In Get Fuzzy, Satchel's dog group is called Canines Against Traffic. Bucky suggests that a better title would be Dogs On Ridiculous Krusades.
Possibly the Atlantic Research of Supernatural Entities Group.
Also, Minks Against Yearly Being Eviscerated - one of the minks wanted to change this not-so-assertive name to MACHO, but as the other mink pointed out, "It doesn't stand for anything!"
A more recent comic has Intelligence Department Institute Of The International Cathood.
Eyebeam had the absurd megacorp TIC — "Three Initial Corporation".
One FoxTrot strip featured a dish called STEAK in the high school cafeteria. The name was an acronym for "Squid Tentacles, Eggplant, And Ketchup."
In another, Jason offers Peter a PB&J. Turns out the "J" in this case stood for jalapenos.
In the mid-1960s, Al Capp's comic strip "Li'l Abner" had Students Wildly Indignant about Nearly Everything, or SWINE, an unsubtle parody of student radical groups.
The Fabulous Furry Freak Brothers once caught the attention of an ultra right-wing paramilitary group calling themselves the Americans Secretly Serving a Higher Order of Law Enforcement and Subservience.
Calvin: Our top-secret club, G.R.O.S.S. — Get Rid Of Slimy girlS! Susie: Slimy girls? Calvin: I know it's redundant, but otherwise it doesn't spell anything.
In another strip when Calvin and Hobbes had a fight, Hobbes threatened to quit the club and start his own. When Calvin said his club wouldn't have a "cool acronym" for a name, Hobbes said he'd call it C.A.D. (For "Calvin's a Dope". This, of course, made Calivin change the name of his club to "Hobbbes is an ugly flea bag" and only made them fight more.)
In the early 1990's, when the World League of American Football (later NFL Europe) was starting, the comic strip Tank Mc Namara showed a group of executives upset that people were calling the league, "What-A-Laugh". One suit suggested changing the name to American World Football League, until he realized that this was just as AWFL.
Dykes To Watch Out For: A hidden one: it is not clear if the Marriage, Order, and Family Organization actually uses its acronym.