- The name.
- It's a primer (information given to bring one up to date on what's happening).
- And prime is also used in physics for when a variable changes slightly. Not only does the box send them to a slightly different time, but it's also a slightly different 'them'.
- "Prime" also means "first." Once Abe and Aaron begin working at cross purposes, each is trying to travel back further to get the edge on the other; each is trying to be primer. Their names reflect this too: both are names that can be reasonably expected to be first in an alphabetic list. But as long as it's spelled that way, "Aaron" will always come first.
- One of the major themes of the movie is discoveries often being accidental and unceremonious; the creators mention penicillin as an example of such a major and accidental discovery. Abe and Aaron discover they have a time travel device via a weird pattern of fungus growth, which parallels the discovery of penicillin.