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the whole point of a macguffin is that the story wouldn't meaningfully change if you swapped the item out—nearly all the discussed items have very important properties, such as granting superpowers.
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* ''Manga/JoJosBizarreAdventure'':
** ''Manga/BattleTendency'': The Red Stone of Aja. When placed in a stone mask, it allows a Pillar Man to transcend their being the same way the stone masks do for humans. Kars and his followers want it to become the UltimateLifeform, which Joseph and his allies quickly rush to obtain before that happens.
** ''Manga/GoldenWind'': The [[SacredBowAndArrows Stand Arrow]] that grants [[FightingSpirit Stands]] is revealed to possess a unique secret that the team learns to help them defeat Diavolo. [[spoiler:As [[Manga/StardustCrusaders Polnareff]] explains, if a Stand is pierced by the arrow, the user will be granted the power of Requiem, granting them abilities that can nullify all manner of attacks]].
** ''Manga/StoneOcean'': Enrico Pucci's EvilPlan involves using a bone from [[BigBad Dio Brando]] by having various Stand abilities implemented into it to create [[spoiler:[[EnfantTerrible The Green Baby]], a [[OurHomunculiAreDifferent homunculus]] that Pucci intends to absorb with his Stand to gain the power needed for him to obtain 'Heaven']].
** Surprisingly PlayedWith in ''Manga/SteelBallRun'': the Corpse Parts, ten separate pieces of the body of [[spoiler:Jesus Christ]], end up playing an important role in the last few story arcs as they serve as the key to unlock [[spoiler:D4C Love Train, Valentine's nigh-invincible ability]]. However, this is only the case in the Base Universe, the one where the part's events take place in: in the infinite worlds parallel to the Base, the Corpse Parts don't exist and are replaced with far more mundane and interchangeable objects, like diamonds. The alternate universe iterations of Valentines are fully aware of this.
** ''Manga/JoJolion'': The Locacaca Fruit that's sought by the heroes and villains forces a form of EquivalentExchange, one that can "cure" the Rock Disease, which is why they desire it.
** ''Manga/BattleTendency'': The Red Stone of Aja. When placed in a stone mask, it allows a Pillar Man to transcend their being the same way the stone masks do for humans. Kars and his followers want it to become the UltimateLifeform, which Joseph and his allies quickly rush to obtain before that happens.
** ''Manga/GoldenWind'': The [[SacredBowAndArrows Stand Arrow]] that grants [[FightingSpirit Stands]] is revealed to possess a unique secret that the team learns to help them defeat Diavolo. [[spoiler:As [[Manga/StardustCrusaders Polnareff]] explains, if a Stand is pierced by the arrow, the user will be granted the power of Requiem, granting them abilities that can nullify all manner of attacks]].
** ''Manga/StoneOcean'': Enrico Pucci's EvilPlan involves using a bone from [[BigBad Dio Brando]] by having various Stand abilities implemented into it to create [[spoiler:[[EnfantTerrible The Green Baby]], a [[OurHomunculiAreDifferent homunculus]] that Pucci intends to absorb with his Stand to gain the power needed for him to obtain 'Heaven']].
** Surprisingly PlayedWith in ''Manga/SteelBallRun'': the Corpse Parts, ten separate pieces of the body of [[spoiler:Jesus Christ]], end up playing an important role in the last few story arcs as they serve as the key to unlock [[spoiler:D4C Love Train, Valentine's nigh-invincible ability]]. However, this is only the case in the Base Universe, the one where the part's events take place in: in the infinite worlds parallel to the Base, the Corpse Parts don't exist and are replaced with far more mundane and interchangeable objects, like diamonds. The alternate universe iterations of Valentines are fully aware of this.
** ''Manga/JoJolion'': The Locacaca Fruit that's sought by the heroes and villains forces a form of EquivalentExchange, one that can "cure" the Rock Disease, which is why they desire it.
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* In the ''Anime/DragonBallGT'' TV special, Goku Jr is out to find the Dragon Ball to cure his sick grandmother--Ball, singular. As the viewer knows, and he comes to find out, the Dragon Balls only do anything when all seven are brought together, and otherwise, they're just shiny rocks. As a result, his quest was pointless--but it does let him learn a lesson and find his courage.
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** ''Manga/SteelBallRun'': The Corpse Parts, being ten separate pieces of the body of [[spoiler:Jesus Christ]]. Being in possession of all of the Corpse Parts blesses the owner with a powerful ability.
to:
** Surprisingly PlayedWith in ''Manga/SteelBallRun'': The the Corpse Parts, being ten separate pieces of the body of [[spoiler:Jesus Christ]]. Being Christ]], end up playing an important role in possession of all of the last few story arcs as they serve as the key to unlock [[spoiler:D4C Love Train, Valentine's nigh-invincible ability]]. However, this is only the case in the Base Universe, the one where the part's events take place in: in the infinite worlds parallel to the Base, the Corpse Parts blesses the owner don't exist and are replaced with a powerful ability.far more mundane and interchangeable objects, like diamonds. The alternate universe iterations of Valentines are fully aware of this.
