Dubai to recon the place after a massive sandstorm, after [[Series/Babylon5 John Sheridan]] botches up the first rescue mission accidentally. [[Film/StarshipTroopers Ace]] operates the Dubai Radio whereas Agents [[VideoGame/BatmanArkhamOrigins Deadshot]] and [[VideoGame/MafiaII Vito Scaletta]] are on [=CIA=] duty. Things go FromBadToWorse.
* ''VideoGame/SpiderMan2000'': When [[WesternAnimation/TheBatman Bruce Wayne]] is framed for stealing a seemingly-reformed [[WesternAnimation/BatmanTheAnimatedSeries Alfred Pennyworth's]] technology, Bruce, with help from [[VideoGame/KnightsOfTheOldRepublic Bastila Shan]], must fight his old enemies [[WesternAnimation/TransformersPrime Knock Out]], [[WesternAnimation/MuppetBabies2018 Baby Animal]], [[Anime/TigerAndBunny Alexander Lloyds]], and [[WesternAnimation/StarWarsTheCloneWars Commander Rex]], all while being pursued by his old nemesis [[Series/VeronicaMars Cliff McCormack]], who has taken Bruce's wife [[WesternAnimation/BrandyAndMrWhiskers Margo]] hostage.
** ''VideoGame/SpiderMan2EnterElectro'': The electric-charged [[WesternAnimation/MilesFromTomorrowland M.E.R.C.]] kidnaps [[WesternAnimation/TheAvengersEarthsMightiestHeroes Carol Danvers]] in hopes of forcing her to make him an invincible being. Bruce springs back into action and fights against the vibration-charged [[Series/{{iZombie}} Johnny Frost]], sand creature [[Series/BigTimeRush Buddha Bob]], old-fashioned gangster [[WesternAnimation/GravityFalls Waddles the Pig]], and TragicMonster [[WesternAnimation/JakeAndTheNeverlandPirates Tick Tock Croc]] to stop M.E.R.C. before its too late.
* ''VideoGame/SpiderManPS4'': Eight years into his crime-fighting career, [[VideoGame/Persona3 Makoto Yuuki]] succeeds with assisting NYPD Captain [[WebAnimation/{{RWBY}} Kali Belladonna]] in getting crime lord [[VideoGame/SonicBoom Knuckles]] sent to prison. When not stopping crimes, Makoto can often be found either working at [[VideoGame/MassEffect3 Mordin Solus]]' lab or volunteering at the homeless shelter with his aunt [[WesternAnimation/TheAddamsFamily1992 Morticia Addams]]. Over time, however, Makoto and his ex-girlfriend VideoGame/{{Catherine}} find themselves embroiled in [[Series/TheLastSHip Lau Hu]]'s plot against Mayor [[VideoGame/InjusticeGodsAmongUs Lex Luthor]], which results in the death of [[VideoGame/CallOfDutyWWII CPL Marcus Howard]], [[VideoGame/TheLastOfUs Sam]]'s father. As the situation escalates, Makoto does battle against his old foes [[WesternAnimation/GreenLanternTheAnimatedSeries Hal Jordan]], [[WesternAnimation/Ben10 Dr. Animo]], [[WesternAnimation/YoungJustice2010 Kid Flash]] and [[VideoGame/KidIcarusUprising Magnus]]. All the while, he gets badmouthed on the internet by [[VideoGame/HearthstoneHeroesOfWarcraft Anub'arak]].
* ''VideoGame/SpiderManShatteredDimensions'': After [[WesternAnimation/BatmanUnderTheRedHood Nightwing]] gets into a fight with [[Manga/InuYasha Sesshomaru]] and destroys a powerful tablet by accident, [[VideoGame/GodOfWar Gaia]] recruits Nightwing, [[Franchise/TransformersGeneration1 Bumblebee]], [[WesternAnimation/TheLittleMermaid1989 Prince Eric]], and [[WesternAnimation/GreenLanternTheAnimatedSeries Hal Jordan]] to find the fragments and put the tablet back together. Along the way, they encounter WesternAnimation/DarkwingDuck, [[Manga/{{Naruto}} Orochimaru]], [[WesternAnimation/Ben10UltimateAlien Zombozo]], [[Franchise/BackToTheFuture Biff Tannen]], [[Series/CriminalMinds Lyov Lysowsky]], [[Series/TalesFromTheCrypt the Crypt Keeper]], [[WesternAnimation/TheLegendOfKorra Amon]], [[WesternAnimation/TransformersPrime Smokescreen]], [[Series/{{Chuck}} Yuri The Gobbler]], WesternAnimation/{{Cinderella|IIDreamsComeTrue}}, [[WesternAnimation/TransformersAnimated Sari Sumdac]], [[WesternAnimation/SonicTheHedgehogSatAM Dr. Robotnik]], and [[VideoGame/GearsOfWar Damon Baird]]. Nightwing, Bumblebee, Eric, and Hal then take turns battling Sesshomaru.
** ''VideoGame/SpiderManEdgeOfTime'': Bumblebee [[TheOtherDarrin is now]] [[Film/TheBradyBunch Greg Brady]] and he must find a way to save Nightwing, [[TheOtherDarrin who is now]] [[VideoGame/NinjaGaiden Ryu Hayabusa]], from the TimeTravel machinations of Film/{{Batman|Forever}}, who's also employed [[WesternAnimation/LilBush George Sr.]] and is controlling [[WesternAnimation/TransformersPrime Starscream]]. [[Series/{{Smallville}} Supergirl]] is Ryu's girlfriend and [[Series/BattlestarGalactica2003 Kara "Starbuck" Thrace]] is a clone of one of Ryu's old girlfriends from the future. [[spoiler: George Sr., Starscream, and Batman merge into [[Manga/{{Naruto}} Gato]]. It also turns out that Ryu goes bad in the future and runs the MegaCorp that Greg and Batman work for.]]
* ''WesternAnimation/SpongeBobSquarePants'':
** ''VideoGame/SpongeBobSquarePantsBattleForBikiniBottom''/''[[VideoGameRemake Rehydrated]]'': When [[WesternAnimation/CampLazlo Ping-Pong]] unleashes an army of destructive robots across Bikini Bottom, [[WesternAnimation/FostersHomeForImaginaryFriends Eduardo]] and his friends [[WesternAnimation/WanderOverYonder Prince Cashmere]] and [[VideoGame/ResidentEvil4 Ashley Graham]] must team up to defeat them by learning different abilities from their friends, which include Eduardo and Cashmere's neighbor [[WesternAnimation/InvaderZim Professor Membrane]], Eduardo's pet snail [[WesternAnimation/AdventureTime Ice King]], Eduardo and Membrane's boss [[WesternAnimation/ChickenLittle the Oakey Oaks Mascot]], Eduardo's teacher [[Series/DifferentStrokes Pearl Gallagher]], elderly superheroes [[WesternAnimation/HotelTransylvania Tinkles]] and [[Series/TheCarolBurnettShow Mr. Tudball]], bubble creature [[WesternAnimation/{{Delgo}} Spog]], and muscular lobster [[WesternAnimation/RockosModernLife Filburt]]. Ghostly pirate [[WesternAnimation/MyGymPartnersAMonkey Coach Gills]] also makes an appearance. In the end, the true culprit is revealed to be Ping-Pong's robotic doppelganger [[WebAnimation/MightyMagiswords Ralphio]].
** ''VideoGame/TheSpongeBobMovieGame'': Eduardo and Cashmere set off on a quest to retrieve the crown of [[Film/TheHangover Sid Garner]] before he burns the Oakey Oaks Mascot (now [[WesternAnimation/SupermanTheAnimatedSeries Lex Luthor]]) alive. Meanwhile, Ping-Pong sends hitman [[VideoGame/RatchetAndClankIntoTheNexus Neftin Prog]] to stop them. The two are assisted by Garner's daughter [[Franchise/MarvelCinematicUniverse Black Widow]], who communicates with them through a clam-shaped monitor.
** ''VideoGame/SpongeBobSquarePantsLightsCameraPants'': Film producer [[VideoGame/{{Uncharted}} Nathan Drake]] holds an audition for the role of a villain in an episode of Tinkles (now [[Film/LooneyTunesBackInAction Bugs Bunny]]) and Tudball's TV show, which Eduardo and his friends must compete for in a series of minigames hosted by other denizens of Bikini Bottom including FatBastard [[WesternAnimation/StarWarsTheCloneWars Captain Rex]], Filburt, Pearl Gallagher, Membrane's rival [[WesternAnimation/CodenameKidsNextDoor Heinrich]], Ping-Pong's computer wife [[WesternAnimation/TheLoudHouse Rita Loud]], snobbish geek [[WesternAnimation/AmericanDad Klaus]], muscular whale [[WesternAnimation/MyFriendsTiggerAndPooh Buster the Dog]], and elderly daredevil [[WesternAnimation/TheFairlyOddParents Sanjay]]. Bugs and Tudball's arch-enemies [[WesternAnimation/BigCityGreens Bill Green]] and [[WesternAnimation/ATrollInCentralPark King Llort]] show up as well.
** ''VideoGame/SpongeBobSquarePantsCreatureFromTheKrustyKrab'': We explore the dreams of Eduardo, Cashmere, and Ping-Pong, whose dreams slowly converge together involving a monstrous Krabby Patty that Ping-Pong accidentally created. In the end, [[spoiler: it all turns out to be Ice King's dream]]. Pearl Gallagher, Bugs, and Sanjay also make appearances, and Eduardo competes in various challenges that [[WesternAnimation/TheFairlyOddParents Doug Dimmadome]] and [[VideoGame/RatchetAndClank Captain Quark]] provide commentary on.
** ''VideoGame/SpongeBobsTruthOrSquare'': It's the eleventy-seventh anniversary of the Krusty Krab, and Eduardo has been tasked by Lex Luthor (now [[WesternAnimation/TheWackyAdventuresOfRonaldMcDonald Mayor McCheese]]) with protecting the Krabby Patty secret formula from Ping-Pong, only for him to forget where he put it. It falls upon Eduardo's friends to help him remember where he put the formula via memories of events in his life. Bugs is now [[Film/IceStationZebra Boris Vaslov]].
* ''Franchise/SpyroTheDragon'':
** ''VideoGame/SpyroTheDragon1998'': When all of the other dragons in the Dragon Lands are imprisoned in crystal statues by [[VideoGame/{{Diablo}} Deckard Cain]], [[WesternAnimation/TheFairlyOddParents Mr. Crocker]] steps up to the plate to rescue them all, including [[VideoGame/CrashBandicoot Uka-Uka]], [[VideoGame/MarvelUltimateAlliance M.O.D.O.K]], [[VideoGame/EverquestII Sir Laughlin]], [[VideoGame/CrashTeamRacing Fake Crash]] and WesternAnimation/{{Rocko|sModernLife}}.
** ''VideoGame/Spyro2RiptosRage'': Crocker, having matured into WesternAnimation/SpongeBobSquarePants, decides to take a vacation, but is instead dragged to another world by [[Franchise/RatchetAndClank Courtney Gears]], [[WesternAnimation/AaahhRealMonsters the Gromble]] and [[WesternAnimation/AdventureTime the Ice King]], who needed a dragon to help save them from the tyranny of [[WesternAnimation/TheGarfieldShow Odie]] and his accomplices [[Franchise/WinnieThePooh Eeyore]] and [[WesternAnimation/MuppetBabies1984 Fozzie Bear]]. [=SpongeBob=] is frequently obstructed and sold out throughout his journey by the money-hungry bear [[VideoGame/DiabloII Baal]].
** ''VideoGame/SpyroYearOfTheDragon'': [=SpongeBob=] and his faithful companion [[WesternAnimation/AvatarTheLastAirbender King Bumi]], alongside the Gromble and with support from the fairy [[WesternAnimation/TheAdventuresOfJimmyNeutronBoyGenius Cindy Vortex]], set out to recover the dragon eggs from the clutches of [[WesternAnimation/StarWarsTheCloneWars Jocasta Nu]] and her apprentice [[WesternAnimation/TheSimpsons Milhouse Van Houten]] (whom the Gromble subsequently gets romantically involved with). On the journey, [=SpongeBob=] rescues [[VideoGame/VampireTheMasqueradeBloodlines Ming-Xiao]], [[WesternAnimation/UltimateSpiderMan2012 Dr. Octopus]], [[WesternAnimation/HarveyBirdmanAttorneyAtLaw Vulturo]] and [[WesternAnimation/StaticShock Omar Harmozi]], who all agree to aid him in his quest. Meanwhile, Baal, now [[VideoGame/MetalGearSolid3SnakeEater Colonel Volgin]], once again tries to profit off the whole scheme.
** ''VideoGame/SpyroEnterTheDragonfly'': Odie returns, this time with a plan to capture all of the dragonflies from the Dragon Realms, but [=SpongeBob=] won't let him do that.
** ''VideoGame/SpyroAHerosTail'': [=SpongeBob=], now [[WesternAnimation/{{Animaniacs}} Wakko Warner]], is tasked by Ice King, now [[VideoGame/Shrek2 Shrek]], with stopping [[WesternAnimation/DrawnTogether Captain Hero]] from shrouding the Dragon Realms in darkness, and along the way meets Shrek's nephew [[WesternAnimation/Ben10 Ben Tennyson]], a young dragoness named [[WesternAnimation/TeenTitans2003 Raven]], and another young dragon named [[WesternAnimation/TheFairlyOddParents Timmy Turner]]. Captain Hero sends Deckard Cain, [[Franchise/KingdomHearts Maleficent]], and [[WesternAnimation/SpongeBobSquarePants Bubble Buddy]] to stop Wakko, while the Gromble is now [[WesternAnimation/TheClevelandShow Tim the Bear]], Dr. Octopus is now [[Franchise/WinnieThePooh Gopher]], and Colonel Volgin is now [[WesternAnimation/SofiaTheFirst Cedric]].
** ''VideoGame/TheLegendOfSpyro'': Wakko, now [[Film/TheLordOfTheRings Frodo Baggins]], sets out on an epic quest to save Avalar from destruction at the hands of the evil Dark Master [[WesternAnimation/RegularShow Skips]]. He teams up with King Bumi (who is now [[WesternAnimation/TheEmperorsNewGroove Kuzco]] and later becomes [[WesternAnimation/TheRenAndStimpyShow Stimpy]], then [[Series/HowIMetYourMother James Stinson]]) and [[Franchise/HarryPotter Sirius Black]] to stop Skips, who has sent his servant [[WesternAnimation/TinyToonAdventures Elmyra Duff]] (later [[WesternAnimation/TeenageMutantNinjaTurtles2012 April O'Neil]] and finally [[Film/TheSmurfs2 Vexy]]) to defeat him.
** ''VideoGame/{{Skylanders}}'': Frodo is now [[WesternAnimation/TheSpectacularSpiderMan Spider-Man]] (later [[Manga/JoJosBizarreAdventureStardustCrusaders Jotaro Kujo]]) and teams up with other heroes such as [[WesternAnimation/MyLifeAsATeenageRobot Misty]], [[VideoGame/Fallout4 the Sole Survivor]], [[Series/TalesFromTheCrypt the Crypt Keeper]], and [[VideoGame/TheElderScrollsVSkyrim M'aiq the Liar]] to defeat the evil forces of WesternAnimation/InvaderZim.
** ''VideoGame/SpyroReignitedTrilogy'': In [[VideoGameRemake updated versions]] of the first three games, Jotaro [[TheOriginalDarrin is back to being]] [=SpongeBob=], as are James/King Bumi, Gopher/Dr. Octopus, and Shrek/Ice King. Cain, Odie, Eeyore, Fozzie, and Omar Harmozi return, while Tim the Bear is now [[WesternAnimation/{{Breadwinners}} SwaySway]], Courtney Gears is [[Anime/PuellaMagiMadokaMagica Kyuubey]], Milhouse is [[VideoGame/WarioWare 9-Volt]], Cindy Vortex is [[WesternAnimation/TheLoudHouse Lori Loud]], Vulturo is [[VideoGame/SpiderManPS4 Shocker]], Cedric is [[VideoGame/SaintsRowIV Zinyak]], and Jocasta Nu is [[WesternAnimation/TheOwlHouse Lilith Clawthorne]]. Also starring [[VideoGame/MarvelVsCapcom3 Hulk]], [[WesternAnimation/AdventureTime Magic Man]], [[VideoGame/Persona5 Ryuji]], [[VideoGame/SuperSmashBrosUltimate Master Hand]], [[VideoGame/SonicLostWorld Zavok]], and [[VideoGame/RatchetAndClankFutureToolsOfDestruction Mr. Zurkon]].
* ''VideoGame/SplosionMan'': [[Manga/SoulEater Ragnarok]] makes things blow up. The final boss is [[spoiler:[[Anime/DragonBallZ Vegeta]]]].
** ''VideoGame/MsSplosionMan'': [[Manga/SoulEater Tsubaki Nakatsukasa]] makes things blow up.
* ''VideoGame/{{Starfield}}'': The silent protagonist, along with robot companion [[WesternAnimation/TransformersEarthspark Laserbeak]] is sent from one planet to another planet by [[WesternAnimation/TransformersPrime Arcee]] . At the new planet, the protagonist meets and assists [[VideoGame/GodOfWarRagnarok Verdani]] in searching for remnants of an anicent artifact. Also starring are [[VideoGame/TheElderScrollsVSkyrim Ulfric Stormcloak]], [[WesternAnimation/TurningRed Meilin Lee, Miriam Mendelsohn, and Tyler Nguyen-Baker]].
* ''Franchise/StarFox'':
** ''VideoGame/StarFox64'': [[VideoGame/StarFoxZero James McCloud, Andrew Oikonny]], [[VideoGame/TeamFortress2 Soldier]], and [[VideoGame/DeadOrAlive Nicole-458]] are space mercenaries who have to fight against the evil emperor [[VideoGame/Sly3HonorAmongThieves Dr. M]], under the orders of General [[VideoGame/FireEmblemRadiantDawn Black Knight]]. Their rivals are [[VideoGame/StarFoxZero Wolf O'Donnell]] and [[VideoGame/{{Shank}} Denny]].
** ''VideoGame/StarFoxAdventures'': Eight years later, James, now [[VideoGame/BanjoTooie Jolly Roger]], ventures out to the faraway Dinosaur Planet, along with Soldier and Nicole (who are now [[VideoGame/ConkersBadFurDay Conker and Professor Von Kripplesack]] respectively), to save it from a tyrannical [[VideoGame/PerfectDark dataDyne Guard]], and ends up rescuing and taking care of a young prince named [[VideoGame/KillerInstinct Glacius]]. Meanwhile, a female vixen is on a quest to return the Krazoa Spirits to their home in [[TempleOfDoom Krazoa Palace]].
** ''VideoGame/StarFoxAssault'': A year after the mission on Dinosaur Planet, Jolly, now [[VideoGame/SuperSmashBrosBrawl Leon Powalski, Zero Suit Samus]], Andrew, now VideoGame/SpyFox, and Kripplesack, now [[VideoGame/FreddiFish Luther]], must face [[VideoGame/TeamFortress2 Engineer]] and his team, consisting of [[VideoGame/SlyCooperThievesInTime Dimitri]] and [[VideoGame/Halo3 Sgt. Avery Johnson]], amidst the threat of an Aparoid invasion. Conker (now [[VideoGame/TronTwoPointOh Z-Lot]]) and [[VideoGame/MarioParty Lakitu]] end up performing a HeroicSacrifice to save Black Knight's life. [[Franchise/SuperMarioBros Bowser]] is Luther's father.
** ''VideoGame/StarFoxZero'': Same premise as ''64'', except Leon is now James again, Spy Fox is now [[VideoGame/Halo3 a civilian]], Z-Lot is now [[VideoGame/StarFox64 Bill Grey]], Luther is now Nicole again, and they are now antagonized by [[VideoGame/Halo3 a Marine]].
* ''VideoGame/StarOcean'': [[WesternAnimation/Ben10AlienForce Ben Tennyson]] and his girlfriend [[WesternAnimation/AdventuresOfTheGummiBears Sunni Gummi]] travel back in time with [[WesternAnimation/TheMrMenShow Mr. Bounce]] and [[VideoGame/DynastyWarriors Bao Sanniang]] to discover the origin of a malady that's turning everyone on their planet to stone, including their friend [[Manga/AttackOnTitan Eren Yeager]]. Along the way you can recruit the HotBlooded [[WesternAnimation/AvengersAssemble Ant-Man]], guard captain [[Manga/{{Trigun}} Meryl Stife]], werewolf [[Manga/FullmetalAlchemist Edward Elric]], the winged [[Anime/AldnoahZero Soma Yagari]], and [[Manga/{{Naruto}} Temari]][[spoiler:, who is actually Soma's sister Anime/SailorMoon in disguise.]]
* ''VideoGame/StarOceanTheLastHope'': [[VideoGame/ResidentEvil6 Leon S. Kennedy]] and his childhood friend [[Manga/{{Naruto}} Kushina Uzumaki]] travels the universe alongside [[Literature/{{Baccano}} Luck Gandor]], [[VideoGame/FireEmblemAwakening Nowi]], [[Manga/FullMetalAlchemist Roy Mustang]], [[Manga/OnePiece Kaya]], [[VideoGame/DotHackGU Pi]], [[Manga/DragonBallZ Adult Gohan]] and [[VideoGame/SoulSeries Seong Mi-Na]] while searching for Leon's friend, [[Manga/{{Naruto}} Kiba Inuzaka]].
* ''[[VideoGame/KnightsOfTheOldRepublic Star Wars: Knights of the Old Republic]]'': A recruit of the Republic learns the ways of the Jedi to stop the brother of [[WesternAnimation/{{Mulan}} Shan Yu]] from taking over the galaxy. Joining the recruit are the Republic soldier [[Series/OnceUponATime Jiminy Cricket]], snarky teenage Twi'lek [[WesternAnimation/StarWarsTheCloneWars Padmé Amidala]], Jedi Knight [[VideoGame/FindingNemo Dory]], Mandalorian warrior [[VideoGame/MetalGearSolid2SonsOfLiberty Solidus Snake]], Jedi Paladin [[VideoGame/MassEffect2 Jack]], and moody old Jedi [[WesternAnimation/TheClevelandShow Cleveland Brown Jr.]]
* ''VideoGame/StarWarsRebelAssault II'': Rebel pilot [[Series/BeverlyHills90210 Booth Gunderson]] reunites with former teammate [[Film/IndianaJonesAndTheLastCrusade Irene]] to halt the deployment of TheEmpire's new secret weapon that threatens to bring down the Alliance.
* ''Franchise/StarWars: VideoGame/TheForceUnleashed'': [[Series/BattlestarGalactica2003 Lt. Crashdown]] becomes the apprentice of WebVideo/ChadVader.
* ''VideoGame/StarWarsJediFallenOrder'': [[Series/{{Gotham}} Jerome Valeska]] is a Jedi in hiding after [[Film/RevengeOfTheSith Order 66]].
* ''Franchise/StreetFighter'':
** ''VideoGame/StreetFighterIV'': [[Anime/TengenToppaGurrenLagann Kamina]] and [[VideoGame/DevilMayCry Dante]] are two friends who practice martial arts. [[Manga/SoulEater Maka Albarn]], [[Manga/{{Naruto}} Zetsu]], and [[Manga/FullmetalAlchemist Winry Rockbell]] are members of an organization intent on defeating [[VideoGame/DissidiaFinalFantasy Exdeath]]. [[Manga/IkkiTousen Kokin Shuyu]] is a [[JokeCharacter somewhat weak fighter]] who taught [[Anime/RODTheTV Tohko Shigeno]] how to fight, as well as having [[VideoGame/MortalKombatVsDCUniverse the Flash]] for a friend. [[VideoGame/DissidiaFinalFantasy Squall Leonheart]] is obsessed with beauty, while [[Manga/{{Bleach}} Grimmjow]] is an Indian pacifist. [[Manga/BlackCat Train Heartnet]] is an amnesiac Frenchman who is implied to be the clone of [[Anime/LupinIII Cagliostro]]. Other combatants include Muay Thai master [[Manga/{{Hellsing}} Incognito]] (chief rival to Kamina and a former member of Exdeath's crime syndicate), BloodKnight [[Manga/{{Monster}} Petr Capek]], [[WebVideo/ThereWillBeBrawl Ganondorf]] as a BruceLeeClone, [[Manga/{{Bleach}} Sajin Komamura]] as a Mexican chef and MaskedLuchador, and [[Anime/TengenToppaGurrenLagann Kittan]] as a [[MotorMouth fast-talking]] [[{{Acrofatic}} fat guy]] who wants his shot at Dante for the title of best Street Fighter IN AMERICA!
** ''Super Street Fighter IV'': Cagliostro enlists [[VideoGame/InFamous Sasha]] to test a dangerous new weapon, and [[WesternAnimation/{{Hoodwinked}} Klaus]] likes to wrestle with copious amounts of oil.
** ''Ultra Street Fighter IV'': The above cast is joined by a clone of Winry, peppy African dancer [[VideoGame/ResidentEvil5 Sheva]], pro wrestler [[Franchise/OnePiece Franky]], his manager [[Anime/CodeGeass Kallen Kouzuki]], and the mercenary [[Franchise/DragonBall Cell]] (the last three of whom once belonged to [[VideoGame/FinalFight the same gang]]).
** ''VideoGame/StreetFighterV'': With his body failing, Exdeath makes one last attempt to take Kamina's body to keep himself alive, with his newest, poison-wielding lieutenant [[Anime/HellsingUltimate Makube]] on board and Squall and [[VideoGame/MortalKombat2011 Shao Kahn]] back in the fold. Meanwhile, on the orders of [[Manga/OnePunchMan Groribas]], [[Manga/{{Naruto}} Kushina Uzumaki]] ressurects [[Manga/FullmetalAlchemist Jean Havoc]] and sends him on a mission with Sasha to stop Exdeath. [[VideoGame/DeadOrAlive Kasumi]] organizes her own cadre of fighters to stop Exdeath's plans including Dante, Maka, Zetsu, Winry, Grimmjow, ninja [[VideoGame/SengokuBasara Tsuruhime]], wrestlers [[VideoGame/FinalFantasyIV Golbez]] and [[Manga/IkkiTousen Shiko Sojin]] and Kasumi's layabout servant [[VideoGame/{{Tekken}} Craig Marduk]]. Elsewhere, Emirati prince Anime/SpaceDandy is searching for his missing friend [[Anime/{{Pokemon}} Ursula]], Brazilian fighter [[VideoGame/MarvelVsCapcom3 Felicia]] looks to promote her family's jiu-jitsu style, Exdeath clone [[VideoGame/KillerInstinct Kan-Ra]] looks for a new purpose in life along with [[Anime/{{Charlotte}} Ayumi Otosaka]], [[VideoGame/Persona5 Ren Amamiya]]'s car goes missing, Egyptian fortune teller [[Anime/LoveLive Eli Ayase]] warns the fighters of their changing fates, [[Anime/GatchamanCrowds Berg Katze]] ponders how to continue his ninjitsu teachings, and all the while HumanoidAbomination [[Anime/MassEffectParagonLost Mason]] searches for strong fighters' souls to consume. Tohko, Kasumi's FriendlyRival, now works part-time at an arcade, [[VideoGame/MortalKombatVsDCUniverse Superman]] is the self-proclaimed "President of Earth" on a mission to unity humanity as one, Kallen is on the lookout for new wrestlers to manager after a falling-out with Franky, ex-con [[VideoGame/MegaMan11 Tundra Man]] takes over for [[Franchise/KingdomHearts Xemnas]] as mayor of [[VideoGame/FinalFight Metro City]], and [[Manga/ThePromisedNeverland Norman]] is the fiery police officer working for both of them.
* ''Franchise/SuperMarioBros'': [[VideoGame/RatchetAndClankFutureToolsOfDestruction Orvus]] and [[VideoGame/JetSetRadio Gouji Rokkaku]] are two brothers who regularly save [[Franchise/{{Halo}} Cortana]] (later [[VideoGame/BackyardSports Sunny Day]]) from [[VideoGame/StarFox Beltino Toad]] (later [[Manga/OnePiece Nubon]]) and his son [[VideoGame/BackyardSports Vinny the Gooch]]. Orvus occasionally gets help from various [[VideoGame/Left4Dead Zoeys]] (who later become [[VideoGame/MarioParty Toadettes]]), a princess named [[VideoGame/GenshinImpact Noelle]], and a dinosaur named [[VideoGame/LuigisMansion Professor E. Gadd]] as well. Orvus and Gouji's rivals are [[VideoGame/TheElderScrollsVSkyrim Paarthurnax]] and [[VideoGame/ShadowOfDestiny Homonculus]] and Orvus sometimes battles a gorilla named [[VideoGame/TheLegendOfZeldaOcarinaOfTime Ganondorf]] (whose best friend is a monkey named [[Anime/YuYuHakusho Elder Toguro]]). Occasionally, Nubon and Vinny are assisted by septuplets consisting of [[VideoGame/SpiderManWebOfShadows Spider-Man]], VideoGame/{{Bubsy}}, [[Series/{{Leverage}} Turk]], [[VideoGame/FinalFantasyType0 King]], [[VideoGame/SonicAdventure2 Rouge the Bat]], [[VideoGame/SuperSmashBrosBrawl Pit, and Lucas]]. Orvus' former girlfriend [[Franchise/{{Naruto}} Sakura Haruno]] also occasionally shows up from time to time. Professor E. Gadd also sometimes looks after younger versions of Orvus and Gouji named Literature/TheCatInTheHat and [[Anime/DragonBallSuperSuperHero Magenta]].
