S may refer to:
- Esu, known in the US as S, a Boys Love Genre Light Novel series by Saki Aida and Chihara Nada.
- S, a shoujo tennis manga by Setona Mizushiro.
- S., a novel by John Updike.
- S, a novel told via marginal notes in another novel, by J. J. Abrams and Doug Dorst.
- S, a short-lived K-Pop group.
- The page on One Letter Titles.