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* ''Manga/KoroshiyaYametai'' involves a political struggle between the church and a secret organization known as "Babylon." The head of the church, Archbishop Ildebrando, gives Father Shirafune a rosary, which actually contains classified information the church has amassed for blackmail purposes. The protagonist Rose's mission is to retrieve the rosary from Father Shirafune, with Hibai being dispatched in her stead after Rose chooses to protect Father Shirafune instead, and Gina being sent to retrieve the rosary for the church. [[spoiler:After Rose defeats both Hibai and Gina, she uses the rosary as leverage, turning it over to her employers in exchange for Father Shirafune and his daughter Benika's safety]].
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* ''Manga/StarStrikeItRich'': The chemicals weapons that were stolen from the Army of God. Ichika, Nozomi and Hana are trying to get their hands on it to ensure to be in the good graces of the police. Hina knows where they are (and Ichika suspects she stole them), but refuses to reveal their locations until either Nozomi fight her for real or they find someone stronger than her, leading to the others redoubling efforts to find her strong opponents.
to:
* ''Manga/StarStrikeItRich'': The chemicals weapons that were stolen from the Army of God. Ichika, Nozomi and Hana are trying to get their hands on it to ensure to be in the good graces of the police. Hina knows where they are (and Ichika suspects she stole them), but refuses to reveal their locations location until either Nozomi fight her for real or they find someone stronger than her, leading to the others redoubling efforts to find her strong opponents.
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* ''Manga/StarStrikeItRich'': The chemicals weapons that were stolen from the Army of God. Ichika, Nozomi and Hana are trying to get their hands on it to ensure to be in the good graces of the police. Hina knows where they are (and Ichika suspects she stole them), but refuses to reveal their locations until either Nozomi fight her for real or they find someone stronger than her, leading to the others redoubling efforts to find her strong opponents.
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* Celty's head in ''LightNovel/{{Durarara}}'' is a [=MacGuffin=] that falls in and out of focus, as no one who has it knows quite what to do with it, and Celty herself isn't sure she wants it.
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* Celty's head in ''LightNovel/{{Durarara}}'' ''Literature/{{Durarara}}'' is a [=MacGuffin=] that falls in and out of focus, as no one who has it knows quite what to do with it, and Celty herself isn't sure she wants it.
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** ''Anime/FutariWaPrettyCure'' has the Prism Stones, which are needed to restore the Garden of Light.
to:
** ''Anime/FutariWaPrettyCure'' has the Prism Stones, Stones in the first half, which are needed to restore the Garden of Light.Light. The Cures have two at the start, and the remaining five are all in the possession of one member of the QuirkyMinibossSquad.
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* With the exceptions of ''Anime/FreshPrettyCure'', ''Anime/HeartcatchPrettyCure'' and ''Anime/DokiDokiPrettyCure'', all of the ''Anime/PrettyCure'' series tend to have the girls go after various [=MacGuffins=] of various sizes and states of sentience.
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* With the exceptions of ''Anime/FreshPrettyCure'', ''Anime/HeartcatchPrettyCure'' ''Anime/HeartcatchPrettyCure'', ''Anime/DokiDokiPrecure'', and ''Anime/DokiDokiPrettyCure'', ''Anime/HirogaruSkyPrettyCure'', all of the ''Anime/PrettyCure'' series tend to have the girls go after various [=MacGuffins=] of various sizes and states of sentience.sentience.
** ''Anime/FutariWaPrettyCure'' has the Prism Stones, which are needed to restore the Garden of Light.
** ''Anime/SmilePrecure'' as the Cure Decors (Glitter Charms in the ''Anime/GlitterForce'' cut), which are needed to restore Marchenland.
** ''Anime/DeliciousPartyPrettyCure'' has the Recipepes, which are little food-themed fairies, without which the food in question will become disgusting to eat.
** ''Anime/FutariWaPrettyCure'' has the Prism Stones, which are needed to restore the Garden of Light.
** ''Anime/SmilePrecure'' as the Cure Decors (Glitter Charms in the ''Anime/GlitterForce'' cut), which are needed to restore Marchenland.
** ''Anime/DeliciousPartyPrettyCure'' has the Recipepes, which are little food-themed fairies, without which the food in question will become disgusting to eat.