** ''VideoGame/SuperMarioOdyssey'': On his latest adventure, Orvus teams up with a talking hat with eyes named [[Anime/PokemonTheSeries Houndoom]] to rescue Sunny Day and Houndoom's sister [[WesternAnimation/TeenTitans2003 Raven]] from Nubon while travelling to many new lands. Sakura Haruno sings the game's theme song, and [[WesternAnimation/TransformersAnimated Shockwave]], [[VideoGame/TheLegendOfZeldaSpiritTracks Link]], [[WesternAnimation/{{Chowder}} Gazpacho]], and [[Anime/KillLaKill Shiro Byakko]] are hired by Nubon to stop him.
** ''VideoGame/SuperMarioBrosWonder'': Orvus and Gouji are now both voiced by [[VideoGame/GenshinImpact Ask-Me-For-Directions-Arnold]], who are joined by Sunny and [[VideoGame/CookieRunKingdom Fig Cookie]] to save the Flower Kingdom and its ruler [[Anime/LittleWitchAcademia2017 Croix Meridies]] from Nubon and Vinny. They are also joined by thief [[WebAnimation/ChiknNuggit Sody Pop]] as well as several Professor E. Gadds. Citizens of the Flower Kingdom include various [[VisualNovel/Danganronpa2GoodbyeDespair Chiaki Nanamis]] and [[WesternAnimation/AvengersAssemble Iron Mans]].
* ''Sword of the Manga/{{Berserk}}: Guts' Rage'': [[Franchise/GIJoe Duke is protecting a crippled Scarlet]] while they're with a tiny flying [[VideoGame/MetalGearSolid Liquid Snake]], where they save [[WesternAnimation/MightyMax Caitlin]] from bandits. Soon afterwards Duke is enlisted by [[WesternAnimation/KimPossible Señor Senior Sr.]] to find and destroy the Mandragora, a type of monstrous evil plant creatures and doing so they might find a way to cure Scarlett. However, Duke soon learns from [[Franchise/TransformersGeneration1 Perceptor]] and his wife [[WesternAnimation/HouseOfMouse Cruella DeVille]] over just what are Senor's true intentions. Duke will fight all sorts of enemies, including an old foe of his, the monstrous [[WesternAnimation/WolverineAndTheXMen2009 Sabretooth]].
!!T
* ''VideoGame/TakAndThePowerOfJuju'': [[WesternAnimation/TheGarfieldShow Nermal]] is a young Pupununu warrior who is guided by [[VideoGame/MetroidPrime Samus Aran]] to defeat the evil shaman [[WesternAnimation/TeenageMutantNinjaTurtles1987 Raphael]] and his henchmen [[WesternAnimation/CampLazlo Raj]] and [[WesternAnimation/FostersHomeForImaginaryFriends Bendy]]. Along the way, Nermal receives help from characters such as [[WesternAnimation/BeeMovie Ken]], [[Series/TalesFromTheCrypt the Crypt Keeper]], WesternAnimation/JohnnyBravo, [[VideoGame/MetalGearSolid Frank Jaeger]], and [[Manga/LuckyStar Misao Kusakabe]].
* ''VideoGame/TalesOfArise'': [[VideoGame/FinalFantasyXV Noctis Lucis Caelum]], a slave who FeelsNoPain, has a chance encounter with [[VideoGame/FireEmblemGaiden Celica]], a noblewoman whose touch brings pain to others. Together, they set off to free Noctis' people, assisted by BlackMagicianGirl [[Anime/PuellaMagiMadokaMagica Madoka Kaname]], BareFistedMonk [[Manga/DemonSlayerKimetsuNoYaiba Inosuke Hashibira]], benevolent ruler [[Manga/{{Beastars}} Louis]] and his loyal bodyguard [[Anime/{{Aggretsuko}} Fenneko]].
* ''VideoGame/TalesOfBerseria'': [[Anime/FateStayNightHeavensFeel Sakura Matou]] was an ordinary village girl whose world was afflicted with a mysterious disease that turned humans into demons. Even then, she led a relatively peaceful life until it was shattered one day when her brother-in-law [[Literature/FateApocrypha Vlad III]] murdered her younger brother [[VideoGame/FateGrandOrder Fou]] as a ritual sacrifice. In the process, she was turned into a demon as well and was hauled to an island prison. For three years, her rage towards Vlad only grew, and when she was freed by the mysterious [[Anime/GAROCrimsonMoon Abe no Seimei]] she immediately embarked on a quest for revenge against him, who was by then revered by the world for halting the demonblight. Along her journey, she attracted a ragtag bunch of allies with varying agendas, starting with the demon swordsman [[Literature/FateApocrypha Darnic Yddgmillennia]], and self-proclaimed witch [[Literature/FateApocrypha Mordred]] followed by [[Anime/GaroVanishingLine Sword]], [[VideoGame/FireEmblemGaiden Faye]], and [[VideoGame/FateGrandOrder Mash Kyrielight]].
* ''VideoGame/TalesOfGraces'': [[VideoGame/DissidiaFinalFantasy Zidane Tribal]] is the eldest son of a feudal family who has made a friendship pact with [[Manga/KOn Ritsu Tainaka]] and [[VideoGame/HyperdimensionNeptuniaMk2 CFW Brave]] when he was a kid. But life takes a harsh turn for him when [[spoiler:Ritsu sacrificed herself to save him]], prompting him to become a knight who swears to protect everyone. With additional companions like childhood friend [[VideoGame/FinalFantasyXIII Serah Farron]], mentor [[VideoGame/TalesOfVesperia Duke Pantarei]], younger brother [[VideoGame/TalesOfLegendia Jay]], and quirky genius [[VideoGame/Disgaea4APromiseUnforgotten Fuka Kazamatsuri]], he sets out on a journey to discover who Ritsu really is and to find out the reason for Brave's complete change in attitude.
* ''VideoGame/TalesOfSymphonia'': [[WesternAnimation/TeenTitans2003 Robin]], [[Manga/{{Naruto}} Ino]], and [[VideoGame/CommandAndConquer Tanya]] help escort [[VideoGame/TheWorldEndsWithYou Shiki]] on a mission to save the world. Along the way, they meet [[WesternAnimation/TheAvengersEarthsMightiestHeroes Ms. Marvel]], [[VideoGame/Disgaea2CursedMemories Adell]], [[WesternAnimation/MyLittlePonyFriendshipIsMagic Twilight Sparkle]], and [[Manga/{{Naruto}} Itachi Uchiha]]. [[spoiler:[[WesternAnimation/TeenageMutantNinjaTurtles1987 Leonardo]] turns out to be his father.]]
** ''VideoGame/TalesOfSymphoniaDawnOfTheNewWorld'': [[Manga/TriGun Vash The Stampede]] and [[Franchise/{{Negima}} Evangeline A.K. McDowell]] travel around the world with [[Manga/MagicKnightRayearth Ferio]] in order to wake up [[Anime/CodeGeass Lelouch]], and get revenge on [[Anime/DigimonTamers Takato]] for destroying Vash's hometown. Unfortunately, Vash is also friends with [[Manga/{{Bleach}} Sosuke Aizen]], who wants to kill Evangeline.
* ''VideoGame/TalesOfXillia'': In the world of Rieze Maxia, [[VideoGame/TalesOfVesperia Flynn Scifo]], a medical student, and [[Series/GeneralHospital Dr. Kelly Lee]], a girl who claims to be the Lord of the Spirits, are both caught up in a circumstance just as Rieze Maxia's two countries are on the verge of war. They both meet allies such as [[VideoGame/ResidentEvil6 Leon S. Kennedy]], a mercenary; [[VideoGame/Persona4 Nanako Dojima]], a girl whose companion is a talking doll named [[VideoGame/{{Persona 4}} Chie Satonaka]]; [[Manga/FairyTail Natsu Dragneel]], a BattleButler; and [[VideoGame/{{Skullgirls}} Squigly]], Flynn's childhood friend and apprentice nurse.
* ''VideoGame/TazWanted'': [[WesternAnimation/CodenameKidsNextDoor Father]] has kidnapped WesternAnimation/DarkwingDuck and plans to turn his home island into an amusement park. It's up to Darkwing to stop him with a little help from [[VideoGame/SpiderMan2 Dr. Curt Connors]]. The final boss fight turns out to be against [[spoiler: Dr. Connors]].
* ''VideoGame/TeamFortress2'': A group of nine mercenaries made of [[VideoGame/Left4Dead a church lunatic]], [[VideoGame/StarFox64 Andross]], [[VideoGame/Halo3ODST Tom]], [[Series/ZoobileeZoo Bravo Fox]], [[VideoGame/AliensVsPredator2 Dr. Eisenberg]], [[Series/Dynasty1981 Chris Deegan]], [[Franchise/KingdomHearts Luxord]], [[VideoGame/{{Infamous}} Warden Harm]], and [[VideoGame/Dota2 Invoker,]] and fight for control of land with the aid of [[VideoGame/{{Portal}} GLaDOS]] and [[Anime/AttackOnTitan Sasha Blouse]], with [[VideoGame/Diablo3 Diablo]] supplying the weapons. Every Halloween, the mercs are harassed by the wizard, [[VideoGame/CrashTagTeamRacing Dr. N. Gin]].
* ''Franchise/{{Tekken}}'':
** Tekken 1: When [[Manga/SgtFrog Giroro]] is 5 years old, his father [[Manga/BakiTheGrappler Dorian]] carries him to the top of a mountain and callously throws him off a cliff to test his son's strength, whether he is fit to lead the Mishima Zaibatsu, the family business, and to see if he will be able to climb back up the same cliff. Giroro survives the initial fall, but left a large scar on his chest which causes a demonic entity within him, called the Devil Gene, to activate, offering Giroro the opportunity to gain immense strength and power. Driven by his thirst for revenge, he climbs up the mountainside. To further motivate Giroro, Dorian adopts [[Manga/{{Hellsing}} Alucard]] and raises him as a rival to his true son. Over the years, Giroro travels around the world and competes in martial arts championships, becoming an undefeated champion, with the only blemish on his record being a draw against Paul Phoenix, an American martial artist who seeks to settle the score with him. 21 years later, Dorian decides to test his son's strength and worth and announces the King of Iron Fist Tournament, after Giroro defeated Alucard in the later stages of the tournament, and narrowly defeated Paul Phoenix in a furious battle that lasted for hours in the semi-finals, Giroro reaches the finals where he battles Dorian. However, Dorian is unexpectedly defeated by Giroro, empowered by the strength given to him by the Devil Gene, in an intense father-son battle. In an act of revenge, Kazuya picks up his father's unconscious body and tosses him down the same cliff that he was thrown off as a child. Smiling to himself, Giroro becomes the owner of the Mishima Zaibatsu.
** Tekken 2: Two years after the events of the King of Iron Fist Tournament, the Mishima Zaibatsu, under the leadership of Giroro, has become more corrupt and powerful than ever before, and is involved in many illegal operations. While his father [[Manga/GreatTeacherOnizuka Eikichi Onizuka]] was rather ruthless in his endeavors, Giroro acts completely without a conscience. He hires assassins to eliminate any of his critics and rivals, attempts to extort money from several businesses and organizations, and smuggles endangered species to conduct genetic experiments on them. The reason for his evil deeds is because he has allowed the Devil Gene within him to consume him as a result of his hatred towards Onizuka. Meanwhile, Giroro is sentenced to being arrested by animal rights activist and operative [[VideoGame/TheKingOfFighters Whip]] for his experiments. Onizuka on the other hand, whom Giroro had defeated and thrown off a cliff two years ago, has climbed back up and is training himself, plotting to overthrow Giroro. In an attempt to rid himself of Onizuka and his enemies once and for all, Giroro announces the King of Iron Fist Tournament 2, with a large cash prize of one trillion dollars, knowing that Onizuka will appear. When Whip enters the second tournament and eventually comes face to face with Giroro, she tries to arrest him, but instead the both of them can not help being drawn to one another, propelled by a mystic force beyond Whip's control, at some point during this time, Whip became pregnant with Giroro's child and drops out of the tournament as a result. Meanwhile, during the tournament, Onizuka defeats the opposing fighters but he was defeated by Paul Phoenix. In the finals of the tournament, Onizuka replaces Paul when he was forced to forfeit after getting stuck in traffic as result of a multi-car collision on the expressway, and therefore unable to make the match on time. Whilst Whip was able to cause conflict within Giroro, swaying Devil's hold over him, ultimately she was unable to prevent him from going to meet his father, Heihachi, in the tournament finals, Onizuka confronts Giroro and they battle once again. The Devil Gene takes over Giroro's body, resulting in Giroro becoming a Devil creature. However, despite this, Giroro is not strong enough to overpower Onizuka because of the internal conflict within him, between his evil side - represented by Devil within him - and his good side - represented by an unknown entity called Angel, which was brought forth after his meeting with Whip. Onizuka takes Giroro's unconscious body to a volcano, and throws him into it before escaping on a helicopter just as the volcano erupts behind him, having taken his revenge and regained the Mishima Zaibatsu. In the meantime, Whip gives birth to Giroro's illegitimate son, resulting in her leaving everything behind to raise their child.
** Tekken 3: Fifteen years after the King of the Iron Fist Tournament 2, [[Franchise/DragonBall Mr.Satan]] has established the Tekken Force: a paramilitary organization dedicated to the protection of the Mishima Zaibatsu. Using the company's influence, Mr.Satan is responsible for many events that have ultimately led to world peace. One day, a squadron of Tekken Force soldiers search an ancient temple located in Mexico under the premise of an excavation project. Soon after arriving there, Mr.Satan learns that they were obliterated by a mysterious and malevolent creature known as Ogre. Mr.Satan, having captured a brief glimpse of Ogre before its immediate disappearance, seeks to capture Ogre in the hopes of harnessing its immense fighting power for his own personal gain. Soon after, various known martial artists end up dead, attacked, or missing from all over the world, with Ogre behind all of it. Whip has been living a quiet life in Yakushima with her young son, [[Manga/{{Chobits}} Zima]], fathered during the events of the previous tournament by Mr.Satan's son Giroro. However, their peaceful life is disrupted when Whip begins to sense Ogre's encroaching presence and knowing that she is now a target, instructs Zima to seek Mr.Satan if anything happens. Sometime after Zima's fifteenth birthday, Ogre attacks. Against Whip's wishes, Zima valiantly tries to fight Ogre off, but Ogre knocks him unconscious. When Zima awakens, he finds that the ground surrounding his house has been burnt and his mother is missing and most likely dead. Driven by revenge, Jin is confronted by the Devil, which brands Zima's left arm and possesses him. Zima goes to his grandfather, Mr.Satan, explaining his situation and begging him for training to become strong enough to face Ogre. Mr.Satan accepts and takes Zima under his wing, as well as sending him to Mishima High School where Zima meets a classmate named [[VideoGame/DeadOrAlive Lei-Fan]] and her pet Panda. Four years later, Zima masters the Mishima karate style. On Zima's nineteenth birthday, Heihachi announces the King of Iron Fist Tournament 3, and Zima himself prepares for his upcoming battle, having no idea that his grandfather is secretly using him, Lei-Fan, and the rest of the competitors as bait in order to lure Ogre out into the open. Paul Phoenix makes it to the finals of the tournament, after defeating the opposing fighters including Kuma and Zima in the previous rounds. He enters a large temple, defeats Ogre, and walks away from the tournament, thinking he is victorious. However, unbeknownst to Paul, Ogre morphs into his second, monstrous form known as "True Ogre" after absorbin Mr.Satan's fighting force and the tournament continues after his departure. Zima is reinstated in the tournament and replaces Paul in the finals, confronts True Ogre and manages to defeat him as Ogre completely dissolves, avenging his mother's death and winning the tournament as a result. Moments later, Zima is suddenly gunned down by a squadron of Tekken Force led by Mr.Satan, who no longer needing him, personally fires a final shot into his grandson's head. Zima, however, revived by the Devil within him, reawakens and dispatches the soldiers, smashing Mr.Satan through the wall of the temple. Zima then sprouts black, feathery wings and flies off into the night as Mr.Satan, who survived the fall, looks on from the ground.
* ''VideoGame/ThemsFightinHerds'': [[WesternAnimation/TheFairlyOddParents Timmy Turner]], [[Manga/NewGame Hajime Shinoda]], [[Anime/LoveLive Honoka Kousaka]], [[VideoGame/FinalFantasyXV Crowe Altius]], [[Series/AllTheWrongPlaces Lexi]], and [[VideoGame/SkylandersSuperChargers Queen Cumulus]] go head to head in a four-legged free-for-all.
* ''VideoGame/TimeCrisis''
** ''Time Crisis 1'': [[VideoGame/ResidentEvil Rebecca Chambers]], daughter of the president of Sercia, is kidnapped by Chris Redfield, the chief mercenary of [[VideoGame/CastlevaniaSymphonyOfTheNight Dracula]], former dictator of Sercia.
** ''Time Crisis 4'': [[VideoGame/TalesOfPhantasia Chester Barklight]] and [[VideoGame/StreetFighterIV Guile]] are [[HeroesRUs VSSE agents]] who must hunt down terrorists that carry insect-like weapons of mass destruction. [[VideoGame/DissidiaFinalFantasy Garland]] assists the agents, and [[VideoGame/ValkyrieProfile Lenneth Valkyrie]] acts as MissionControl.
* ''VideoGame/Titanfall2'': This isn't the first time [[Creator/MatthewMercer Cooper]] has had to deal with [[Anime/AttackOnTitan Titans]]. The bosses Cooper faces are [[VideoGame/TeamFortress2 Saxton Hale]] and his group of mercs.
* ''VideoGame/TombRaiderUnderworld'': [[Series/AshesToAshes2008 DI Alex Drake]] hunts down an artifact to help her kill [[WesternAnimation/AvatarTheLastAirbender Azula]], who has teamed up with [[VideoGame/BrutalLegend Lita Halford]].
* ''VideoGame/TonyHawksProSkater'': A popular video game franchise starring the legendary skateboarder [[WesternAnimation/KickButtowskiSuburbanDaredevil Hush]] and other popular skaters.
** ''Underground'': The player character (who is either [[VideoGame/MetalGearSolid Null]] or [[WesternAnimation/AsToldByGinger Ginger Foutley]]) is an aspiring skateboarder from New Jersey whose best friend is [[WesternAnimation/CodenameKidsNextDoor Numbuh One]]. They sign up for a skateboarding competition sponsored by Stacey Peralta and get to meet Hush as well as their team's lazy fat manager [[Manga/{{Naruto}} Kakashi]].
** ''Underground 2'': The player character (still Null or Ginger; with [[VideoGame/FinalFantasyXIII Yuj]], [[WesternAnimation/TransformersRobotsInDisguise Jazz]] and VideoGame/NancyDrew as other voice options) goes on a world tour with Hush, half the cast of ''Series/{{Jackass}}'', [[Manga/ZatchBell Kiyo Takamine]], Numbuh One, and some other pro skaters. The group is frequently pestered during the trip by a British TV producer named [[WesternAnimation/HeyArnold Eugene Horowitz]]. And for some reason, [[WesternAnimation/InvaderZim Almighty Tallest Red]] is every secret character.
** ''American Wasteland'': [[WesternAnimation/Thundercats2011 Lion-O]] is an aspiring skateboarder who moves to Los Angeles, where he meets [[WesternAnimation/DrawnTogether Foxxy Love]] and her friends, who plan to reopen an abandoned skate park in Beverly Hills.
** ''Downhill Jam'': Hush, [[WesternAnimation/TeenTitans2003 Starfire]], WesternAnimation/SamuraiJack, Kyla, [[WesternAnimation/TheLoudHouse Lori Loud]], [[VideoGame/ResidentEvil6 Ada Wong]], [[Film/ScaryMovie Warren]], [[Series/{{Mom}} Phil]], Budd, and the player character race downhill around the world. [[spoiler: [[VideoGame/{{Skylanders}} Eon]] is the FinalBoss, and Warren's father.]]
* ''VideoGame/TransformersDevastation'': [[Franchise/WinnieThePooh Eeyore]], [[WesternAnimation/SpiderManAndHisAmazingFriends Spider-Man]], [[WesternAnimation/GIJoeARealAmericanHero Duke]], [[VideoGame/SpiderManWebOfShadows the Kingpin]], and [[VideoGame/LEGODimensions Beetlejuice]] must stop [[WesternAnimation/InspectorGadget Dr. Claw]] from cyberforming Earth.
* ''VideoGame/TransformersWarForCybertron'': On an alien planet, [[Franchise/MassEffect Saren Arterius]] leads a army composed of [[Anime/TengenToppaGurrenLagann Viral]], [[Anime/{{Hellsing}} Incognito]], [[WesternAnimation/TheAvengersEarthsMightiestHeroes Loki]], [[Franchise/GhostInTheShell Batou]], WesternAnimation/{{Wolverine|AndTheXMen2009}}, [[Franchise/AssassinsCreed Desmond Miles]], [[WesternAnimation/TheSpectacularSpiderMan Electro]], [[VideoGame/SoulSeries Zasalamel]], [[Anime/MobileSuitGundamUnicorn Full Frontal]], [[WesternAnimation/Ben10 Way Big]], [[Anime/WolfsRain Darcia]] (or in commercials, [[WesternAnimation/StarWarsTheCloneWars Cad Bane]]), and [[VideoGame/StreetFighterIV Juri Han]] to take over/corrupt the planet and overthrow/capture/kill [[WesternAnimation/GeneratorRex Van Kleiss]]. To stop them, [[Franchise/{{Predator}} the Predator]] must replace Van Kleiss and lead [[VideoGame/DevilMayCry Nero]], [[WesternAnimation/WolverineAndTheXMen2009 Beast]], [[Series/{{Angel}} Daniel Holtz]], [[WesternAnimation/Ben10 Charmcaster]], [[Manga/{{Naruto}} Gaara]], [[VideoGame/MortalKombatVsDCUniverse Scorpion]], [[Manga/FullmetalAlchemist Roy Mustang]], [[Anime/CodeGeass Schniezel el Britania]], [[Manga/{{Bleach}} Chad]], and [[VideoGame/MarvelUltimateAlliance Ben Grimm]] to victory.
** ''VideoGame/TransformersFallOfCybertron'': The Predator is racing to get everyone off the planet when Saren's forces attack. To fend them off, he awakens [[WesternAnimation/Ben10 Cannonbolt]], who crushes Saren to pieces, allowing Viral take his place. [[VideoGame/{{Uncharted}} Nathan Drake]] and [[Manga/{{Naruto}} Yamato]] are sent to go look for [[WesternAnimation/SpiderManTheAnimatedSeries Mysterio]], who has been captured by Darcia. Later on, Viral leads [[VideoGame/CastlevaniaSymphonyOfTheNight Death]], [[VideoGame/MassEffect2 Grunt]], [[Franchise/KingdomHearts Lexaeus]], [[Manga/{{Monster}} Johann Liebert]], and Desmond into an attack which he messes up, so the latter five have to combine into [[WesternAnimation/HulkVs Deadpool]]. Incognito later rebuilds Saren, who drives Viral off and retakes command of his forces. Mysterio's fellow captured teammates are [[Anime/YuGiOh Tristan Taylor]], [[Series/{{NCIS}} Stefano Delmar]], and [[VideoGame/SonicColors Knuckles the Echidna]]. [[Anime/DigimonTamers Guilmon]] and [[VideoGame/MassEffect3 Kai Leng]] are among many of Darcia's experiments. Nero lost his voice at one point during the war.
%% * ''VideoGame/Toonstruck'': [[WesternAnimaion/Anastasia Rasputin]] has a meeting with his boss [[Film/TheMask Dr. Arthur Neuman]]
