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Anime & Manga
- Mr. Shytte and Mr. Pysse, two royal guards attending Queen Gloriana, in The League of Extraordinary Gentlemen.
- Mr. Schlubb and Mr. Klump of Sin City, better known to those not in their habit of referrating to each other by their respectablive patronism as Fat Man and Little Boy.
- In Harry Potter and the Methods of Rationality, Crabbe and Goyle are faithfully following minions clichés and call each other "Mr. Crabbe" and "Mr. Goyle".
Films — Live-Action
- Those Two Bad Guys in Neverwhere: Mr. Croup and Mr. Vandemar.
- Those Two Bad Guys in The Truth: Mr. Pin and Mr. Tulip.
- Those Two Bad Guys in Hamish X: Mr. Candy and Mr. Sweet.
- Those Two Bad Guys in Peter Straub's story Mr. Clubb and Mr. Cuff.
- Those Two Guys in American Gods: Mr. Ibis and Mr. Jacquel. Furthermore, the Spookshow agents have names like Mr. Town, Mr. Wood, Mr. Stone, Mr. Road and Mr. World, and they tend to introduce themselves like this.
- The song "Mister Gallagher and Mister Shean" by Ed Gallagher and Al Shean. Probably the Trope Maker; certainly the exchange "Absolutely, Mr. Gallagher?" — "Positively, Mr. Shean" became a popular meme.
- In The Golden Apple, shifty stockbrokers Mister Scylla (played by the same actor as Menelaus) and Mister Charybdis (alias Hector) do a pastiche of the Gallagher and Shean number.
- In 1776, when John Adams and Thomas Jefferson are arguing over who will write the Declaration of Independence they refer to each other as Mr. A and Mr. J.
- Classic Vaudeville Schtick: e.g. Mr. Bones and Mr. Jones, done by such as... Mr. Gallagher and Mr. Shean.
- Fur Fighters has two villains, Mr. Grr and Mr. Argh, a parody of Mr. Wint and Mr. Kidd who also happen to be conjoined twins.
- Sam and Fuzzy has several instances of these. The two highest ranking assassins in the Ninja Mafia have names like this which often pair together. The first we see are Mr. Blank and Mr. Black. The two most recent are literally Mr. X and Mr. Y.
- Mr. Wink and Mr. Fibb (parodies of Wint and Kidd) from Codename: Kids Next Door.
- Mr. Doe and Mr. Cardholder, the mysterious OSI agents, in The Venture Bros.
- Mr. Touch and Mr. Go on Teenage Mutant Ninja Turtles (2003).
- Mr. Black and Mr. White from Johnny Test. Interestingly enough, Mr. Black is white, and Mr. White is black.
- Mr. White and Mr. Whyte from Ruby Gloom.