In one episode of Sukisho, Sora and Sunao are given drugged tea and awaken alone in a dark, empty hospital. The kidnapping turns out to be the work of two family friends, who took them in for a non-consensual "examination" tied to the plot. While it's a Jerkass thing to do, the horrifying element comes later, when we learn that the boys were brutally experimented on as children in a hospital setting. The dreamlike moment Sora has on the gurney, where he sees Sunao being wheeled away and remembers a child screaming? It dawns that, good intentions or not, Ayano's little secret checkup was a pretty damn cruel stunt to pull, and could have seriously affected two already messed up kids.
Sukisho is notable for having no women depicted at all within the anime. All relationships, pornography, and everything is male-oriented homosexual in nature. Raising the question, what happened to all of the girls?