** ''VideoGame/TransformersRiseOfTheDarkSpark'': Taking place in two different universe, part of it between the first two games and features Viral, Darica, and Incognito retrieving the titular MacGuffin for Saren, while the Predator, Roy, Holtz, Schniezel, the mute Nero, Nathan, and Yamato try to stop them, only for it to end up in [[Film/TransformersFilmSeries another universe]], where alternate versions of the Predator, the mute bot, and Mysterio are joined by [[Manga/JojosBizarreAdventure Esidisi]], and must stop [[WesternAnimation/MenInBlack Kay]] from getting his hands on it. [[spoiler:TheStinger shows it becoming [[Franchise/TransformersGeneration1 yet another version of the Predator]]'s problem.]]
* ''VideoGame/TrillionGodOfDestruction'': [[Franchise/StreetFighter Vega]] is killed by a [[TheJuggernaut nigh-unstoppable]] demon with a '''''[[MarathonBoss TRILLION]]''''' hit points, but is brought back to life when [[Franchise/LittleWitchAcademia Diana Cavendish]] offers him one last chance to kill it before it destroys his netherworld. Rather than put his own frail body at risk again, Vega decides to train his loyal subordinates--who include [[VideoGame/SamuraiWarriors Kunoichi]], [[VideoGame/Disgaea3AbsenceOfJustice Princess Sapphire]], [[VideoGame/FireEmblemGaiden Mae]], [[VideoGame/{{Skullgirls}} Peacock]], [[Literature/Overlord2012 Albedo]], and [[Anime/DarlingInTheFranXX Zero Two]]--to become strong enough to sacrifice ''their'' lives in his place to slow it down.
* ''VideoGame/TrinityUniverse'': To stop space debris from destroying his planet, demon god [[WesternAnimation/TeenageMutantNinjaTurtles2003 Donatello]] and his loyal retainer [[Manga/{{Naruto}} Sakura]] go on adventures to knock these objects out of orbit. The duo frequently crosses paths with space valkyrie [[VideoGame/BlazBlue Rachel Alucard]] and dark hero [[VideoGame/RadiataStories Jack Russell]], who believe the only way to save the universe is to confine Donatello inside a crystal for all eternity. Among the others involved in the conflict are would-be universal conqueror [[Manga/{{Bleach}} Rukia]] and her slave penguin [[VideoGame/DisgaeaHourOfDarkness Mid-Boss]], angel-turned-witch [[VideoGame/PhantomBrave Marona]], creepy ghost girl [[Manga/TriGun Meryl Strife]], snow cat-girl [[Manga/{{Bleach}} Orihime]], and hot-headed treasure hunter [[Manga/{{Naruto}} Kimimaro]].
* ''VideoGame/TwelveMinutes'': [[Film/XMenFilmSeries Young Charles Xavier]] and [[Franchise/StarWars Rey]] are a married couple visited by officer [[Film/SpiderManTrilogy Norman Osborn]] who accuses the latter of murder and demands that she reveal the location of the watch. [[spoiler:Norman turns out to be the true father of Xavier and Rey]].
* ''VideoGame/TYTheTasmanianTiger'': [[WesternAnimation/TheLionGuard Mzingo]] is a Tasmanian Tiger who has been called upon by [[WesternAnimation/AaahhRealMonsters the Gromble]] to defeat the wicked cassowary [[WesternAnimation/AvatarTheLastAirbender Great Sage]] and his two henchmen [[WesternAnimation/HouseOfMouse Goofy]] and [[VideoGame/LeagueOfLegends Dr. Mundo]]. During his journey, Mzingo is assisted by a crumudgeonly cockatoo, his girlfriend [[Manga/{{Naruto}} Tsunade]], an obnoxious lyre bird named [[WesternAnimation/DuckTales1987 Launchpad McQuack]], and a large wolverine park ranger named [[WesternAnimation/StarWarsTheCloneWars Eeth Koth]].
* ''VideoGame/{{Tyranny}}'': In a world ruled by the EvilOverlord Kyros, the fatebinder, an agent of Kyros, must stop a rebellion with the aid of two armies, the Disfavored led by [[Anime/CodeGeass Kaname Ohgi]] and the Scarlet Chorus led by [[VideoGame/Persona5 Joker]]. Under the watch of the archon of justice/their boss [[Manga/JoJosBizarreAdventureGoldenWind Bruno Bucciarati]] and the archon of shadows [[Toys/MonsterHigh Deuce Gorgon]]. And in their journey they would meet allies in [[Manga/JojosBizarreAdventure Dio Brando]], a soldier of the Disfavored, [[VideoGame/FireEmblemThreeHouses Shamir]], an elite soldier of the Chorus, [[VideoGame/ResidentEvil Albert Wesker]], an old sage, [[VideoGame/Persona4 Naoto Shirogane]], a mage who lost her family, [[VideoGame/DragonsCrown an elf]] who is the archon of sound wearing a RestrainingBolt, and [[VideoGame/{{Desperados III}} Isabelle Moreau]], a beastwoman who is the last of her tribe.
!!U
* ''[[VideoGame/UltimateSpiderMan2005 Ultimate Spider-Man]]'': Teenage superhero [[WesternAnimation/FostersHomeForImaginaryFriends Mac]] battles his former friend [[VideoGame/{{Yakuza}} Shinji Tanaka]], who is possessed by a living suit that transforms him into [[WesternAnimation/TheTransformers Devastator]]. Mac's girlfriend is [[WesternAnimation/TotallySpies Clover]]. Also during the game, Mac and Devastator battle other supervillains such as [[Anime/DigimonTamers Gorou 'Shibumi' Mizuno]], [[VideoGame/XMenLegends Sabretooth]], and [[VideoGame/FinalFantasyX Tidus]], while Mac finds himself being pursued by the mercenary [[Franchise/ThePowerpuffGirls Ms. Keene]], who works for [[Series/StarTrekEnterprise Phlox]] and [[WesternAnimation/GreenLanternTheAnimatedSeries Appa Ali Apsa]]. All of this over the work of Mac's dad [[VideoGame/BatmanArkhamKnight Kirk Langstrom]] and Shinji's dad. [[Film/TheDarkKnight Detective Stephens]] is a superhero who fights Shinji/Devastator in a bar, Mac has a friendly rivalry with [[WesternAnimation/BackToTheFuture Marty McFly]], and [[WebAnimation/{{RWBY}} Pietro Polendina]] runs a spy agency.
* ''VisualNovel/UminekoWhenTheyCry'':
* ''VideoGame/{{Uncharted}}'': [[VideoGame/SpecOpsTheLine Captain Martin Walker]], the supposed descendant of Sir Francis Drake, searches for treasure around the world with the help of his mentor [[Film/RulesOfEngagement Judge Col. Warner]]. He somehow repeatedly runs into reporter [[Series/{{Haven}} Audrey Parker]].
** ''VideoGame/UnchartedDrakesFortune'': Walker searches for the last treasure sought by his ancestor Sir Francis Drake, only to run across [[Series/TheNeighbors Larry Bird]] and his henchman [[VideoGame/JustCause Rico Rodriguez]].
** ''VideoGame/Uncharted2AmongThieves'': Walker is hired by [[Film/TheHobbit Dwalin]] through [[Series/CrossingJordan Nigel Townsend]] and [[Series/{{Farscape}} Aeryn Sun]] to find Shangri-La. He discovers that an expedition led by [[Series/StarTrekDeepSpaceNine Odo]] already found it.
** ''VideoGame/Uncharted3DrakesDeception'': Walker competes against [[Film/Titanic1997 Lady Duff-Gordon]] and her henchman [[WesternAnimation/TheAvengersEarthsMightiestHeroes Baron Zemo]] to locate the lost city of Ubar, but he's sidetracked when he ends up getting attacked by the pirate [[Film/YouDontMessWithTheZohan Hamdi]]. [[Series/TwentyFour Mikhail Novakovich and Tarin Faroush]] are new allies helping Walker out. Flashbacks show how a younger Walker, then [[Series/LabRats Chase Davenport]], met Warner.
** ''VideoGame/Uncharted4AThiefsEnd'': Walker is reunied with his long-lost brother [[Anime/FullmetalAlchemistBrotherhood Greed]], who convinces him to come out of retirement for OneLastJob. Along the way they come into conflict with their former partner [[Series/ShadesOfBlue Robert Stahl]], who has hired [[VideoGame/LegoBatman Wonder Woman]] to assist him.
** ''VideoGame/UnchartedTheLostLegacy'': Aeryn and Wonder Woman, with some assistance from [[spoiler:Greed]], team up to locate a lost artifact while fighting off [[Series/ASeriesOfUnfortunateEvents2017 Fernald the Hook-Handed Man]] and his forces.
* ''VideoGame/UntilDawn'': In a mountain hotel a killer is targetting [[Film/Scream4 Kirby Reed]][[note]]again[[/note]], [[Series/TenThingsIHateAboutYou Bianca Stratford]] (or [[Franchise/KingdomHearts Kairi and Naminé]], if you prefer), [[Series/AgentsOfSHIELD Grant Ward]], [[Series/TheMiddle Cassidy Finch]], [[Series/LivAndMaddie Holden Dippendorf]], [[Series/TheWarAtHome Kenny]], [[Series/ShamelessUS Amanda]], and [[Series/{{Fringe}} Luke]], with [[Series/{{Arrow}} Werner Zytle]] in attendance. Will [[EverybodyLives they survive?]] Will anyone survive?
!!V
* ''VideoGame/ValkyriaChronicles'': After the small and peaceful nation of Gallia is attacked by TheEmpire, [[VideoGame/FinalFantasyVI Kefka]], [[VideoGame/{{Xenosaga}} KOS-MOS]], [[Manga/{{Bleach}} Tier Halibel]], [[VideoGame/FinalFantasyX Yuna]], and [[Manga/{{Naruto}} Gato]] enlist in the army to fight against [[VideoGame/BlazBlue Ragna the Bloodedge]], [[VideoGame/MarvelUltimateAlliance Ms. Marvel]], [[VideoGame/BaldursGate Keldorn Firecam]], and [[WesternAnimation/GIJoeRenegades Tunnel Rat]]. They can also recruit the ManlyGay [[VideoGame/GearsOfWar Marcus Fenix]].
* ''VideoGame/ViewtifulJoe'': While enjoying a flick at a movie theater with his girlfriend [[VideoGame/{{Xenosaga}} MOMO]], [[WesternAnimation/StarWarsTheCloneWars Captain Rex]] watches in horror as the villain of the superhero movie they're watching drags MOMO into the movie. Rex is also brought to Movieland and taken under the wing of [[Franchise/TransformersGeneration1 Grimlock]], who teaches him how to control the special effects of a movie to use to his advantage. In order to win back his girlfriend and return home, Rex must face [[WesternAnimation/BatmanTheBraveAndTheBold Superman]], [[WesternAnimation/LiloAndStitch Captain Gantu]], [[Film/TeenageMutantNinjaTurtles1990 Michelangelo]], and [[spoiler:Grimlock himself]].
** ''Viewtiful Joe 2'': Having saved MOMO, Rex and his newly {{Henshin|Hero}}'d girlfriend are sent out on another adventure by Grimlock, one that's quickly intercepted by the coming of the newest evil syndicate invading Movieworld. This time, however, Rex gets some help on the other side of the silver screen from his father [[VideoGame/DissidiaFinalFantasy Gilgamesh]]. Together, Rex and MOMO must now face [[VideoGame/ResidentEvil4 Osmund Saddler]], [[WesternAnimation/TheSuperHeroSquadShow Doctor Strange]], [[VideoGame/Persona4 Teddie]], Mikey ([[TheRival again]]), [[Manga/{{Naruto}} Kakuzu]], [[WesternAnimation/YoungJustice2010 Black Canary]], and [[VideoGame/AssassinsCreedI Al-Mualim]] to make their way to the baddies' leader. [[spoiler:Turns out that Gilgamesh is said leader, albeit corrupted by an ArtifactOfDoom that preyed on his desires to be the ultimate hero for his son Rex.]]
** ''Viewtiful Joe: Double Trouble'': Rex is forced to team up with his [[AnnoyingYoungerSibling bratty younger sister]] [[VideoGame/KidIcarusUprising Viridi]] in order to recover Grimlock's latest film, in which Viridi starred. Along the way, the siblings discover that the evil organization this time is led by [[spoiler:their deceased mother, [[WesternAnimation/GeneratorRex Breach]], who came back from heaven for a day to test her children to see how much they've grown.]] Oh, and Mikey shows up yet again to challenge Rex to a fight. [[spoiler:He ends up [[TakingTheBullet Taking The Giant Fist]] from Breach for Rex because [[TheOnlyOneAllowedToDefeatYou he's the only one allowed to defeat him]].]]
!!W
* ''VideoGame/TheWalkingDeadTelltale'': [[VideoGame/{{Bayonetta}} Rodin]] is an escaped convict who is caught in the middle of a zombie apocalypse. He finds and takes care of a little kid named [[VideoGame/YokaiWatch Komasan]], who was left all alone after his parents go missing.
* ''[[VideoGame/WarioWare WarioWare Gold]]'': [[VideoGame/TheElderScrollsVSkyrim Paarthurnax]] runs a video game-making company along with his employees, which include CreepyChild [[Anime/LoveLive Eli Ayase]] and her pet devil [[Series/AustinAndAlly Clayton]], twin ninjas [[Manga/{{Kon}} Yui Hirasawa]] and [[WesternAnimation/AvengersAssemble the Enchantress]], GenkiGirl [[Manga/SailorMoon Usagi Tsukino]], karaoke-singing robot [[WesternAnimation/{{Breadwinners}} Sway-Sway]], inventor [[Anime/TengenToppaGurrenLagann Kamina]], gaming best friends [[Anime/YoKaiWatch Katie Forester]] and [[Anime/OnePunchMan Hammerhead]], Katie's mother [[VideoGame/BlazBlue Noel Vermillion]], Kamina's [[MadScientistsBeautifulDaughter granddaughter]] [[VideoGame/TheGuidedFateParadox Minamo Kagurazaka]], alien [[Manga/SailorMoon Tuxedo Mask]], Katie's "pet" [[Manga/SoulEater Death the Kid]], dog taxi-driver [[VideoGame/StreetFighterIV Ryu]] and his cat partner [[Manga/{{Beastars}} Louis]], [[DiscoDan disco-dancing party animal]] [[Series/PowerRangersDinoThunder the Black Dino Ranger]], and karate master [[VideoGame/LeagueOfLegends Twisted Fate]] and his apprentice [[WesternAnimation/MarvelsSpiderMan Spider-Man]]. Around town, Hammerhead gets into a rap battle with [[Anime/PuellaMagiMadokaMagica Homura Akemi]] over a game console, [[VideoGame/FireEmblemAwakening Frederick]]'s infomercial convinces Noel to work out with her pots and pans, and [[WesternAnimation/TheLoudHouse Carl Casagrande]] attacks Paarthurnax for stealing an enchanted [[spoiler:chamber]] pot from her kingdom.
* ''VideoGame/WinnieThePoohsRumblyTumblyAdventure'': [[WesternAnimation/SpiderManTheAnimatedSeries Shocker]] celebrates the birthdays of his friends, including [[WesternAnimation/GoofTroop Pete]], [[Film/TwelveAngryMen Juror #2]], [[WesternAnimation/GarfieldAndFriends Odie]], and [[ComicStrip/{{Peanuts}} Rerun Van Pelt]]. Also starring [[WesternAnimation/ScoobyDooAndTheGhoulSchool Ned]], [[WesternAnimation/{{Animaniacs}} Dot Warner]], [[WesternAnimation/RainbowBrite Starlite]], and [[VideoGame/SpyroTheDragon1998 Gnasty Gnorc]].
* ''VideoGame/WolfensteinTheNewOrder'': [[VideoGame/DragonAgeII Varric Tethras]] must team up with either [[VideoGame/DragonAgeII Fenris (again)]] or [[WesternAnimation/KimPossible Josh Mankey]] and [[Series/{{Chuck}} General Diane Beckman]] to defeat Nazi MadScientist [[VideoGame/MassEffect Navigator Pressly]], all the while being pursued by [[TheBaroness Nazi Baroness]] [[{{Series/Lexx}} Grand Prosecutor Jihana]] and her lover [[VideoGame/RedDeadRedemption Muller]].
* ''VideoGame/TheWonderful101'': WesternAnimation/KickButtowski, [[VideoGame/SonicColors Sonic the Hedgehog]], [[Anime/{{FLCL}} Haruko Haruhara]], [[WesternAnimation/DrawnTogether Toot Braunstein]], [[WesternAnimation/BewareTheBatman Alfred Pennyworth]], and [[Manga/{{Naruto}} Sasuke Uchiha]] are an elite team of superheroes commanded by [[VideoGame/FinalFantasyXII Balthier]] and [[VideoGame/FinalFantasyXIII Serah Farron]] who must defend mankind against an evil alien menace led by [[WesternAnimation/TheLegendOfKorra Amon]]. Meanwhile, the team constantly runs into a band of SpacePirates led by [[VideoGame/NoMoreHeroes Henry Cooldown]] and his vassal [[WesternAnimation/TheAvengersEarthsMightiestHeroes the Hulk]], are bugged by [[WesternAnimation/TheAdventuresOfJimmyNeutronBoyGenius Jimmy Neutron]], and helped by the mysterious space cop [[WesternAnimation/YoungJustice2010 Artemis]].
* ''VideoGame/TheWorldEndsWithYou'': [[WesternAnimation/SpongebobSquarepants Little Timmy Monroe]] is an enigmatic loner trying to survive on the streets of Shibuya using pins that grant him PsychicPowers. He unwillingly gets assistance from [[VideoGame/TalesOfSymphonia Colette Brunel]], [[VideoGame/BatenKaitos Sagi]], and [[VideoGame/DissidiaFinalFantasy the Onion Knight]], and is harassed by the likes of [[VideoGame/{{Bulletstorm}} Ishi Sato]], [[Manga/LuckyStar Nanako Kuroi]], [[VideoGame/BlazBlueContinuumShift Relius Clover]], [[VideoGame/LANoire tech officer Ivan Robinson]], [[VideoGame/MetalGearSolid2SonsOfLiberty Rosemary]], and their leader, [[VideoGame/FalloutNewVegas Manny Vargas]].
* ''VideoGame/WWEVideoGames'':
** ''WWE 2K23'': [[VideoGame/StreetFighter6 Blanka]] is an indie wrestler who captured the attention of the WWE after finding success around the world competing for all sorts of wrestling companies and gaining a large following. Unfortunately, his time in the WWE was cut short when he accidentally pushed [[Film/TheMarine Luke Trapper]] off the apron at the start of [=MyRise=], causing the Vice President of Talent Development to fire Blanka. [[VideoGame/TheArtfulEscape Violetta]] the niece of former WWE superstar and legend [[VideoGame/MidnightSun Dread Maiden]] as she attempts to forge her own path in the company. After spending years watching her aunt perform while traveling with her and then training with her to improve her talent, the superstar finally finds herself in the WWE, albeit to the displeasure of many women in the locker room. Unfortunately, the superstar finds herself fighting for not only the biggest prizes in the WWE, but also to stand apart from Dread Maiden and make a name for herself.
!!X
* ''VideoGame/XMenLegends'': [[WesternAnimation/InspectorGadget Penny]] is a mutant with newly awakened powers that gets taken in as the newest member of the X-Men. Led by [[WesternAnimation/AmericanDad Avery Bullock]], the team consists of [[Anime/CowboyBebop Spike Spiegel]], [[VideoGame/UnchartedDrakesFortune Atoq Navarro]], [[VideoGame/MetalGearSolid4GunsOfThePatriots Big Boss]], [[Series/ThePractice Sarah Ehret]], [[Series/GoodLuckCharlie Amy Duncan]], [[WesternAnimation/CodenameKidsNextDoor Numbuh 4]], [[Film/TheTerminator Dr. Peter Silberman]] and more, who work together to stop mutant terrorist [[WesternAnimation/TheHunchbackOfNotreDameDisney Frollo]] from eradicating humanity, while also fighting the anti-mutant supremacist [[WesternAnimation/KimPossible Dr. Drakken]]. In the sequel, Frollo becomes [[WesternAnimation/TheBatman Hugo Strange]] and joins forces with Bullock to unite their teams and stop the threat of [[VideoGame/{{Uncharted}} Victor Sullivan]].
* ''VideoGame/{{Xenoblade Chronicles 2}}'': Rex's Titan friend Gramps is voiced by Sean Barrett, who is quite clearly using his [[VideoGame/DarkSouls Andre of Astora]] voice. [[spoiler:When Gramps is nearly killed and regenerates early in the game, he reverts to a much younger Titan form, with a younger voice to match. Now he sounds like Sean Barrett's other Dark Souls role, Petrus of Thorolund.]]
* ''VideoGame/XenobladeChroniclesX'': A lone pod containing an amnesiac individual [[note]](who is [[Anime/TigerAndBunny Barnaby Brooks, Jr.]], [[Manga/AttackOnTitan Eren Yeager]], [[Manga/{{Monster}} Johann Liebert]], [[WesternAnimation/MarvelsSpiderMan Peter Parker]], [[Manga/{{Naruto}} Sai]], [[VideoGame/FinalFantasyXIV Pinpin Tarupin]], or [[Anime/{{Robotech}} Roy Fokker]] if male, or [[Manga/{{Naruto}} Temari]], [[Manga/JojosBizarreAdventureDiamondIsUnbreakable Reimi Sugimoto]], [[Franchise/GhostInTheShell Motoko Kusanagi]], [[Anime/SailorMoon Rei Hino]], [[WesternAnimation/ScoobyDooMysteryIncorporated Mayor Janet Nettles]], [[VideoGame/ProfessorLaytonVsPhoenixWrightAceAttorney Kira]] or [[WesternAnimation/EdEddNEddy Nazz]] if female)[[/note]] is awakened by [[Manga/OuranHighSchoolHostClub Haruhi Fujioka]]. Together alongside [[WebAnimation/HanazukiFullOfTreasures Kiazuki]], the three work together to provide defense to the city of New Los Angeles, and end up with an intentional sidekick in [[Franchise/DragonBall Shou]]. [[Anime/PuellaMagiMadokaMagica Mami Tomoe]], [[VideoGame/BravelySecond Yew Geneolgia]], and [[Manga/{{Hellsing}} Luke Valentine]] often work with Haruhi; with [[VideoGame/TalesOfXillia Alvin]] also providing assistance, [[spoiler:although he turns out to be a spy.]] Alien native [[VideoGame/TalesOfBerseria Artorius Colbrande]] joins the group later on. The team can also recruit [[Literature/ShakuganNoShana Shana]], [[Webcomic/OnePunchMan Lord Boros]], [[VideoGame/FireEmblem Tiki]], [[Manga/{{Bleach}} Gin Ichimaru]], [[VideoGame/MassEffect Legion]], [[Manga/MyBrideIsAMermaid Sun Seto]], [[Anime/YuGiOh Mai Valentine]], [[VideoGame/FinalFantasyIV Rosa Farrell]], [[Manga/BungoStrayDogs Herman Melville]], [[Literature/DateALive Shido Itsuka]], and [[VideoGame/TheLegendOfHeroesTrailsOfColdSteel Gaius Worzel]].
* ''VideoGame/{{Xenosaga}} Episode I'': [[Anime/TheBigO Dorothy Waynewright]] creates [[Anime/DigimonTamers Jeri Kato]], an android, to combat the Gnosis. They eventually meet up with [[Anime/TenchiMuyo Sasami]], [[VideoGame/KingdomHeartsII Ansem]], [[Anime/DigimonAdventure02 Ken Ichijoji]], and [[Franchise/DotHack Tsukasa]]. In the meantime, they deal with [[VideoGame/StarOceanTillTheEndOfTime Albel Nox]], who is obsessing over Sasami and Tsukasa. Also, [[Manga/RurouniKenshin Kenshin]] is head of a industrial corporation and is secretly manipulating events.
!!Y
* ''VideoGame/YakuzaLikeADragon'': After being shot and left for dead by his boss [[Series/StarTrekTheOriginalSeries Hikaru Sulu]], Tojo Clan member [[Film/TomAndJerry2021 Tom]] must start from the bottom and rise to the top. Joining him are ex-detective [[VideoGame/CrashTeamRacingNitroFueled Ripper Roo]], homeless guy [[VideoGame/BlazBlueCrossTagBattle Carmine]], barmaid [[VideoGame/Persona5 Sae Niijima]], hitman [[Series/BetterCallSaul Ko]], gangster [[VideoGame/TheLegendOfHeroesTrailsOfColdSteel Lloyd Bannings]] and secretary [[VideoGame/FinalFantasyXV Iris Amicitia]]. [[VideoGame/TransformersDevastation Shockwave]], the protagonist of the first ''Yakuza'', makes a surprise return. Meanwhile the gang has to contend with Governor of Tokyo [[VideoGame/SleepingDogs2012 Wei Shen]] and his Bleach Japan movement, with [[VideoGame/FireEmblemThreeHouses Byleth]] among its most fanatical members and the one they contend with the most.
* ''VideoGame/YandereSimulator'': [[Literature/LadiesVersusButlers Ayse Khadim]] will do anything for her Senpai and will eliminate [[VideoGame/HuniePop Audrey Belrose]], [[Anime/CrossAnge Liza Landog]], [[WebVideo/SwordArtOnlineAbridged Griselda]], [[VideoGame/FreedomPlanet Sash Lilac]], [[Anime/DanceWithDevils Ritsuka Tachibana]], [[Anime/RioRainbowGate Cartia Goldschmidt]], [[Anime/ShowByRock A]], and more to get to him.
* ''VideoGame/{{Ys}} Book [[VideoGame/YsIAncientYsVanishedOmen I]] and [[VideoGame/YsIIAncientYsVanishedTheFinalChapter II]]'': A redheaded swordsman, aided by twin goddesses [[WesternAnimation/PeterPanAndThePirates Tinker Bell]] and [[WesternAnimation/CareBears1980s Proud Heart Cat]], must recover the Books of Ys and free the eponymous lost continent from the wrath of [[WesternAnimation/HeManAndTheMastersOfTheUniverse1983 Skeletor]], [[WesternAnimation/RubySpearsSuperman Lex Luthor]], and [[WesternAnimation/CaptainPlanetAndThePlaneteers Sly Sludge]].
* ''VideoGame/YoshisStory'': [[VideoGame/LuigisMansion Professor E. Gadd]] ([[CreatorCameo who also happens to be the game's composer]]) is a baby dinosaur who sets out on a somewhat saccharine journey to recover the Super Happy Tree from Baby Bowser.
!!Z
* ''VideoGame/ZettaiHeroProject'': You watch [[Anime/TengenToppaGurrenLagann Kamina]] die, and have to finish his fight against [[VideoGame/TalesOfTheAbyss Dist]]...which you lose horribly. Now, you have to go through TrainingFromHell set up by Kamina and would-be heroine [[VideoGame/SonicColors Tails]] until you become strong enough to face off against Dist one last time and save the world.
-----

** ''VideoGame/HyruleWarriorsAgeOfCalamity'': A small guardian named Terrako goes into the past to help Donatello and Princess Ash SetRightWhatOnceWasWrong, alongside a younger Jane. Along the way, they join forces with the Champions as well as the Korok [[Anime/LoveLive Kotori Minami]], and receive assistance from Sakura and her brother [[VideoGame/StarFoxZero Falco Lombardi]]. They end up fighting the evil sorcerer [[VideoGame/MultiVersus the Iron Giant]], while also dealing with Hop Pop, who is now [[VideoGame/FireEmblemEngage Sombron]], and his henchman [[VideoGame/StreetFighterIV M. Bison]]. [[spoiler:The new guardians also go back in time to help.]] [[VideoGame/BatmanTheTelltaleSeries Vicki Vale]], [[Anime/YoKaiWatchTheMovie Miradox]], [[WesternAnimation/OKKOLetsBeHeroes Wilhamena]] and [[Literature/KonoSuba Megumin]] are a group of Great Fairies, [[VideoGame/BlazBlue Ragna the Bloodedge]] is a horse god, and [[VideoGame/TacticsOgre Jeunan Avertif]] is a Sheikah monk.

** From Legion's universe: [[Manga/{{Bleach}} Shinji Hirako]] is a member of the BSAA and opposes Legion, [[Anime/TengenToppaGurrenLagann Kamina]] is a wandering martial artist, [[Manga/SoulEater Maka Albarn]] is an Interpol agent, [[Manga/{{Monster}} Petr Capek]] is Kamina's EvilCounterpart, [[Anime/LupinIII Fuijko Mine]] is a spy, [[Series/BigTimeRush Arthur Griffin]] is the mayor of Metro City, [[Manga/TriGun Vash the Stampede]] is Dr. Wily's final creation, [[VideoGame/{{Tekken}} Anna Williams]] is a genius pirate, [[VideoGame/StreetFighterIV Ken Masters]] is a demon hunter, [[ArtificialHuman Artificial Demon]] [[Series/TheWalkingDead2010 Judy]] is Ken's lover, [[Anime/DragonBallZ Cell]] is a cyborg commando, [[Literature/{{Durarara}} Mikado Ryugamine]] is an AscendedFanboy, [[Anime/GunXSword Gadved]] is a knight, [[Anime/RODTheTV Wendy Earhart]] is a [[SuccubiAndIncubi succubus]], [[VideoGame/StreetFighterXTekken Asuka Kazama]] is a CatGirl, [[Manga/GirlsBravo Lisa Fukuyama]] is a [[ChineseVampire jiang-shi]]. There's also a sun goddess wolf and for DLC, [[Anime/EurekaSeven Anemone]] is an ally of Shinji's who is BrainwashedAndCrazy by Legion.

*** From Legion's universe: Ken's twin brother [[Series/PowerRangersTimeForce Eric Myers]], photojournalist [[Series/PowerRangersInSpace Dark Specter]], ninja [[VideoGame/DeadRising Brad Garrison]], and lawyer [[WesternAnimation/TeenageMutantNinjaTurtles2003 Donatello]]. There's also a mutant zombie who's crossed paths with Shinji and Anemone and a gargoyle who's crossed paths with Gadved.
* ''VideoGame/MarvelVsCapcomInfinite'': The genocidal androids [[ComicBook/DCTheNewFrontier Slam Bradley]] and [[WebComic/OnePunchMan Tank-Top Tiger]] team up, even [[TwoBeingsOneBody fusing into one]]. To stop them, the heroes of the universes must turn to [[WesternAnimation/JusticeLeagueCrisisOnTwoEarths Wonder Woman]]'s adopted father, [[VideoGame/TransformersWarForCybertron Soundwave]] (who's obsessed with [[Manga/YoKaiWatch Jibanyan]]), for help. Zartan, Hiro, Saren, Kamina, Shinji, Ken, Wendy, Brad, Vash, Captain Atom, Dark Specter, Gadved, Arthur, and Cell remain the same, but now Arishok is [[VideoGame/BatmanTheTelltaleSeries Two-Face]], Malchior is [[Manga/BlackLagoon Mr. Chang]], Hercules is now [[WesternAnimation/{{Breadwinners}} SwaySway]], Vito is [[Manga/{{Naruto}} Gaara]], Maka is now [[Manga/AttackOnTitan Sasha Braus]], Van Kleiss is now [[WesternAnimation/HeyArnold Eugene Horowitz]], Dennis is now [[WesternAnimation/MarvelsSpiderMan Max Modell]], and Jarod is now WesternAnimation/SamuraiJack. In addition to Wonder Woman, they're joined by [[VideoGame/MetalGearSolid Sigint]], [[WesternAnimation/GIJoeResolute the Baroness]], [[Manga/IkkiTousen Koukin Shuuyu]], [[WesternAnimation/Ben10Omniverse Khyber]], [[VideoGame/TheWalkingDeadTelltale Clementine]], Zartan's former sidekick [[VideoGame/Injustice2 Robin]], spy (and teammate of Zartan, Hiro, Two-Face, Saren, Captain Atom, and Signit) [[VideoGame/BloodRayne Rayne]], and the symbiotic [[Series/{{Grimm}} Zerstörer]]. Additionally, the gargoyle is [[WesternAnimation/BeastWars Cheetor]], the mutant zombie is now [[Series/{{Stitchers}} Quincy Fisher]], and [[WesternAnimation/TransformersPrime Bulkhead]] is a plant creature that helps Wonder Woman and Mr. Chang.

** ''VideoGame/NoMoreHeroes2DesperateStruggle'': In retaliation for Jotaro's murder, Zemo goes on a RoaringRampageOfRevenge against [[Anime/DigimonFusion Beelzemon]], [[WesternAnimation/TeenTitans2003 Cyborg]], [[Manga/{{Naruto}} Sasuke Uchiha]], [[WesternAnimation/TheAdventuresOfJimmyNeutron Jimmy Neutron]], [[WesternAnimation/BatmanTheAnimatedSeries Batgirl]], a returning Rex (who is now ComicBook/TheIncredibleHulk), [[VideoGame/MetalGearSolid Roy Campbell]], ''[[DualBoss two]]'' Spider-Men, [[WesternAnimation/FamilyGuy Mr. Washee-Washee]], [[WesternAnimation/MyLittlePonyFriendshipIsMagic Twilight Sparkle]], [[Franchise/Ben10 Max Tennyson]], [[WesternAnimation/CinderellaIIDreamsComeTrue Cinderella]], and finally [[Anime/TengenToppaGurrenLagann Simon]]. Hunter J also returns to deal with Campbell and the Spider-Men on Zemo's behalf. [[VideoGame/RatchetAndClankRiftApart Rivet]] is an assassin in training, and [[VideoGame/CrashBandicoot Coco Bandicoot]] is a foe that Axel fights in a dream. Creator/TakashiMiike appears as a friend of Jotaro.

* ''VideoGame/NicktoonsUnite'': The nefarious [[Film/HomeAlone2 Mr. Hector]] has stolen the plans for WesternAnimation/JayJayTheJetPlane’s latest invention, allowing him to go to other dimensions, where he recruits an alliance of villains including [[{{Film/Clue}} Colonel Mustard]], [[Series/Reno911 Deputy Garcia]], and [[WesternAnimation/RockosModernLife Filburt Turtle]]. To counter this evil syndicate, Jay Jay recruits his own band of heroes from the same dimensions including [[WesternAnimation/BackToTheFutureTheAnimatedSeries Marty McFly]], [[WesternAnimation/TheAdventuresOfRockyAndBullwinkle Rocky]] (accompanied by [[Series/NedsDeclassifiedSchoolSurvivalGuide Gordy]] and [[Franchise/KingdomHearts Maleficent]]), and Franchise/SpyroTheDragon.

* ''VideoGame/LollipopChainsaw'': [[VideoGame/BatmanArkhamCity Harley Quinn]] is a chainsaw-wielding cheerleader who fights zombies while carrying the still-living (courtesy of some magic taught by [[Series/MortalKombatConquest Shang Tsung]]) severed head of her boyfriend [[WesternAnimation/JusticeLeague The Flash]] on her belt. Harley's sisters are [[Film/ScoobyDoo2002 Velma Dinkley]] and [[VideoGame/NoMoreHeroes Shinobu]], and her parents are [[Series/Castle2009 Winston Wellesley]] and [[VideoGame/MetalGearSolid2 Olga Gurlukovich]]. Together, Harley and The Flash must fight baddies such as [[Music/MindlessSelfIndulgence Jimmy Urine]], [[Series/TheWalkingDead2010 Merle Dixon]], [[Franchise/{{Saw}} Amanda Young]], [[WesternAnimation/StarWarsTheCloneWars Pong Krell]] and [[WesternAnimation/TheAvengersEarthsMightiestHeroes Thor]], in order to stop [[Series/GilmoreGirls Kirk Gleason]] from summoning [[spoiler:[[Manga/{{Naruto}} Kakuzu]]]].

** ''VideoGame/StreetFighterIV'': [[Anime/TengenToppaGurrenLagann Kamina]] and [[VideoGame/DevilMayCry Dante]] are two friends who practice martial arts. [[VideoGame/Persona4 Rise Kujikawa]], [[Manga/{{Naruto}} Zetsu]], and [[Manga/FullmetalAlchemist Winry Rockbell]] are members of an organization intent on defeating [[VideoGame/DissidiaFinalFantasy Exdeath]]. [[Manga/IkkiTousen Kokin Shuyu]] is a [[JokeCharacter somewhat weak fighter]] who taught [[Anime/RODTheTV Tohko Shigeno]] how to fight, as well as having [[VideoGame/MortalKombatVsDCUniverse the Flash]] for a friend. [[VideoGame/DissidiaFinalFantasy Squall Leonheart]] is obsessed with beauty, while [[Manga/{{Bleach}} Grimmjow]] is an Indian pacifist. [[Manga/BlackCat Train Heartnet]] is an amnesiac Frenchman who is implied to be the clone of [[Anime/LupinIII Cagliostro]]. Other combatants include Muay Thai master [[Manga/{{Hellsing}} Incognito]] (chief rival to Kamina and a former member of Exdeath's crime syndicate), BloodKnight [[Manga/{{Monster}} Petr Capek]], [[WebVideo/ThereWillBeBrawl Ganondorf]] as a BruceLeeClone, [[Manga/{{Bleach}} Sajin Komamura]] as a Mexican chef and MaskedLuchador, and [[Anime/TengenToppaGurrenLagann Kittan]] as a [[MotorMouth fast-talking]] [[{{Acrofatic}} fat guy]] who wants his shot at Dante for the title of best Street Fighter IN AMERICA!

** ''VideoGame/StreetFighterV'': With his body failing, Exdeath makes one last attempt to take Kamina's body to keep himself alive, with his newest, poison-wielding lieutenant [[Anime/HellsingUltimate Makube]] on board and Squall and [[VideoGame/MortalKombat2011 Shao Kahn]] back in the fold. Meanwhile, on the orders of [[Manga/OnePunchMan Groribas]], [[Manga/{{Naruto}} Kushina Uzumaki]] ressurects [[Manga/FullmetalAlchemist Jean Havoc]] and sends him on a mission with Sasha to stop Exdeath. [[VideoGame/DeadOrAlive Kasumi]] organizes her own cadre of fighters to stop Exdeath's plans including Dante, Rise, Zetsu, Winry, Grimmjow, ninja [[VideoGame/SengokuBasara Tsuruhime]], wrestlers [[VideoGame/FinalFantasyIV Golbez]] and [[Manga/IkkiTousen Shiko Sojin]] and Kasumi's layabout servant [[VideoGame/{{Tekken}} Craig Marduk]]. Elsewhere, Emirati prince Anime/SpaceDandy is searching for his missing friend [[Anime/{{Pokemon}} Ursula]], Brazilian fighter [[VideoGame/MarvelVsCapcom3 Felicia]] looks to promote her family's jiu-jitsu style, Exdeath clone [[VideoGame/KillerInstinct Kan-Ra]] looks for a new purpose in life along with [[Anime/{{Charlotte}} Ayumi Otosaka]], [[VideoGame/Persona5 Ren Amamiya]]'s car goes missing, Egyptian fortune teller [[Anime/LoveLive Eli Ayase]] warns the fighters of their changing fates, [[Anime/GatchamanCrowds Berg Katze]] ponders how to continue his ninjitsu teachings, and all the while HumanoidAbomination [[Anime/MassEffectParagonLost Mason]] searches for strong fighters' souls to consume. Tohko, Kasumi's FriendlyRival, now works part-time at an arcade, [[VideoGame/MortalKombatVsDCUniverse Superman]] is the self-proclaimed "President of Earth" on a mission to unity humanity as one, Kallen is on the lookout for new wrestlers to manager after a falling-out with Franky, ex-con [[VideoGame/MegaMan11 Tundra Man]] takes over for [[Franchise/KingdomHearts Xemnas]] as mayor of [[VideoGame/FinalFight Metro City]], and [[Manga/ThePromisedNeverland Norman]] is the fiery police officer working for both of them.

* ''[[VideoGame/{{Contra}} Neo Contra]]'': [[Manga/OutlawStar Gene Starwind]] and his partner [[Anime/CowboyBebop Jet Black]] must fight a terrorist organization led by [[Anime/CowboyBebop Spike Spiegel]]. The members of said terrorist organization includes [[VideoGame/DynastyWarriors Zhang Fei]], [[Anime/DigimonAdventure Gabumon]], and [[Anime/CowboyBebop Faye Valentine]]. [[Franchise/BlazBlue Valkenhayn R. Hellsing]] is Gene's mentor.

** ''VideoGame/ShadowTheHedgehog:'' Jack, who is now [[Anime/PokemonTheSeriesBlackAndWhite Cilan]], is confronted by alien leader [[Anime/UltimateMuscle Kid Muscle]] and must choose whether to side with him or military commander [[Anime/YuGiOhGX Chazz Princeton]]. Eliot, Reese, Paco, the pink hedgehog, Masami, Wendy, the Postal Dude, Strider, Agrippa, Justine, the rabbit, Allard, Setsuna and Dudley are now respectively [[Manga/OnePiece Usopp]], [[Anime/OjamajoDoremi Dorie Goodwyn]], [[Manga/YuGiOh Yugi Muto]], [[Literature/{{Slayers}} Lina Inverse]], [[WesternAnimation/{{Ratatoing}} Greg]], [[Manga/YuGiOh Mai Valentine]], [[VideoGame/NightsJourneyOfDreams an owl]], [[WesternAnimation/TeenageMutantNinjaTurtles2003 Raz]], [[Anime/FZeroGPLegend Captain Falcon]], [[Anime/PokemonTheSeriesRubyAndSapphire Max]], [[Manga/ArcadeGamerFubuki Ruriko Sakuragasaki]], [[Anime/PokemonTheOriginalSeries Meowth]], [[Manga/IchiTheKiller Midori]] and [[Anime/PokemonTheSeriesBlackAndWhite Drayden]]. In [[Anime/SonicX a different continuity]], Duke Nukem and Clayton are now [[Anime/YuGiOhGX Aster Phoenix]] and [[Anime/KirbyRightBackAtya Chief Bookem]].
** ''VideoGame/SonicRush'': Usopp helps [[Anime/ShamanKing Lyserg Diethel]], the princess of the Sol Dimension, open up by showing her ThePowerOfFriendship and the duo take down Greg and his alternate dimension counterpart [[Anime/UltimateMuscle Meat]]. [[VideoGame/SonicRushAdventure Sometime later]], Usopp and Dorie end up in the Sol Dimension to take down an even bigger threat in the form of a pirate named Captain Whisker.

** ''VideoGame/SonicTheHedgehog2006:'' When the princess of Soleanna, [[WesternAnimation/TheWildThornberrys Eliza Thornberry]], is under attack by Greg's robots, Usopp has to save her. Along the way, he has to deal with [[Anime/YuGiOh5Ds Dexter]], a hedgehog from the future who is manipulated by [[Anime/PokemonMewtwoReturns Mewtwo]] into trying to kill Usopp. The owl is now [[Anime/PokemonTheOriginalSeries Lt. Surge]], and Eliza's father was [[WesternAnimation/TurtlesForever 1987 Splinter]].

** ''VideoGame/SonicColors:'' Chris and C.C. discover a plot by Greg to harness aliens using an interstellar amusement park, with help from his robotic minions [[Anime/DigimonAdventure Gabumon]] and [[WesternAnimation/TheGarfieldShow Jon Arbuckle]]. In the Nintendo DS version, Aster, Lt. Surge, Captain Falcon and Max are now [[Anime/TengenToppaGurrenLagann Kamina]], [[Franchise/DragonBall Broly]], [[VideoGame/TheLastOfUs Joel]] and [[WesternAnimation/DannyPhantom Jazz Fenton]] respectively.

** ''VideoGame/SonicLostWorld:'' Chris, C.C. and Greg reluctantly team up against the Deadly Six, consisting of [[WesternAnimation/AvengersAssemble Thor]], [[Manga/{{Naruto}} Gaara]], [[Manga/MyHeroAcademia Endeavor]], [[Franchise/KingdomHearts Saix]], Manga/SailorMoon and [[VisualNovel/AceAttorney Phoenix Wright]].

** ''VideoGame/SonicForces:'' Greg's newest creation, the reality-warping [[VideoGame/Persona3 Akihiko Sanada]], defeats Chris and causes the others to form a resistance against them, with a [[PlayerCharacter new face]] (either [[Anime/TigerAndBunny Chopman]] or [[Anime/PuellaMagiMadokaMagica Madoka Kaname]][[note]]Japanese; the Avatar has no English voice actor[[/note]]) joining the fight. Joel is now [[VideoGame/FireEmblemAwakening Chrom]].

* ''VideoGame/LollipopChainsaw'': [[VideoGame/BatmanArkhamCity Harley Quinn]] is a chainsaw-wielding cheerleader who fights zombies while carrying the still-living (courtesy of some magic taught by [[Series/MortalKombatConquest Shang Tsung]]) severed head of her boyfriend [[WesternAnimation/JusticeLeague The Flash]] on her belt. Harley's sisters are [[Film/ScoobyDoo2002 Velma Dinkley]] and [[VideoGame/NoMoreHeroes Shinobu]], and her parents are [[Series/{{Castle}} Winston Wellesley]] and [[VideoGame/MetalGearSolid2 Olga Gurlukovich]]. Together, Harley and The Flash must fight baddies such as [[Music/MindlessSelfIndulgence Jimmy Urine]], [[Series/TheWalkingDead2010 Merle Dixon]], [[Franchise/{{Saw}} Amanda Young]], [[WesternAnimation/StarWarsTheCloneWars Pong Krell]] and [[WesternAnimation/TheAvengersEarthsMightiestHeroes Thor]], in order to stop [[Series/GilmoreGirls Kirk Gleason]] from summoning [[spoiler:[[Manga/{{Naruto}} Kakuzu]]]].

** ''VideoGame/SuperMarioBrosWonder'': Orvus and Gouji are now both voiced by [[VideoGame/GenshinImpact Ask-Me-For-Directions-Arnold]], who are joined by Sunny and [[VideoGame/CookieRunKingdom Fig Cookie]] to save the Flower Kingdom and its ruler [[Anime/LittleWitchAcademia2017 Croix Meridies]] from Nubon and Vinny. They are also joined by thief [[WebAnimation/ChiknNuggit Sody Pop]]. Citizens of the Flower Kingdom include various [[VisualNovel/Danganronpa2GoodbyeDespair Chiaki Nanamis]] and [[WesternAnimation/AvengersAssemble Iron Mans]].

** ''VideoGame/SonicRushSeries'': Usopp helps [[Anime/ShamanKing Lyserg Diethel]], the princess of the Sol Dimension, open up by showing her ThePowerOfFriendship and the duo take down Greg and his alternate dimension counterpart [[Anime/UltimateMuscle Meat]]. Sometime later, Usopp and Dorie end up in the Sol Dimension to take down an even bigger threat in the form of a pirate named Captain Whisker.

** ''Nickelodeon All-Star Brawl 2'': Joining the roster this time around are (as of this writing) cynical clarinet player [[WesternAnimation/TeenTitans2003 Doctor Light]], evil fast food rival [[WebAnimation/MightyMagiswords Ralphio]], boy genius and Cupid's son [[Manga/ZatchBell Zatch Bell]], hot-headed ninja [[WesternAnimation/CodenameKidsNextDoor Robin Food]], calculating inventor [[WesternAnimation/PacMan Inky]], tiger-themed superhero/supervillain [[WesternAnimation/OzzyAndDrix Mayor Spryman]], spectral metalhead [[VideoGame/BatmanArkhamCity Harley Quinn]], eccentric grandmother [[WesternAnimation/TheSimpsons Agnes Skinner]], the grandmother's grandson's BlackBestFriend[[note]]It is unknown who Gerald's voice actor in this game is.[[/note]], beaver siblings [[WesternAnimation/SquirrelBoy Rodney J. Squirrel]] and [[WesternAnimation/SabrinaTheAnimatedSeries Salem Saberhagen]], and sadistic Firebender [[WesternAnimation/HiHiPuffyAmiYumi Yumi Yoshimura]].

** ''VideoGame/SuperMarioBrosWonder'': Orvus and Gouji are now both voiced by [[VideoGame/GenshinImpact Ask-Me-For-Directions-Arnold]], who are joined by Sunny and [[VideoGame/CookieRunKingdom Fig Cookie]] to save the Flower Kingdom and its ruler [[Anime/LittleWitchAcademia2017 Croix Meridies]] from Nubon and Vinny. They are also joined by thief [[VideoGame/FireEmblemWarriorsThreeHopes Female Shez]]. Citizens of the Flower Kingdom include various [[VisualNovel/Danganronpa2GoodbyeDespair Chiaki Nanamis]] and [[WesternAnimation/AvengersAssemble Iron Mans]].

* ''VideoGame/YakuzaLikeADragon'': After being shot and left for dead by his boss [[Series/StarTrekTheOriginalSeries Hikaru Sulu]], Tojo Clan member [[Film/TomAndJerry2021 Tom]] must start from the bottom and rise to the top. Joining him are ex-detective [[VideoGame/CrashTeamRacingNitroFueled Ripper Roo]], homeless guy [[VideoGame/BlazBlueCrossTagBattle Carmine]], barmaid [[VideoGame/Persona5 Sae Niijima]], hitman [[Series/BetterCallSaul Ko]], gangster [[VideoGame/TheLegendOfHeroesTrailsOfColdSteel Lloyd Bannings]] and secretary [[VideoGame/FinalFantasyXV Iris Amicitia]]. [[VideoGame/TransformersDevastation Shockwave]], the protagonist of the first ''Yakuza'', makes a surprise return. Meanwhile the gang has to contend with Governor of Tokyo [[VideoGame/SleepingDogs Wei Shen]] and his Bleach Japan movement, with [[VideoGame/FireEmblemThreeHouses Byleth]] among its most fanatical members and the one they contend with the most.

* ''VideoGame/{{Starfield}}'': The silent protagonist, along with robot companion [[WesternAnimation/TransformersEarthspark Laserbeak]] is sent from one planet to another planet by [[WesternAnimation/TransformersPrime Arcee]] . At the new planet, the protagonist meets and assists [[VideoGame/GodOfWarRagnarok Verdani]] in searching for remnants of an anicent artifact. Also starring are [[VideoGame/TheElderScrollsVSkyrim Ulfric Stormcloak]], [[WesternAnimation/TurningRed Meilin Lee, Miriam Mendholsen, and Tyler Nguyen-Baker]].

* ''VideoGame/{{Starfield}}'': The silent protagonist, along with robot companion [[WesternAnimation/TransformersEarthspark Laserbeak]] is sent from one planet to another plane [[WesternAnimation/TransformersPrime Arcce]] . At the new planet, the protagonist meets and assists [[VideoGame/GodOfWarRagnarok Verdani]] in searching for remnants of an anicent artifact. Also starring are [[VideoGame/TheElderScrollsVSkyrim Ulfric Stormcloak]], [[WesternAnimation/TurningRed Meilin Lee, Miriam Mendholsen, and Tyler Nguyen-Baker]].

* ''VideoGame/{{Starfield}}'': The silent protagonist, along with robot companion [[WesternAnimation/TrasnformersEarthspark Laserbeak]] is sent from one planet to another plane [[WesternAnimation/TransformersPrime Arcce]] . At the new planet, the protagonist meets and assists [[VideoGame/GodOfWarRagnarok Verdani]] in searching for remnants of an anicent artifact. Also starring are [[VideoGame/TheElderScrollsVSkyrim Ulfric Stormcloak]], [[WesternAnimation/TurningRed Meilin Lee, Miriam Mendholsen, and Tyler Nguyen-Baker]].

* ''VideoGame/{{Starfield}}'': The silent protagonist, along with robot companion [[WesternAnimation/TrasnformersEarthspark Laserbeak]] is sent from one planet to another plane [[WesternAnimation/TransformersPrime Arcce]] . At the new planet, the protagonist meets and assists [[VideoGame/GodOfWarRagnarok Verdani]] in searching for remnants of an anicent artifact. Also starring are [[VideoGame/TheElderScrollsVSkyrim Ulfric Stormcloak]], [[WesternAnimation/TurningRed Meilin Lee, Miriam Mendholsen, and Tyler Nguyen-Baker]].